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PubMedDate not supplied

[Definition of what is accepted as "organic" digestive disease and "functional" digestive disease].

The classification of etiopathogenic factors in organic and functional ones, is not enough precise or clear. Whenever an anatomic or biochemical (metabolic, enzymatic or hormonal) cause exists, the disease is called "organic". Psychologic factors can account for "organic" or "functional" manifestations. A digestive disease is said to be functional, when, in spite of present knowledge, no anatomic or biochemical cause is found, whether or not psychologic factors are present. It would be simpler to adopt the multifactorial etiopathogenic concept multiple possible causes acting alone or in combination to produce the disease, because, in the great majority of digestive diseases, organic, functional and psychologic causes coexist.

Diagnosis, Differential↗
PubMed1997

[Digestive and extra-digestive complications of nonsteroidal anti-inflammatory drugs. Preventive and curative strategies].

The authors review the digestive ulceration risk factors and the criteria for selecting a non steroidal antiinflammatory (NSAI), included the most recent drugs, such as selective anti-cyclo-oxygenases 2. They actualize the preventive strategies and insist on the values of misoprostol and of slow acting anti-rheumatic drugs. In the case of digestive ulcerations, they plead for the immediate stop of the NSAI and its replacement if necessary by corticosteroids, for the prescription of a proton pump inhibitor (PPI) or mesalazine according to the localisation of the lesion, finally for the eradication within 8 days of Helicobacter pylori.

Anti-Inflammatory Agents↗
PubMed1986

[Protein and amino acid metabolism in the digestive tract of growing bulls. 6. Apparent digestibility of the amino acids entering the duodenum and of amino acid from feed].

After studies with young bulls provided with duodenal cannulas the apparent digestibility (AD) of the individual amino acids getting into the duodenum (AAD) was ascertained on the basis of 28 different rations. The AD of the AAD is defined as follows: AAD--AAfaeces/AAD X 100. The results thus obtained show a relative constancy, only insignificantly impaired by the consideration of the dependence of the AD of the AAD on the AA concentration in the ration. The average value for the AD of the sigma AAD was 72.5 +/- 4.9%. The dependence of the AD of the sigma AAD on the sigma AA concentration in the ration is: y = 67.8 + 0.51x +/- 4.6; r = 0.355x. In addition, the relation between AD AAD and AD AAfeed protein' each in % of AA intake and AA concentration in the ration, was studied and reported on.

Aging↗
PubMed1987

Are chronic digestive complaints the result of abnormal dietary patterns? Diet and digestive complaints in children at 22 and 40 months of age.

We studied 149 healthy children at 22 months of age and 74 at 40 months of age, employing a 24-hour dietary record based on premailed food measurement guide and telephone questionnaire. Parents cooperated in 94% of contacts. Chronic digestive complaints decreased from 27% to 5% of the sample over the study period: constipation from 16% to 3%, chronic diarrhea from 8% to 1%, and abdominal pain from 5% to 1%. Excessive fluid intake (1470 +/- 600 vs 840 +/- 300 mL/d) correlated most strongly for seven children at 22 months experiencing alternating symptoms of chronic diarrhea and constipation or abdominal pain. Many other children tolerated dietary extremes without complaint. All macronutrient categories except dietary fiber intake increased over the study period. Thus, excessive fluid intake may provoke symptoms suggesting the irritable bowel syndrome in a susceptible group of younger children. Failure to increase fiber intake from 22 to 40 months of age leaves children on an immature diet whose effects require further study.

Child, Preschool↗
PubMed1980

Studies on secretory component in digestive disease. III. Levels of serum secretory component in digestive disease.

The levels of serum secretory component (SC) were measured in 147 patients with digestive disease. Decreased levels were found patients with acute hepatitis, HBs-antigen associated chronic hepatitis, HBs-antigen associated liver cirrhosis and hepatoma. Normal levels were observed in patients with diabetes mellitus, gastric cancer and colonic carcinoma. Elevated levels were found in patients with cholecystitis, obstructive jaundice and acute pancreatitis. The serum SC level in almost all disease groups showed no correlation with immunoglobulin levels.

Diabetes Mellitus↗
PubMed2004

Digestive enzyme profiles reveal digestive capacity and potential energy sources in fed and starved spiny lobster (Jasus edwardsii) phyllosoma larvae.

The impact of starvation on the digestive enzyme (protease, trypsin, lipase and amylase) activities of Stage I and IV Jasus edwardsii phyllosoma larvae was used to identify the nutrients metabolised or conserved during food deprivation, highlighting the most critical energy reserves. Protease activities increased significantly in both Stages I and IV phyllosoma, suggesting that protein catabolism provided energy during food deprivation. Lipase activity decreased significantly in starved Stages I and IV larvae indicating that lipid may be spared for fuelling later developmental moults. The use of protein, while sparing lipid, may provide immediate energy but not at the expense of long-term lipid energy stores which are known to be important during their lengthy larval phase. The preferential use of protein during short-term periods of starvation suggests that particular attention must be given to providing sufficient protein in artificial diets at all times. Amylase activity in starved Stage I larvae was lower than in fed animals, suggesting that the starved animals are not gaining sufficient carbohydrate. However, amylase activity was similar in fed and starved Stage IV larvae, possibly due to the catabolism of accumulated glycogen stores that were not sufficiently developed in Stage I animals.

Amylases↗
PubMed1998

Strategies to improve the nutritive value of rice bran in poultry diets. II. Changes in oil digestibility, metabolisable energy and attempts to increase the digestibility of the oil fraction in the diets of chickens and ducklings.

1. In experiment 1, the effects of age on oil digestibility and apparent metabolisable energy (AME) were measured in chickens and ducklings between 3 and 28 d of age on a diet with 400 g rice bran/kg. In experiment 2, a biosurfactant and a food lipase were added to diets of chickens containing 200 and 400 g rice bran/kg. In experiment 3, chicken diets containing 0 or 400 g rice bran/kg were supplemented with a food lipase (2 concentrations) or a food enzyme or their combination. 2. In experiment 1, oil metabolisability and AME increased substantially as chickens aged. Oil metabolisability was much higher in ducklings, when comparisons were made with chickens of similar age. 3. In experiment 2, lipase or biosurfactant gave no improvement in bird performance. Growth rate and food conversion ratio were, respectively, 23% and 10% better on diets with 200 compared to 400 g rice bran/kg. 4. In experiment 3, there was a significant growth response to lipase plus the enzyme mixture on the diet with 200 g rice bran/kg. On the diet with 400 g rice bran/kg, growth improvement was seen with the enzyme mixture only. 5. In experiment 3, enzyme addition did not increase oil metabolisability or AME. At 4 to 8 d of age AME was higher on the diet without rice bran but oil metabolisability was the same as on the diet with rice bran. At 19 to 23 d of age AME was similar but oil metabolisability was higher on the diet with rice bran than without. Droppings' dry matter was higher on diets without than with rice bran (32.4 vs 27.1%). 6. The response to lipase and the combination of this and a food enzyme suggest that there may be benefit in examining this interaction further although they had no effect on oil metabolisability or on AME. It is concluded that a stable AME for rice bran cannot be provided for chickens until at least 21 d of age.

Aging↗
PubMed1975

[Influence of mechanical and thermal treatment of animal feed on the true digestibility of amino acids. 2. True digestibility of amino acids in treated horse beans].

Trials were performed to investigate in which way mechanical and/or thermal treatment of horse beans would have an effect on the harmful components that were shown to be present in horse beans. In the course of these trials amino acids from heat-treated horse beans (variety Fribo) were analyzed for their true digestibility. Apart from heat-treated horse beans the investigation included undecorticated and decorticated beans and a mixture of horse beans with spring barley.

Animal Feed↗
PubMed1975

[Influence of thermal and mechanical treatment of animal feed on the true digestibility of amino acids. 3. Influence of pelleting coarsely-ground cereals on the true digestibility of amino acids].

It was found that different procedures of heat treatment influenced the true digestibility of nitrogen and of the amino acids in cereals. In view of the fact that under practical feeding conditions pelleting is the most widely used procedure studies were made in trials with young pigs fed coarsely ground barley or maize of pellets of these as sole diet.

Amino Acids↗
PubMed1993

[Dependence of gross energy, digestive energy and metabolizable energy of feed and the energy disposition on the content of digestible nutrients in relation to starch and sugar. The progress of energetic feed evaluation. 1. Results from studies on swine].

On the basis of an analysis of energy metabolism measurements on adult pigs, fed on 92 ratios with very heterogeneous nutrient composition, the following prediction equations for gross energy (y1), digestible (y2) and metabolizable energy (y3) as well as for energy deposition effect of ratios (y) (kJ) are presented: y1 = 23.6z1 + 39.8z2 + 17.3z3 + 16.0z4 + 18.9z5 y2 = 23.6x1 + 39.8x2 + 17.3x3 + 16.0x4 + 17.2x5 y3 = 20.5x1 + 39.8x2 + 17.3x3 + 16.0x4 + 17.0x5 y = 11.0x1 + 34.0x2 + 12.7x3 + 11.6x4 + 5.0x7 + (12.0-0.14(80-x6))(x5-x7) [table: see text]

Animal Feed↗
PubMed1993

[Dependence of gross energy, digestible and metabolizable energy of feed and the energy onset on the content of digestible nutrients in regard to starch and sugar. A contribution to the further development of energetic feed evaluation. 2. Results from studies of cattle].

On the basis of an analysis of energy metabolism measurements on adult cattle (oxen), fed on 110 rations with very heterogeneous nutrient composition, the following prediction equations for gross energy (y1), digestible (y2) and metabolizable energy (y3) as well as for energy deposition effect of rations (y) (kJ) are presented: y1 = 23.6z1 + 34.0z2 + 17.3z3 + 16.0z4 + 19.1z5 y2 = 23.6x1 + 34.0x2 + 17.3x3 + 16.0x4 + 18.0x5 y3 = 17.3x1 + 34.0x2 + 15.9x3 + 15.1x4 + 15.4x5 y = (6.5x + 26.6x2 + 10.1x3 + 7.5x4 + 8.9x5) (-0.5574 + 0.04050x6 - 0.0002633x6(2)) [table: see text]

Animal Feed↗
PubMed1995

Effect of roasting on site and extent of digestion of soybean meal by sheep: II. Digestion of artifacts of heating.

Six mature wethers (BW 72 kg) with ruminal, duodenal, and ileal cannulas were fed a basal (no added soybean meal [SBM]) diet or diets containing unheated SBM or SBM roasted at 165 degrees C for 75, 150, 180 or 210 min in a 6 x 6 Latin square experiment. Concentrations of indicators of heat exposure (NDF, ADF, and ADIN) in SBM increased with increasing roasting time. Organic matter digestion characteristics were not affected (P > .05) by supplementation or roasting of SBM. Daily intakes of NDF, ADF, and ADIN were higher (P < .05) when wethers were fed SBM-containing diets than when they were fed the basal diet and also were higher (P < .05) when wethers were fed diets containing roasted SBM than when fed the diet containing unheated SBM. Roasting time of SBM had a quadratic effect (P < .05) on intakes of NDF, ADF, and ADIN, with the lowest intakes observed for diets containing unheated SBM or SBM roasted for 75 min and the highest intakes observed for diets containing SBM roasted for 180 or 210 min. Disappearance of ADF in the stomach (grams per day) was not affected by supplementation or roasting of SBM. Disappearance of NDF and ADIN in the stomach (grams per day) were higher (P < .05) when wethers were fed SBM-containing diets than when they were fed the basal diet and also were higher (P < .05) when wethers were fed diets containing roasted SBM than when they were fed those containing unheated SBM.(ABSTRACT TRUNCATED AT 250 WORDS)

Animal Feed↗
PubMed1987

Digestibility of carbohydrate foods in an ileostomate: relationship to dietary fiber, in vitro digestibility, and glycemic response.

The aim of this study was to assess differences between starchy foods in the amount of carbohydrate which escapes small intestinal absorption. One ileostomate volunteer tested in metabolic feeding trials a total of 20 starchy foods (nine of which were repeated on two to seven occasions, mean 3.5 +/- 1.7). This ileostomate volunteer exhibited macronutrient and fiber losses that were within 97.3 +/- 6.6% of the mean, for a range of foods eaten by three other ileostomates and was therefore believed to be representative. Measurement of available carbohydrate in ileal effluent demonstrated a wide range of recoveries from 2.7 to 18% from different starchy foods. The available carbohydrate losses related to the fiber content (r = 0.885, p less than 0.001), in vitro digestibility of the food (r = -0.867, p less than 0.01), and their glycemic responses (r = -0.611, p less than 0.05). Our data support the concept that available carbohydrate losses to the colon may be greater in many foods than the carbohydrate entering the colon as dietary fiber. The food factors responsible are diverse and the possible metabolic consequences of carbohydrate malabsorption may be broad.

Blood Glucose↗
PubMed1990

Evidence of 1,25-dihydroxyvitamin D3-receptors in human digestive mucosa and carcinoma tissue biopsies taken at different levels of the digestive tract, in 152 patients.

Epidemiological and experimental data suggest that dietary calcium and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) are protective against colorectal cancers, while their activity on colon mucosa still remains unknown. Since the presence of receptors is required for steroid action, specific 1,25-(OH)2D3 receptors were investigated in biopsies taken at different levels of the digestive tract from the oesophagus to the rectum and in pancreas. The total study involved biopsies from 152 patients. In 82% of the cases they were paired biopsies in adenocarcinoma tissue and in adjacent normal mucosa (NM). There were 120 operated on for colorectal adenocarcinoma (HCRA). 1,25-(OH)2D3 receptor was assayed in tissue extract by the dextran-coated charcoal (DCC) technique and also characterised by sucrose density gradient centrifugation. Scatchard analyses showed a single class of specific high affinity-low capacity sites binding for 1,25-(OH)2D3 with a Kd = 1.48 +/- 0.8 x 10(-10) M (n = 119). The sedimentation coefficient of the steroid receptor complex was approximately 3.2 S. The incidence of 1,25-(OH)2D3 receptors was significantly higher in NM (82.5%) than in HCRA (34.5%). In HCRA this incidence decreased from right colon (64.7%) to left colon (27.7%) and rectum (15%). All positive HCRA in left colon and rectum (16/76) were histologically well differentiated. The receptor content in NM and HCRA was in the same range: (median) 10-314 (58) and 13-175 (64) fmol/mg protein. These data suggest that 1,25-(OH)2D3 may modulate calcium transport in colon, as in the intestine. Also, loss of receptivity to 1,25-(OH)2D3 is observed as associated with malignant transformation of the human colorectal mucosa.

Biopsy↗
PubMed2006

Anaerobic digestion of food waste: comparing leachate exchange rates in sequential batch systems digesting food waste and biosolids.

Over 35,000 tonnes of food waste are generated from high concentration point sources (i.e., restaurants, hospitals and markets) in metropolitan Adelaide (Australia) each year. Anaerobic digestion is a preferred method of treatment to degrade highly putrescible waste streams such as food waste due its high methane potential. To maximise methane yield, a sequential batch anaerobic system was chosen as the most appropriate system. Two sets of sequential batch systems consisting of mature and start-up reactors in triplicate exchanged leachate. One set exchanged twice as much leachate by volume as the other set to determine the effects of different leachate exchange volumes. Results show that by increasing the leachate volume between mature and start-up reactors, the time to degrade feedstock decreases, but total methane generation yields did not markedly differ, being 229LCH4 kg(-1) VSadded and 214LCH4 kg(-1) VSadded. Process parameters used to determine when to cease leachate exchange in start-up reactors were a pH of 6.5 and methane generation rate of >0.5LCH4 kg(-1) VSadded day(-1). Changes in carbon dioxide and methane biogas composition in the mature reactors reflected process stress caused by the addition of leachate with high VFA concentrations from the start-up reactors and indicate there may be limits to leachate exchange rates and subsequent loading of mature reactors.

Anaerobiosis↗