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PubMed1983

Choledocholithiasis and cystic duct obstruction: difficult ultrasonographic diagnosis.

Ultrasonography of 53 patients with stones in either the common bile duct (CBD) or the gallbladder neck/cystic duct revealed respective sensitivities of only 30% and 29% for detection of calculi. The data, which were collected over a period of 40 months, were also analyzed with respect to our early experience (first 24 months) versus our later experience (last 16 months). Although there was no improvement in the diagnosis of gallbladder neck/cystic duct calculi (only those in the gallbladder neck could be identified), significant improvement occurred in the diagnosis of choledocholithiasis, with a sensitivity of 15% in the early period and a sensitivity of 55% in the later period. In part this was due to greater dependence upon real-time equipment and more emphasis on the examination of the distal CBD. A limiting factor in the diagnosis of choledocholithiasis was the normal caliber of the duct in 30% of these patients. Despite improved equipment and technique, ultrasonography cannot detect cystic duct obstruction, and the ultrasonographic diagnosis of CBD calculi remains difficult.

Cholelithiasis↗
PubMed1997

Detection of choledocholithiasis: comparison of unenhanced helical CT and endoscopic retrograde cholangiopancreatography.

PURPOSE: To compare unenhanced helical computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) in the detection of common bile duct calculi. MATERIALS AND METHODS: Within 13 months, 51 patients (aged 18-94 years) with clinically suspected choledocholithiasis underwent unenhanced helical CT immediately before undergoing ERCP. CT scans were evaluated for the presence of bile duct stones, ampullary stones, the gallbladder and gallbladder stones, intrahepatic biliary dilatation, and the size of the bile duct at the porta hepatis and in the pancreatic head. ERCP images were evaluated for the presence of bile duct or ampullary stones, as well as for biliary dilatation. RESULTS: Unenhanced helical CT depicted common bile duct stones in 15 of 17 patients found to have stones at ERCP. Three patients had stones impacted at the ampulla, all of which were detected with CT. In addition, there was one false-positive finding at CT. CT had a sensitivity of 88%, a specificity of 97%, and an accuracy of 94% in the diagnosis of common bile duct stones. CONCLUSION: Unenhanced helical CT is useful for evaluating suspected choledocholithiasis.

Adolescent↗
PubMed1997

Choledocholithiasis and bile duct stenosis: diagnostic accuracy of MR cholangiopancreatography.

PURPOSE: To evaluate the accuracy of magnetic resonance (MR) cholangiopancreatography for detecting bile duct calculi and stenosis. MATERIALS AND METHODS: At MR cholangiopancreatography, 108 patients suspected of having bile duct calculi or stenosis were examined with two-dimensional fast spin-echo MR sequences and respiratory gating. On the basis of findings at surgery and/or intraoperative, endoscopic retrograde, and/or percutaneous cholangiography, final diagnoses were normal bile ducts (n = 38), choledocholithiasis (n = 23), Mirizzi syndrome (n = 3), benign or malignant bile duct stenosis (n = 40), choledochal cyst (n = 1), and bile duct dilatation without calculi or stenosis (n = 3). MR cholangiopancreatographic images were analyzed retrospectively by three reviewers who were unaware of final diagnoses. RESULTS: Choledocholithiasis was diagnosed with a sensitivity of 88%-92% and a specificity of 91%-98%. False-negative readings occurred because small or impacted calculi at the distal common bile duct or ampulla were difficult to detect or distinguish from stenosis. Bile duct stenosis was diagnosed with a sensitivity of 93%-100% and a specificity of 98%. Presence or absence of bile duct abnormality was assessed with a sensitivity of 97%-99% and a specificity of 95%-97%. Interobserver agreement was very good (kappa = 0.86-0.96). CONCLUSION: With MR cholangiopancreatography, bile duct calculi and stenoses can be diagnosed with high accuracy and good interobserver agreement.

Adult↗
PubMed1984

A comparison of computed tomography and sonography in choledocholithiasis.

A comparison was made of sonography and computed tomography (CT) for the diagnosis of choledocholithiasis. Sonography correctly diagnosed nine of 49 patients with choledocholithiasis for a sensitivity rate of 18%. The accuracy rate for sonography was 19%; there were five false-positive examinations. CT correctly identified common duct stones in 26 of 30 patients for a sensitivity rate of 87%. The accuracy rate was 84%; there was one false positive. Sonography is limited in its ability to image calculi in the distal common bile duct. CT is effective for imaging common duct stones and is superior to sonography for diagnosing this cause of biliary obstruction.

Diagnosis, Differential↗
PubMed2001

Mr cholangiography with volume rendering: receiver operating characteristic curve analysis in patients with choledocholithiasis.

OBJECTIVE: The purpose of our study was to compare observer performances for the diagnosis of choledocholithiasis using MR cholangiography with volume-rendered, maximum-intensity-projection, and thick-section half-Fourier rapid acquisition with relaxation enhancement sequences. MATERIALS AND METHODS: The images from three types of MR cholangiography performed on 43 patients with biliary calculi were retrospectively analyzed. Image review was conducted for two anatomic compartments (upper biliary tract and common bile duct). A total of 86 compartments, including 19 with bile duct calculi, were reviewed by three independent off-site gastrointestinal radiologists. Observer performance was determined by receiver operating characteristic curve analysis. Image quality was subjectively judged by three radiologists. RESULTS: Sensitivity was higher with volume-rendered MR cholangiography (58%) than with thick-section (54%, not significant) and maximum-intensity-projection MR cholangiography (47%, p < 0.07). Specificity was higher with volume-rendered MR cholangiography (92%) than with thick-section (86%, p < 0.03) and maximum-intensity-projection MR cholangiography (88%, not significant). Accuracy was higher with volume-rendered MR cholangiography (84%) than with thick-section and maximum-intensity-projection MR cholangiography (79% for both, not significant). Observer performance with volume-rendered MR cholangiography (A(z) = 0.791--0.952) was better than that with thick-section (A(z) = 0.722--0.834) and maximum-intensity-projection MR cholangiography (A(z) = 0.771--0.887). Image quality was better with maximum-intensity-projection MR cholangiography and thick-section MR cholangiography than with volume-rendered MR cholangiography (p < 0.0001). CONCLUSION: Observer performance with volume-rendered MR cholangiography was better than that with maximum-intensity-projection and thick-section MR cholangiography for the diagnosis of choledocholithiasis. Volume rendering may be an efficient technique for the reconstruction of MR cholangiography.

Adult↗
PubMedDate not supplied

[Role of intravenous cholangio-cholecystography in the diagnosis of asymptomatic choledocholithiasis].

INTRODUCTION: Standard diagnostic procedures (anamnesis, physical examination, laboratory analyses, ultrasound diagnosis), commonly used in diagnosis and preparation for surgical intervention of patients with cholelithiasis, are in most cases a reliable indicator for evaluation of the disease and conditions planned for surgery. DISCUSSION: In some cases by application of these narrow diagnostic models, some conditions, anatomic variations and biliary tract malformations remain unrecognized. Asymptomatic ("silent") choledocholithiasis (2.02%) represents a special diagnostic and therapeutic problem. CONCLUSION: Our extended diagnostic protocol includes routine intravenous cholangio-cholecystography as a standard diagnostic procedure for evaluation of cholecysto-choledocholithiasis prior planning cholecystectomy.

Cholangiography↗
PubMedDate not supplied

[Endoscopic retrograde cholangiopancreatography prior to laparoscopic cholecystectomy in patients with suspected choledocholithiasis].

BACKGROUND: Laparoscopic cholecystectomy is the treatment of choice for patients with symptomatic gallstones. The management of choledocholithiasis in these patients remains controversial. Endoscopic retrograde cholangiopancreatography (ERCP) with ductal stone clearance prior to laparoscopic cholecystectomy is one of the options. OBJECTIVE: To evaluate the results of ERCP prior to laparoscopic cholecystectomy in patients with suspected ductal stones. METHODS: We performed a retrospective study from patients who underwent ERCP prior to laparoscopic cholecystectomy in a four years period. RESULTS: ERCP was successful in 86 out of 88 patients (97.7%). Common bile duct (CBD) stones were found in 34 patients (39.5%). Sixty two of 86 patients had symptomatic gallstones with abnormal liver function test and/or ultrasound. CBD stones were found in 25 of the 62 symptomatic patients (40.3%). Twenty four patients had acute biliary pancreatitis. CBD stones were found in nine of these patients (37.5%). All patients with CBD stones underwent stone extraction after endoscopic sphincterotomy (ES). Sixteen other patients underwent ES for suspected obstruction at the ampulla. Stone extraction was successful in 100% of patients. There were six patients with complications (6.9%). Four patients had pancreatitis (4.6%), one patient hemorrhage (1.1%) and one patient cholangitis (1.1%). Analysis using logistic regression model showed that CBD stones on ultrasonography was the only variable significantly associated with choledocholithiasis (P < 0.001). CONCLUSIONS: Preoperative ERCP is useful in the management of CBD stones prior to laparoscopic cholecystectomy.

Adult↗
PubMedDate not supplied

[A rare nosological association: a villous gastric polyp and asymptomatic choledocholithiasis].

The authors present the case of a male patient, aged 68, admitted in our department for a upper gastrointestinal hemorrhage. The upper gastrointestinal series showed a large gastric villous adenoma located in the body of the stomach. Intraoperative, we found a gastric villous adenoma and multiple choledocholithiasis and gallbladder stones which evolved completely asymptomatic. We performed a mediogastric resection, Fredet pyloroplasty and laterolateral choledochoduodenostomy with a good postoperative result. This case is peculiar due to the concomitant occurrence of two rare diseases the gastric villous adenoma and the asymptomatic multiple choledocholithiasis.

Adenomatous Polyps↗
PubMedDate not supplied

Is choledocholithiasis a late complication of nonresectional therapies for hepatocellular carcinoma?

We present 3 patients who developed choledocholithiasis 10, 13, and 12 months after percutaneous ethanol injection and/or transcatheter arterial chemoembolization for hepatocellular carcinoma. Since none of these patients had stones in the gallbladder or in the bile ducts before treatment, bile duct stones might have resulted from local injury in the bile ducts by percutaneous ethanol injection and/or transcatheter arterial chemoembolization. Choledocholithiasis may be a late complication of nonresectional and local therapies for hepatocellular carcinoma tumors.

Aged↗
PubMed2000

Choledocholithiasis: evolving intraoperative strategies.

In the era of open cholecystectomy, common bile duct stones were approached by traditional choledocholithotomy. Retained or recurrent stones discovered after cholecystectomy were approached by endoscopic extraction techniques or repeat surgery. With the advent of laparoscopic cholecystectomy, the approach to choledocholithiasis became more problematic as techniques for laparoscopic extraction were rudimentary. Preoperative endoscopic retrograde cholangiopancreatography rapidly became an adjunct to laparoscopic cholecystectomy when common duct stones were likely. Experience, however, revealed that many of these procedures were unnecessary. With developing sophistication of laparoscopic techniques, a variety of approaches to common duct stones developed. These included: transcystic extraction, direct laparoscopic choledocholithotomy, intraoperative endoscopic retrograde cholangiopancreatography, antegrade sphincterotomy, and transcystic placement of a common duct stent with subsequent endoscopic sphincterotomy and stone extraction. It is the purpose of this article to define the current role of each of these methods in the laparoscopic approach to choledocholithiasis.

Cholangiopancreatography, Endoscopic Retrograde↗
PubMed2000

[Diverticuli of duodenal papillar region and their role in development of choledocholithiasis and strictures of bile and pancreatic ducts].

Up to present time there is no common view on the role of diverticuli of the papillar region of the duodenum (DPRD) in development of the strictures of terminal parts of the common bile duct and major pancreatic duct. The main method for the diagnosis of DPRD is fibroduodenoscopy (FDS). Relaxational FDS is the most informative method for detailed examination of diverticulum and for assessment of its interrelations with longitudinal crease and the major duodenal papilla (MDP). During the last 2 years all patients with DPRD underwent ERCPG, which helped to obtain more complete information of the presence and the character of the strictures of terminal parts of the common bile duct and the pancreatic duct. DPR has been revealed in 5% of patients with calculous cholecystitis and in 9.5% of patients with choledocholithiasis. Of the patients, admitted to the Institute for postcholecystectomy syndrome from 1994 to 1999, DPRD were revealed in 30% of cases. The patients with DPR and chronic pancreatitis of nonalcoholic and nonlithogenic etiology, made up 9% of all patients with DPR and chronic pancreatitis. In 87 patients with DPR, suffering from various surgical diseases, following changes of bile and pancreatic ducts were revealed: choledocholithiasis (47%), stenosis of the large bile duct (15%), strictures of terminal parts of the large bile duct and major pancreatic duct (10%). There is evidence, that para- and peripapillary diverticuli deteriorate evacuatory function of the bile and pancreatic tracts due to compression of terminal parts of the choledochus and the pancreatic ducts with strictures formation, which promote disturbances of the bile and pancreatic juice passage. Biliary stasis and pancreatic juice passage disturbances create favorable conditions for lithogenesis and promote development of cholangitis, mechanical jaundice and chronic pancreatitis. Patients with choledochal and major pancreatic duct strictures and stenoses of the papilla in DPR underwent EPST with favorable initial and long-term results. The authors suggest, that DPR are an important etiopathogenetic link in the development of many diseases of the organs of hepatobiliary region, associated with biliary and pancreatic hypertension.

Aged↗
PubMed1999

[The immunological changes and prognosis of cholestatic jaundice in choledocholithiasis].

Fifty-six patients presenting choledocholithiasis are covered by the study. They are distributed in groups according to total serum bilirubin values, as follows: with total serum bilirubin < 20 mumol/l--17; 20 to 50 mumol/l--13; 50 to 80 mumol/l--9; and > 80 mumol/l--17 cases. Sixty healthy, sex and age matched individuals serve as controls. The immunocompetent cells are determined flow cytometrically with FACS TAR (BECTON DICKINSON). A panel of monoclonal antibodies (Becton Dickinson) is used, including: Leu4 (anti-CD3+)--T-lymphocytes; Leu3a (anti-CD4+)--helper/inducer lymphocytes; Leu2a (anti-CD8+)--suppressor/cytotoxic cells; Leu11a (anti-CD16+)--cells with a natural killer activity; Leu12 (anti-CD19+)--B-lymphocytes. As shown by the obtained results there are no changes in cell-mediated immune response among choledocholithiasis patients with normal values of total serum bilirubin. Parallel to increasing the degree of cholestatic jaundice (ChJ) severity, the absolute values of lymphocytes and their subpopulations decrease. The deficit is most clearcut in patients presenting the highest degree cholestasis, as compared to healthy individuals ((Ly: 1690 +/- 174/2277 +/- 186; CD3+: 956 +/- 119/1793 +/- 67; CD4+: 607 +/- 83/988 +/- 80; CD8+: 239 +/- 52/639 +/- 85; CD16+: 146 +/- 38/367 +/- 55; CD19+: 181 +/- 33/200 +/- 13. In 11 cases with early restored biliary drainage (by the 21st day of ChJ), total serum bilirubin decreases within 10 days after the operation (choledochoduodenoanastomosis), whereas lymphocytes and their subpopulations show an increase in absolute values. Two months after choledochoduodenoanastomosis, the total serum bilirubin and the lymphocyte subpopulations being examined regain their normal values. In two instances with rather late biliary drainage recovery (30 days after ChJ) the total serum bilirubin and lymphocyte subpopulations under study show no tendency whatsoever towards normalization at 10 days postoperatively. The results of the study demonstrate that the poor prognosis among ChJ patients is also related to inhibition of the cell-mediated immune response. The early biliary drainage recovery (at 21 days of ChJ) exerts a more favourable effect on the immune system, and improves the prognosis of the clinical course run by the pathological process.

Aged↗
PubMed2000

Long-term stenting for choledocholithiasis.

Endoscopic biliary sphincterotomy and stone removal has become the standard of care for choledocholithiasis. Surgical intervention has been undertaken when stones cannot be removed endoscopically. In such patients who are high risk surgical candidates, an alternative therapy is the endoscopic placement of long-term plastic stents to allow biliary decompression. Though such stents usually occlude by three months, they may act as a wick to allow drainage of bile into the duodenum. This case report describes a patient with choledocholithiasis who was treated for 19 months with a biliary stent before expiring from unrelated causes.

Aged↗
PubMed2000

[Endoscopic surgery for management of cholecystolithiasis and choledocholithiasis: basic and clinical aspects].

At present, laparoscopic surgery is considered to be the method of first choice for the management of cholecystolithiasis or choledocholithiasis. The clinical advantages and problems inherent to endoscopic surgery for the management of cholecystolithiasis or choledocholithiasis described in the literature are summarized and their reasons are discussed in this paper. Moreover, methods overcome the problems of endoscopic surgery are discussed. Among the problems inherent to laparoscopic surgery, the prevention of perioperative and postoperative complications has reserved serious attention of surgeons because surgery is carried out using mismatched instruments in a two-dimensional field monitored on a TV screen. However, the main causes of complications are attributable to the immature techniques of surgeons. Therefore, an increase in the number of educated surgeons is strongly awaited. To solve the problems mentioned above, better training in endoscopic surgery should be included in postgraduate surgical educational programs.

Cholecystectomy, Laparoscopic↗
PubMed2000

[Changes in the treatment of choledocholithiasis].

UNLABELLED: The therapeutic approaches to gallstone disease and bile duct stone changed dramatically in the last decade by spreading of endoscopic and laparoscopic methods. The authors have reviewed the most frequent curing methods of bile duct stone recently. They examined patients treated for gallstone and common bile duct stone in Surgical Department and Gastroenterological Department of their hospital. Retrospective study was performed to evaluate the issue of treatment for gallstone disease in addition to common bile duct stone (CBDS) and papillary stenosis in the last six years from 1993 to 1998, in the era of laparoscopic cholecystectomy (LC). There was formed a control group from similar patients of these two departments, between 1986-1991, in the six-year period before the laparoscopic era. The postoperative complications and perioperative mortality were analysed in present period compared with the outcome of control group. RESULTS: 734 patients were treated by sequential endoscopic laparoscopic approach or open operation between 1993-1998: 632 endoscopic sphincterotomy (EST), from which 236 LC followed the preoperative EST, 102 open choledochotomy were performed. Overall complications were 4.4% and mortality was 0.9% (EST plus LC plus open operations.) The control group made up of 534 patients underwent a treatment of choledocholithiasis: 196 EST and 338 open choledochotomy were achieved. Complications were 10.6% and mortality was 1.9%. The authors statistically evaluate the retrospective results. They conclude that there is a significant difference in the complications rate between the two groups, but the decrease of mortality is not significant. The mean hospital stay is 6.5 days in the recent group and this value was 13.4 days in the control group. Saving of hospital cost is 62,100 Ft for one patients. The authors think that this sequential approach results in a safer and more effective treatment of cholecysto-choledocholithiasis than the former period's.

Adult↗
PubMedDate not supplied

[Multiple choledocholithiasis].

OBJECTIVE: The authors report their experience about the endoscopic (ERCP) treatment of multiple choledocholithiasis. DESIGN: Report of 5 cases; evaluation of mortality and effectiveness of the treatment. SETTING: Operative Unit of General and Thoracic Surgery, Department of Surgical, Anatomical and Oncological Disciplines. Policlinico, University of Palermo. INTERVENTIONS: ERCP + ES + clearance of bile duct stones in all 5 patients. RESULTS: 100% successful. CONCLUSION: ERCP is choice treatment of multiple choledocholithiasis, only in well experienced teams.

Adult↗
PubMed2003

[A case of gastric cancer with liver metastasis in which obstruction of the bile duct and choledocholithiasis was caused by intra-hepatic arterial infusion chemotherapy].

A 64-year-old man underwent gastrectomy and partial liver resection for gastric cancer and liver metastasis, and was administered intra-arterial infusion chemotherapy for metastases of the remnant liver. This treatment was very effective against the liver metastases, but 13 months after the operation obstructive jaundice occurred. An examination revealed obstruction of the bile duct and choledocholithiasis. The choledocholithiasis was treated using a percutaneous transhepatic cholangio-scope, and choledocho-duodenostomy was performed for the obstruction of the bile duct. Findings from the operation suggested that the obstruction was caused by the intra-arterial infusion chemotherapy. At present, 2 years after the first operation, the patient is alive without the regrowth of the liver metastasis.

Angiotensin II↗
PubMedDate not supplied

Use of the transcystic guidewire in single-intervention treatment for cholecysto-choledocholithiasis. A case report and technical notes.

Videolaparoendoscopic treatment of choledocholithiasis in a single stage is an important option for this disease. We currently adopt this approach to choledocholithiasis in our department. We report here the case of a woman with stones in the biliary tract and gallbladder. After videolaparoscopic cholecystectomy we performed a transcystic cholangiography. A guidewire was used to show Vater's papilla during endoscopic papillosphinterotomy, because this was in a duodenal diverticulum that made it impossible to cannulate the papilla. We propose this method in all those cases in which, for anatomical reasons, the papilla cannot be easily cannulated.

Aged↗