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Results for “Hyperkinesis”

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[Concentration of lead in the blood of children with hyperkinesis].

The concentration of lead in bloods of 25 hyperkinetic children was compared to that found in a corresponding number of healthy children of the same age group. It was found that 3 hyperkinetic children showed levels above 40 mug/100 ml. The findings are discussed and the importance of substances containing this element bears on the child's environment are pointed out. Besides, stress is placed on the consequence that a high concentration of lead in the blood may show on mental development and it is suggested that through studies be carried out in every child with the habit of pica added to hyperkinesia.

Child↗
PubMed1984

Efficacy of ACTH 4-9 analog, methylphenidate, and placebo on attention deficit disorder with hyperkinesis.

The present study compared the efficacy of ACTH 4-9 analog, methylphenidate, and placebo on attention deficit disorder with 30 (HK) children with attention deficit disorder and psychometric measurements. HK children were randomly placed into three groups, according to body weight, and treated with placebo, methylphenidate, and adrenocorticotropic hormone fractions (ACTH 4-9 analog). The results revealed that HK children on methylphenidate manifested a significantly greater vasomotor reactivity, behavioral improvement, and learning receptivity than HK children taking ACTH 4-9 analog and/or placebo. Future research implications with ACTH 4-9 and HK children are discussed.

Adrenocorticotropic Hormone↗
PubMed1981

Spinal motoneuronal excitability in hyperkinesis: H-reflex recovery function and homosynaptic depression during wakefulness.

Variations in amplitude of the spinal monosynaptic H-reflex were examined during relaxed wakefulness in three unmedicated groups of subjects, hyperactive children (n=5), an age-matched group of control children (n=5), and a group of young adults (n=10), using techniques involving equal intensity percutaneous stimuli delivered in pairs or trains at varying rates. The paired-stimuli procedure generates a recovery function, the outstanding features of which are early depression, a peak of facilitation occurring between 100-300 msec, and complete recovery by 2-5 sec. Trains of stimuli delivered at rates greater than or equal to 1/sec effect a reduction in reflex amplitude which is termed homosynaptic depression. Both procedures revealed differences between hyperkinetic children and comparison groups. The paired-stimulus technique revealed a generalized reduction in excitability for hyperkinetic children for intervals extending up to 800 msec. In particular, hyperkinetic children were characterized by a significantly increased variability at the longer stimulus intervals. Hyperkinetic children also showed a more rapid reduction in reflex amplitude to initial stimuli in stimulus trains delivered at rates greater than or equal to 1/sec. Trains of stimuli at rates effecting facilitation in terms of the paired stimulus technique, i.e., 3,4 and 5/sec, revealed sustained amplitude enhancement for control subjects only. The recovery function data are consonant with spinal motoneuronal hypoexcitability in hyperkinetic children. Possible neruophysiological and neurochemical mechanisms underlying the reduced capability of hyperkinetic children to respond to rapidly delivered, repetitive stimuli are discussed.

Adult↗
PubMed1983

Spinal motoneuronal excitability during wakefulness and non-REM sleep in hyperkinesis.

Variations in spinal motoneuronal excitability were assessed during wakefulness and non-REM sleep in hyperkinetic and normal children by determining the recovery cycle of the H-reflex following a conditioning stimulus. Reflex facilitation which generally occurs 100-300 msec after a conditioning stimulus was markedly reduced during sleep in both groups and during wakefulness as well in hyperkinetic subjects. Among possible mechanisms which might underlie the observed reductions in facilitation, emphasis is placed on decreased central excitability resulting from depressed fusimotor activity.

Attention Deficit Disorder with Hyperactivity↗