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At least 217 records · Page 12Linked to original sources
PubMed1991

Effects of monitoring under high and low taskload on detection of flashing and coloured radar targets.

While midair collisions between aircraft are extremely rare occurrences, 'near midair' incidents are more common. The present study sought to evaluate the gains in conspicuity that might be realized if flashing or colour were added as redundant cues to indicate the presence of unexpected, non-tracked aircraft entering controlled airspace, and to examine the extent to which increased taskload and fatigue might influence the expected gains. Sixty-four subjects monitored a simulated air traffic control task over a 2 h period for possible conflict situations (their primary task) under either high or low primary taskload conditions. They also monitored for occasional intrusions by light aircraft identifiable on the basis of target shape alone or with colour and/or flashing added as redundant cues. Flashing as a redundant cue was found to be superior to colour in all aspects tested; unlike colour, detection of flashing targets was unaffected by screen location and by changes in primary taskload. Flashing was also least affected by monitoring fatigue. It was concluded that the superiority of flashing over colour in attracting attention to objects in a display must be weighed against its possible potential for distraction. A practical means of accomplishing this in operational situations is through the use of touch sensitive displays to both acknowledge/confirm target location and to deactivate flashing.

Accidents, Aviation↗
PubMedDate not supplied

Non-invasive estimation of arterial blood pH using exhaled CO/CO2 analyser, microwave radar and infrared thermography for patients after massive haemorrhage.

In order to conduct non-contact estimation of arterial blood pH after massive haemorrhage, we calculated the arterial pH based on linear-regression analysis of exhaled gas concentrations (CO and CO2) and vital signs (heart rate, respiratory rate, and surface temperature) measured using non-contact methods in hypovolemic animals.

Acidosis↗
PubMed2005

A randomized controlled trial to evaluate antiretroviral salvage therapy guided by rules-based or phenotype-driven HIV-1 genotypic drug-resistance interpretation with or without concentration-controlled intervention: the Resistance and Dosage Adapted Regimens (RADAR) study.

BACKGROUND: It is not well defined whether concentration-controlled intervention (CCI) and rules-based human immunodeficiency virus (HIV) type 1 genotype drug-resistance interpretation (GI) or virtual phenotype drug-resistance interpretation (VPI) may improve the outcome of HIV salvage therapy. METHODS: In a prospective, randomized, controlled trial, patients were randomized (on a factorial basis) to change treatment after either GI or VPI, and they then were further randomized to the control arm (no CCI) or the CCI arm. Protease inhibitor (PI) and nonnucleoside reverse-transcriptase inhibitor (NNRTI) trough concentration (Ctrough) values were determined at weeks 1, 4, 12, and 24 of the study. RESULTS: Among 230 patients, virological benefit (defined by an HIV RNA load of <400 copies/mL at week 24) was not statistically different, either between patients in the GI and VPI arms or between patients in the CCI and control arms. A virological benefit was found for patients in the CCI arm, compared with patients in the control arm, but this benefit was not statistically significant (56.8% vs. 64.3% at week 4 and 63.6% vs. 74% at week 12). Dosage adaptation was possible for only a fraction of patients, because of low rates of treatment adherence or patient refusal to increase dosages. In the logistic regression analysis, independent predictors of virological response at week 24 were a PI Ctrough value and/or an NNRTI Ctrough value in the higher quartiles (or above cutoff levels) and a low number of PIs previously received. Moreover, receipt of a regimen that contained PIs boosted with ritonavir was an independent predictor of virological response. CONCLUSIONS: The present study did not support the routine use of CCI for patients undergoing salvage treatment, probably as a result of existing difficulties associated with its clinical application. However, a higher Ctrough value appeared to be correlated with treatment response. No major differences were found between VPI or GI when they are used together with expert advice for the selection of salvage treatment combinations.

Adult↗