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At least 217 records · Page 12Linked to original sources
PubMed1990

Conditioned taste aversion is disrupted by prolonged retrograde effects of intracerebral injection of tetrodotoxin in rats.

Acquisition of conditioned taste aversion (CTA) is disrupted when 10 ng tetrodotoxin (TTX) is injected into both parabrachial nuclei of rats immediately after saccharin drinking and before LiCl poisoning (Ivanova & Bures, in press). Further analysis of this finding showed that parabrachial TTX injection (a) elicited retrograde amnesia also when applied 1, 2, or 4 days but not 8 days after CTA acquisition; (b) did not abolish CTA produced by 2 or 3 saccharin-LiCl pairings; (c) did not cause persistent increase of quinine threshold; and (d) elicited anterograde CTA amnesia when applied 1 but not 2, 4, or 8 days before CTA acquisition. TTX-induced amnesia is not due to persistent gustatory agnosia but rather to disruption of the protracted consolidation of the permanent CTA engram by prolonged cessation of impulse activity in the information storing network.

Animals↗
PubMed1985

Serial ablations of the telencephalon and avoidance learning by goldfish (Carassius auratus).

Simultaneous bilateral ablation of the teleost telencephalon was confirmed to dramatically impair the retention, extinction, and "reversal learning" of a preoperatively learned instrumental avoidance response in a shuttle box. The focus of the experiment was on whether two-stage serial unilateral ablations of the teleost telencephalon would ameliorate the effects seen following one-stage bilateral ablation and whether such amelioration would be a function of the fish's experiences between the staged ablations. The degree of retention, relearning, and extinction of the avoidance response was not modulated by the serial ablation procedure whether or not there was interoperation retraining experience. However, reversal learning, in which the previous warning signal became the safety signal and the previous safety signal became the new warning signal, was less impaired following serial ablations than following single-stage bilateral ablation. These results are contrasted with those from experiments with mammalian subjects.

Animals↗
PubMed1991

Age, activity, and physical performance: an evaluation of performance models.

Two performance models relating age, physical activity, and physical performance were evaluated on 5 age cohorts involving more than 6,000 persons ranging in age from 20 to 69 years. Significant age and activity main effects, without 1 Age X Activity interaction, were obtained on 5 fitness measures and 2 activity indexes. These results are inconsistent with predictions from the moderation model, but they fit predictions from a recently formulated tonic and overpractice model of physical performance.

Activities of Daily Living↗