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PubMed2006

Multistage graph-based segmentation of thoracoscopic images.

This paper presents a graph-based segmentation method using multiple criteria in successive stages to segment thoracoscopic images acquired during a diskectomy procedure commonly used for thoracoscopic anterior release and fusion for scoliosis treatment. Starting with image pre-processing, including Gaussian smoothing, brightness and contrast enhancement, and histogram thresholding, a standard graph-based method is applied to produce a coarse segmentation of thoracoscopic images. Next, regions are further merged in a multistage graph-based process based on features like grey-level similarity, region size and common edge length. Experimental results show that our approach achieves good spatial coherence, accurate edge location and appropriate segmentation of the regions of interest from a sequence of thoracoscopic images.

Algorithms↗
PubMed2005

Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery.

STUDY OBJECTIVE: The aim of this study was to investigate the influence of 2 established anesthetic techniques: total intravenous anesthesia and balanced inhalation anesthesia (BAL) on the perioperative-induced changes of peripheral blood mononuclear cells (PBMCs), changes in lymphocyte subsets, and the balance of proinflammatory and anti-inflammatory cytokines. DESIGN: This is a prospective, randomized, clinical comparison study. SETTINGS: This study was set at a university hospital. PATIENTS: This study involved 50 patients with American Society of Anesthesiologists physical status I who were scheduled for elective minimal invasive partial diskectomy. INTERVENTIONS: There was no intervention involved in this study. MEASUREMENTS: Changes in differential counts, lymphocyte subsets, and proliferation rates were determined before surgery and in the early postoperative period. Plasma concentrations of proinflammatory cytokines (IL-2, IL-6, IL-12, interferon gamma) and anti-inflammatory cytokines (IL-10, IL-1RA, transforming growth factor beta), and plasma concentrations of cortisol, epinephrine, and norepinephrine were measured before, during, and after surgery. MAIN RESULTS: Absolute number of CD3+, CD4+, and CD8+, and expression of HLA-DR and activation marker CD25+, CD26+, and CD69+ decreased more in response to surgery after BAL. Changes in distribution of T-lymphocyte cells seem to be in part related to severe postoperative pain. Plasma concentration of IL-6 significantly increased during and after surgery with BAL without relation to pain. CONCLUSION: Anesthetic management may have varying influences on the postoperative immune response. Surgery-induced inflammatory response and alteration in cell-mediated immunity seem to be more pronounced after BAL. These effects were attributed to the enhanced stress response after BAL.

Adult↗
PubMed1998

Thoracoscopic anterior spinal procedures in children.

METHODS: From February 1996 through July 1997, 20 patients were determined to be appropriate for a thoracoscopic approach for the anterior portion of their spinal surgery. Ages ranged from 8 to 17 years of age and weight from 20 to 70 kg. The diagnosis included severe idiopathic and neurogenic scoliosis or kyphosis (n = 20) and congenital hemivertebra (n = 4). The procedures performed included diskectomy and anterior release from two to nine vertebral levels, hemivertebrectomy, and epiphysiodesis. Four patients also had an open lumbar exposure and all had a posterior fusion. RESULTS: All procedures were completed successfully endoscopically. Surgical times for the thoracoscopic portion of the procedure averaged 106 minutes and total procedure times were comparable with the standard open technique. Three patients were extubated at the end of the procedure with the majority extubated on postoperative day 1. Average intensive care unit stay was 1.8 days, and chest tubes were removed between postoperative day 1 and 5 (average, 2.2 days). In follow-up, surgical correction was deemed to be acceptable and equivalent to open techniques in all cases. CONCLUSION: This technique has proven to be safe and effective in children and appears to be associated with less pain and morbidity as evidenced by earlier extubation and chest tube removal and shorter ICU stay.

Adolescent↗
PubMed1998

Evaluation and treatment of clinical instability associated with pseudoarthrosis after anterior cervical surgery for ossification of the posterior longitudinal ligament.

BACKGROUND: Between 1989 to 1993, clinical instability associated with pseudarthrosis was evaluated in 76 patients with cervical ossification of the posterior longitudinal ligament (OPLL). Average 2.5 level extended anterior diskectomy and fusion and average 3.0 level anterior corpectomy and fusion were performed without anterior plate instrumentation using iliac crest or fibular strut autografts. METHODS: Fusion versus pseudarthrosis resulting in clinical instability, as defined by White and Panjabi, was assessed using flexion and extension X-rays 3 and 6 months post-operatively. Radiographic instability was defined by > 3.5 mm. of sagittal plane translation (or 20%) and > 20 degrees of sagittal plane rotation on dynamic X-rays. Two and 3 dimensional (D) computed tomography (CT) scans, also obtained 3 months postoperatively, either confirmed fusion or indicated failed bony union. The average clinical follow up period was 3 years (range, 25-52 months). RESULTS: Three months postoperatively, dynamic X-rays in 20 patients demonstrated radiographic instability consistent with pseudarthrosis, whereas 2 and 3D CT studies indicated a lack of fusion. At 6 months, flexion and extension X-rays revealed that 10 patients were fused and that another 7 were clinically stable despite persistent, irregular, linear lucencies at graft/body interfaces. Three (4%) patients with clinical instability associated with pseudarthrosis required secondary posterior wiring and fusion. CONCLUSION: Only 4% of patients undergoing average 2.75 level anterior OPLL surgery without anterior plate instrumentation required secondary posterior wiring and fusion for clinical instability associated with pseudarthrosis.

Aged↗
PubMedDate not supplied

Endoscopic instrumentation, correction, and fusion of idiopathic scoliosis.

BACKGROUND CONTEXT: Endoscopic techniques have been used since 1993 to treat thoracic disk disease. Thorascopic techniques evolved into means of treating not only disk disease but also correcting thoracic spinal deformity with instrumentation and fusion. PURPOSE: To evaluate the efficacy of endoscopic instrumentation, correction, and fusion of thoracic idiopathic scoliosis. STUDY DESIGN: A retrospective review of 50 patients who have undergone endoscopic instrumentation, correction, and fusion for scoliosis. PATIENT SAMPLE: Fifty consecutive patients undergoing treatment for primary thoracic idiopathic scoliosis. OUTCOME MEASURES: Evaluation of operative time, curve correction, and fusion rates were evaluated. METHODS: Fifty patients with the diagnosis of primary thoracic scoliosis underwent thoracoscopic techniques of instrumentation, correction, and fusion. On follow-up, the patients were evaluated for spinal alignment restoration, axial derotation, postoperative pain, rehabilitative time, and complications. RESULTS: The initial curve correction averaged 50%, improving to over 68% in the last 10 cases. Hypokyphosis correction averaged 21 degrees. Additionally, there has been a decrease in rehabilitation time, less time off work or school, and decreased blood loss and postoperative pain. There were 14 complications and no deaths recorded. The factors involved in a successful fusion include total diskectomy, complete cartilaginous end plate removal, and autogenous bone graft. CONCLUSIONS: The initial results of the thoracoscopic-assisted techniques for primary thoracic scoliosis are promising. As with most evolving techniques, surgical times are decreasing and rates of correction are improving.

Adolescent↗
PubMed2003

Fixed vs dynamic plate complications following multilevel anterior cervical corpectomy and fusion with posterior stabilization.

STUDY DESIGN: Comparison of fixed vs dynamic plate complications in cervical surgery. SETTING: : New York, USA. METHODS: Anterior cervical plate-related complications were evaluated following 66 anterior cervical corpectomy and fusion (ACF) with posterior stabilization (PWF) procedures performed in patients with ossification of the posterior longitudinal ligament (OPLL). Clinical data were comparable for both patient populations. Patients averaged between 52 and 53 years of age. The male to female ratio was approximately 2:1. Surgery addressed MR and CT documented multilevel OPLL in all patients accompanied by spondylosis and stenosis. Preoperatively average Nurick Grades ranged from 3.6 to 3.7. Anterior cervical corpectomies included an average of 2.6-3.0 vertebral bodies, while PWF covered seven levels. Fixed plates were applied in the initial 38 patients, while the latter 28 patients had dynamic plates (ABC, Aesculap, Tuttlingen, Germany) applied. Halo devices were used until fusion was documented on both X-ray and 2D-CT studies. Patients were followed-up for an average of 5.4 years in the fixed-plated groups, and 2.7 years in the dynamic-plated population. RESULTS: CT and dynamic X-ray confirmed that fusion occurred an average of 4.5-4.9 months postoperatively. Five (13%) fixed plates (Medtronic, Sofamor Danek, Memphis, TN, USA) failed warranting secondary surgery, while only one (3.6%) dynamic-plated patient developed a pseudarthrosis and required secondary posterior fusion. DISCUSSION/CONCLUSION: Higher failure rates follow multilevel ACF as compared with anterior diskectomy and fusion required to resect multilevel OPLL. Vaccaro et al observed a 9% failure rate following two-level ACFs and 50% failure rate following three-level ACFs performed with fixed plates. In this series, the plate extrusion rate was reduced to 3.6% when dynamic plates were applied.

Adult↗
PubMed2001

Thoracic disk herniation presenting as abdominal and pelvic pain: a case report.

We report the case of a young woman who presented with a 2-month history of severe abdominal and pelvic pain. The past history was significant for a fall from a bicycle 1 week before the onset of her pain. Physical examination was remarkable for periumbilical tenderness. Work-up including pelvic sonogram and diagnostic laparoscopy suggested endomyometritis. The pain was minimally relieved by nonsteroidal anti-inflammatory drugs and narcotic analgesics. Thoracic spine magnetic resonance imaging (MRI) revealed a large disk herniation at the T9-10 level compressing the spinal cord. The patient subsequently underwent T9-10 diskectomy and laminectomy with dramatic relief of her symptoms. Postoperative rehabilitation hastened her functional improvement. This is a rare case of symptomatic thoracic disk herniation after trauma presenting as abdominal and pelvic pain. Physicians should be aware of this unusual presentation of thoracic disk herniation to avoid invasive diagnostic procedures.

Abdominal Pain↗
PubMed2003

Endovascular exclusion of iliac artery to iliac vein fistula after lumbar disk surgery.

Iliac arteriovenous (AV) fistula is rare after lumbar disk surgery. Traditionally, open repair through the arterial lumen was performed. We report endovascular exclusion of an iliac AV fistula in a 41-year-old woman 8 years after lumbar diskectomy. An angiogram showed an AV fistula connecting the right common iliac artery and vein. This was repaired with placement of two covered wall stents in the right common artery and external iliac artery, and embolization of the right internal iliac artery. Contrast medium-enhanced computed tomography scan at 5 months confirmed elimination of the AV fistula and right iliac artery patency. This technique should be considered in management of iliac AV fistulas.

Adult↗
PubMed1995

Low-dose chemonucleolysis combined with percutaneous nucleotomy in herniated cervical disks.

The combination of low-dose chemonucleolysis with 500 IU chymopapain followed by an automated percutaneous nucleotomy of the cervical spine is a new procedure. A follow-up of at least 1 year of the first 22 patients showed in 19 patients good or excellent results. In one patient a fair result was obtained, and in two patients the symptoms were unchanged; one of these patients subsequently underwent diskectomy and anterior cervical spine fusion. Preoperatively, all patients showed a clear cervical disk herniation with predominantly radicular pain. The procedure has been performed so far in approximately 100 patients. No intra- or postoperative complications have been noted.

Adult↗
PubMed2003

Recurrent central cord syndrome at the level of a solid cervical vertebral fusion.

STUDY DESIGN: A case of a solid cervical vertebral fusion that failed to protect against recurrent central cord syndrome at the same spinal level is described. OBJECTIVES: To alert clinicians to the potential for incomplete spinal cord lesions at the same level as cervical vertebral fusions. SUMMARY OF BACKGROUND DATA: The clinical symptomatology of central cord syndrome is discussed and the advantages of T2-weighted magnetic resonance imaging in such cases is considered. No prior reports of central cord syndrome occurring directly posterior to a solidly fused disc segment were found in the literature. METHODS: The clinical and T2-weighted magnetic resonance imaging features associated with central cord syndrome are presented. The traumatized region developed immediately posterior to the site of an anterior cervical diskectomy and uncovertebral osteophytectomy between the fourth and fifth cervical vertebrae with bone grafting that had been performed more than 3 years earlier. RESULTS: Symptoms of the central cord syndrome resolved over the course of 4 months with no other intervention other than the use of a Philadelphia cervical collar. Five years later, the patient remained symptom free. CONCLUSION: This case illustrates that clinicians must be aware of the potential occurrence of central cord syndrome in patients with solidly fused cervical segments, and that cervical fusion does not necessarily protect against future incomplete spinal cord injury, such as central cord syndrome, at the level of the fusion.

Adult↗
PubMed2004

Early experiences with video-assisted thoracoscopic surgery: our first 70 cases.

STUDY DESIGN: Prospective consecutive series. OBJECTIVE: Analysis of the results and outcomes of patients treated with video-assisted thoracoscopic surgery for spinal pathology. SUMMARY OF BACKGROUND DATA: Video-assisted thoracoscopic surgery is an alternative to open thoracotomy. It has been suggested that the learning curve is substantial. The authors present their early experience in treating a variety of spinal pathologies with this technique. METHODS: Seventy cases were available at the 2-year follow-up. Video-assisted thoracoscopic surgery with the goal of anterior spinal release and fusion was carried out on patients with the following diagnoses: idiopathic scoliosis, neuromuscular spinal deformity, Scheuermann kyphosis, congenital and infantile scoliosis, neurofibromatosis, Marfan syndrome, postradiation scoliosis, and repair of pseudarthrosis. Three patients had excision of the first rib to treat thoracic outlet syndrome. Two patients had excision of intrathoracic neurofibroma and a benign rib tumor. One had anterior fusion following thoracic spine fracture-dislocation. RESULTS: The average operative time for the thoracoscopic anterior release with discectomy and fusion procedure was 256 minutes (range 150-405 minutes). The average number of discs excised was 8 (range 4-11 discs). The average operative time per disc was 32.5 minutes (range 20-45 minutes). The average blood loss during the thoracoscopic anterior release with diskectomy and fusion was 285 mL (range 150-405 mL). Final postoperative scoliosis and kyphosis corrections were 68% (range 41-91%) and 90% (range 47-100%), respectively. Complications related to thoracoscopy occurred in 3 patients. All deformity patients had evidence of anterior fusion radiographically. CONCLUSION: Video-assisted thoracoscopic surgery provides a safe and effective alternative to open thoracotomy in the treatment of thoracic pediatric spinal deformities. The procedure remains time consuming.

Adolescent↗
PubMed2006

Effect of high-dose intravenous dexamethasone on postlumbar discectomy pain.

STUDY DESIGN: A prospective, randomized triple-blind clinical trial. OBJECTIVE: To evaluate the effect of 40 and 80 mg intravenous (IV) dexamethasone versus placebo to reduce postlumbar diskectomy pain. SUMMARY OF BACKGROUND DATA: Lumbar discectomy is a procedure to ablate radicular and low pack pain (LBP) in select patients. Unfortunately, some patients have radicular pain for several days after successful surgery, possibly caused by nerve root inflammation. METHODS: A total of 61 patients with single-level herniated lumbar disc at L4-L5 or L5-S1 were randomly assigned to 3 groups. After the skin incision, group 1 received 40 mg, group 2 received 80 mg IV dexamethasone, and group 3 received placebo. All patients also received 50 mg ranitidine IV at the same time. Preoperative and postoperative radicular and LBP were evaluated using the visual analog scale. Morphine was administered and recorded as a sole pain-killer during hospital admission if indicated. Collected data were analyzed using the 1-way analysis of variance test. RESULTS: A total of 61 consecutive patients entered the study. There were 19 patients who received 40 mg dexamethasone IV (group 1), 20 received 80 mg (group 2), and 22 received placebo (group 3). Preoperative data, including age, sex, level of disc herniation, and radicular and LBP, were statistically matched among groups. Postoperative LBP was decreased in all groups equally. Based on the visual analog scale, mean radicular pain was significantly decreased 4.26 points in group 1, 4.15 points in group 2 versus 2.73 points in group 3 (P = 0.006). Mean total morphine used was also significantly lower in group 1 versus group 3 (5.26 vs. 9 mg P = 0.012). CONCLUSION: Intraoperative IV injection of 40 mg dexamethasone could effectively reduce postoperative radicular leg pain and narcotics usage in patients with single-level herniated lumbar disc.

Adult↗
PubMed2004

Do well-publicized risk-adjusted outcomes reports affect hospital volume?

BACKGROUND: Report cards on hospital performance are common but have uncertain impact. OBJECTIVES: The objective of this study was to determine whether hospitals recognized as performance outliers experience volume changes after publication of a report card. Secondary objectives were to test whether favorable outliers attract more patients with related conditions, or from outside their catchment areas; and whether disadvantaged groups are less responsive to report cards. STUDY DESIGN: We used a time-series analysis using linear and autoregressive models. SUBJECTS: We studied patients admitted to nonfederal hospitals designated as outliers in reports on coronary bypass surgery (CABG) mortality in New York, acute myocardial infarction (AMI) mortality in California, and postdiskectomy complications in California. MEASURES: We studied observed versus expected hospital volume for topic and related conditions and procedures, by month/quarter after a report card, with and without stratification by age, race/ethnicity, insurance, and catchment area. Potential confounders included statewide prevalence, prereport hospital volume and market share, and unrelated volume. RESULTS: In California, low-mortality and high-mortality outliers did not experience changes in AMI volume after adjusting for autocorrelation. Low-complication outliers for lumbar diskectomy experienced slightly increased volume in autoregressive models. No other cohorts demonstrated consistent trends. In New York, low-mortality outliers experienced significantly increased CABG volume in the first month after publication, whereas high-mortality outliers experienced decreased volume in the second month. The strongest effects were among white patients and those with HMO coverage in California, and among white or other patients and those with Medicare in New York. CONCLUSIONS: Volume effects were modest, transient, and largely limited to white Medicare patients in New York.

Aged↗
PubMed1994

Metallic artifacts on MR images of the postoperative spine: reduction with fast spin-echo techniques.

PURPOSE: To determine whether the relative insensitivity of T2-weighted fast spin-echo (FSE) techniques to magnetic susceptibility can be exploited to reduce metallic artifacts on images of the postoperative spine and, thus, improve the interpretation of the postoperative study. MATERIALS AND METHODS: Three neuroradiologists retrospectively evaluated sagittal T2-weighted conventional spin-echo and FSE images obtained in 15 patients with metallic artifacts from various sources including drill particles from anterior cervical diskectomy, posterior fixation wires, fixation rods or plates, and an inferior vena cava filter. The amount of artifact present and whether these artifacts affected image interpretation were evaluated. RESULTS: Among the 45 paired evaluations, the artifact was judged to be less apparent with FSE sequences in 39. In eight of 45 evaluations (18%), the interpretation of the area of interest was possible only on the FSE images. CONCLUSION: FSE imaging, especially when performed with shorter echo spacing, increases the amount of T2-weighted information in the presence of metallic artifact because it decreases magnetic susceptibility effects.

Artifacts↗
PubMedDate not supplied

Can administrative data be used to ascertain clinically significant postoperative complications?

The purpose of this study is to assess whether postoperative complications can be ascertained using administrative data. We randomly sampled 991 adults who underwent elective open diskectomies at 30 nonfederal acute care hospitals in California. Postoperative complications were specified by reviewing medical literature and by consulting clinical experts. We compared hospital-reported ICD-9-CM data and independently recoded ICD-9-CM data with complications abstracted by clinicians using detailed criteria. Recoded ICD-9-CM data were more likely than hospital-reported ICD-9-CM data to capture true complications, when they occurred, but they also mislabeled more patients who never experienced clinically significant complications. This finding was most evident for mild or ambiguous complications, such as atelectasis, posthemorrhagic anemia, and hypotension. Overall, recoded ICD-9-CM data captured 47% and 56% of all mild and severe complications, respectively, whereas hospital-reported ICD-9-CM data captured only 37% and 44%, respectively, of all mild and severe complications. These findings raise questions about the validity of using administrative data to ascertain postoperative complications, even if coders are carefully hired, trained, and supervised. ICD-9-CM complication codes are more promising as a tool to help providers identify their own adverse outcomes than as a tool for comparing performance.

Abstracting and Indexing↗
PubMed1995

Microdiskectomy for lumbar disk herniation: a review of 100 cases.

One hundred patients who underwent microlumbar diskectomy over 5 years were retrospectively reviewed. L4-5 and L5-S1 were compared to determine whether a patient's post-surgical outcome is related to the level where a herniation has occurred. Overall results included 70 excellent, 19 good, 2 fair, and 9 poor. Statistical analysis showed that neither the level involved, length of follow-up, nor degree of manual labor predicted outcome. Older patients and females tended to fare worse, but the trends were not significant. Three recurrent herniations occurred, 1 in the L4-L5 group and 2 in the L5-S1 group. No variable predicted recurrence.

Adult↗
PubMed2003

Minimally invasive procedures for disorders of the lumbar spine.

In the past decade, there has been a substantial increase in interest in minimally invasive procedures in all areas of medicine, particularly for spinal disorders. Some of these techniques represent notable advances in spinal care and have major roles in the care of patients with back-related symptoms. Other techniques appear to offer no benefit and in some cases may be less effective than conventional treatments. Percutaneous lumbar diskectomy techniques hold considerable promise; however, lumbar microdiskectomy is the gold standard for surgical treatment of lumbar disk protrusion with radiculopathy. Intradiskal electrothermal therapy is emerging as a useful option for selected patients with intractable mechanical back pain whose only other option historically has been a spinal fusion. Percutaneous fusion techniques are in their infancy and may prove to be beneficial for these patients as well. Percutaneous vertebral augmentation, including vertebroplasty and kyphoplasty, has become the treatment of choice for many patients with intractable back pain secondary to vertebral insufficiency fractures. Spinal injections are important for evaluating and managing spinal pain and can be extremely useful diagnostically and therapeutically. This multidisciplinary review outlines the status of these procedures and offers suggestions for their use in patient care.

Diskectomy↗
PubMedDate not supplied

Surgical management of cervical radiculopathy.

Cervical radiculopathy presents as pain in a dermatomal distribution. Despite conservative nonoperative therapy, a large subset of patients will require surgical intervention. Indications for surgery include recalcitrant radiculopathy despite nonoperative treatment for more than 6 weeks and progressive motor deficit or disabling motor deficit (deltoid palsy, wrist drop) prior to 6 weeks. Anterior and posterior approaches have both yielded successful results in appropriately selected patients. Anterior cervical diskectomy and fusion is the generally preferred treatment for radiculopathy when there is a significant component of axial neck pain, when the disease is centrally located, or when there is any degree of segmental kyphosis. Posterior laminoforaminotomy is an acceptable choice for lateral soft disk herniations with predominant arm pain and for caudal lesions in large, short-necked individuals.

Bone Transplantation↗