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At least 217 records · Page 12Linked to original sources
PubMed1979

Geographic and host-related variation among species of Fessisentis (Acanthocephala) and confirmation of the Fessisentis fessus life cycle.

Specimens of the 4 known species of Fessisentis, acquired through new collections in 6 states and laboratory infections, were compared with existing descriptions and collections. It was concluded that the number od longitudinal rows of proboscis hooks and lengths of proboscis receptacles, largest proboscis hooks, and reproductive systems are not useful in distinguishing the species. Egg size is of limited usefulness. Regardless of host or geographical locality, proboscis shape and length, the number of proboscis hooks in each longitudinal row, hook shape and size distribution, number of testes, number of cement glands, and female genital pore position are consistent differences. Cystacanths of Fessisentis fessus occurred in aquatic isopods, Asellus forbesi and Lirceus lineatus, in Jackson County, Illinois, where Siren intermedia is the usual definitive host. Laboratory infections confirmed the life cycle of this species.

Acanthocephala↗
PubMed1974

Recovery of poliovirus from turbid estuarine water on microporous filters by the use of celite.

The application of a new step for recovering poliovirus from moderately to highly turbid estuarine water by the filter virus-adsorption technique was investigated. The experiments were conducted under both (i) laboratory-based conditions (200-ml volumes) where the turbidity was controlled and (ii) simulated field conditions (15- to 100-gal volumes) where the turbidity varied depending upon the hydrology of the raw estuarine water. The new step consisted of adding Celite to the turbid water prior to sampling for virus. In the experiments, the pH of the water was first adjusted to 3.5 and then AlCl(3) was added to 0.0005 M. Celite was added to a concentration of 0.01% and mixed thoroughly. Either an HE Cox M-780 microfilter (Cox Instrument, Div. of Lynch Corp., Detroit, Mich.) or an MF-membrane filter (Millipore Corp., Bedford, Mass.) was used as the virus adsorbent. Virus was eluted from the Celite-filter complex in situ at pH 9 with 5x nutrient broth. In the laboratory-based experiments, when turbidity ranged from 5.0 to 30.0 Jackson turbidity units (JTU), virus recovery ranged from 66 to 89%. In the simulated field experiments, when the turbidity ranged from 8.5 to 80.0 JTU, virus recovery ranged from <1 to 74%, depending upon the multiplicity of virus input and the level of turbidity. The new step greatly improved the filtration-flux of turbid water and significantly reduced the premature clogging problem usually observed with microporous filters.

Adsorption↗
PubMedDate not supplied

Expression of latent allotypes in SJL mice.

SJL mice (CH allogroup Igb) were immunized against immunoglobulins from strain BALB/c (allogroup Iga). We used either animals purchased directly from the Jackson Institute, or Jackson-derived mice which had been inbred further in our laboratory. In some mice from three independent immunization series we observed, contrary to expectation, the expression of molecules carrying allotypic determinants of Iga instead of the expected production of antibodies against these determinants. Various types of breeding experiments were carried out with parents being either "orthodox" SJL mice, or animals expressing the "wrong" allotype. Among the progeny, as analyzed so far, we again found animals which changed their allotype after antiallotypic immunization. The data do not appear to be compatible with a single-gene, dominant mendelian inheritance of allotypic determinants in this stock of mice.

Alleles↗
PubMed1980

Environmental and biological effects following application of diazinon impregnated strips within a laboratory animal room.

Rats were exposed to diazinon impregnated strips in a conventional laboratory animal room. The air in the room was monitored for the pesticide. Erythrocyte acetylcholinesterase and plasma pseudocholinesterase activities were determined periodically. Air concentration of the pesticide never exceeded 1.34 microgram/m3. No significant change in enzyme activities were observed.

Acetylcholinesterase↗
PubMed1985

Hematologic values of normal Bolivian squirrel monkeys (Saimiri sciureus): a comparison between wild-caught and laboratory-bred male animals.

Complete and differential blood counts were conducted on 23 male squirrel monkeys (Saimiri sciureus) of Bolivian origin. The sample included 9 laboratory-bred and 14 wild-caught adult monkeys weighing between 600 and 1,500 g. The means of total white blood cell (WBC) counts, total hemoglobin and hematocrits of laboratory-bred animals were found to be significantly different from those of wild-caught monkeys (p less than 0.01). Other hematologic parameters showed no significant differences between the two experimental groups. 3 of 14 (21.0%) wild-caught animals each had 1 reactive lymphocyte and 7% of the same group had 10 nucleated erythrocytes per 100 WBC. No reactive lymphocytes or nucleated erythrocytes were observed in laboratory-bred animals. The importance of these baseline data and the basis for the differences observed between laboratory and wild-caught monkeys are discussed within the context of experimental studies involving primates in which hematologic parameters are valuable.

Animals↗
PubMed2002

Concurrent validity of caregiver/parent report measures of language for children who are learning both English and Spanish.

The validity of two analogous caregiver/parent report measures of early language development in young children who are learning both English and Spanish is examined. Caregiver/parent report indices of vocabulary production and grammar were obtained for 26 children using the MacArthur Communicative Development Inventory: Words & Sentences (CDI; Fenson et al., 1994) and the Inventario del Desarrollo de Habilidades Comunicativas: Palabras y Enunciados (IDHC; Jackson-Maldonado, Bates, & Thal, 1992). Scores were significantly correlated with analogous laboratory measures in both English and Spanish, including a real-object naming task and spontaneous language use during free-play. The findings offer evidence that the CDI and IDHC provide valid assessments of early language milestones in young English- and Spanish-speaking children. Factors that may influence the validity of these tools for use with this population are also discussed.

Attitude↗
PubMed1991

A double-blind, placebo-controlled, parallel dose-response study of amlodipine in stable exertional angina pectoris.

A placebo-controlled, double-blind, dose-response study of amlodipine (1.25, 2.5, 5, and 10 mg once daily) was carried out in 136 patients with stable exertional angina pectoris. Improvements in total exercise tolerance, time to onset of angina during exercise, ST-segment deviation at maximum common load, frequency of angina attacks, and nitroglycerin consumption were greater following amlodipine than placebo. The maximum improvement in exercise parameters occurred with the highest dose of amlodipine. All doses produced significant reductions in angina attack frequency and the rate of nitroglycerin consumption. Amlodipine was well tolerated and no patients were withdrawn due to adverse events or laboratory abnormalities.

Adult↗
PubMed1994

Effect of specimen storage on absolute CD4 counts.

We have evaluated the effect of specimen storage on absolute CD4 counts by a commercially available manual assay. This assay utilizes latex particles coated with CD4 monoclonal antibodies that are mixed with lymphocytes in whole blood. Thirty blood samples were analyzed on days 1, 2, 4, and 7 postcollection. Linear regression analysis and Pearson correlation coefficients were used to determine the relationship between the absolute CD4 count and the storage time after sample collection. There was a significant decrease in absolute CD4 counts from baseline over time, dropping 3.6% at day 2, 10.1% at day 4, and 18.8% at day 7. However, the standard error of the B coefficient was constant [SE (B) = 0.031] up to day 4, indicating that reliable estimates of the baseline CD4 counts could be made from the CD4 counts determined up to day 4 from the time of sample collection. In addition to being sample, rapid, and inexpensive, the manual assay is capable of giving a reliable absolute CD4 count after specimen storage of up to 4 days. The application of this assay in the limited facilities of developing countries' laboratories is attractive.

Blood Specimen Collection↗
PubMed1984

Morphological assessment of testicular maturity in marmosets (Callithrix jacchus).

The onset of spermatogenesis in relation to age, bodyweight and testes weight in 105 marmosets used in safety studies has been reviewed. The histological recognition of adverse effects on spermatogenesis is an important part of these studies and this survey indicates that male marmosets should be at least 50 weeks and preferably 60 weeks of age if an assessment of all stages of spermatogenesis is required for safety evaluation.

Animals↗
PubMed1985

Use of ferrets in studies of the visual system.

The ferret (Mustela putorius furo) is proving to be an excellent experimental animal for many anatomical and physiological studies of the adult and developing visual system. As a result, the amount of data available on the ferret's visual system is increasing at a rapid rate. The purposes of this paper are to briefly review some of those data and to present some of the reasons why the ferret is an appropriate choice as an experimental animal for visual system studies.

Animals↗