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At least 217 records · Page 12Linked to original sources
PubMed1976

[An unusual complication of calculous cholecystitis: transparietal migration of a calculus into a circumscribed peritoneal sac without a fistulous passage].

A rare complication of calculous cholecystitis (calculous that had migrated from the gallbladder and held in a circumscribed peritoneal sac with no fistula between this and the gallbladder) was observed in a woman who had been suffering from dropsy of the gallbladder with calculi for some 13 years. The most recent literature on acute and chronic perforations of the gall bladder and on known pathogenetic mechanisms regarding transparietal migration of calculi and the establishment of bilio-digestive and bilio-biliar fistulas is reviewed. A number of hypotheses are put forward to explain the unusual operative finding but the impossibility of formulating any precise preoperative diagnosis is recognized and it is stressed that many cases are recognized only following surgery.

Calculi↗
PubMed1997

[Ovarian and oviduct tuberculosis imitating ovarian neoplasm].

The case of organ tuberculosis with an enormous abdominal dropsy in a 57 year old woman is presented. It was diagnosed before the operation as ovary cancer. The histopathological examination of the taken during the operation tissues permitted to diagnose of tuberculous salpingitis. The specific therapy of the patient led to her complete recovery.

Animals↗
PubMed1996

Albumin binding sites for etodolac enantiomers.

Non-steroidal anti-inflammatory drugs (NSAIDs) are strongly bound to human serum albumin (HSA), mainly to sites I and II. The aim of this study was to characterize the binding site(s) of etodolac enantiomers under physiological conditions (580 microM HSA) using equilibrium dialysis. The protein binding of etodolac enantiomers, alone or in various ratios, was studied in order to evaluate the potential competition between them. Our results showed that (S)-etodolac was more strongly bound to HSA than (R)-etodolac. The displacement of one enantiomer by its antipode was observed only at high concentrations of the competitor, and was more pronounced for (S)-form. Displacement studies of the enantiomers by specific probes of sites I and II of albumin, dansylamide, and dansylsarcosine, respectively, showed that (R)-etodolac was slightly displaced by both these probes whereas the free concentration of (S)-etodolac increased markedly in the presence of dansylsarcosine. Moreover, the binding of ligands to sites I and II is usually affected by alkaline pH, by chloride ions, and by fatty acids. For etodolac, the presence of 0.1 and 1 M chloride ions and increasing pH (5.5-9) decreased the binding of both enantiomers. The same result was obtained with addition of octanoic acid. Conversely, the addition of oleic, palmitic, or stearic acid to the protein solution increased the binding of (R)-etodolac, but decreased that of its antipode. All these findings suggest (R)- and (S)-etodolac interact mainly with site II of HSA, and that the (R)-isomer is also bound to site I under physiological conditions.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1992

Stereoselective binding of etodolac to human serum albumin.

The protein binding of etodolac enantiomers was studied in vitro by equilibrium dialysis in human serum albumin (HSA) of various concentrations varying from 1 to 40 g/liter, by addition of each enantiomer at increasing concentrations. In the 1 g/liter solution, at the lowest drug levels, the (R)-form is more bound than its antipode, the contrary being observed at the highest drug levels. For higher albumin concentrations, S was bound in a larger extent than R. Using the displacement of specific markers of HSA sites I and II, studied by spectrofluorimetry, it was suggested that R and S are both bound to site I, while only S is strongly bound to site II.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1977

[Exploration of humoral immunity in aspergillosis: value of enzyme linked immuno-electro-diffusion assay].

In order to increase the sensitivity of the method of immunoelectrodiffusion (I.E.D.) and to isolate the class of immunoglobulins implicated or involved in the Aspergillose antigen-antibody reaction, we supplemented the I.E.D. by combining or incorporating it with an enzymatic technique. By this method the immune complexes precipitated are taken up by antibodies conjugated to one enzyme and specific to the immunoglobulins of each class. This constitutes the technique of E.L.I.E.D.A. (enzyme-linked-immuno-electro-diffusion assay). The sensitivity and the specificity of the proposed method would allow us to follow the qualitative evolution of the aspergillar antibodies and would lend support to further arguments on the evolutionary character of the inflammatory response.

Aspergillosis↗
PubMed1977

ELIEDA (enzyme-linked-immuno-electro-diffusion-assay): application of a combined immunoelectrodiffusion and immunoenzyme method to the study of immune response in parasitic infections.

The sensitivity of the technique of immunoelectrodiffusion (IED) has been enhanced by combining it with an enzyme method; this also enabled the class of immunoglobulins involved in the reactions to be determined by treating the precipitated immune complexes with enzyme-labelled class-specific antisera. The method has been employed in studies of the immunology of parasitic infections and these confirmed its sensitivity and specificity. ELIEDA provides a valuable tool for analysing responses to complex immunogens.

Animals↗
PubMed1987

Instantaneous roll-blot from cellulose acetate after electrophoresis. A versatile tool for monoclonal antibody characterization.

An instantaneous blotting method from cellulose acetate to nitrocellulose was developed using a high pressure roll apparatus. This method was applied to the early characterization of monoclonal antibody specificity and to monoclonal immunoglobulin typing in mouse hybridoma supernatants, human sera or unconcentrated urines. Immunoglobulins were then revealed using, successively, anti-isotype specific monoclonal or polyclonal antibodies, avidin-biotinylated peroxidase complexes and cobalt-enhanced diaminobenzidine substrate.

Antibodies, Monoclonal↗
PubMed1978

The use of ELIEDA (enzyme-linked-immuno-electro-diffusion-assay)) in the study of humoral antibodies in human schistosomiasis.

In order to improve the sensitivity of immuno-electrodiffusion (IED) we have developed a technique of treating the precipitated immune complexes with enzyme-labelled antibodies. This technique we term ELIEDA (Enzyme-Linked-Immuno-Electro-Diffusion-Assay). The enzyme-labelled antibodies can be made monospecific for each class of immunoglobulins found in patients with schistosomiasis and which precipitate with schistosome antigens. We believe that this sensitive technique will prove valuable in studying the sequential development of antibodies in human and experimental schistosomiasis.

Antibodies↗
PubMedDate not supplied

Detection and measurement of rheumatoid factor using a new immunoenzyme technique with peroxidase/anti-peroxidase complex.

A new, solid-phase enzymatic technique is proposed for the detection and measurement of rheumatoid factors (RF). A complex (PAP) consisting of peroxidase and rabbit IgG anti-peroxidase antibodies was used as antigen. The sensitivity of the technique is such that even "physiological" levels of RF may be detected in the majority of serum samples. The intra-assay and inter-assay repeatability (6-8% and 12%) is better than that for either of the traditional agglutination techniques (latex fixation test and Waaler-Rose reaction, or LWR) and this means that the serological evolution of the illness may be followed more accurately for each patient. The detection of non-agglutinating RF was also possible. The antigen used (i. e. rabbit IgG) was fixed immunologically to the enzyme, hence it was not denatured by chemically labelling. This antigen resembles that of the Waaler-Rose reaction. A variation of this method enabled the detection of RF immunoglobulin class, when only the IgM fraction of the sera tested could be fixed to the solid phase by means of anti-mu F(ab')2 antibody before introduction of the antigen. The affinity constant could be measured without antibody purification. In 211 cases of adult rheumatoid arthritis, abnormally high levels of RF were revealed in 78% of the subjects using the PAP technique and in only 53% with the agglutination (LWR) techniques. On the other hand, the RF levels were within normal limits in the 51 cases of other inflammatory rheumatisms lacking RF according to LWR techniques, in 62 cases of non-inflammatory diseases (hip osteoarthrosis, low back pain) and also in the 42 cases of other inflammatory diseases.

Animals↗
PubMed2002

[Results of rehabilitation on quality of walking and outcome in elderly patients following femoral neck fracture. Development after one year].

OBJECTIVES: To examine effects of coordinated multidisciplinary inpatient rehabilitation for older patients with hip fractures. MATERIAL AND METHOD: 187 (42 men and 147 women: mean age 80.9 +/- 8.4 years) admitted with a diagnosis of fracture neck of femur. Before fracture 183 patients were living in their own house. We examine medical state before fracture, type of fracture, type of surgery, walking performance at hospital discharge and at one year, destination at this discharge, living location and quality of life at one year. RESULTS: The length stay after intracapsular fracture and prosthesis is significatively lower (p<0.01). At discharge 28% were walking alone, 38% with stick, 17% with technical aid, 8% with human aid, 2% were bedridden and 7% were dead. After hospitalisation 7% were dead, 70% were living in their own homes, 18% were in old people's homes and 6% in another hospital. One year after fracture, 19% were dead, 65% were living in their own homes, 16% were in old people's homes. Older age, medical state before fracture and male gender was found to increase mortality risk following hip fracture (p<0.01). CONCLUSIONS: Hip fracture is a major cause of morbidity in older people and its impact, both on the individual and to society is substantial. Many people do not return to their pre-fracture life style. Coordinated multidisciplinary care of patients with fractured neck of femur seems essential.

Aged↗
PubMedDate not supplied

[Efficacy, tolerability and therapeutic benefit of etodolac (Lodine 200) in rheumatologic practice].

Efficacy, safety and therapeutic benefit of etodolac (Lodine 200) in rheumatological practice. An open clinical trial performed by 974 rheumatologists enabled an evaluation of efficacy, safety and therapeutic benefit of etodolac (Lodine 200) on 4,947 patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis of the lower limbs; the initial dosage was 600 mg/d (for 2 weeks), then 400 to 600 mg/d (for 2 to 4 weeks, according to the indication). Efficacy, assessed by classical items for NSAID's, was shown to be excellent to good by 61-77 p. 100 of patients, according to the indication. 7.7 p. 100 of patients only dropped out for lack of efficacy. 20.4 p. 100 of patients developed adverse effect(s) (AE), but the relationship between etodolac and AE was assessed "possible" or "probable" only for 9.6 p. 100 of patients; this figure should be compared to the 7.6 p. 100 of patients who dropped out for AE and to the 92 p. 100 of patients who assessed the global safety as "excellent or good". The therapeutic benefit was estimated very favorable: 75 p. 100 of patients felt better than at the beginning of the study, 64.5 p. 100 of patients wished to continue the treatment and the (mean) benefit-risk ratio assessed with a logarithm scale (-1 to +1), ranged from 0.45 to 0.6 according to the indication. Therefore, this trial confirmed the good efficacy and safety profile of etodolac on a large scale in normal clinical practice in France, following assessments during controlled trials. It also permitted to perfect new items of evaluation for NSAID's, in particular for therapeutic benefit.

Adult↗
PubMed1976

Immunological study of hydatidosis. I. Evaluation of the test of immuno-electrodiffusion in the humoral study of human hydatidosis.

The importance of immunological arguments in the discussion of hydatidosis, the permanent increase of requirements, the risk of cross reactions, the frequency of sero-epidemiological surveys imply the utilisation of specific and rapid micro-methods. The technique of immunoelectrodiffusion on a cellulose acetate membrane answers partly to those criteria; we have used it since 1971 in the diagnosis of parasitic infections and mainly to that of hydatidosis. Two hundred cases (400 samples) of the latter were studied longitudinally and reported. This micro-method is very specific (co-immunoelectrodiffusion), equal to that of immunoelectrophoresis. Its rapidity (3 to 4 hours) is close to that of indirect immunofluorescence. The revelation of suggestive diagrams of fissuration underlines the relative emergency of the definitive interpretation of an immunological examination in the diagnosis of hydatidosis.

Antibody Specificity↗
PubMed2000

[Descriptive epidemiological study of acne on scholar pupils in France during autumn 1996].

BACKGROUND: Acne is the most common symptom prompting patients to consult a dermatologist. No previous study has been conducted in France to determine the prevalence of acne and describe the main epidemiological features. SUBJECTS AND METHODS: A cross sectional study was conducted in November 1996 and included 913 school children aged 11 to 18 years. This sample was statistically representative of the entire secondary school population in France during the 1996-1997 school year. The subjects were stratified by 5 criteria: age, sex, rural or urban residence, sun exposure, type of school. RESULTS: Taking the clinical diagnosis made by the dermatologist investigator as the main criteria, the overall prevalence of acne was 72 p. 100. It was 76.1 p. 100 using the new ECLA grading system previously described. The prevalence of acne was sex and age dependent: highest scores were found for girls aged 14-16 years and for boys aged 16-17 years. Genetic factors were very important for the outcome of acne. Finally, 41 p. 100 of the acneic subjects were following a treatment, prescribed by a dermatologist in two-third of the cases. DISCUSSION: These results are in agreement with those previously published in the literature although some differences were disclosed. It would appear important to distinguish between minimal acne with a few retentional pimples occuring during adolescence and severe acne (more than 20 pimples on the face) requiring early medical care to avoid scarring.

Acne Vulgaris↗
PubMed1979

Immunological study of hydatidosis. I. Evaluation of immunoelectrodiffusion tests and enzyme-linked immunoelectrodiffusion assay (ELIEDA) in human hydatidosis.

The comparative sensitivity, specificity and rapidity of immunoelectrodiffusion (IED) on cellulose acetate membranes and of immunoelectrophoresis (IEP) on agarose gel, were evaluated in the diagnosis of hydatidosis. Pooled crude fluid from several cattle hydatis cysts was used as antigen in tests on 1,750 non-hydatis and 400 hydatis sera obtained from patients with hepatic, pulmonary, splenic, peritoneal and cerebral hydatidosis before and after surgery. Coupled to a specific human reference serum for arc 5, IED shows a specificity comparable to that of IEP but its sensitivity is slightly higher and the amount of antigen needed is very small. The appearance of a typical "gloved finger" pattern in sera from patients with ruptured cysts emphasizes the interest of quick results (3 hours) obtained by this method. In order to increase the sensitivity of IED and to define the class of immunoglobulins involved in the antigen-antibody reaction, we have coupled this method to an enzymatic technique. The immune complexes precipitated by IED were treated with peroxidase-labelled antibodies specific to each class of human immunoglobulins. The specificity of this enzyme-linked immunoelectrodiffusion assay (ELIEDA) permits one to follow the immunologic evolution of hydatidosis and to identify IgM in ruptured hepatic cysts and IgA in pulmonary cysts.

Antigen-Antibody Reactions↗