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Results for “RODENT DISEASES”

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At least 217 records · Page 12Linked to original sources
PubMed1998

Rodent models of cardiopulmonary disease: their potential applicability in studies of air pollutant susceptibility.

The mechanisms by which increased mortality and morbidity occur in individuals with preexistent cardiopulmonary disease following acute episodes of air pollution are unknown. Studies involving air pollution effects on animal models of human cardiopulmonary diseases are both infrequent and difficult to interpret. Such models are, however, extensively used in studies of disease pathogenesis. Primarily they comprise those developed by genetic, pharmacologic, or surgical manipulations of the cardiopulmonary system. This review attempts a comprehensive description of rodent cardiopulmonary disease models in the context of their potential application to susceptibility studies of air pollutants regardless of whether the models have been previously used for such studies. The pulmonary disease models include bronchitis, emphysema, asthma/allergy, chronic obstructive pulmonary disease, interstitial fibrosis, and infection. The models of systemic hypertension and congestive heart failure include: those derived by genetics (spontaneously hypertensive, Dahl S. renin transgenic, and other rodent models); congestive heart failure models derived by surgical manipulations; viral myocarditis; and cardiomyopathy induced by adriamycin. The characteristic pathogenic features critical to understanding the susceptibility to inhaled toxicants are described. It is anticipated that this review will provide a ready reference for the selection of appropriate rodent models of cardiopulmonary diseases and identify not only their pathobiologic similarities and/or differences to humans but also their potential usefulness in susceptibility studies.

Air Pollutants↗
PubMed2007

Cytologic diagnosis of diseases of rabbits, guinea pigs, and rodents.

This article reviews the diseases most amenable to cytologic diagnosis in clinical small mammal practice. Diseases of pet rabbits, guinea pigs, rodents, chinchillas, sugar gliders, and hedgehogs are addressed. The small size of these patients, risk of anesthesia and invasive surgery, and cost factors make small mammals ideal patients for cytologic evaluation when applicable; however, surprisingly few reports exist in the literature, and no other reviews of cytology in these species exist. Much of the data in this article is derived from case submissions to Northwest ZooPath, and disease presentations that seem to be common in this group of animals are emphasized. Diseases of the skin are particularly well represented, especially tumors and inflammatory processes.

Animals↗