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PubMed1997

Childhood laterality and later risk of schizophrenia in the 1946 British birth cohort.

An increased rate on non-righthandedness and other abnormalities of lateralization have been reported in schizophrenia. We investigated childhood hand preference and eye dominance as risk factors for adult schizophrenia among a general population birth cohort. Pre-schizophrenic children showed a significant excess of left-eye dominance at age 11 when compared with controls (OR 2.5, 1.0-5.8, p = 0.03), but there was no significant difference in hand preference between pre-schizophrenic children and controls.

Brain↗

PubMed1999

Lateralized brain dysfunction in schizophrenia: a comparison with patients with lateralized structural lesions.

A comparison was made among participants with schizophrenia and those with structural lateralized or diffuse brain damage in order to determine the extent to which the cognitive profile of the schizophrenia sample resembled the profiles obtained from patients with left-hemisphere, right-hemisphere, and diffuse brain damage. The Halstead-Reitan Neuropsychological Battery was used as the testing procedure. The data were subjected to discriminant analysis in order to obtain frequencies of predicted classification of the participants with schizophrenia into schizophrenia, left-hemisphere, right-hemisphere, and diffuse groups. Half of the participants with schizophrenia were classified into the schizophrenia group. The other half was evenly distributed across the left-hemisphere, right-hemisphere, and diffuse brain damage groups. There was not a disproportionately large number of participants classified into the left-hemisphere group. Comparisons among these four predicted groups were accomplished for each of the Halstead-Reitan Battery measures using one-way analysis of variance. The comparison of the subtest scores among the predicted groups indicated that the patients classified into the left-hemisphere group were characterized by a pattern of language dysfunction thought to be developmental in nature, and an abnormal lack of asymmetry in tapping speed favoring the right hand.

Adult↗

PubMed1996

[Dwyer osteotomy with or without lateral stabilization in calcaneus varus with lateral ligament insufficiency of the upper ankle joint].

Varus deformity is a well known problem in the treatment of chronic lateral ankle instability. Surgical correction is recommended occasionally. The goal of this study was to show the effect of a calcaneal Dwyer osteotomy in patients suffering from a functional instability. We examined 6 patients, who underwent 7 calcaneal osteotomies. Postoperatively all patients maintained stability. No recurrence of a supination trauma was observed.

Adult↗

PubMed1998

Immunohistochemical localization of brain-derived neurotrophic factor in the spinal cords of amyotrophic lateral sclerosis and non-amyotrophic lateral sclerosis patients.

Brain-derived neurotrophic factor (BDNF) has a trophic effect on several neuronal subtypes including motor neurons. To localize and assess BDNF in the human spinal cord with particular reference to amyotrophic lateral sclerosis (ALS), we immunohistochemically studied spinal cords from 8 ALS and 13 non-ALS patients. Punctate staining for BDNF was observed in neuronal somata and proximal processes of large-sized anterior horn cells of non-ALS patients, as were distal axons immunolabeled in the neuropil. The same immunostaining pattern was found in the anterior horn cells of ALS patients. Neurons of the dorsal nucleus of Clarke, intermediolateral nucleus, and posterior horn sensory system were also stained in both groups. The results suggest that BDNF may act widely as a trophic factor in the human spinal cord, and motor neurons in ALS patients might be sufficiently supplied with endogenous BDNF from other neuronal subpopulations in the spinal cord.

Adult↗

PubMed1993

Monocular deprivation effects in the rat visual cortex and lateral geniculate nucleus are prevented by nerve growth factor (NGF). II. Lateral geniculate nucleus.

In the preceding paper (Berardi et al. Proc. R. Soc. Lond. B 251, 17 (1993)), it has been shown that nerve growth factor (NGF) prevents the functional and anatomical alterations induced by monocular deprivation (MD) at the level of the visual cortex. Here we report that an exogenous supply of NGF prevents the shrinkage of neurons in the deprived laminae of lateral geniculate nucleus (LGN). The soma size distribution for the deprived ipsilateral laminae of MD rats is shifted towards smaller sizes (mean percentage of shrinkage with respect to the ipsilateral undeprived lamina = 21%, s.d. = 2%). As in other mammals, MD affects LGN relay neurons and spares LGN neurons projecting to the monocular portion of primary visual cortex. In NGF-treated animals we found that the soma size distributions for the deprived and undeprived ipsilateral laminae extensively overlap. The results of the two papers show that an exogenous supply of NGF prevents MD effects at both levels, visual cortex and LGN, and suggest a role for NGF in the plasticity of the geniculo-cortical pathway.

Animals↗

PubMed1986

Asymmetrical head-turning of preterm infants: some effects on later postural and functional lateralities.

Asymmetrical head-turning and its effects on subsequent functional lateralities and postural asymmetries were examined in 44 relatively low-risk preterm and 53 fullterm infants. Persisting head-turning to the right was observed more often among preterm infants, as was an asymmetrical skull with flattened right occiput and head-turning to the right. Asymmetrical trunk posture was present in 20 preterm and four fullterm infants. At nine months right-hand preference was more marked in preterm infants, and hand preference was well coincident with head-turning. Changes in hand preference occurred more often among fullterm infants. Asymmetrical gait seemed to correlate with head-turning in preterm infants.

Functional Laterality↗

PubMed1996

Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS Study Group. Western Amyotrophic Lateral Sclerosis Study Group.

We designed a phase II trial to evaluate the efficacy of gabapentin in slowing the rate of decline in muscle strength of patients with amyotrophic lateral sclerosis (ALS) and to assess safety and tolerability. Gabapentin (800 mg) or placebo was administered t.i.d. in a randomized, double-blinded, placebo-controlled, trial for 6 months. We enrolled 152 patients at eight sites in the United States. The primary outcome measure was the slope of the arm megascore, the average maximum voluntary isometric strength from eight arm muscles standardized against a reference ALS population. A secondary outcome measure was forced vital capacity. Slopes of arm megascores for patients on gabapentin were compared with slopes of those taking placebo using a two-way ANOVA. We observed a nonstatistically significant trend (p = 0.057-0.08) toward slower decline of arm strength in patients taking gabapentin compared with those taking placebo (mean difference 24%, median 37%). We observed no treatment effect on forced vital capacity. Gabapentin was well tolerated by patients with ALS. These results suggest that further studies of gabapentin in ALS are warranted.

Acetates↗

PubMed2026

Oblique Lateral Interbody Fusion With Lateral Vertebral Screw Fixation Versus Transforaminal Lumbar Interbody Fusion for Severe Lumbar Stenosis: Results of a Multicenter Randomized Controlled Trial.

BACKGROUND AND OBJECTIVES: The benefits of oblique lateral interbody fusion (OLIF) vs transforaminal lumbar interbody fusion (TLIF) in severe lumbar stenosis (Schizas C/D) remain uncertain. This randomized trial compared clinical, radiographic, and safety outcomes of OLIF and TLIF. METHODS: From November 2018 to December 2021, a prospective, multicenter, randomized controlled trial enrolled 260 adults with single-level severe stenosis and instability. In total, 224 patients were randomized to OLIF or TLIF. Prespecified outcomes followed consolidated standards of reporting trials. Primary outcomes were visual analog scale back/leg pain and Oswestry Disability Index (ODI), with minimal clinically important difference thresholds of ODI ≥12-13 points or ≥30% improvement, and visual analog scale ≥1.5-2.0 points. Radiographic measures included disc height, lumbar and segmental lordosis, and canal cross-sectional area (CSA). Complications were recorded. Ethics approval was obtained from the institutional review board, the trial was registered with ISRCTN.com , and all patients provided written informed consent. RESULTS: In total, 224 patients were randomized, 5 were lost to follow-up (TLIF n = 2, OLIF n = 3). Baseline features were comparable. OLIF was associated with shorter operative time, less blood loss, earlier ambulation, and shorter hospital stay (all P < .05). Both groups achieved significant, clinically meaningful improvements. OLIF showed greater back pain reduction at 3-6 months and 2 years ( P < .05) and superior ODI improvement at 3 and 6 months ( P < .001), although long-term ODI scores were similar. Radiographically, OLIF provided greater restoration of disc height and segmental lordosis (all P < .001) and demonstrated progressive CSA increase (dynamic decompression), whereas TLIF achieved immediate, sustained CSA enlargement. Fusion rates were comparable at 1-2 years. Complication rates were low and similar (7.3% TLIF vs 5.5% OLIF), with most OLIF-specific events transient. CONCLUSION: Both OLIF and TLIF yield improvements in severe lumbar stenosis. OLIF offers perioperative advantages, earlier functional recovery, radiographic restoration, and dynamic canal remodeling, supporting its role as an equivalent alternative for lumbar spinal stenosis with some secondary advantages.

Humans↗

PubMed2006

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.

Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease is caused by a selective loss of motor neurons. One form of juvenile onset autosomal recessive ALS (ALS2) has been linked to the loss of function of the ALS2 gene. The pathogenic mechanism of ALS2-deficiency, however, remains unclear. To further understand the function of alsin that is encoded by the full-length ALS2 gene, we screened proteins interacting with alsin. Here, we report that alsin interacted with glutamate receptor interacting protein 1 (GRIP1) both in vitro and in vivo, and colocalized with GRIP1 in neurons. In support of the physiological interaction between alsin and GRIP1, the subcellular distribution of GRIP1 was altered in ALS2(-/-) spinal motor neurons, which correlates with a significant reduction of AMPA-type glutamate receptor subunit 2 (GluR2) at the synaptic/cell surface of ALS2(-/-) neurons. The decrease of calcium-impermeable GluR2-containing AMPA receptors at the cell/synaptic surface rendered ALS2(-/-) neurons more susceptible to glutamate receptor-mediated neurotoxicity. Our findings reveal a novel function of alsin in AMPA receptor trafficking and provide a novel pathogenic link between ALS2-deficiency and motor neuron degeneration, suggesting a protective role of alsin in maintaining the survival of motor neurons.

Adaptor Proteins, Signal Transducing↗

PubMed2001

Lateral difference in reaction times to lateralized auditory stimuli.

Evidence suggests that Reaction time (RT) is affected by human behaviour in that stimuli are processed and conducted faster and more accurately when they are presented directly to the specialised hemisphere and responded to more quickly when stimulus and response are mediated by the same hemisphere. The purpose of the current study was to investigate the effect of laterality using one parameter-reaction time (RT) on ipsilateral reactions to monuaural latralized stimuli. Twenty-four undergraduate polytechnic students and 10 representative level Rugby players participated in the study by reacting unilaterally to single and choice RT using simple and complicated sensor motor reactions (SMR). Results Shorter reaction times by the dominant hand while testing simple and complicated audio SMR, without reference to sex and sport skills results have been explained in terms of specialisation of left hemisphere in different aspects of information processes mechanisms, geared towards programming of the movement.

Acoustic Stimulation↗

PubMed2005

Does apoptosis occur in amyotrophic lateral sclerosis? TUNEL experience from human amyotrophic lateral sclerosis (ALS) tissues.

The role that apoptosis plays in the pathogenesis of amyotrophic lateral sclerosis (ALS) is still unclear. From our autopsy samples, we have undertaken an effort to verify if apoptosis in ALS really occurs or if can at least be detected. The study was performed using TUNEL method for screening the apoptotic changes in the autopsy samples from 8 ALS cases compared with 16 control cases. No features of apoptosis (DNA cleavages) were noted in any of the investigated regions of the central nervous system in ALS cases as well as in controls. These preliminary results seem to support the reports, which deny the role of apoptosis in human ALS. The following investigations using additional methods will be performed for detection the apoptotic signals in ALS.

Aged↗

PubMed1988

[Amyotrophic lateral sclerosis. Physiopathology and experimental models. Chemical neuroanatomy of the human spinal cord: applications to pathologic cases including amyotrophic lateral sclerosis].

The purpose of this paper is to illustrate the advantages of the chemo-morphological approach in the study of pathological material. On one hand, the analysis of selected pathological cases (amputations, spinal transections) is able to provide invaluable information concerning the cells of origin of certain spinal transmitters in the human being. On the other hand, chemical neuropathology allows a more precise identification of the neuronal nets or types that are involved in a disease process. This advantage is underlined by studies performed in amyotrophic lateral sclerosis. In this condition, certain modifications, such as the reductions of acetylcholinesterase, choline acetyltransferase, cholinergic muscarinic, glycine or TRH receptors, are probably a consequence of motoneuron degeneration. In contradistinction, other findings, such as specific metabolic changes of motoneurons or early disappearance of SP-containing fibers in lamina IX, might be relevant for the pathogenesis of the disease.

Amyotrophic Lateral Sclerosis↗

PubMed1986

[Clinico-electromyographic characteristics of amyotrophic lateral sclerosis and the syndrome of amyotrophic lateral sclerosis of vertebrogenic etiology].

Fifteen patients with lateral amyotrophic sclerosis (LAS) and 37 patients with the LAS syndrome of vertebrogenic etiology were examined by global electromyography and recording of the H-reflex. The findings confirmed the diagnostic significance of electromyography in specifying the localization and severity of the pathological process. The method of monsynaptic testing was found to be especially valuable for diagnosing the disease at the early stage of development which helps to differentiate between LAS and the LAS syndrome of vertebrogenic etiology.

Adult↗

PubMedDate not supplied

Temporal lobe pathology in amyotrophic lateral sclerosis. Do amyotrophic lateral sclerosis and Alzheimer's disease share a common etiological factor?

An autopsy study was performed on temporal lobe samples from 20 non-demented patients with amyotrophic lateral sclerosis (ALS), 17 age-matched non-demented controls and 4 Alzheimer's disease (AD) patients. Formalin fixed, paraffin embedded sections from the hippocampus with adjacent parahippocampal gyrus and from the superior temporal gyrus were stained with conventional and immunohistochemical stains. Immunohistochemical staining for the A4 protein was enhanced by pretreatment with 0.25% pepsin before 100% formic acid. The incidence and severity of AD-like pathological changes were similar in ALS patients and non-demented controls. In both groups, pathological changes increased with age. This study does not support the hypothesis that ALS and AD share an etiopathogenetic background.

Aged↗

PubMed1996

The Amyotrophic Lateral Sclerosis Functional Rating Scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I-II Study Group.

OBJECTIVES: To test the utility of a new, easy to administer instrument for assessing activities of daily living in patients with amyotrophic lateral sclerosis (ALS), to validate its accuracy, and to assess its ability to record disease progression in patients with ALS against other functional scales, quantitative isometric muscle testing, and global assessment scales. DESIGN: Serial assessments of patients who presented to four ALS treatment centers in two multicenter studies. PATIENTS: Study 1 (cross-sectional) evaluated 75 consecutive patients who presented to four ALS treatment centers during a 2-month period. Study 2 (longitudinal) evaluated the progression of 53 patients who were enrolled in a multicenter, phase I-II clinical trial of recombinant human ciliary neurotrophic factor for treatment of ALS. OUTCOME MEASURES: The ALS Functional Rating Scale (ALSFRS) was compared with quantitative myometry and with other measures of daily function in patients with ALS both cross-sectionally and longitudinally. RESULTS: The first study of 75 patients evaluated the internal consistency, the test-retest reliability, and the construct validity of the ALSFRS. Internal consistency and test-retest reliability were high. Patient self-rating of upper- and lower-extremity-dependent tasks were highly correlated with measures of upper- and lower-extremity strength, respectively. Thus, the ALSFRS has good construct validity. In the second study, ALSFRS scores declined in tandem with deterioration in motor and pulmonary function, indicating its sensitivity to change. CONCLUSIONS: The ALSFRS is a useful instrument for evaluation of functional status and functional change in patients with ALS. Its results are in close agreement with objective measures of muscle strength and pulmonary function. The ALSFRS may be used as a screening measure for entry into clinical trials, as a surrogate measure of function in situations in which muscle strength cannot be measured directly, or as an adjunct to myometry.

Activities of Daily Living↗

PubMed1995

Natural history of amyotrophic lateral sclerosis. Observations with the Charing Cross Amyotrophic Lateral Sclerosis Rating Scales.

Natural history data increase the descriptive knowledge about amyotrophic lateral sclerosis (ALS), help define primary outcome variables and numbers of patients needed on clinical trials, and may give valuable predictive information. Global scores do not adequately represent the clinical variability of ALS. The Charing Cross Quantitative and Qualitative ALS Rating Scales assess disease severity and progression by validated regional scores (bulbar, respiration, upper limb, lower limb) and activities of daily living. The main stages in the development of these scales are summarized. Interval, or quantitative, scales provide accurate and sensitive measurements of the evolution of the disease and are useful for phase II therapeutic trials. The deterioration rates of regional scores in individual patients may not be linear. Rates of disease progression in ALS vary (1) among patients, (2) among topographical regions within a single patient, and (3) at different stages of the disease in a single region in the same patient. The deterioration rates of the regional scores of an ALS population depend critically on whether deaths are included or excluded from the population mean scores. Qualitative scales with simple scores are best suited for large-scale, phase III trials and for life table analysis of times to failure.

Amyotrophic Lateral Sclerosis↗

PubMed2004

A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee.

OBJECTIVE: To assess the effect of a lateral-wedge insole with elastic strapping of the subtalar joint on the femorotibial angle in patients with varus deformity of the knee. METHODS: The efficacy of a wedged insole with subtalar straps and that of a traditional wedged insole shoe insert were compared. Sixty-six female outpatients with knee osteoarthritis (OA) were randomized (according to birth date) to be treated with either the strapped or the traditional inserted insole. Standing radiographs with unilateral insole use were used to analyze the femorotibial angles for each patient. In both groups, the baseline and 6-month visual analog scale (VAS) scores for subjective knee pain and the Lequesne index scores for knee OA were compared. RESULTS: The 61 patients who completed the 6-month study were evaluated. At baseline, there was no significant difference in the femorotibial angle (P = 0.66) and the VAS score (P = 0.75) between the 2 groups. At the 6-month assessment, the 29 subjects wearing the subtalar-strapped insole demonstrated a significantly decreased femorotibial angle (P < 0.0001) and significantly improved VAS scores (P = 0.001) and Lequesne index scores (P = 0.033) compared with their baseline assessments. These significant differences were not observed in the 32 subjects assigned to the traditional shoe-inserted wedged insole. CONCLUSION: These results suggest that an insole with a subtalar strap maintained the valgus correction of the femorotibial angle in patients with varus knee OA for 6 months, indicating longer-term clinical improvement with the strapped insert compared with the traditional insert.

Aged↗

PubMed1977

Normal limits of the lateral cerebral ventricles on the lateral phlebogram: a statistical analysis.

The highest points of the subependymal veins of the lateral cerebral ventricles (frontal horn, body and atrium) and the height of the body have been evaluated in selected patients. Through a statistical analysis, they have been demonstrated to depend on the height of the supratentorial compartment of the skull. Taking into account this relation, the results obtained furnish reliable criteria for evaluating ventricular enlargement or sectional deformity.

Humans↗