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PubMed1996

[Effectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension type].

The effect of a locally applied peppermint oil preparation on tension-type headache was examined in the design of a randomized, placebo-controlled double-blind crossover study for the first time. The preparation was tested against both the reference substance acetaminophen and to the corresponding placebo. The liquid test preparation contained 10 g of peppermint oil and ethanol (90%) ad 100 (test preparation LI 170, Lichtwer Pharma, Berlin); the placebo was a 90% ethanol solution to which traces of peppermint oil were added for blinding purposes. The reference preparation contained 500 mg acetaminophen; the placebo tablet was identical to the verum in size and appearance. The study included the analysis of 164 headache attacks of 41 patients of both sexes ranging between 18 and 65 years of age, suffering from tension-type headache in accordance with the IHS classification. Four headache episodes per patient were treated in a double-blind, randomized crossover design. Each headache attack was treated by the application of 2 capsules of the oral medication (1,000 mg of acetaminophen or placebo) and the cutaneous application of the oil preparation (peppermint oil or placebo solution). The oil was spread largely across forehead and temples which was repeated after 15 and 30 minutes. Using a headache diary, the headache parameters were assessed after 15, 30, 45 and 60 minutes. Compared to the application of placebo, a 10% peppermint oil in ethanol solution significantly reduced the clinical headache intensity already after 15 minutes (p < 0.01). This significant clinical reduction of the pain intensity continued over the one hour observation period. Acetaminophen, too, proved to be efficient compared to placebo (p < 0.01). There was no significant difference between the efficacy of 1,000 mg of acetaminophen and 10% peppermint oil in ethanol solution. Simultaneous application of 1,000 mg of acetaminophen and 10% peppermint oil in ethanol solution leads to an additive effect which remains below the significance threshold, however. The patients reported no adverse events. This controlled study showed for the first time that a 10% peppermint oil in ethanol solution efficiently alleviates tension-type headache. Peppermint oil thus proves to be a well-tolerated and cost-effective alternative to usual therapies.

Acetaminophen↗
PubMed2005

Sleep changes vary by odor perception in young adults.

Peppermint, a stimulating odor, increases alertness while awake and therefore may inhibit sleep. This study examined peppermint's effects on polysomnographic (PSG) sleep, alertness, and mood when presented before bedtime. Twenty-one healthy sleepers (mean age +/- S.D., 20.1 +/- 2.0 years) completed three consecutive laboratory sessions (adaptation, control, and stimulus nights). Peppermint reduced fatigue and improved mood and was rated as more pleasant, intense, stimulating, and elating than water. These perceptual qualities associated with sleep measures: subjects rating peppermint as very intense had more total sleep than those rating it as moderately intense, and also showed more slow-wave sleep (SWS) in the peppermint than control session. Furthermore, subjects who found peppermint stimulating showed more NREM and less REM sleep while those rating it as sedating took longer to reach SWS. Peppermint did not affect PSG sleep, however, when these perceptual qualities were not considered. Peppermint also produced gender-differentiated responses: it increased NREM sleep in women, but not men, and alertness in men, but not women, compared with the control. Thus, psychological factors, including individual differences in odor perception play an important role in physiological sleep and self-rated mood and alertness changes.

Adolescent↗
PubMed1987

Single-unit analysis of postnatal olfactory learning: modified olfactory bulb output response patterns to learned attractive odors.

Neonatal rats learn to approach odors associated with stimulation normally provided by their mother. The present report describes changes in olfactory bulb single-unit activity following olfactory learning in young rats. Rat pups were exposed from postnatal day 1 to 18 to either (1) peppermint-scented air while receiving tactile stimulation (Pepp-Stroked), (2) peppermint-scented air with no tactile stimulation (Pepp-Only), (3) clean air and tactile stimulation (Stroked-Only), or (4) clean air and no tactile stimulation (Naive). On day 19, single-unit activity was recorded from mitral/tufted cells in urethane-anesthetized, freely breathing pups in response to either peppermint or a novel orange odor. Mitral/tufted cell response patterns to peppermint were significantly altered in Pepp-Stroked animals compared to control pups. Peppermint exposure alone, not associated with tactile stimulation (Pepp-Only), did not affect subsequent single-cell response patterns to that odor. In addition, the modification of response patterns was specific to peppermint and was not associated with a change in respiration rate. Furthermore, Pepp-Stroked pups had a relative behavioral preference for peppermint on day 19 compared to control pups. These results demonstrate that postnatal olfactory learning selectively modifies the subsequent response patterns of olfactory bulb output cells to the attractive odor. Furthermore, these results indicate that the initial coding of an odor's attractive value occurs within the olfactory bulb.

Animals↗
PubMed1983

Establishing an "affective scale" for odor preferences of infant rats.

To establish an "affective scale" for odor preferences, the scale must indicate aversion as well as attraction to odors. Because the construction of preference scales requires repeated tests with a set of odors, and because exposure to aversive odors may lead to a reduction in the aversiveness of these odors, the effects of repeated exposure to an aversive odor (peppermint) on preferences for this odor were examined. Eighteen-day-old Long-Evans rats were given three preference tests using all pairs of three odors: unscented pine shavings (N), own maternal odors (M), and peppermint odors (P). Before these tests rats were exposed to the test arena and unscented pine shavings or peppermint odor for 0, 1, or 4 days. All rats showed an attraction to their maternal odor and an aversion to peppermint odor, showing the preference scale M greater than N greater than P. Preexposure to peppermint in the test apparatus only slightly reduced the aversion to peppermint odor. The results indicate that scaling procedures will accurately detect odor aversions as well as attractions and that the preference scales are only slightly altered by repeated exposure to odors during the testing period.

Affect↗
PubMed1998

An ex vivo investigation into the effects of chemical solvents on the debond behaviour of ceramic orthodontic brackets.

The problems of ceramic bracket debond have been well documented. A peppermint oil material has been marketed previously as a debonding agent. This study assessed ex vivo the effects of peppermint oil application on the debond behaviour of ceramic brackets compared with ethanol and acetone which are recognized softening agents. Intrigue brackets were bonded to 100 extracted premolar teeth. Groups of 20 bonded teeth were then placed in a test solution, control (distilled water), peppermint oil (5 minutes and 1 hour), acetone (1 hour), and ethanol (1 hour). The teeth were debonded using an Instron. Universal Testing Machine and debond forces recorded. The site of bond failure along with the adhesive remnant index was recorded for each tooth. One hour placement in peppermint oil produced the lowest mean and maximal debond forces (77 and 114 N, respectively). Weibull analysis showed that the probability of failure at 100 N was increased for the 1-hour peppermint group at 88 per cent compared with 52 per cent for the control. Placement in peppermint oil produced the lowest levels of retained resin. There was no evidence of enamel fracture with any of the groups, but bracket fracture remained a problem.

Acetone↗
PubMed1986

Odor specificity of the enhanced neural response following early odor experience in rats.

The enhanced neural response in the olfactory bulbs of rat pups following early olfactory experience is specific to the familiar odor. Pups were exposed daily to either peppermint or cyclohexanone odor for the first 18 postnatal days. On day 19, peppermint-familiar pups exposed to peppermint had significantly higher [14C]2-deoxyglucose (2-DG) uptake in a focal glomerular area compared with the response to peppermint by cyclohexanone-familiar pups. We also found that cyclohexanone-experienced pups had a subsequent enhanced response to cyclohexanone odor in glomerular areas medial and caudal to those responding to peppermint. None of the 2-DG uptake differences were attributable to respiration differences between the groups during any part of the odor test.

Animals↗
PubMed1980

Establishment and maintenance of preference for natural and artificial olfactory stimuli in juvenile rats.

The role of sensory-affective bias and of two types of experience (simple exposure to an odor and exposure to an odor in association with conspecifics) in the establishment and maintenance of preference of rat pups for odorants was investigated. (a) Simple exposure of pups to a mildly aversive odorant (peppermint extract) from birth to 21 days of age was sufficient to establish a preference for that odorant in 21-day-olds as strong as their normal preference for maternal excreta. (b) Simple exposure of pups to peppermint extract for 33 days following birth was not sufficient to maintain preference for peppermint extract to 33 days of age. (c) Exposure of pups to peppermint extract painted on the dam for 33 days following birth was sufficient to maintain pup preference for peppermint extract to 33 days of age. (d) Pups reared artificially with very limited contact with conspecificies, exhibited robust preferences for conspecific odors. Taken together, the data suggest that a variety of mechanisms play complementary roles in the development and maintenance of preference for olfactory stimuli.

Age Factors↗
PubMed2006

Contextual olfactory learning in cockroaches.

We investigated the capability of context-dependent olfactory learning in cockroaches. One group of cockroaches received training to associate peppermint odor (conditioning stimulus) with sucrose solution (appetitive unconditioned stimulus) and vanilla odor with saline solution under illumination and to associate peppermint with aversive unconditioned stimulus and vanilla with appetitive unconditioned stimulus in the dark. Another group received training with the opposite stimulus arrangement. Before training, both groups exhibited preference for vanilla over peppermint. After training, the former group preferred peppermint over vanilla under illumination but preferred vanilla over peppermint in the dark, and the latter group exhibited the opposite odor preference. We conclude that cockroaches are capable of disambiguating the meaning of conditioning stimuli according to visual context.

Animals↗
PubMed1993

Serotonergic influence on olfactory learning in the neonate rat.

The role of the serotonergic innervation of the olfactory bulb was examined in neonate rat pups (Sprague-Dawley) by utilizing an olfactory learning paradigm (Sullivan, McGaugh, & Leon, 1991; Sullivan, Wilson, & Leon, 1989). One hundred fifty nanoliters of the neurotoxin 5,7-dihydroxytryptamine (5,7-dHT, 10 micrograms/microliters) was injected into each anterior olfactory nucleus of Postnatal Day 2 (PND 2) pups in order to selectively deplete the serotonergic (5-HT) innervation of the olfactory bulb. On PND 8, control, sham-operated, or 5-HT-depleted pups were presented with stroke (unconditioned stimulus) paired with peppermint odor (conditioned stimulus) or were presented with peppermint alone. Other pups remained naive, i.e., they were not presented with either stroke or odor. The following day, the pups were placed on a mesh screen above two boxes containing either fresh bedding or bedding with peppermint odor for five 1-min trials. Control and sham-operated pups that were previously trained by the odor/stroke paradigm spent significantly more time over the peppermint odor than similarly trained 5-HT-depleted pups, pups trained using the odor only paradigm, or naive pups. Immunocytochemistry verified that the 5,7-dHT injections specifically depleted the 5-HT innervation of the olfactory bulb and left the 5-HT innervation of more caudal levels of the neuraxis (e.g., piriform cortex) intact. The locomotor behavior of the pups was not affected by the 5-HT depletions. This study is the initial investigation to suggest that 5-HT innervation to the olfactory bulb is important in the acquisition or expression of olfactory-based learned behavior in the neonate rat.

5,7-Dihydroxytryptamine↗
PubMedDate not supplied

Experimentally induced glucose intolerance increases oral ethanol intake in rats.

A number of studies have shown a relationship between glucose tolerance and ethanol intake. The present study uses a relatively simple procedure to induce glucose intolerance to test whether this condition is sufficient to produce an increase in chronic ethanol intake in male rats. Subjects were divided equally into four groups where they were given access to one of four solutions: peppermint-flavored sucrose (40%), peppermint-flavored saccharin (0.1%), peppermint in water (0.1%), or water alone presented three times a week, for a period of 11 weeks. After 12 weeks all animals were subjected to an oral glucose tolerance test which revealed that the chronically prepared sucrose animals had become glucose intolerant. At the start of week 13 all animals were given access to a 6% ethanol solution flavored with peppermint in place of the previous solutions for a period of 11 weeks. Sucrose animals displayed an immediate preference for ethanol and consumed approximately three times more ethanol than the remaining groups. The results of this study indicate that rats that are made glucose intolerant by long term access to a high concentration of sucrose, when given the opportunity, will subsequently choose to drink more ethanol than control animals.

Alcohol Drinking↗
PubMed2006

Antimicrobial and antiplasmid activities of essential oils.

The antimicrobial and antiplasmid activities of essential oils (orange oil, eucalyptus oil, fennel oil, geranium oil, juniper oil, peppermint oil, rosemary oil, purified turpentine oil, thyme oil, Australian tea tree oil) and of menthol, the main component of peppermint oil, were investigated. The antimicrobial activities were determined on the Gram (+) Staphylococcus epidermidis and the Gram (-) Escherichia coli F'lac K12 LE140, and on two yeast Saccharomyces cerevisiae 0425 delta/1 and 0425 52C strains. The antiplasmid activities were investigated on E. coli F'lac bacterial strain. Each of the oils exhibited antimicrobial activity and three of them antiplasmid action. The interaction of peppermint oil and menthol with the antibiotics was studied on the same bacterial strain with the checkerboard method. Peppermint oil and menthol displayed additive synergy with oxytetracycline. A new mechanism of plasmid curing was established for one of the oil components.

Anti-Bacterial Agents↗
PubMed2000

A single amino acid substitution (F363I) converts the regiochemistry of the spearmint (-)-limonene hydroxylase from a C6- to a C3-hydroxylase.

The essential oils of peppermint and spearmint are distinguished by the position of oxygenation on the constituent p-menthane monoterpenes. Peppermint produces monoterpenes bearing an oxygen at C3, whereas spearmint produces monoterpenes bearing an oxygen at C6. Branching of the monoterpene biosynthetic pathways in these species is determined by two distinct cytochrome P450s that catalyze the regiospecific hydroxylation of (-)-4S-limonene at C3 or C6 exclusively. cDNAs encoding the limonene-3-hydroxylase from peppermint and the limonene-6-hydroxylase from spearmint have been isolated, shown to be 70% identical at the amino acid level, and functionally expressed. A combination of domain swapping and reciprocal site-directed mutagenesis between these two enzymes demonstrated that the exchange of a single residue (F363I) in the spearmint limonene-6-hydroxylase led to complete conversion to the regiospecificity and catalytic efficiency of the peppermint limonene-3-hydroxylase.

Amino Acid Sequence↗