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At least 217 records · Page 12Linked to original sources
PubMed2004

[Ossifying fibroma in nasal cavity and paranasal sinus (with 9 cases reported)].

OBJECTIVE: To improve the clinical diagnosis and treatment of ossifying fibroma in nasal cavity and paranasal sinus. METHOD: The data of 9 cases with ossifying fibroma in nasal cavity and paranasal sinus were analyzed retrospectively and the relative literatures were reviewed. RESULT: Two cases recurred after operation eight to nine months later and had to receive the second operation but the other 7 cases cured without complications. CONCLUSION: Ossifying fibroma in nasal cavity and paranasal sinus was found mainly in juveniles and was a benign tumor with local aggression. Clinical diagnosis was established by the clinical representation, epecially CT scanning. Complete excision of the lesions was the only curing treatment. It is easy to make a proper diagnosis with understanding of the disease characteristic. Prognosis is good after surgical excision.

Adolescent↗
PubMedDate not supplied

[Primary malignant melanoma of the nasal cavity].

We report a case of primary malignant melanoma of the nasal cavity in an adult white man, 69 years old, who appeared with recurrent epistaxis of several months duration. Inspection of the nasal cavity revealed a greyish polypoid tumor in the right fossa close to the septum.

Aged↗
PubMed1987

Chondrogenic neoplasms of the nasal cavity.

Chondrogenic neoplasms of the nasal cavity are rare. Clinically, presentation is often late, with expansion and destruction of the middle facial skeleton. Local radical surgical excision is the preferred treatment, with regular life-long follow-up. Risk of local recurrence and distant metastases may occur many years after initial treatment. All chondrogenic tumours should be carefully followed up because the natural course of the disease may not match the histological differentiation.

Adult↗
PubMed2004

The nervous supply to the nasal cavity of the Bactrian camel (Camelus bactrianus).

The Bactrian camel is an important domestic animal in some of the desert and semi-desert areas of the world. However, there is no detailed report about the nervous supply to the nasal cavity of the Bactrian camel. In the present study, seven heads of adult Bactrian camels were collected and the nerve distribution in the nasal cavity was dissected grossly. The results demonstrated that the nerves supplying to the nasal cavity included the olfactory nerve, the ethmoidal nerve from the ophthalmic nerve, and the caudal nerve from the maxillary nerve. The general patterns of nervous distribution in the nasal cavity of the Bactrian camel corresponded with those of other domestic animals. However, the terminal nerve was not observed by this gross anatomical method in the Bactrian camel.

Animals↗
PubMed2002

[Pleomorphic adenoma of the nasal cavity: a case arising from the wall of the maxillary sinus].

INTRODUCTION: Pleomorphic adenoma is a common and benign tumour, originating from sero-mucous glands. Location in the nasal cavity and particularly on the medial wall of the maxillary sinus is very rare. PATIENTS AND METHODS: One patient with a pleomorphic adenoma of the nasal cavity and a review of literature are reported in order to describe the diagnostic and therapeutic management of this tumour. RESULTS: A 63-year-old woman was referred to our institution for evaluation of an unilateral nasal tumour. Clinical and radiological studies revealed an intra-nasal tumour, slightly lytic in nature, arising from the mucosa of the medial wall of the maxillary sinus. More than 2 years after complete excision of the tumour using an endoscopic procedure, the nasal cavity was free of tumour. DISCUSSION: Pleomorphic adenoma of the nasal cavity is a rare and benign tumour, usually presenting as a unilateral nasal tumour. Prognosis of this tumour is mainly linked to recurrences in cases of incomplete resection and to possible metastasis, such as an eventual malignant evolution. The gold standard treatment is complete surgical resection. After a complete imaging study for patient selection (CT scan and MRI), endonasal endoscopic surgery seems to be a reliable therapeutic treatment. CONCLUSION: Intra-nasal pleomorphic adenoma originates from nasal seromucous glands. Radiological study reveals a slightly lytic tumour developed from the septum of the medial wall of the maxillary sinus. Resecton can be performed with endoscopic endonasal surgery as long as the orbital bony framework and the ethmoidal roof are free of tumour. Whatever technique is employed, long term follow-up has to be used to detect any recurrence.

Adenoma, Pleomorphic↗
PubMed1994

Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the dissociation of the drug.

We aimed to clarify the relationship between drug dissociation (sulphisomidine) and its direct transport from the nasal cavity to the cerebrospinal fluid (CSF). Rat nasal cavities were perfused in a single pass system with buffers (pH 5.5, 6.5, 7.4, 8.7 and 9.4). Plasma and CSF were collected and the concentration of sulphisomidine was measured. Nasal clearance increased with the increase in the un-ionized fraction of the drug. The ratio of the drug concentration in CSF to that in the nasal perfusion fluid (the index of the degree of the drug transport from the nasal cavity to CSF), was changed in accordance with the un-ionized fraction of drug. These results show that both the nasal absorption and the drug transport conform to the pH partition theory.

Absorption↗
PubMed1980

Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses.

International incidence and mortality data for ICD rubric 160 (nose and nasal cavities, middle ear and accessory sinuses) are reviewed, the relative frequency data for cancer for each of the constituent anatomical locations presented and the histological types of neoplasms encountered tabulated to determine if geographical differences exist which might be worth further investigation. Relatively high rates for this generally rare disease were found in Asian and African populations, the highest age-adjusted rates, between 2.6 and 2.5 per 100,000 per annum, occurring in Japanese males. Independent of the higher rates, the extremely low proportion of cancers of the nose and nasal cavities together with the very high proportion of cancer of the maxillary sinus in Japan are in contrast with a much higher relative frequency of nose and nasal cavity cancer in other countries. These findings seem to justify further studies of these tumours in this country, particularly as none of the known aetiological factors reviewed in this paper explain the high rates for this cancer in Japan.

Adult↗
PubMed2005

A novel population of neuronal cells expressing the olfactory marker protein (OMP) in the anterior/dorsal region of the nasal cavity.

The olfactory marker protein (OMP) is expressed in mature chemosensory neurons in the nasal neuroepithelium. Here, we report the identification of a novel population of OMP-expressing neurons located bilaterally in the anterior/dorsal region of each nasal cavity at the septum. These cells are clearly separated from the regio olfactoria, harboring the olfactory sensory neurons. During mouse development, the arrangement of the anterior OMP-cells undergoes considerable change. They appear at about stage E13 and are localized in the nasal epithelium during early stages; by epithelial budding, ganglion-shaped clusters are formed in the mesenchyme during the perinatal phase, and a filiform layer directly underneath the nasal epithelium is established in adults. The anterior OMP-cells extend long axonal processes which form bundles and project towards the brain. The data suggest that the newly discovered group of OMP-cells in the anterior region of the nasal cavity may serve a distinct sensory function.

Animals↗
PubMed1991

Nasal cavity enzymes involved in xenobiotic metabolism: effects on the toxicity of inhalants.

A decade ago, the ability of nasal tissues to metabolize inhalants was only dimly suspected. Since then, the metabolic capacities of nasal cavity tissues has been extensively investigated in mammals, including man. Aldehyde dehydrogenases, cytochrome P-450-dependent monooxygenases, rhodanese, glutathione transferases, epoxide hydrolases, flavin-containing monooxygenases, and carboxyl esterases have all been reported to occur in substantial amounts in the nasal cavity. The contributions of these enzyme activities to the induction of toxic effects from inhalants such as benzo-a-pyrene, acetaminophen, formaldehyde, cocaine, dimethylnitrosamine, ferrocene, and 3-trifluoromethylpyridine have been the subject of dozens of reports. In addition, the influence of these enzyme activities on olfaction and their contribution to vapor uptake is beginning to receive attention from the research community. Research in the next decade promises to provide answers to the many still unanswered questions posed by the presence of the substantial xenobiotic metabolizing capacity of the nasal cavity.

Administration, Inhalation↗
PubMedDate not supplied

Computed tomography of the normal feline nasal cavity and paranasal sinuses.

Computed tomography (CT) images of the feline nasal cavity and paranasal sinuses were acquired from normal adult cats. Good resolution and anatomic detail were obtained from the CT images using soft tissue formatting. A description of normal feline nasal cavity and paranasal sinus anatomy using CT is presented.

Animals↗
PubMed1982

Regional variation in respiratory epithelium of the nasal cavity of the bandicoot (Isoodon macrourus).

The non-olfactory ciliated epithelium of the nasal cavity was investigated in the bandicoot (Isoodon macrourus), a small ground-dwelling marsupial. Two distinct epithelial types were identified and designated conchal and septal. Conchal epithelium is non-secretory. It covers most of the naso- and maxilloturbinates, the lateral nasal wall, and part of the maxillary sinus. Septal epithelium contains mucus-secreting goblet cells. Rostrally, it covers the nasal septum and mid-ventral floor of the nasal cavity. Further caudally it lies on the ventral part of the septum and ventrally facing parts of naso- and ethmoturbinates. It corresponds closely to most published descriptions of respiratory epithelium. Ciliated and basal cells are common to both types. Conchal epithelium has a nonciliated domed cell with a rounded surface projecting into the ciliary border. This epithelium has a rich innervation and axon terminals are frequent almost to the cell surface. Septal epithelium contains goblet cells whose appearance varies according to secretory activity, and two rarer cells of unknown function, brush and pale cells, which are also seen in the olfactory epithelium of the bandicoot.

Animals↗
PubMed2000

Epithelial-myoepithelial carcinoma of the nasal cavity.

A 22-year-old male presented with a 1-year history of nasal obstruction due to a polypoid mass in the right nasal cavity. Histopathologic examination revealed the tumor to consist of a mixture of a trabecular structure with a double-layered arrangement of inner dark cells and outer clear cells. Immunohistochemical examination showed the clear cells to be positive for alpha-smooth muscle actin and S-100 protein. Ultrastructural examination confirmed the myoepithelial cell origin. The tumor was excised and no recurrence or metastasis was found 40 months after surgery. We describe here a rare case of epithelial-myoepithelial carcinoma arising from the nasal cavity, one of the most unusual locations.

Actins↗
PubMed1997

Oncocytoma of the nasal cavity: report of a case and review of the literature.

The authors present a case of oncocytoma of the nasal cavity in a 60-year-old woman. The tumour shows the same histological and ultrastructural characteristics of oncocytomas arising in minor salivary glands of other sites and major salivary glands. The authors stress that the biological behaviour of oncocytomas of the nasal cavity seems related to their local growth rather than to the cytological characteristics of the tumour. The extreme rarity of this tumour in the nasal cavity is particularly emphasized. The few cases reported previously in literature are briefly reviewed.

Adenoma, Oxyphilic↗
PubMed1980

Primary meningioma of the nasal cavity and paranasal sinuses.

A case of primary meningioma of the nasal cavity and ethmoidal sinus of a 65-year-old man is described. The clinical and pathologic characteristics of the 18 cases previously reported in the literature are reviewed. Although the histological features and biological behavior of the tumors were found to be similar to that of intracranial meningioma, primary meningiomas of the nasal cavity and paranasal sinuses were found more often to involve male patients and young individuals. Meningiomas should be considered in the differential diagnosis of any lesion in a young patient with progressive exophthalmos, nasal obstruction, or episodes of epistaxis. The pathogenesis of extracranial meningiomas is briefly discussed.

Age Factors↗
PubMed1996

[Radiation treatment in the carcinoma of paranasal sinuses and nasal cavity].

The authors evaluate 32 patients affected by paranasal sinuses and nasal cavity carcinoma observed at Orl-Rt Department of Oncologic Center at Umberto l(zero) Hospital in Mestre (VE), Italy from 1985 to 1994. Among these: 16 maxillary sinus, 10 ethmoid and 6 nasal cavity carcinomas. Histologic diagnosis showed squamous cell carcinoma in 15 cases, adenocarcinoma in 8 cases, lymphoma in 2 cases, transitional cell carcinoma in 2 cases, undifferentiated carcinoma in 2 cases and adenoidocistic carcinoma in 3 cases. The mean age was 64.5 years (range 46-88 years), and mean performance status was 80 (range 60-90). Four patients had lymphonodal involvement. Eleven patients were operated, eight of them radically. All patients were treated with radiation therapy. Treatment planning was performed using Theraplan V05-B program, on extensive number of CT scans. The minimal tumor dose was 50 Gy for patients operated radically and was 60 Gy with maximum of 73-80 Gy for the others. The follow-up is 39.7 months (range 10-108). Three patients treated with radical surgery developed local relapses, two of them died. Fourteen patients treated with non radical or diagnostic surgery and radiotherapy obtained local complete remission, five of them developed local relapses inside treatment volume. Ten patients died (eight for neoplastic disease). The 3 years, 5-years and 7-years overall survival are respectively 72% and 51%. The 5-years and 7-years disease free survival rate are respectively 48% and 19% with median at 3.7 years. Complication have been minimal. Only one patient affected by glaucoma had a severe and permanent reduction of the virus. The authors conclude that 2D and 3D treatment planning can assure a better accuracy for target definition and a better precision of the treatment with a reduction of complications.

Aged↗
PubMed2003

[Pleomorphic adenomas of the nasal cavity].

The authors presents three cases of pleomorphic adenoma of the nasal cavity treated in the ENT Department, Medical University of Gdańsk in years 1974-2002. That material was also extended in analysis of fourth case treated in our Department and described earlier. In that group were three men and one woman in age of 31-62 years. The most common symptoms were unilateral nasal obstruction, headache or feel of expansion in the nose lasted from 3 months to 10 years. In three cases the tumor was localized in the nasal septum and in one case on the lower nasal concha. All cases were treated surgically--in three cases the lateral rhinotomy was performed and in one case--subperichondral excision of the tumor. In none of cases the recurrence was observed. The authors reviewed polish references and found four cases of these tumor localized in the nasal cavity. This material extended of our cases served to the attempt of epidemiological-clinical evaluation of these tumors.

Adenoma, Pleomorphic↗
PubMed2003

A case of an inverted tooth in the nasal cavity.

We report a case of an inverted tooth in the nasal cavity. The patient was a 27-year-old man who attended our hospital in May 1998, complaining of left cheek-pain. There was nothing remarkable in his medical or family history. Fiberscopic (intranasal) and radiological examinations revealed a white foreign body in the left nasal cavity, within 2 cm of the left nostril. This foreign body was diagnosed as an inverted tooth. It was removed under general anesthesia and found to be 17 mm in length. Although the tooth showed a single root, it possessed two cusps and we deduced it to be a molar.

Adult↗
PubMed1989

Malignant lymphomas of the nasal cavity and paranasal sinuses.

The incidence of malignant lymphomas in the nasal cavity and paranasal sinuses was found to be 0.17% of all malignant lymphomas and 0.44% of all extranodal malignant lymphomas registered in the Kiel Lymph Node Registry from 1972 to 1987. Fifty-nine cases of malignant lymphoma presenting in the nasal cavity and paranasal sinuses were investigated with morphological and immunological methods. The median age of the patients was 64.5 years, with a female predominance (m:f = 0.87:1). In the 59 cases a marked preponderance of B-cell lymphomas was found (centroblastic n = 15, immunoblastic n = 8, Burkitt's lymphoma n = 6, Immunocytoma n = 3, centrocytic n = 1, centroblastic/centrocytic n = 1, plasmacytic n = 11); only a small number (n = 5) was of T-cell lineage (pleomorphic types). Nine further cases could not be assigned with certainty to either the T or B cell system. Angiocentricity with infiltration and destruction of vessel walls by tumour cells was demonstrated only in the T-cell lymphomas; the B-cell lymphomas, in contrast, often surrounded and compressed blood vessels with intact endothelium. No similarity to malignant lymphomas of mucosa associated lymphoid tissue, such as those in the gastrointestinal tract, was detected.

B-Lymphocytes↗