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At least 217 records · Page 12Linked to original sources

[Diabetic retinopathy. Analysis of progressive attacks, prophylaxis and therapy with light coagulation].

If one follows the course of diabetic retinopathy on the basis of retinal fluorescence angiography one can distinguish two main courses: Cases displaying an evolution mainly characterized by an increase of capillary hyperpermeability, and others in which the capillary occlusive processes outweigh hyperpermeability. Fluorescence angiography in addition provides paramount clues in regard to initiation of photocoagulation as well as its mode and extent of application and will furthermore render an adequate documentation of successful treatment.

Blood Vessels↗

[Light coagulation in central and paracentral choroiditis (author's transl)].

Since 1966 photocoagulation has been performed in 52 cases and 54 eyes of choroiditis located on the posterior pole. The course of the cases treated is compared with a control group treated with drugs. Photocoagulation shortens the duration of the acute inflammatory process, decreases the frequency of recurrences by about 40% and improves the visual prognosis. The follow-up 1 year to 9 years later (average 7 years) showed in the control group a visual function of 0.5, in the treated group of 0.8.

Acute Disease↗

[Histologic studies on the effect of light coagulation of the retina on the vitreous body].

Up to 6 months after panretinal photocoagulation of rabbit eyes the subsequent changes in the vitreous body were examined histologically by means of a stereomicroscope. Marked changes were evident: severe exudation into all of the vitreous tissue during the early follow-up period, circumscribed areas of higher density or loss of normal density, membrane-like structures, confluent cavities and liquefaction of most of the tissue at the later postcoagulative stage.

Animals↗

[Pilot study of transscleral light coagulation of retinal breaks using diode laser].

PURPOSE: We conducted a pilot trial to evaluate the efficacy and safety of transscleral diode laser photocoagulation in the management of retinal breaks. MATERIAL AND METHODS: Fourteen patients (14 eyes) were enrolled in the study. Twelve patients showed opaque media which prevented transpupillary argon laser photocoagulation (10 eyes) and/or a retinal detachment after previous failed surgery (3 eyes), and/or retinal tears with a curled and fixed posterior edge (6 eyes). Twenty five retinal breaks were treated in the 14 eyes (7 breaks in attached retina and 18 in detached retina). RESULTS: A satisfactory retinochoroidal scar with permanent sealing of the retinal breaks was achieved in all eyes. The retina was attached in all eyes. The follow-up ranged from 2 to 12 months. Ten patients had a minimum 6 month-follow-up. Overtreatment attributed to technical mistake occurred in two eyes. It has no adverse effect on the final result. CONCLUSION: Transscleral diode laser photocoagulation of retinal breaks is efficacious and safe. It is a valuable alternative to cryo treatment in eyes at high risk of postoperative PVR and/or when argon laser photocoagulation cannot be used, and/or in retinal detachments after previous failed surgery.

Adolescent↗

[Control of intensity of light coagulation by thermo-induced release of a fluorescent marker encapsulated in liposomes. In vivo/ex vivo preliminary study].

PURPOSE: The aim of this in-vivo/ex vivo study was to assess the possible use of temperature sensitive liposomes in an established model such as the liver as a new approach to monitor the temperature induced by a laser. METHOD: Temperature sensitive liposomes (DSPC: DiStearoylPhophatidyl-Choline: critical temperature: 55 degrees C) loaded with carboxy-fluoresceine were prepared by the Bancham procedure. These liposomes (1 ml solution) were injected to adult male wistar rats. Two hours later, the liver was exposed and irradiated with a 100 W Nd: YAG laser (single pulse mode, pulses ranging from 100 to 260 ms, spot diameter: 4 mm). Simultaneously, the surface temperature was recorded with a infrared thermographic camera (Aga). The fluorescence emission was then measured with a fluorescent imaging system (Hamamatsu). RESULTS: The dye was released in response to laser energy. The amount of the drug release increased linearly with increasing temperature in the range 42 to 60 degrees C. The estimated latency of release seems more related to the heating pattern (i.e. to laser parameters) than to the liposomes. CONCLUSION: This preliminary study assesses the possible use of laser-induced release of liposome-encapsulated dye to monitor tissue temperature and then thermal damage.

Animals↗

[Vascular anastomoses at the posterior pole of the eye (author's transl)].

Anastomoses between vessels of the fundus may occur as congenital malformations or secondary to vascular diseases affecting the eye. Congenital anastomoses can be of the racemose hemangioma type, with severe malformation of the retinal vessels, ocular complications, and neurologic manifestations, or as simple A-V shunts with visual impairment but limited tendency to show other ocular or neurologic involvement. These anastomoses must be distinguished from other vascular malformations like telangiectasis (Leber, Coats) or the angiomatous lesions of von Hippel's disease. Secondary anastomoses may be confined to the retinal vessels or involve chorioretinal connections. Retinal anastomoses occur in vascular disorders like retinal vein occlusions, diabetes, periphlebitis and hemoglobinopathies. They are often amenable to treatment by light coagulation. Chorioretinal anastomoses occur whenever Bruch's membrane is destroyed by traumatic, inflammatory, degenerative or physical (light coagulation) influences. Light coagulation may be the appropriate treatment, although complications are not rare.

Adolescent↗

Atrial ablation with an IRK-151 infrared coagulator.

BACKGROUND: The purpose of this study was to develop a method of atrial ablation. In the IRK-151 infrared coagulator, light from a tungsten-halogen lamp is focused into a quartz rod. The distal exit plane is connected to a tip made of sapphire to allow linear ablation. METHODS: Thirty-six lesions were created in 9 mongrel dogs. The beating ventricular myocardium was ablated from the epicardium. In each dog, 4 lesions were created by using the following durations of application: 3, 9, 15, and 21 seconds. After the ablation, the myocardium was fixed and stained. A linear lesion on the beating right atrial free wall was created. Before and after the ablation, epicardial plaque-electrode mapping was performed. Three months after ablation, remapping was performed. RESULTS: The ablated myocardium had well-demarcated necrosis without carbonization or vaporization. The maximum depth was 10.3 +/- 0.8 mm. The conducting pathway was blocked. The block, once made, continued for 3 months. CONCLUSIONS: The IRK-151 produces well-demarcated lesions that were deep enough for atrial ablation to block the conducting pathway.

Aluminum Silicates↗

[Treatment and follow-up of retinal tears associated with avulsed overlying retinal vessels (author's transl)].

The present clinical study is based on 17 cases of a specific clinical entity, which is characterised by a retinal break without retinal detachment, the tear being spanned by an avulsed patient retinal vessel invariably adjoining the operculum. The vessel was in the vitreous cavity and formed an arch above the break. All cases began with a sudden decrease or loss of visual acuity due to the rupture of the avulsed vessel and the occurrence of hemorrhages within the vitreous. These hemorrhages recurred in the course of the follow-up of the patients which lasted from 1-8 years. The recurrence of the bleeding was in most instances related to the mobility and the size of the vessel overlying the break. During treatment the cases were divided into two groups, group 1 comprising cases which were subjected only to light-coagulation, whereas in the cases of group 2 scleral buckling was performed in conjunction with cryopexy or light-coagulation. The comparatively best results were achieved in group 2. This condition is rare and amounted to only 1.5% of our total number of cases of retinal tears treated with light-coagulation during the last 8 years.

Aged↗

The role of the haemocytes of Clitumnus extradentatus in haemolymph coagulation.

Light and electron-microscopic observations of the blood cells (haemocytes) of the stick insect Clitummus extradentatus in vitro showed that two morphologically distinct cell types, the cystocytes and granular cells are involved in haemolymph coagulation. Both these cell types contain a variable number of electron-dense granules which upon release cause progressive coagulation and precipitation of the haemolymph. In the cystocytes this release is extremely rapid (30-60s) while in the granular cells it only occurs after 1-2 min in vitro. The role of these cells in haemostasis is discussed together with the possible significance of the involvement of two cell types in the coagulation process.

Animals↗