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PubMed1999

Digital information evolution: the AIDS Library experience.

The AIDS Library evolved out of consumer health activism in response to the need for the latest HIV information, materials, and technology. In 1998, staff implemented a microcomputer-based integrated automated library system with Web publishing capability to link catalogs, databases of Philadelphia regional services, online publications, and fact sheets. The Web site, , became "live" December 1, 1998. History leading to its development and future plans are presented.

Acquired Immunodeficiency Syndrome↗
PubMed2005

Libraries of strategies and ontology-driven subject area models as "corner stones" in Grid development.

Series of experiments of Grid-based calculations by Monte-Carlo simulation of molecular conformations have shown that there are classes of problems that could be "gridified" in short time with reasonable efforts. That could awake serious interest in the Grid from the biophysics and biochemistry community. Experiments with scientific problems that include both intensive computations and intensive data interchange have shown that libraries of strategies could provide an effective tool to adapt Grid-node infrastructure to problem structure. Libraries of strategies on different levels of Grid hierarchy--from local clusters to regional segments--could provide an effective usage of Grid resources. Ontologies provide a universal tool to link distributed databases. Besides, ontologies also allow for the formal construction of models of subject areas. These models are the tools to formalize information requests and to construct intellectual queries to information space. There should be a multi-level hierarchy of ontologies and a critical mass of low-level ontologies must be reached in order to build a knowledge space for a subject area.

Algorithms↗
PubMed2005

[A meta-analysis of treatment of infantile diarrhea with bifid triple viable bacterial tablet].

OBJECTIVE: To assess the efficacy and safety of bifid triple viable bacterial tablet in treatment of infantile diarrhea. METHODS: According to the requirements of Cochrane systematic review, a thorough literature search was performed among Chinese Digital Hospital Library (www.chkd.cnki.net) and Chinese Biomedical Literature Disk Database (CBMdisk). A meta analysis was performed on a total of 1326 patients involved in 12 papers which met the inclusion criteria. RESULTS: Publication bias analysis showed that the funnel plot was symmetrical. Test for heterogeneity showed that the groups treated with bifid triple viable bacterial tablet and antibiotics or anti-viral agents or placebo control had clinical homogeneity and statistical homogeneity (P = 0.66, 0.67, 0.85, respectively, I(2) = 0%), which allowed to use fixed effect model analysis. The bifid triple viable bacterial tablet and Smecta did not have statistical homogeneity (P = 0.02, I(2) = 70.9%), therefore random effect model analysis was applied. Incorporation analysis showed that in comparison of the bifid triple viable bacterial tablet versus antibiotics or anti-viral agents or placebo control, the odds ratios were 5.34, 4.74 and 6.43, respectively, and 95% CIs were [2.81, 10.16], [2.47, 9.09], and [2.61, 15.83], on test for overall effect, Z = 5.11, 4.67 and 4.04, P < 0.00001. In the forest plot the 95% CI horizontal line of incorporation odds ratio droped to the right side of the vertical line indicating the border of effectiveness. However, no statistically significant difference was found between bifid triple viable bacterial tablet and Smecta. CONCLUSION: The clinical evidences available so far indicated that treatment of infantile diarrhea with bifid triple viable bacterial tablet is safe and effective although rigorously designed large sample size randomized double blind clinical trials are required to further demonstrate and support the conclusion.

Administration, Oral↗
PubMedDate not supplied

Three-dimensional geometrical models of the liver.

In this work we used a virtual approach to study the human liver by three-dimensional geometrical models. We built the models through computer aided geometric modelling techniques starting from pictures taken during both real dissections and diagnostic medical imaging. The results show in a complete modular synthesis and with a schematic iconology the structural organization of this organ in a logic sequence of layers and topographic and spatial relationship among its components. This approach represents an amazing support to clinical anatomy for teaching and research.

Computer Simulation↗
PubMed2005

Understanding nurses' information needs and searching behaviour in acute care settings.

UNLABELLED: We report the results of a pilot study designed to describe nurses' information needs and searching behaviour in acute care settings. Several studies have indicated that nurses have unmet information needs while delivering care to patients. AIM: Identify the information needs of nurses in acute care settings. METHODS: Nurses at three hospitals were asked to use an information retrieval tool (CPG Viewer). A detailed log of their interactions with the tool was generated. RESULTS AND CONCLUSIONS: Our findings suggest that nurses' information needs are different from what is reported in the literature in terms of physicians' information needs. Questions regarding a nursing procedure or protocol were the most common needs nurses had.

Attitude of Health Personnel↗
PubMed2006

Maternity care in the bush: using the Internet to provide educational resources to isolated practitioners.

INTRODUCTION: Telecommunication infrastructure is being rolled out across Australia with little knowledge about the uptake by health professionals in remote areas. Computer mediated communication has the potential to offer educational support to remote practitioners; however, the viability of this is uncertain. The aim of this research was to establish and evaluate an internet-based resource library targeting the needs of remote area maternity service providers. METHODS: A participatory action research (PAR) approach was used to involve remote area maternity service providers in the Northern Territory of Australia. The evaluation of the resource library included its performance on reach, agency affiliation and richness, factors identified to affect the sustainability and utility of such a resource. An additional component of the evaluation framework documented the facilitators of and barriers to using an information technology strategy to reduce the isolation of remote area maternity service providers. RESULTS: Overall, the evaluation of the resource library was very positive. Feedback from the PAR team described the resource as contemporary, useful and relevant. Practitioners in leadership and education positions identified the resource library as a valuable tool that enabled them to access professional knowledge, which could then be distributed to any remote-based practitioners, who experienced difficulties with access themselves. The evaluation found that logistical issues were a major problem for potential users. Hardware inadequacies, access difficulties, unfamiliarity with computers, and a lack of management support for nursing and midwifery staff to utilise the resource, were all identified barriers. Remote-area practitioners highlighted education, training and 24 hour support as key priorities. CONCLUSIONS: Results from this research clearly showed the potential of web-based resources to offer educational support through access to clinical guidelines, reports and research, thus reducing the isolation of the remote practitioner. However, it highlighted the need for clear strategic direction at policy level, whereby all stakeholders unite to synchronise the rollout of information technology infrastructure with the necessary education, training and support as an integral component.

Attitude of Health Personnel↗
PubMed2006

Open access: implications for scholarly publishing and medical libraries.

PURPOSE: The paper reviews and analyzes the evolution of the open access (OA) publishing movement and its impact on the traditional scholarly publishing model. PROCEDURES: A literature survey and analysis of definitions of OA, problems with the current publishing model, historical developments, funding agency responses, stakeholder viewpoints, and implications for scientific libraries and publishing are performed. FINDINGS: The Internet's transformation of information access has fueled interest in reshaping what many see as a dysfunctional, high-cost system of scholarly publishing. For years, librarians alone advocated for change, until relatively recently when interest in OA and related initiatives spread to the scientific community, governmental groups, funding agencies, publishers, and the general public. CONCLUSIONS: Most stakeholders acknowledge that change in the publishing landscape is inevitable, but heated debate continues over what form this transformation will take. The most frequently discussed remedies for the troubled current system are the "green" road (self-archiving articles published in non-OA journals) and the "gold" road (publishing in OA journals). Both movements will likely intensify, with a multiplicity of models and initiatives coexisting for some time.

Access to Information↗
PubMedDate not supplied

[The RCN go to SciELO].

Explore the source record for details and available documents.

Developing Countries↗
PubMedDate not supplied

Cytoplasmic tutor: a program for teaching interpretation of a microscope-based laboratory test.

Antibodies to cytoplasmic antigens can be identified with a microscope-based indirect immunofluorescence assay that uses a mouse stomach-kidney substrate. The antibodies are diagnostic markers in chronic active hepatitis, primary biliary cirrhosis, pernicious anemia, and other autoimmune diseases. We describe the development and features of an image-based computer program for teaching medical technologists and other health care workers the proper interpretation of cytoplasmic fluorescence staining patterns. The program, called Cytoplasmic Tutor, is written in Microsoft Visual Basic for Windows and runs on an 80486 microcomputer. it is based on a library of digital images, with key features described by overlays of text. The images were collected and processed with a computer-based fluorescence video microscopy system assembled in our laboratory.

Animals↗
PubMed1998

Peer reviewing and curating the health care information infrastructure: experiences and recommendations.

As part of a digital health sciences library's continuous quality improvement process, a digital textbook of common medical problems was created which contained links to authoritative medical information on the Internet for patients and health care providers. The accomplishments of this project were the: 1) Identification of 50 common medical problems, 2) Development of a methodology for identifying authoritative medical information related to these problems, 3) Creation of a digital textbook containing links to this information with a problem-based interface, 4) Development of a methodology to allow local peer review of this information, and 5) Evaluation of the use of the information and the local peer review methodology.

Evaluation Studies as Topic↗
PubMed1993

Hydropathy and molar volume constraints on combinatorial mutants of the photosynthetic reaction center.

Combinatorial cassette mutagenesis was used to substitute randomly nine amino acid residues in the vicinity of the active branch monomeric bacteriochlorophyll in the photosynthetic reaction center of Rhodobacter capsulatus. The bacteriochlorophyll environment was targeted because of the potential role of this cofactor in the initial charge separation event of photosynthesis. Mutants with perturbed binding and which have altered energy levels of this chromophore, would be useful for electron transfer studies. Four sites in the M-subunit D-helix and five sites in the L-subunit cd-helix, including residue L153, the axial histidine ligand to the bacteriochlorophyll, were randomly substituted. The cd and D-helix regions were mutagenized independently of each other and simultaneously, resulting in three libraries of mutants. Digital imaging spectroscopy was used to screen photosynthetically selected mutants for ground state absorption spectra in the visible and near-infrared. The functional mutants of each library have distinct spectroscopic characteristics. One unusual spectral phenotype with an absorbance band at 825 nm occurred only in the nine-site library, with a frequency of about one out of 10(6) mutants. A mutant with an 825 nm band also has an unusual light-minus-dark difference spectra, which does not show a blue shift of the 800 nm absorption band. The mean molar volume and hydropathy of the substitutions occurring in functional mutants are biased towards the mean values of a random dope to various extents, indicating different stringencies at each site for these physicochemical properties.

Amino Acid Sequence↗
PubMed1987

Computer-aided infrared analysis of urinary calculi.

We have created a library of 497 digitized infrared spectra of 58 components of urinary calculi and of their usual binary and ternary mixtures. We tested the operation of the "Birsy" search program (Bruker Analytische Messtechnik) with this library for the interpretation of infrared spectra of 50 urinary calculi, selected from both classical and difficult cases. This program correctly identifies the two first components 98% of the time and the third (minor) component 70% of the time. Using this program, those without training or experience in infrared analysis can routinely use the infrared method of analysis of urinary calculi.

Humans↗
PubMed2004

A framework for a distributed, hybrid, multiple-ontology clinical-guideline library, and automated guideline-support tools.

Clinical guidelines are a major tool in improving the quality of medical care. However, most guidelines are in free text, not in a formal, executable format, and are not easily accessible to clinicians at the point of care. We introduce a Web-based, modular, distributed architecture, the Digital Electronic Guideline Library (DeGeL), which facilitates gradual conversion of clinical guidelines from text to a formal representation in chosen target guideline ontology. The architecture supports guideline classification, semantic markup, context-sensitive search, browsing, run-time application, and retrospective quality assessment. The DeGeL hybrid meta-ontology includes elements common to all guideline ontologies, such as semantic classification and domain knowledge; it also includes four content-representation formats: free text, semi-structured text, semi-formal representation, and a formal representation. These formats support increasingly sophisticated computational tasks. The DeGeL tools for support of guideline-based care operate, at some level, on all guideline ontologies. We have demonstrated the feasibility of the architecture and the tools for several guideline ontologies, including Asbru and GEM.

Computer Communication Networks↗
PubMed2006

Hybrid specification, storage, retrieval and runtime application of clinical guidelines.

Clinical guidelines are a major tool in improving the quality of medical care. However, most guidelines are in free text, are not machine-comprehensible and are not easily accessible to clinicians at the point of care. We have designed and implemented a web-based, modular, distributed architecture, the Digital Electronic Guideline Library (DeGeL), which facilitates gradual conversion of clinical guidelines from text to a formal representation in the chosen target guideline ontology. The architecture supports guideline classification, semantic markup, context-sensitive search, browsing, run-time application and retrospective quality assessment. The DeGeL hybrid meta-ontology includes elements common to all guideline ontologies, such as semantic classification and domain knowledge; it also includes four content-representation formats: free text, semi-structured text, semi-formal representation and a formal representation. These formats support increasingly sophisticated computational tasks. Guidelines can thus be in a hybrid representation in which guidelines, and even parts of the same guideline, might exist at different formalisation levels. We have also developed and rigorously evaluated a methodology and an associated web-based tool, Uruz, for gradually structuring and semi-formalising free-text clinical guidelines. Finally, we have designed, implemented and evaluated a new approach, the hybrid runtime application model, for supporting runtime application of clinical guidelines that are not necessarily in a machine-comprehensible format; in particular, when the guideline is in a semi-formal representation and the patient's data are either in an electronic medical record or in a paper format. The tool implementing this new approach, the Spock module, is customised at this point to the Asbru guideline specification language and exploits the hybrid structure of guidelines in DeGeL. The Spock module also exploits our temporal-abstraction mediator to the patient record, IDAN, and our interactive intelligent-visualisation tool, KNAVE-II.

Decision Support Systems, Clinical↗