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PubMed1995

Cod-liver oil, vitamin D and the fight against rickets.

Although rickets has all but disappeared as a medical problem, the disease caused serious concern in turn-of-the-century England, where it reached epidemic proportions. The connection between rickets and a lack of vitamin D wasn't made until shortly after World War I, when it was determined that regular exposure to sunlight would eliminate the problem; another solution was to provide vitamin D supplements in milk. The problem hasn't disappeared entirely, however. Seventeen cases of rickets have been diagnosed at Toronto's Hospital for Sick Children in the past 5 years.

Cod Liver Oil↗
PubMed1991

Reduced neutrophil superoxide generation and plasma lipoperoxide levels in pigs fed with cod liver oil.

Circulating neutrophils, isolated from pigs fed for 8 weeks with a diet supplemented with CLO, had an accentuated n-3 fatty acid incorporation into the plasma membrane, as evidenced by an approximately four-fold greater n-3/n-6 ratio as compared with the control diet group. Moreover, the neutrophils of the CLO fed pigs produced less superoxide when stimulated with PMA or f-MLP, as well as showing a more prolonged latency period before O2(-)-generation. In the plasma of pigs fed with CLO there were higher levels of thiobarbituric reactive material and lipofuscin, while the content of GSSG was similar in both dietary groups. The results of this study indicate that dietary supplementation with CLO reduces the activation of circulating neutrophils and favours the presence in the plasma of lipoperoxides.

Animals↗