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Dietary vitamin C and uterine cervical dysplasia.

A case-control study of women with cervical abnormalities identified through Pap smears, was conducted in the Bronx, New York, to explore the relationship between nutritional intake and cervical dysplasia. Nutrient intake was estimated from computer analysis of three-day food records and 24-hour recall for 169 study participants (87 cases, 82 controls), including a subset of 49 pairs matched for age, race and parity. Mean vitamin C intake per day from three-day food record for controls was 107 mg, compared to 80 mg for cases (p less than 0.01). Analysis of matched pairs showed similar results; 29% of cases compared to 3% of controls in matched subset had vitamin C intake less than 50% of the recommended daily allowance, yielding a ten-fold increase in risk of cervical dysplasia as estimated by odds ratio (p less than 0.05). Younger age, greater frequency of sexual intercourse and younger age at first intercourse were associated with higher risk of cervical dysplasia. Multiple logistic analyses indicated that low vitamin C intake is an independent contributor to risk of severe cervical dysplasia when age and sexual activity variables are controlled. Approximately 35% of US women in their reproductive years have daily vitamin C intake below 30 mg, and 68% have vitamin C intake below 88 mg. If other studies confirm these findings, it may be important to explore a possible protective role of supplementary vitamin C for women at high risk of cervical cancer.

Adolescent↗

Anal intercourse and sexual risk factors among college women, 1993-2000.

OBJECTIVE: To determine trends and sexual risk behaviors associated with anal intercourse among college women over an 8-year period. METHODS: A sexual activity questionnaire was used to collect data from 813 students enrolled in a women's health course. RESULTS: Thirty-two percent of the women had engaged in anal intercourse, and this measure was consistent across time. Women who had engaged in anal intercourse were significantly younger at first intercourse and had a greater lifetime number of partners and more reported STIs. CONCLUSION: This study underscores the importance of expanding our understanding of sexual behaviors of college women and openly addressing anal intercourse as a part of the sexual repertoire of college women.

Adolescent↗

[Effect of oral contraceptive administration on the frequency of estrogen receptor and cervical intraepithelial neoplasia].

A study of 56 sexual active women with cervical intraepithelial neoplasia (CIN) was conducted in Mexico City, to determine wether the risk for this condition is altered by using oral contraceptives. Responses of a standardized questionnaire compared 29 patients under oral contraceptive (OC) treatment and 27 control subjects selected from the same screening program, though which the cases were detected. Estrogen receptor (ER) levels were determined in each hyperplastic tissue. The ER frequency was approximately the same in women under oral contraceptive (OC) treatment and in women without it. (P > 0.05). Among other risk factors, first intercourse at an early age, first pregnancy age, number of pregnancies and multiple sexual partners were consistently no significant (p > 0.05) when both groups were compared. In this study, we have found no evidence of an etiologic relationship between neither oral contraceptive usage or non usage and CIN.

Adolescent↗

Risk-taking behaviour of Cape Peninsula high-school students. Part VIII. Sexual behaviour.

The prevalence of a wide range of risk-taking behaviour among high-school students in the Cape Peninsula, South Africa, was investigated. In this article, the results for sexual behaviour are presented. Cluster sampling techniques produced a sample of 7,340 students from 16 schools in the three major education departments, of whom 79.7% answered the section dealing with sexual behaviour. A self-administered questionnaire was completed in a normal school period. Estimates for each education department were weighted to produce an overall estimate. Of the sample, 17.4% indicated a previous episode of heterosexual intercourse. The median age at first intercourse was 15.1 years. The median number of partners in the previous 12 months was 1.0. The median number of weeks since the most recent coital episode was 6.6; on this episode 76.6% had known their partners for more than 7 days, while 60.5% had done something to avoid pregnancy. The most frequently used method of contraception was injectable steroids for Xhosa-speaking students and condoms for the other students. Males and Xhosa-speaking students appear to be particularly at risk for the adverse consequences of sexual activity. The HIV epidemic has increased the urgency of introducing meaningful sexuality education in South African schools.

Adolescent↗

Alternative methods in the investigation of adolescents' sexual life.

PURPOSE: To describe two methodological approaches to surveying adolescents' sexual life which were combined within a national survey. METHODS: The questionnaire was designed during a 5-day workshop. Ten adolescents played the roles of imaginary adolescents involved in different situations related to sexual life. The information obtained through the analysis of these role-plays was used to establish the sequence of the questions, their content, and wording. The questionnaire was computerized so that it could be completed by the adolescents using laptop computers. Its arborescent structure, leading each respondent from one module to another, made possible the adjustment of the questions to each respondent's stage of development and type of sexual experience. RESULTS: A total of 4283 teenagers (2075 girls and 2208 boys, and 4 refusals) 16-20 years were included. Only 7.6% did not fill in the whole questionnaire. By the age of 18 years, more than 50% of boys and girls were sexually active. Half of sexually active teenagers have discussed contraception issue before engaging in their first intercourse, but much fewer (14-35%) have discussed issues related to HIV transmission. During their first sexual intercourse, the majority of the respondents used a condom (girls, 63%; boys, 58%) or condom plus oral contraception (girls, 11%; boys, 17%). CONCLUSION: Youth participation and role-play decrease the conceptual biases often associated with professionals' perceptions and bring tools enabling a better exploration of circumstances and negotiations surrounding the sexual encounter. The computerized questionnaire increases confidentiality, attractiveness, easy data collection, and, above all, adjustment of the questions to the respondent's level of experience. These methods could be more systematically used in surveys targeting sensitive issues related to adolescents' health.

Adolescent↗

Sexual activity, contraception, and reproductive factors in predicting endometriosis.

To examine the belief that women with endometriosis have "voluntarily" delayed childbirth, the authors used a case-control approach to assess the relation between sexual, contraceptive, and reproductive factors and endometriosis. A total of 104 laparoscopically confirmed newly diagnosed cases of endometriosis were identified from a gynecologic specialty clinic in western New York state in 1987. Two control groups were used: 1) 100 friend controls, and 2) 98 medical controls. No differences were found between study groups on use of reliable birth control, use of birth control before a first pregnancy, age at first intercourse, frequency of intercourse, decisions to delay pregnancy, age at first pregnancy, or measures of body size. Cases were older than medical controls by about 1 year when they first began using birth control (19.8 vs. 18.6 years, p < 0.05). Cases were also 1 year older than friend controls when they began regular intercourse (20.9 vs. 19.5 years, p < 0.005) and at first marriage (22.8 vs. 21.7 years, p < 0.05). A larger percentage of cases than friend controls were never pregnant (p < 0.0001) and were more likely to have problems becoming pregnant (p < 0.0001). Results, overall, do not support simplistic assumptions that characterize endometriosis patients as career women who voluntarily delay pregnancy. Rather, the results point to a complex relation between endometriosis and reproductive, sexual activity, and fertility-related factors.

Adult↗

The association between childhood and adolescent sexual abuse and proxies for sexual risk behavior: a random sample of the general population of Sweden.

OBJECTIVE: Several studies with small and "high risk" samples have demonstrated that a history of childhood or adolescent sexual abuse (CASA) is associated with sexual risk behaviors (SRBs). However, few studies with large random samples from the general population have specifically examined the relationship between CASA and SRBs with a comprehensive set of measures. DESIGN: The study was a cross-sectional retrospective survey of past and current sexual health and behavior. METHODS: A random sample of 4781 persons from the Swedish Post Address Register was obtained, which included 6,119,000 Swedish citizens in 1996. Of those persons, 2810 participants agreed to participate in the study. Participants were interviewed as well as administered a questionnaire regarding their sexual health and behavior. RESULTS: Using Mann-Whitney U tests, a history of CASA was found to be associated with younger age at first intercourse; younger age at diagnosis of first sexually transmitted infection (STI); greater frequency of unintended pregnancy; greater likelihood of participation in group sex; higher likelihood of not interrupting sexual intercourse despite the risk of pregnancy or risk of an STI; greater likelihood of exchanging sex for money or other necessities/drugs; more frequent substance use in the last 48 hours; and higher likelihood of adult sexual and physical assault. CONCLUSIONS: The findings of this study confirm previous research, which has reported an association between CASA and SRBs in smaller and high-risk samples. Clinicians working with adults with a history of CASA should be aware of the relationship between CASA and SRBs and be prepared to address such issues during therapy.

Adolescent↗

[The first coitus as an outcome indicator].

BACKGROUND: For evaluation of the health status in specialized medical disciplines and comparisons in different regions (countries, world-wide comparisons) the World Health Organization recommends and uses so-called indicators. In the sphere of human sexuality the use of such indicators is difficult, because it cannot be assessed by objective data. The purpose of the present study was to assemble information on the time and course of the first sexual intercourse of contemporary Czech girls. METHODS AND RESULTS: A total of 700 Czech girls aged 16-18 years were interviewed; all menstruated already. 344 girls (49.1%) reported that they had heterosexual intercourse: in 24.1% the first intercourse occurred at the age of 15 years and in 75.9% between 16 and 18 years. As to the place where it occurred, in 64% it was the parents' apartment. For the contemporary Czech society it is typical that in cca 20% the place of the first intercourse was a weekend house. In 8.5% of the girls the intercourse was implemented by force or under the influence of abundant alcoholic drinks. As far as prevention of unwanted pregnancy is concerned, in 42.0% no contraception was used, coitus interruptus was practiced in 25.3%--i.e. unreliable contraception in 67.3% of sexual intercourse. A condom was used by 30.4% partners, hormonal birth control only by 2.3% girls. CONCLUSIONS: Information on "outcome indicators" on the time of the first sexual intercourse and the place where it occurred was assembled. The authors recorded also data on the use of force, the influence of alcohol and the use of contraception. These data make it possible to gain an idea on the sexual life during adolescence.

Adolescent↗

Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies.

Squamous cell carcinomas account for about 80% of cancers of the uterine cervix, and the majority of the remainder are adenocarcinomas. There is limited evidence on the extent to which these histological types share a common etiology. The International Collaboration of Epidemiological Studies of Cervical Cancer has brought together and combined individual data on 8,097 women with invasive squamous cell carcinoma, 1,374 women with invasive adenocarcinoma and 26,445 women without cervical cancer (controls) from 12 epidemiological studies. Compared to controls, the relative risk of each histological type of invasive cervical cancer was increased with increasing number of sexual partners, younger age at first intercourse, increasing parity, younger age at first full-term pregnancy and increasing duration of oral contraceptive use. Current smoking was associated with a significantly increased risk of squamous cell carcinoma (RR = 1.50, 95% CI: 1.35-1.66) but not of adenocarcinoma (RR = 0.86 (0.70-1.05)), and the difference between the two histological types was statistically significant (case-case comparison p < 0.001). A history of screening (assessed as having had at least one previous nondiagnostic cervical smear) was associated with a reduced risk of both histological types, but the reduction was significantly greater for squamous cell carcinoma than for adenocarcinoma (RR = 0.46 (0.42-0.50) and 0.68 (0.56-0.82), respectively; case-case comparison, p = 0.002). A positive test for cervical high-risk HPV-DNA was a strong risk factor for each histological type, with 74% of squamous cell carcinomas and 78% of adenocarcinomas testing positive for HPV types 16 or 18. Squamous cell and adenocarcinoma of the cervix share most risk factors, with the exception of smoking.

Adenocarcinoma↗

Health status and risk behavior of adolescents in the north of Madrid, Spain.

PURPOSE: To study the health status and risk behavior in an adolescent population of Madrid, Spain. METHODS: An anonymous self-administered questionnaire was completed by 2831 pupils aged 14-20 years from urban, suburban, and rural populations in the north of Madrid. A large number of questions were from the Minnesota Adolescent Health Survey questionnaire, which included sociodemographics, health status, drug use, sexual practices, suicidal thoughts, emotional problems, and injury risk. Student's t-test, analysis of variance, and Chi-square statistics are used for analyzing associations between the different variables. RESULTS: A majority (80%) of students thought they are in good or very good health (better for males than females); 18.3% had had intercourse, the average age of the first intercourse was 15.4 years +/- 1.68 SD for males and 16.1 years +/- 1.46 SD for females. Most (73%) had used some kind of contraception. Eighty-five percent had tried alcohol, and regular use (frequently or every day) was as high as 24%. Males drank more than females (28% vs. 20%); 58.2% of the population drink only during weekends, the percentage increasing with age. Seventy percent of the sample had smoked at least once; 34. 5% reported regular tobacco use and this increased with age. Males smoked less than females (27% vs. 42%); 3.2% smoked more than 20 cigarettes/day. The consumption of illegal drugs was very low (20% had tasted cannabis and use by males was higher). Cocaine, heroin, etc. were used by less than 5%. CONCLUSION: In general, our adolescents are in good health with most problems being preventable. Sexual activity was lower than in other European and American countries. The consumption of tobacco and alcohol started early and in general was high. Our study confirms the relationship among different health-compromising behaviors. There is a need to implement health promotion and preventive programs for adolescents.

Adolescent↗

Attitudes of female college students toward over-the-counter availability of oral contraceptives.

STUDY OBJECTIVE: To determine female college students' beliefs about oral contraceptive pill (OCP) availability and use, and to examine significant factors associated with these beliefs. DESIGN: Cross-sectional survey. SETTING: Urban women's liberal arts college. PARTICIPANTS: Two hundred ninety female undergraduates who completed surveys. INTERVENTION: An anonymous survey was placed in all undergraduate mailboxes. Surveys were returned to a locked collection box in the mailroom. Within 4 weeks after distribution. 290 surveys were completed. MAIN OUTCOME MEASURES: Sexual and contraceptive practices and students' beliefs regarding whether OCPs should be made available without prescription. RESULTS: The respondents' average age was 20.9 +/- 3.3 years; 84% reported previous sexual intercourse with the mean age of first intercourse at 16.6 +/- 2.2 years. Seventy-five percent of the sexually active women reported use of OCPs and 52% had used OCPs at their last intercourse. Sixty-five percent of all respondents felt OCPs should not be available without prescription. The two most commonly cited reasons for not wanting OCPs to be available over the counter (OTC) were that (1) side effects might occur that a health care provider could have prevented (59%), and (2) people would not go to their providers for regular check ups (56%). The most commonly cited reason for believing that OCPs should be available OTC was that there would be fewer unwanted pregnancies (74%). Race, previous OCP use, previous sexual activity, and perceived risk of pregnancy were not significant predictors of believing OCPs should be available OTC. Having had a previous pregnancy was a significant predictor of believing OCPs should be available OTC (p = 0.047). Those who believed OCPs should be available only with a prescription were willing to pay more for OCPs (p = 0.033). Logistic regression controlling for race revealed that both younger age (p = 0.03) and previous pregnancy (p = 0.002) were independent predictors of believing OCPs should be available OTC. CONCLUSIONS: The majority of our sample believe that OCPs should remain as a prescription medication. Previous pregnancy and younger age are important factors in determining beliefs regarding OCP availability. Further studies in a more diverse population are needed to explore the relationship between age, previous pregnancy, and desire for contraceptive availability without prescription.

Adolescent↗

[Human papillomavirus type 16 and human cytomegalovirus in cervical carcinoma].

Using techniques of DNA-DNA dot blot hybridization, we examined 98 cervical specimens for the presence of human papillomavirus type 16 HPV-16 and human cytomegalovirus (HCMV) sequence and analysed the relationship between virus infection and various cervical diseases, age of patients, age at first coitus, age of first child birth, the number of pregnancy, use of oral contraceptives. The results showed that the rate of HPV DNA and HCMV DNA positivity in cervical carcinoma is significantly higher than that of non-carcinomatous tissue. In addition, the positivity correlates with age, at first intercourse, but not with age of first child birth, the number of pregnancy and use of oral contraceptives. These data suggested that HPV-16 and HCMV infection is associated with cervical carcinoma. Some cases of cervical erosion with HPV infection may lead to cervical. The high incidence of cervical carcinoma in women married early in life may be related to virus infection in adolescence. HPV acting with other synergistic factors, such as HCMV is considered to lead to the occurrence of cervical carcinoma.

Adult↗

[Sexuality and AIDS. KAPB study accomplished in 1989 in a school environment in Ouagadougou (Burkina Faso)].

AIDS is nowadays one of the major problems of public health in Burkina Faso. In order to get informations on pupils' sexual behaviour and knowledge about AIDS, we conducted a study on a representative sample from secondary schools' students in Ouagadougou (n = 466). The mean age was 18.2 years old; 48.7% among these pupils declared to have had least one sexual intercourse. The mean age of the first intercourse was 16.3 years old. For them, media was the main information source on AIDS (72.1%), whereas schools were not named. 58.4% mentioned condom as a mean of prevention and 64.1% among males who have had a sexual experience used condom. Although they were afraid of AIDS the school students asked did not think they were likely to contract the illness; but they pointed out the prostitutes as a risk behaviour group. These results are discussed according to the gravity of AIDS. So, the risky sexual behaviour, due to ignorance and/or thoughtlessness, endanger this youth and challenge all actors.

Acquired Immunodeficiency Syndrome↗

Sexual risk factors for cervical cancer among rural Indian women: a case-control study.

BACKGROUND: The association between sexual behaviour and cervical cancer is well established. Despite a high incidence of cervical cancer in India, its role has not been widely investigated in Indian women among whom the rate of sexual promiscuity is known to be very low. A hospital-based case-control study was carried out to investigate the role of sexual risk factors in cervical cancer among rural Indian women. METHODS: A case-control design was used in which a total of 268 subjects, comprising 134 women with invasive cervical cancer as cases and 134 control women were studied. A multiple logistic regression model was used to analyse the data. RESULTS: The risk factors found to be associated with cervical cancer were early age at first coitus, extramarital sex partners of women and the time interval since first exposure. In a multiple logistic regression model, independent effects were observed for early age at first coitus, showing maximum risk in women who reported their first intercourse at < 12 years of age, compared to that of women at > or = 18 years (odds ratio [OR] = 3.5. 95% confidence interval [CI]: 1.1-10.9). Increased risk was also seen for women who had extramarital sex relationships (OR = 5.5, 95% CI: 1.5-19.5). The significant effect of early age at first coitus persisted after adjustment for latency period which also showed its independent risk association with cervical cancer in the multivariate analysis. CONCLUSION: These findings confirm the association between early age at first coitus and cervical cancer in women with a low rate of sexual promiscuity and define the role of these risk factors in cervical carcinogenesis among rural Indian women.

Adult↗

Sources of prescription contraceptives and subsequent pregnancy among young women.

For more than four in 10 teenage women who first obtained a prescription contraceptive from a private doctor or family planning clinic prior to pregnancy, marriage or interview in 1979, that method was the first they had ever used. Whites were over two times more likely to have previously used a nonprescription method than were blacks. Blacks, on the other hand, were two times more likely than whites to have been virgins before first using a prescription method. Slightly more than half of all young women who used a prescription method first obtained it from a family planning clinic, and the remainder got it from a private physician. Blacks were much more likely to have gone to a clinic than were whites. Nine in 10 of those who obtained a prescription method chose the pill. Among blacks, there was no appreciable difference between those who got the method from a clinic and those whose source was a private doctor. Whites who obtained their method from a private doctor, however, were somewhat more likely to choose the pill than were those who got it from a clinic. Of all who had been sexually active before ever using a prescription method, about eight out of 10 whites, but only about five in 10 blacks, had previously used a nonprescription method. Overall, there was an interval of about one year between first intercourse and the time the young women first got a prescription method. Among whites, there was no difference in parental education or family stability between clinic and private physician patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

Context counts: long-term sequelae of premarital intercourse or abstinence.

An individual's first sexual experience is a highly salient and meaningful event, with potential to shape sexual scripts and the affect associated with sexual expression. Using data from the National Health and Social Life Survey, we tested abstinence-only advocates; assertions that premarital sex results in psychological and physical harm such as sexual dysfunction, sex guilt, poor health, sexually transmitted diseases, and poor life satisfaction. The first vaginal intercourse was premarital in 82.9% of the sample. Average age at first intercourse was 17.7 years. Relationship status as first intercourse was not consistently associated with later psychological or physical health outcomes. If the first experience was prepubertal, forced, with a blood relative or stranger, or the result of peer pressure, drugs, or alcohol, poorer psychological and physical health outcomes in adulthood were reported consistently. There is little evidence that premarital sex per se is disastrous for later sexual functioning or sex guilt; insofar as first sexual experiences are related to later functioning, the context of the experience is the crucial element.

Adult↗

Contraceptive behaviour of Norwegian adolescents.

This paper describes contraceptive practices among Norwegian adolescents. The data stem from a survey of a random sample of 3000 adolescents aged 17 - 19, yielding a response rate of 60.9%. On the most recent occasion when intercourse took place, every fifth adolescent did not use any contraception; one in three used a condom and approximately 40% reported having used the pill. Multiple logistic regression analysis showed that among both girls and boys non-use of contraception increased with alcohol consumption prior to intercourse. Among girls utilization of contraception was positively associated with educational aspirations whereas non-utilization was associated with number of sexual partners during the previous year. Among both boys and girls condom use declined with increased age, but was positively associated with both increased age at first intercourse and use of a condom at first experience of intercourse. Use of a condom most frequently occurred in relationships which had lasted for a period between 1 week and 6 months. Condom use was not associated with intake of alcohol prior to intercourse. A total of 33.4% of the girls and 43.3% of the boys reported that they had engaged in casual sex. Approximately one in four used a condom on the most recent occasion, whereas approximately four out of 10 did not use any contraception. It is concluded that a substantial proportion of adolescents indulge in high-risk practices both for unwanted pregnancies and sexually transmitted diseases. Moreover, despite the more prominent place given to matters of sexuality in schools and health centres during the last few decades, the proportion of non-users of contraception appear not to have substantially decreased. It is, therefore, clearly important to develop health promotion activities capable of reaching those groups of adolescents who fail to use contraception.

Adolescent↗

The resistance to contraceptive use in young Italian women.

OBJECTIVE: To investigate the personal relationship and social factors that influence young women not to use contraceptives. METHODS: A total of 104 young women aged 14-23 years were studied using a 26-item questionnaire which was to be filled out individually. The questionnaire addressed use of contraceptives at the first intercourse and current use, together with various items related to age, educational level, self-image, fantasy about parenthood, and characteristics of the relationships with the partner and the family. A descriptive analysis and a multivariate logistic regression model investigated the relationship between contraceptive non-use and selected variables. RESULTS: Twenty-four percent of the girls did not use any effective contraceptive method at the first sexual intercourse and 21% were current non-users. The study of characteristics associated with inconsistent contraceptive use shows a complex picture where young age, poor knowledge of the partner, an older partner and living in a incomplete family nucleus or outside the family represent significant risk factors. Considering our results as a whole, contraceptive non-use is not only a marker of risk-taking behavior, but sometimes expresses irrational feelings which emerge when facing new sexual experience.

Adolescent↗