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Conservatism in the management of aortic aneurysms.

The authors discuss in general, conservative surgical therapy in the management of thoracic aneurysms and the principle that the purpose of such surgery is to prevent rupture and not "extirpation of a tumor". As an illustrative example, they present a case in which a large thoracoabdominal aneurysm was managed by bypass exclusion and individual grafting of the visceral arteries and-in the same patient-two aneurysms of the ascending aorta and aortic regurgitation caused by dissection were handled by valve suspension, limited resection, and external grafting. They promote the usage of conservative procedures versus radical resection in selected cases of aortic aneurysms as an effective alternate.

Aortic Dissection↗
PubMed1983

Evolutionary conservatism in the arrangement of autosomal gene loci in mammals.

The effects of chromosomal rearrangements on gene function and mutation are poorly understood. Although the extensive conservation of autosomal linkage among diverse mammals may indicate physiological significance for some gene arrangements, the majority of linkages have probably been conserved by chance. The establishment of a Chinese hamster gene map has provided further evidence for the conservation of mammalian autosomal linkage and the study of gene rearrangements in cultured Chinese hamster cell lines is beginning to provide information on the genetic consequences of chromosomal rearrangements.

Animals↗