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Polymorphism of human color vision.

The genetic polymorphism of human color vision is examined within the framework of a photopigment replacement model. An analysis of the X-linked recessive dichromacies and anomalous trichromacies indicates that one source of variability of normal color perception may be the inclusion of several distinct phenotypes in what is usually described as normal color vision. This analysis also reveals the cause of the dominance hierarchy at the protan and deutan loci, the perceptual effects of dosage compensation, and the phenotypes of various compound hemizygotes.

Alleles

Color and form perception on the Rorschach as a function of eye color.

Recent research had demonstrated that dark-eyed individuals are more reactive than light-eyed people. The present paper investigated one area of reactivity, ease of emotional arousal. The hypothesis that dark-eyed male subjects (n equals 40) would show greater ease of arousal than light-eyed male subjects (n equals 40) was tested using color and form responses on the Rorschach as dependent measures. The predicted interaction was significant; light-eyed subjects gave relatively more form responses, but dark-eyed subjects gave relatively more color responses. Implications for future research and application were discussed.

Arousal

A bidimensional theory of achromatic color vision.

The theory is based on a perceptive color system where the achromatic colors are specified by their degree of similarity to the three qualities white, black and luminous. Black and luminous are treated as opponent variables. It is assumed that white and luminous/black are determined by different kinds of visual processes termed the w- and the b-process. The relationship between these processes and luminance parameters in a simple disc/ring configuration is derived from available data. The b-process is related to stimulus contrast in a simple manner. It is assumed to involve cells with antagonistic center/surround organization of the receptive field. The w-process is primarily determined by the local luminance, and it is assumed to involve cells that lack a center/surround organization of the receptive field. The w-process has properties similar to the processes involved in chromatic color vision. The theory can account for different kinds of psychophysical data on achromatic colors like data on simultaneous contrast, color scaling, and color constancy.

Color Perception

[The molecular genetics of color blindness].

The gene structures of three color pigments have been reported by Nathans et al. in 1985. One copy of red gene and 1 to 3 copies of green genes are tandemly repeated on X chromosome. As the structures of red and green genes are highly homologous (96%) and tandemly repeated, they cross-over on chromosome during meiosis and hybrid genes were produced. The function of these hybrid genes exhibits abnormal spectrum for red and green light. The 5' portion of the gene determines which cone cell type express the gene and the 3' portion of the gene determines the type of spectrum. In the 3' portion, exon 4 are associated with a small shift of spectrum and exon 5 determines a large shift of spectrum. For example, a hybrid gene with 5' region of red and 3' region of green is expressed in the red cones and exhibits green spectrum. Abnormality of color perception depends on the hybrid ratio of red and green genes.

Base Sequence

[Dyschromatopsias and pictorial art].

The influence of color vision defects on pictorial art was studied using three methods. 1) From a theoretical standpoint, the possibilities of choice of the color-blind painter are determined by the nature of his color perception. Characteristic errors result from the fact that he has to choose between many hues which are different to a normal individual but which all look the same to him. 2) Evaluation of the clinical cases of painters with dyschromatopsias has shown evidence of the following: a) the color-blind painter makes mistakes according to the type of color defect; b) if the color-blind painter makes several copies of the same model, he makes different mistakes at each attempt; c) when several color-blind painters make copies of the same model, they also make different mistakes, even when they suffer from the same type of color vision defect. Preferences for some colored patterns were studied by means of a forced choice procedure and choices of color-blind individuals were often characteristic of their dyschromatopsia. Recent clinical case of acquired dyschromatopsia reported in the literature are discussed, as is a personal case of a painter suffering from tapeto-retinal degeneration. This was a severe dyschromatopsia with a neutral zone in purple (so-called scotpic axis, by Verriest's terminology). The painting of this artist tended to be monochromatic, mainly in green and green-blue colors. 3) Recent studies in art history have shown that only the romantic etcher Meryon was definitively color deficient. The more dubious cases of the Polish painter Grottger and of Eugène Carrière are discussed and conclusions are negative. Among acquired dyschromatopsias, there have been many recent papers devoted to cataract dyschromatopsias, concerning the cases of Rouault, Monet and Mary Cassatt. The hypothesis of a degree of chromatopsia or dyschromatopsia of toxic origin in the case of Van Gogh is also assessed. In conclusion, the problem of the relations between congenital or acquired dyschromatopsias and pictorial art seems very complex and great care is required when making deductions and advancing hypotheses.

Color Perception

Color "amnesia" without aphasia.

Following an apparent left parietal CVA, a patient developed a severe and nearly complete color amnesia which was not associated with any disturbance in color vision or color perception. Like all previously reported cases with color amnesia, this patient was alexic but, unlike most previously reported cases, he was not aphasic.

Agnosia

[Retinal function under conditions of artificial illumination with varying spectral makeup in patients with sclerotic macular dystrophy].

In conditions of a laboratory experiment using illumination of various light sources (by incandescent, luminescent, arc-mercury, natrium lamps), determination of visual acuity, visual field, color perception, restoration time of visual acuity after macular flash lighting (photostress test), Heidinger's phenomenon as well as visocontrastometry after V. V. Volkov, Weston's correction test were conducted in 46 patients (92 eyes) with macular dystrophy and 50 healthy persons in the dynamics of a working day. It was found that the spectral composition of the visible light has a remarkable influence on the function of color perception, contrast sensitivity, reaction of visual analyser on light load, visual ability to work. In patients with macular dystrophy, the dependence on the light medium was expressed much greater than in healthy persons. The highest functional state of the retina and visual ability to work in patients with macular dystrophy were provided by natrium lamps having a maximum radiation in the yellow part of the spectrum. The short-wave visible light of arc-mercury and luminescent lamps somewhat suppressed the functional state of the retina and reduced visual ability to work. The results obtained are important for selection of optimal conditions of work for patients with macular dystrophy.

Adult

Perceptions of color preferences-a clue to marital prediction?

In a study of marital adjustment prediction (N = 75 couples), each spouse was asked to indicate a color preference for nine common household articles and predict which color the spouse would choose. A discrepancy score between perceived and actual choices was calculated and compared with scores on the Nye-MacDougall Martial Adjustment Scale. The correlation coefficient between the discrepancy score and ego's marital adjustment was -.27 for the sample as a whole, -.33 for husbands, and -.21 for wives. The correlation between the discrepancy score and mate's marital adjustment was -.17 for the whole sample, -.10 for husbands, and -.23 for wives.

Adaptation, Psychological

Regeneration of specific nerve cells in lesioned visual cortex of the human brain: an indirect evidence after constant stimulation with different spots of light.

The defective parts of the visual field of two brain-injured patients were stimulated with different spots of light. There is evidence for at least five independent visual functions which can be restored due to constant stimulation of the blind part of the visual field: (1) The constant stimulation of the blind part of the visual field with spots of white light leads to an increase of the visual field for the perception of white light only. (2) The constant stimulation with spots of light of different wavelengths leads to an increase of the visual field for different color perception. To enlarge the visual field for the perception of the color red, a light stimulus with the wavelength of 656 nanometers (nm) was used; for the visual field for the perception of the color green 525 nm; for yellow 578 nm; and for blue 450 nm. (3) The constant stimulation of the blind visual field with black and white light bars of different orientations and constellations leads to an increase of the foveal acuity and an improvement of form perception in the periphery of the visual field. The results suggest that the recovery of visual functions, different color perception and form perception, may depend upon neuronal regeneration in the human visual cortex; regeneration occurs with adequate and constant stimulation of its specific neurons.

Adolescent

Observer perception of skin color in a study of malignant melanoma.

Observer perceptions of skin color with a 15-step skin tone panel were evaluated during an as yet unpublished case-control study of malignant melanoma. Skin color is a risk factor for melanoma, and the skin tone panel was introduced in an effort to reduce its misclassification. Reflectances of the 15 artificial skin tones were measured at four wavelengths with a reflectance spectrophotometer. Six observers each evaluated the skin color of eight study subjects twice under three lighting conditions, and the results were transformed to reflectance values. Components of variance analysis demonstrated that between-subject variability contributed 63% or more of the variance at wave-lengths of 400-600 nm, while observers, light source, observation time, and error contributed 30% or less. At 700 nm, only 25.5% of the variance was due to subjects, indicating lower levels of reliability. Similarly, the correlation of visual and spectrophotometric assessment of skin reflectance was higher at 400-600 nm (r = 0.63-0.71) than at 700 nm (r = 0.41). Thus, the value of the skin tone panel-based assessments depends upon knowledge of which wavelengths most closely relate to the physiologic risk factor. For instance, reflectance at 650-700 nm is a better measure of skin melanin content than reflectance at lower wavelengths. Since the role of melanin as a risk factor remains in doubt, the utility of this technique has yet to be demonstrated. However, data from the case-control study and from this validity and reliability study will allow us to develop an analytic approach that minimizes misclassification of skin color as a confounder.

Analysis of Variance

Effects of viewing conditions on standard measures of acquired and congenital color defects.

We examined the effect of variations in viewing distance and viewing duration on the performance of color-normal observers with four standard tests of color vision. Significant effects of the experimental manipulations were obtained: both increasing viewing distance and decreasing viewing duration significantly increased the number of errors made by observers. Moreover, the four tests differed widely in their sensitivity to the variations in viewing conditions. Practical implications of the findings for the administration and selection of plate tests are discussed, and possible mechanisms underlying the results are suggested.

Color Perception

Retinal toxicity after high-dose cisplatin therapy.

Because of increasing complaints of visual dysfunction, 13 patients with refractory or recently diagnosed ovarian carcinoma were evaluated for possible cisplatin-induced ophthalmologic toxicity. All patients had received high-dose cisplatin (200 mg/m2 in five divided daily doses) over two to four cycles. Eight patients (62%) developed symptoms of blurred vision and three (23%) also developed altered color perception. Retinal toxicity in the form of cone dysfunction was documented by electroretinography and color vision testing in 11 patients. Three patients were studied prospectively. Two patients who developed cone dysfunction had normal ophthalmologic exams before the initiation of chemotherapy or after one cycle of cisplatin, suggesting a causal relationship between cisplatin therapy and subsequent retinal abnormalities. Though visual acuity improved off therapy, color vision abnormalities persisted as long as 16 months beyond therapy.

Adult

Chromatic perception in relation to an hypothesized cerebral dominance.

On the basis of the cerebral dominance, we have hypothesized an asymmetry (for saturation or brightness) between the two eyes in perception of chromatic stimuli. 51 subjects were tested on chromatic perception (green, red, yellow, blue). For each subject also an ocular-dominance score was obtained. The results substantially confirmed the hypothesis of cerebral dominance in color perception. Subjects with high ocular-dominance scores (right- or left-dominant subjects) showed for the green stimulus asymmetric behavior, while subjects with low ocular-dominance scores showed a tendency toward symmetry in perception.

Adult

Colorimetry by a new principle.

A simple and informative method is described for determining the type and extent of color defects. The subjects' responses are registered automatically on a chromaticity diagram that is based on the newtonian model. Color defects are readily identifiable by a skewing of the normal central gray area toward the defectively perceived color. The examination permits independent variation of hue and saturation for each color and requires less than five minutes for the entire procedure. Unlike conventional color tests, the present method indicates exactly what colors are or are not seen at any level of saturation.

Adolescent