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At least 217 records · Page 12Linked to original sources
PubMed1979

Work capacity, contractile protein and quantitative electromyogram (EMG) changes following exercise or nandrolone decanoate treatment in experimentally induced muscle disuse atrophy in rats.

Anabolic steroid administration and planned exercise have been the two main methods applied to improve the function and morphology of atrophied muscle tissue. The effects of these two factors-specifically nandrolone decanoate administration and exercise by swimming on muscle weight, EMG activity, work capacity and on contractile protein content of rat gastrocnemius muscle, following experimentally induced atrophy by immobilization, were investigated. The results appear to support the conclusion that although both types of treatment obtain significant positive results exercise acts more effectively than the anabolic steroid in this respect.

Actomyosin↗
PubMed1985

Metabolism and receptor binding of nandrolone and testosterone under in vitro and in vivo conditions.

The metabolism and receptor binding of nandrolone (N) and testosterone (T) were studied under in vitro and in vivo conditions. The results of both in vitro incubation studes with 3H-N and 3H-T in tissue homogenates from rats and in vivo infusion studies with 3H-N and 3H-T in conscious rats show the importance of the enzymes 5 alpha-reductase and 3 alpha/beta-hydroxysteroid-oxidoreductases in the prostate and the importance of the enzyme 17 beta-hydroxysteroid dehydrogenase in the kidney for the effects of N and T on these tissues. Following infusion of a combined dose of 3H-N and 3H-T there is a preferential retention at the receptor of 5 alpha-dihydrotestosterone (DHT) over 5 alpha-dihydronandrolone (DHN), N and T (DHT much greater than DHN greater than N greater than T) in the prostate because T is a better substrate than N for 5 alpha-reductase and because DHT binds more strongly to the androgen receptor than DHN, N and T. In the kidney 5 alpha-reductase is not important; there is a preferential retention of N in T (DHN and DHT were only present in small amounts) because N is less susceptible than T for metabolic inactivation by the enzyme 17 beta-hydroxysteroid dehydrogenase and N binds strongly to the androgen receptor. Both in vitro and in vivo studies show that N and T were relatively stable in spleen, thymus and muscular tissue (only shown in vivo) and, as a result, the same amount of N and T was bound to the receptor in these tissues in the in vivo infusion experiment.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1975

Response of uremic patients to nandrolone decanoate.

The effect of anabolic steroid therapy on anemia in 13 women with and without kidneys undergoing chronic hemodialysis for renal failure was investigated. All but one of the six patients with kidneys demonstrated a noticeable increase in hematocrit level (6.4% to 14.6%). Of the anephric women, four of the seven also showed hematocrit level elevations, but these were less remarkable (3.1% to 6.4%). A majority of patients demonstrated increments in weight and serum creatinine measurements but no definitive alteration in serum blood urea nitrogen levels. The androgenic effects of nandrolone decanoate were minimal and well tolerated. We conclude that anabolic steroid therapy is effective in ameliorating the anemia of women undergoing hemodialysis, if given in a dose that produces minimal and tolerable untoward effects.

Adult↗
PubMed2001

[Urinary nandrolone metabolites in antidoping control].

The French National Laboratory of the International Olympic Committee (IOC) has detected norandrosterone (NA) and noretiocholanolone (NE) in urine samples from several sportsmen. These two substances are known to be urinary metabolites after nandrolone intake. In such cases, the NA level is always higher than the Ne level. However, in the urine samples of sportsmen tested positive, the NE concentrations were systematically higher than the NA levels. We therefore searched for other steroid precursors (commercially available capsules or tablets of dehydroepiandrosterone, 4-androstenediol, 5-androstenediol, 4-androstenedione, 19-norandrostenediol and 19-norandrostenedione, also illegally used in France) which could lead to an excretion of NA and NE and to an inverted ratio of these metabolites.

Anabolic Agents↗
PubMed2002

Nandrolone (Deca Durabolin) disappears in U.S., generic may return in July.

The last regularly available version of nandrolone, a drug widely used to treat AIDS wasting, was suddenly withdrawn in the U.S. in May, and has largely disappeared from pharmacies. A new generic may be introduced this month; meanwhile, a compounded version may be available. We suggest some Web sites to check for background information if your doctor or pharmacy has trouble getting this drug.

Drugs, Generic↗
PubMed2003

[Acute paranoid psychotic symptoms after i.m. injection of nandrolone].

Affective disorders and impulsivity are quite common when using anabolic substances, in this case-study one of the rather rare cases of a psychotic disorder following the abuse of androgenic steroids is described. A 30-year old formerly healthy white male was admitted as inpatient to psychiatric hospital showing symptoms of anxiety and paranoid ideation. In the last 1.5 years he had consumed androgenic steroids, directly before the onset of the first psychotic symptoms 8 weeks before admission he had received an i.m.-injection of nandrolone. Under therapy with neuroleptics the patient recovered completely within 2 months.

Adult↗
PubMed2005

[The effect of nandrolone phenylpropionate on fibroblasts after injury in rats].

OBJECTIVE: To explore the effect of nandrolone phenylpropionate (NP) on rats' fibroblasts after injury. METHODS: After being isolated from granulation tissue of a one-month Wistar rat,the fibroblasts(FB) were grouped into 5 groups and cultured in RPMI1640 and 5% FBS culturing liquid with 0.5, 1.0, 5.0, 10.0, and 15.0 microg/ml NP respectively. The control group was cultured in RPMI1640 and 5% FBS culturing liquid Fibroblasts were isolated from granulation tissue of a one-month Wistar rat and cultured with RPMI1640 culturing liquid with 5% FBS added different doses of NP from 0.5 approximately 15.0 microg/ml in NP group, but only 5% FBS for the control group. Cell validity of fibroblasts was measured by MTT. The proliferative index (PI) of the most effected group was measured by flow cytometry. RESULTS: Compared with control group, higher FB validity occurred in every NP group (P < 0.05) The PI of FB in every NP group measured by flow cytometry was significantly higher than that in control group (P < 0.01). CONCLUSION: NP can promote the replication and proliferation of FB.

Anabolic Agents↗
PubMed1978

[Results of Nandrolone therapy (Keratyl) in lesions and diseases of the cornea (author's transl)].

The authors report on clinical experiences with the topical application of the synthetic hormone Nandrolon (Keratyl) in diseases of the cornea caused by exogenic, neurogenic, and combined exogenic-endogenic factors. In all cases a positive regenerative effect on epithelium and stroma of the cornea seemed to exist. The present results seem to allow the following range of indications: 1. injuries of the epithelial tissue; 2. ulcera of the cornea (combined with antibiotics); 3. dystrophic diseases of the cornea; 4. certain postoperative treatment after keratoplastic surgery.

Chemical Phenomena↗
PubMed1981

Influence of aspirin and/or anabolic steroid (nandrolone decanoate) on experimental metastasis formation.

The influence on transpulmonary passage by an inhibitor of platelet aggregation, aspirin, and/or anabolic steroid, (Nandrolone decanoate), was investigated in syngeneic CBA mice. An increase of extrapulmonary metastases was used as a measure of increased redistribution of tumor cells from lungs to other organs. Aspirin alone did not reduce metastasis formation in lungs and did not significantly increase transpulmonary passage of tumor cells. The anabolic steroid increased the metastasis crop only in the lungs. However, treatment with the two compounds together increased the metastases in lungs and extrapulmonary organs. The results disclosed that in this system inhibition of platelet aggregation did not reduce metastasis formation but in combination with another drug, an anabolic steroid, it increased the number of experimental metastases.

Animals↗
PubMed1976

A model for studies of dermal surface epithelization: with observations on the effects of dexamethasone and nandrolone decanoate.

Experiments were designed to study the events of cell proliferation and migration during epithelization of an intact dermal surface in man. Epidermis was removed by prolonged suction and epithelization was followed by serial skin biopsies. DNA-synthesis and migration of labelled cells were followed by radioautography. Migration and cell proliferation were not found to be exclusive events in this model. Dexamethasone applied locally in a cream base was found to delay epithelization and nandrolone decanoate was found to counteract this to some extent. The model can be used in studies on effects of drugs on events involved in epithelization.

Blister↗
PubMed1988

A radioimmunoassay for the metabolites of the anabolic steroid nandrolone.

A new radioimmunoassay for the major metabolites of nandrolone was developed to overcome the interference of certain contraceptive steroids in the original assay of the parent steroid. The new assay gave greater screening capability by increasing retrospective detection and the signal-to-background ratio.

Journal Article↗
PubMed2001

Gas chromatography-combustion-isotope ratio mass spectrometry analysis of 19-norsteroids: application to the detection of a nandrolone metabolite in urine.

Determination of whether the major metabolite of nandrolone in urine, 19-norandrosterone (19-NA), is exogenous or endogenous in origin is one of the most exciting challenges for antidoping laboratories. Gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) can be used to differentiate these two origins by carbon isotopic ratio analysis. A complete method for purification of 19-NA in urine has been established. Acetylated ketosteroids, and in particular 19-NA, are isolated from the urine matrix before analysis after hydrolysis and purification of urine by reversed-phase and normal solid-phase extraction. The limit of detection for 19-NA was about 60 ng with recoveries of 54-60%. Evidence of exogenous administration of 19-NA may be established from isotope ratio determination from the 13C/12C ratios of several synthetic 19-norsteroids compared to those obtained for endogenous steroids.

Doping in Sports↗
PubMed2003

[Acute Paranoid Symptoms Following Intramuscular Injection of Nandrolone]

Affective disorders and impulsivity are quite common when using anabolic substances, in this case-study one of the rather rare cases of a psychotic disorder following the abuse of androgenic steroids is described. A 30-year old formerly healthy white male was admitted as inpatient to psychiatric hospital showing symptoms of anxiety and paranoid ideation. In the last 1,5 years he had consumed androgenic steroids, directly before the onset of the first psychotic symptoms 8 weeks before admission he had received an i. m.-injection of nandrolone. Under therapy with neuroleptics the patient recovered completely within 2 months.

Journal Article↗
PubMed2004

Effect of Nandrolone Decanoate on serum lipoprotein (a) and its isoforms in hemodialysis patients.

Malnutrition, anemia and increased atherosclerosis are the main causes of mortality in hemodialysis patients. Therapies designed to improve the disorders might therefore be expected to improve outcome. The effects of Nandrolone Decanoate (ND), in 64 stable hemodialysis patients, were studied with respect to the following parameters: nutritional status, hematological indexes, lipid profiles including serum levels of lipoprotein(a) [Lp(a)] in terms of differences in apolipoprotein(a) [apo(a)]. The patients were treated with ND at dose of 100 mg/I.M./week for 4 months. After 2 and 4 months of treatment the elevations in the serum levels of albumin (p < 0.0001), creatinine (p < 0.009), hemoglobin (p < 0.03), hematocrit (p < 0.03), cholesterol (p = 0.007) and triglyceride (p < 0.04) were noticed. Marked decrease in the concentration of high-density lipoprotein cholesterol (p = 0.007) and Lp(a) (p < 0.0001) were also found. These effects after 2 months of treatment withdrawal were relatively constant. By dividing patients according to the baseline Lp(a) levels and molecular weight of apo(a) isoform, it was noticed that the decrease in serum Lp(a) was significant in patients with high Lp(a) (> 30 mg/dl) than those of with low Lp(a) (< 30 mg/dl), irrespective of apo(a) molecular weight. It may be suggested that, ND has beneficial effect on nutritional status and treatment of anemia in hemodialysis patients. In spite the adverse effect of ND on lipid profile, it decreases Lp(a) mostly in patients with high serum Lp(a) preferently by the effect on apo(a) gene transcriptional activity.

Journal Article↗