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At least 217 records · Page 12Linked to original sources
PubMed1995

Improvement of cervical Chlamydia detection in asymptomatic family planning attendees by using Amplicor Chlamydia trachomatis assay.

We evaluated the Amplicor C. trachomatis PCR assay (Roche Molecular Systems, N.J.) for the diagnosis of cervical infection in asymptomatic women attending a family planning clinic, aged between 18 and 25 years. Culture onto McCoy cells with fluorescent monoclonal staining was the reference system. Cervical specimens from 485 women were tested. The prevalence of C. trachomatis was 10.5% by culture and 11% by Amplicor. No specimen was positive by culture and negative by PCR. Three PCR-positive, culture-negative specimens were positive by MOMP-PCR and a second plasmid-based PCR. The resolved sensitivity of PCR and culture were 100% and 94.5%, respectively. Specificities for both were 100%, positive and negative predictive values for culture were 100% and 99.3%. Total test efficiency was 99.4%. The Amplicor C. trachomatis assay gave very clear results, quite above or below the cut-off value, and showed high sensitivity and specificity, improved ease of handling and represented a good alternative to culture for large scale diagnosis of asymptomatic C. trachomatis infection.

Adolescent↗
PubMed1994

[Serodiagnosis of Chlamydia trachomatis and Chlamydia pneumoniae. Evaluation comparing 2 methods: microimmunofluorescence and ELISA. A study of 216 Congolese sera].

Our purpose was to compare two assays for C. trachomatis and C. pneumoniae serology: immunofluorescence and ELISA. With both assays, we tested 216 sera from two populations: risk population of STD (sexually transmitted disease) (women) and a control population "blood donors". Positives percentages of each population were compared by two assays: 87% in MIF and 76% in ELISA (women population); 64.8% in MIF and 53.7% in ELISA (blood donors population). Results were not significantly different. In comparison with ELISA: MIF had a sensitivity of 85% and a specificity of 93%. In comparison with MIF: ELISA had a sensitivity of 98% and a specificity of 48%; agreement between MIF and ELISA in women population and blood donors population is respectively: 88.9% and 78.8%. The discrepancy between both methods is 11.1% in women group and 21.2% in blood donors group. The correlated coefficient (r) between MIF and ELISA was ranged between 0.507 and 0.778 (P < 0.001). Both assays have honourable performance, but no superimposable.

Adolescent↗
PubMed1996

[Clinico-laboratory evaluation of the effectiveness of azithromycin in the treatment of patients with Chlamydia and mixed Chlamydia-gonorrhea infections].

One hundred and fifteen females with nonsevere inflammatory diseases of the urogenital tracts were examined. Mixed chlamydial and gonorrheal infection was stated in 35 patients. In 38 patients chlamydial infection was diagnosed. To develop an optimal procedure for the treatment, the pharmacokinetics of azithromycin was studied. The results showed that the optimal primary dose of the drug was 1000 mg. Two regimens were recommended for the treatment of the patients. According to the first regimen azithromycin was administered in a single dose of 1000 mg. The efficacy amounted to 82.4 per cent in the cases with the mixed infection and to 89.9 per cent in the cases with chlamydiosis. According to the second regimen azithromycin was administered in a course dose of 3000 mg, the duration of the course being 9 days. The efficacy of the therapy amounted to 89.9 and 95 per cent respectively.

Anti-Bacterial Agents↗