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At least 217 records · Page 12Linked to original sources

[The use of pectin-containing enterosorbents in exposure to radionuclides and heavy metals].

The pectin-vitamin composition (PVC) and its complex with active carbon (AC) was investigated for use as an oral sorbent to protect radionuclide (Sr-85, Cs-137) accumulation. PVC is composed of the natural mixture of cellulose, pectin (Ca-salt), flavonoides, vitamins of the B-group, PP and C. Investigation of PVC radioprotective action was carried out on the two groups of rats (n = 30) which received 1306 Bk/animal of Sr-85 or 343 Bk/animal of Cs-137 daily. One of the group of rats received every day also 300 mg of PVC. After 30 days level of Sr-85 was less by 56.6%, level of Cs = 137 was less by 27.6% in PVC-treated than in the control group (P < 0.05). Composite sorbent consisting of PVC and AC was slightly less effective in removing of Sr and Cs.

Animals↗

[Effect of natural enterosorbents in experimental liver disorders].

The effect of enterosorbents of natural origin, zoosterol and sodium alginate, on the main types of metabolism and the macro- and microelement composition (calcium, magnesium, zinc, copper) of the renal tissues was studied in animals with experimental nephrocalcinosis. Increased complex-forming ability of zoosterol, related to a higher absorption activity of low-molecular-weight fragments of this enterosorbent, favors retention of large molecules in the form of calcium salts in the parenchyma. Sodium alginate favors the elimination of calcium compounds and compensates for calcification of the renal tissue, which allows this this enterosorbent to be used as a crystal-inhibiting complex-forming agent for correcting metabolic dysbalance in cases of nephrocalcinosis.

Alginates↗

[The prevention of the translocation of intestinal microflora after the rescue of an organism from a terminal state].

In experiments on guinea pigs, the animals were resuscitated from clinical death caused by the acute loss of blood and subsequently treated intragastrically with enterosorbents: activated carbon fibrous material, alone and in combination with polymyxin B, polyphepan (a lignin derivative), polymethyloxan hydrogel and the sorbent Enterocat. In the animals, not treated during the postresuscitation period, a high population level of enterobacteria and Gram-positive aerobic cocci was registered in the contents of the small and large intestines and their translocation to mesenteric lymph nodes, liver, spleen and blood was observed. The amount of lactobacilli in the small intestine was decreased. Enterosorbents were found to decrease a high population level of intestinal microflora, to prevent the translocation of Gram-positive aerobic cocci and to inhibit the penetration of enterobacteria through the enteric barrier in the postresuscitation period. Combined use of activated carbon fibrous material with polymyxin B proved to be most effective for the elimination of enterobacteria.

Acute Disease↗

[Correction of enteral insufficiency syndrome in general peritonitis].

Efficacy of enteral ozone lavage in combined treatment of patients with general peritonitis is analyzed. It is demonstrated that intestinal lavage with ozone-enriched physiological salt solution through nasointestinal probe in postoperative period eliminates effectively bacterial contamination of the intestine, decreases toxicity of enteral contents and leads to significant improvement of functional characteristics of the small intestine and results of treatment.

Enterosorption↗

[Application of sorbilact in complex correction of enteral insufficiency syndrome in surgical patients].

The most important teoretical aspects of the enteral insufficiency syndrome formation in an acute abdominal surgical diseases were suggested. Basing on the treatment results analysis of 19 patients with different abdominal surgical diseases, using hypertonic sorbitol solution, the authors confirm high therapeutic efficacy of the preparation, administration of which have had promoted the intestinal motor function restoration and optimization, as well as adapting action of the preparation in enteral probe nutrition conduction in patients during ealy postoperative period.

Adult↗

[The use of natural hitamine-based natural substance at chronic cholecystitis].

The results of application of hitamine, enterosorbent of marine origin, by the patients with chronic noncalculous cholecystitis in the remission phase are cited. It has been established that dietotheraphy in complex with hitamine renders the antiinflammatory and lipidcorrected action, favours the increase of remission terms.

Acalculous Cholecystitis↗

[Morphological study of placenta and liver of pregnant rats in experimental endotoxicosis and after ceolite protection].

In 45 rats and 120 fetuses the protective effect of food, containing the additives of natural ceolites, on the outcome of pregnancy complicated by an acute experimental endotoxicosis, caused by hyperthermic challenge of the animals, was studied. Using gravimetric, histological, histochemical, electron microscopical methods and monitoring the markers of endogenous intoxication, it was demonstrated that the consumption of ceolite additives contributed to the increase of resistance of the organism to the extremal challenge. Ceolite enteroprotection of acute endotoxicosis, caused by hyperthermic challenge of the pregnant rats, resulted in the increased survival of animals, lower embryonic losses, adaptive changes in placenta and maternal liver.

Animals↗

[Combined rehabilitation of patients with chronic pyelonephritis].

A total of 47 patients with chronic pyelonephritis in remission were divided into two groups. Group 1 received balneotherapy with attenuated in both groups. In group 1 total cholesterol in blood lowered to normal values, LDLP cholesterol fell by 35.2%, VLDLP cholesterol rose by 17.7%. In group 2, urine Na decreased by 23.8% (p < 0.01), blood Na - by 52.9% (p < 0.01), HDLP cholesterol rose by cholesterol, VLDLP cholesterol, LDLP cholesterol normalized. Thus, it is recommended to include enterosorbents on the basis of alginic acid into therapy of pyelonephritis.

Alginates↗

[Preclinical toxicological study of the new enterosorbent noolit].

The safety of the new enterosorbent noolit has been evaluated within the framework of its preclinical characterization. Single introduction of noolit to rats and mice (females and males) in maximum doses for intragastric administration (5.0 - 20.0 g/kg) does not lead to the loss of experimental animals. Single administration of large doses (5 - 40 times the effective dose) can reduce the growth of the total body weight and lead to the development of nonlethal pathological changes of hemopoietic organs, which is manifested by a weak regenerative anemia (5% of cases); neutrophile, eosinophile, and basophile leukocytosis (3% of cases); and a decrease in the glucose level in blood serum. In chronic experiments on rabbits, the administration of noolit for 3 months in a dose of 0.5 and 2.0 g/kg (2 and 8 times that recommended for humans) did not reveal any toxic action on the functional and morphological state of the main systems and organs (blood, liver, kidneys, lungs, heart, gastrointestinal tract, sex organs, etc.).

Aluminum Oxide↗