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Life Options Patient Opinion Study identifies keys to a long life for dialysis patients.

Results of a recent survey of 31 people on dialysis show that, initially, most of them had no real expectation of living a long life when they started treatment. How and why have their perceptions changed? What can providers and other patients learn from this Life Options Patient Opinion Study? For people on dialysis, rehabilitation means living long and living well, despite the challenges of kidney disease. The first step to successful renal rehabilitation is ensuring that the clinical prerequisites of anemia control, adequate dialysis, a well-functioning vascular access, and proper nutrition are in place. In addition, research indicates that people on dialysis are more likely to experience positive outcomes and better quality of life when they are informed about their disease and its treatments; have solid support systems; exercise regularly and remain active and productive, and engage in self-care. It is the combination of good clinical care plus rehabilitation management that can help dialysis patients return to active and fulfilling lives. In 1993 the Life Options Rehabilitation Advisory Council (LORAC) developed a comprehensive approach to renal rehabilitation, based on the "5E's:" Encouragement, Education, Exercise, Employment, and Evaluation. Since then, the 5E's have served as the basis for numerous activities of the Life Options Rehabilitation Program. The Patient Opinion Study examined the patient experience as a way to begin identifying the keys to a long life on dialysis.

Activities of Daily Living↗

[Measurement of quality of life in patients with dementia of Alzheimer type and their caregivers: Schedule for the Evaluation of Individual Quality of Life (SEIQoL)].

Twelve patients with mild to moderate Alzheimer's Disease (AD) and their caregivers were interviewed with the SEIQoL. The SEIQoL measures quality of life by taking into account the relevant determinants for a particular individual. The subject rates 5 areas in life most important to the quality of life. The relative contribution of each area to the overall quality of life is then calculated with a multiple regression analysis programme developed for the purpose. Next the SEIQoL Index score, validity and reliability are computed. One patient was unable to complete the interview. The remaining (8 women, 3 men, mean age 71.3 years) had a mean SEIQoL Index score of 79.9 (median: 85.4), which is comparable to healthy Dutch elderly. The caregivers (10 spouses, 2 daughters; mean age 67.4 years), on the other hand, had a lower SEIQoL Index score: 62.2 (median: 63.8). Validity and reliability were good for both groups. Thus, caregivers in this pilot study experienced a lower quality of life than AD patients and healthy Dutch elderly. The SEIQoL allows quantitative measurement of completely individualised quality of life for AD patients and their caregivers.

Aged↗

Tamsulosin: effect on quality of life in 2740 patients with lower urinary tract symptoms managed in real-life practice in Spain.

OBJECTIVE: To investigate the influence of tamsulosin treatment on the severity of lower urinary tract symptoms (LUTS) and the impact on quality of life (QoL), including daily life activities and mental well being, in real life practice in Spain. METHODS: 2740 LUTS patients aged 45-75 years who visited a urologist office in Spain received tamsulosin 0.4 mg o.d.. At baseline, after 3 months and after 6 months of treatment a questionnaire was completed by the urologist and the patient. The urologist estimated some aspects of the patient's QoL related to his LUTS. The International Prostate Symptom Score (I-PSS) was used to assess the severity of LUTS, while the BPH-Specific Interference with Activities (BSIA) and the Total Mental Health Rate assessed the impact on daily life activities and psychological well being respectively. RESULTS: After 3 months of treatment tamsulosin significantly improved the mean total I-PSS compared to baseline. After 6 months, the mean total I-PSS was reduced by 11.0 points from a baseline score of 20.3 (> 50% reduction). Tamsulosin also significantly improved the mean total BSIA score and the mean Total Mental Health Rate. These observations were confirmed by the urologists' assessment of the patient's condition: an increase of more than 50% of patients with no or mild voiding and filling LUTS and an increase of 45% of patients with no or only a small interference of their LUTS with daily life activities. The withdrawal rate due to adverse reactions was 2.4%. CONCLUSION: This study shows that tamsulosin improves LUTS and their impact on the patient's QoL and daily life activities, in the opinion of both the patients and the urologists.

Activities of Daily Living↗

Study of life satisfaction and quality of life of patients receiving home oxygen therapy.

An investigation was conducted by mail using a questionnaire regarding the life satisfaction and quality of life (QOL) of patients receiving home oxygen therapy (HOT) to evaluate their support. QOL was evaluated according to 4 scales: (1) activities, (2) state of health and quality of living, (3) physical symptoms, and (4) economic state. The answers of 90 patients (recovery rate: 60%) who responded to the investigation were analyzed, and the following points were clarified. 1. Most of the subjects visited the hospital regularly, and about half the subjects (50.6%) had been treated by hospitalization during the 3 years prior to the investigation. 2. A large majority of the subjects (77.4%) answered they were satisfied with life. 3. Life satisfaction was closely related to the patients' roles and hobbies, and their activities in their communities and families. 4. The quality of living and the state of health were closely related to mental activity. 5. The economic state was closely related to all items of life satisfaction, quality of living, and state of health. From these results, expansion of the range of activities of patients receiving HOT and providing an economic basis for their living as well as preventing exacerbation of the disease are considered to be important for improving their life satisfaction.

Activities of Daily Living↗

[The quality-of-life doctrine and the sanctity of life].

The term "quality of life" might be used to qualify external circumstances with regard to the life of human beings (A). It also can be used to define the quality of a human life itself (B). Then it replaces the idea of "sanctity of life" by an eugenic idea that can be abused as a notion of discrimination. The B-position implies that life is only an instrument in order to serve a separable purpose (i.e. "the quality of being a person"). This specific quality articulates itself in so-called "indicators of humanhood/personhood". In consequence this "quality" is an eugenic expression including a dangerous power of definition and a selective anthropology that does not seem to be convincing theoretically and that can never serve as the basis of a reasonable and good social life of man.

Ethics, Medical↗

A classification system for mosquito life cycles: life cycle types for mosquitoes of the northeastern United States.

A system for the classification of mosquito life cycle types is presented for mosquito species found in the northeastern United States. Primary subdivisions include Univoltine Aedine, Multivoltine Aedine, Multivoltine Culex/Anopheles, and Unique Life Cycle Types. A montotypic subdivision groups life cycle types restricted to single species. The classification system recognizes 11 shared life cycle types and three that are limited to single species. Criteria for assignments include: 1) where the eggs are laid, 2) typical larval habitat, 3) number of generations per year, and 4) stage of the life cycle that overwinters. The 14 types in the northeast have been named for common model species. A list of species for each life cycle type is provided to serve as a teaching aid for students of mosquito biology.

Animals↗

[Quality of life studies in nursing science (2). Community adjustment of chronic schizophrenics: effects on life satisfaction and self-esteem (2)].

The purpose of this study was to test two community adjustment models of the chronically mentally ill developed by this author. The study was to determine the effects of daily living, work, family, and social adjustment on life satisfaction and self-esteem as well as to determine the effects of chronicity and symptomatology on the four adjustments. Twenty schizophrenic inpatients and 120 schizophrenic outpatients from a psychiatric hospital in Tokyo participated in the study: the former group was used for a pilot study of the instruments and the latter for the model testing. Seven instruments were used; two self-administered questionnaires of the Life Satisfaction Scale and the Rosenberg Self-Esteem Scale, two structured interview schedules of the Adjustment Scales and a modified version of the Psychiatric Evaluation Form, the Demographic and Psychiatric History Form, the Cantril Ladder of Satisfaction, and the Global Assessment Scale. Two direct effects of family and social adjustment (beta = 0.326 and 0.262 respectively) explained 22.2% of the variance in life satisfaction. Two direct effects of symptomatology (beta = -0.216) and family adjustment (beta = 0.185) accounted for 10.6% of the variance in self-esteem. It was assumed that dropping of symptomatology as a direct effect on life satisfaction was a type two error. In addition, chronicity and social adjustment failed to enter into the equation of self-esteem due to the type two error as well. The culturally characteristic pattern that emerged was that relationship-oriented variables were directly effective on life satisfaction and self-esteem. However, task-oriented variables of daily living adjustment and work adjustment did not account for life satisfaction and self-esteem despite the hypothetical links in the models. It was concluded that interpersonal relationships were especially important for the well-being of Japanese schizophrenics living in the community. The lack of direct effects of daily living and work adjustment suggested that autonomy in living did not heighten the well-being of the subjects, a result that was different than the findings of American studies. It was probably because that Japanese people in general value interdependence among family members, therefore, relatives of the mentally ill tend to play more roles to take care for them.

Clinical Nursing Research↗

Psychometric validation of the French version of the side-effects and life satisfaction inventory (SEALS) in epileptic patients: comparison with the QOLIE-31 inventory and a generic quality of life questionnaire.

A psychometric evaluation of a French version of the side-effects and life satisfaction inventory (SEALS) was carried out. SEALS was compared to the quality of life in epilepsy-31 questionnaire (QOLIE-31) and a generic, health-related quality-of-life questionnaire, the Nottingham health profile (NHP). The psychometric properties of SEALS, assessed in 190 adult subjects with epilepsy, included: acceptability, test-retest reliability and validity, multitrait analysis including internal consistency and item-to-scale correlations, construct validity using factor analysis and discriminative validity using associations with disease characteristics and treatment effects, and, correlations with NHP and QOLIE-31 scores for convergent and divergent validity. Both acceptability and reproducibility were good and internal consistency was high (Cronbach's alpha coefficient = 0.92). Factor analysis with varimax rotation identified five factors: the first, related to cognitive function accounted for 26.0% of the variance. Discriminative validity was good for most treatment characteristics (tolerability, seizure control, compliance) and clinical features (epilepsy type, seizure frequency and severity, depressive symptoms). Correlations with the NHP and QOLIE-31 scores were consistently strong. It was concluded that the psychometric properties of the French translation of SEALS were similar to the original English version. In addition, SEALS provides information on quality of life that is complementary to that obtained with QOLIE-31. In particular, with respect to the QOLIE-31, the SEALS provides information on cognitive and neuropsychological aspects of impairment of quality of life, whereas the QOLIE-31 has a broader scope, taking into account multiple aspects of quality of life in epilepsy.

Adolescent↗

Assessing quality of life of patients with advanced chronic obstructive pulmonary disease in the end of life.

Given the limitations of existing health-related quality-of-life (QOL) measures in capturing the end-of-life experience of patients with advanced chronic diseases, an empirically grounded instrument, the quality-of-life concerns in the end of life questionnaire (QOLC-E), was developed. Though it was built on the McGill quality of life questionnaire (MQOL), its sphere is more holistic and culturally specific for the Chinese patients in Hong Kong. One hundred and forty-nine patients with advanced chronic obstructive pulmonary disease (COPD) or metastatic cancer completed the questionnaire. Seven factors (28 items) which emerged from the factor analysis were grouped into four positive (support, value of life, food-related concerns, and healthcare concerns) and four negative (physical discomfort, negative emotions, sense of alienation, and existential distress) subscales. Good internal consistency and concurrent validity were shown. The results also revealed that these two groups of patients had similar QOL concerns. The validity of applying QOLC-E as an outcome measure to evaluate the effectiveness of palliative and psychoexistential interventions has yet to be tested.

Activities of Daily Living↗

[Quality of life, subjective health status and health and life satisfaction in rheumatoid arthritis].

A Japanese version of Arthritis Impact Measurement Scales (AIMS) was developed after the original AIMS Version 2 and utilized for Quality of Life (QOL) measurement in 691 patients with Rheumatoid Arthritis (RA). Various medical (physical and laboratory) examinations, which are widely used in the clinical settings for the assessment of RA activity and severity, were also performed by physicians. Interrelationships between QOL, patient subjective health status, and health and life satisfaction were analyzed with the following results: 1: The effect of QOL impairment by RA upon patients' subjective health rating and health satisfaction were not constant over the range of severity of disease status. Pain was found to lower overall subjective health and health satisfaction regardless of RA class. On the other hand, while the deterioration of mobility aspects of QOL had negative effects upon patients' subjective health status and satisfaction among less-disabled RA patients, any of physical aspects of QOL, including the degree of mobility impairment, showed no significant association with patients' subjective health status and satisfaction in the more disabled. 2: Psychological aspects of QOL (mood and tension) had significant associations with patients' subjective health status and satisfaction. In the less severe group, mood impairment had a significant effect on subjective health and satisfaction, while in the more severe group tension showed a significant association. It was indicated that management of psychological aspects of QOL is important in RA patients to improve and advance their subjective health status and satisfaction. 3: Although social aspects of QOL, i.e. social support, social life and job status, showed no significant relationship to subjective health rating and health satisfaction, those with less disease severity who lacked social support and who had a jobless state were likely to have lower disease acceptance and life satisfaction, while those with more severe disease who had less social interaction manifested lower life satisfaction. These results suggested that social aspects of QOL, while not directly associated with subjective health rating, could be important factors affecting disease acceptance and life satisfaction.

Adult↗

[Quality of life in peripheral arterial occlusive disease. Multicenter study of quality of life characteristics with a newly developed disease-specific questionnaire].

AIM: Owing to a lack of disease-specific measuring instruments, no systematic investigations of the impairment of the quality of life in patients with peripheral arterial occlusive disease (PAOD) have so far been possible. The aim of the present study, therefore, was to develop an appropriate questionnaire and to submit it to a psychometric test in a sufficiently large number of patients. PATIENTS AND METHOD: A disease-specific questionnaire comprising 86 individual items was developed (PAVK 86) and was tested in a longitudinal study involving 308 patients with confirmed peripheral arterial occlusive disease, Fontaines's stages I to IV. At the same time, three established generic questionnaires were also employed (SF 36, NHP, Every Day Life). RESULTS: Analysis showed that, in comparison with a normal population, the quality of life in patients with PAOD is considerably impaired, in particular by pain, anxiety, general complaints and reduced physical mobility and performance, and is comparable with that of patients suffering from renal carcinoma. In Fontaine's stage III and IV, the quality of life is significantly more greatly impaired than in patients with stage II disease. No differences in quality of life were to be found between Fontaine's stages III and IV. The psychometric test revealed that the PAVK 86 questionnaire is a sensitive, reliable, valid and practicable measuring instrument. CONCLUSION: The PAVK 86 questionnaire is suitable for determining the course and outcome of therapeutic measures on the quality of life of PAOD patients, and can therefore be included in clinical studies. In addition, its use in combination with established generic questionnaires also permits a comparison with age-matched healthy control groups, and is thus also of importance for the assessment of aspects of health economics.

Activities of Daily Living↗

[Sexuality and quality of life. Results from the quality of life-study of 4,626 Danes aged 31-33 years born at Rigshospitalet 1959-1961].

From a cohort of 7222 31-33-year-olds we obtained answers to a 317-item quality-of-life questionnaire that included five questions on sexuality from 4626 respondents, giving a response rate of 64.1%. Among the women, 1.6% said they were bisexual and 1.4% homosexual; the corresponding figures for men were 1.3% and 1.1% respectively. The quality of life of bisexual persons was somewhat lower than the cohort mean (W: 15.6% lower, M: 19.1% lower), and that of homosexual persons was a little lower than the cohort mean (W: 8.5% lower, M: 3.7% lower). About a quarter of all respondents said they had sexual problems. Most frequent among the women were reduced sexual desire (17.0%) and the absence of a suitable sex partner (7.6%), and among the men, the absence of a suitable sex partner (12.5%) and premature ejaculation (5.5%). The quality of life of persons with sexual problems was measured to be from 7.0% to 24.2% lower than the cohort mean (as expressed in terms of this mean). The intermediate-sized relationship between sexual problems and quality of life suggests that such problems can be symptoms of reduced quality of life, rather than medical problems to be tackled as such. Implications for quality life-sensitive clinical practice are discussed.

Adult↗

Achieving national health objectives: the impact on life expectancy and on healthy life expectancy.

Our study quantifies the impact of achieving specific Healthy People 2010 targets and of eliminating racial/ethnic health disparities on summary measures of health. We used life table methods to calculate gains in life expectancy and healthy life expectancy that would result from achievement of Healthy People 2010 objectives or of current mortality rates in the Asian/Pacific Islander (API) population. Attainment of Healthy People 2010 mortality targets would increase life expectancy by 2.8 years, and reduction of population wide mortality rates to current API rates would add 4.1 years. Healthy life expectancy would increase by 5.8 years if Healthy People 2010 mortality and assumed morbidity targets were attained and by 8.1 years if API mortality and activity limitation rates were attained. Achievement of specific Healthy People 2010 targets would produce significant increases in longevity and health, and elimination of racial/ethnic health disparities could result in even larger gains.

Adolescent↗