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209 records · Page 12Linked to original sources
PubMed1976

[Fludilat treatment of vagotonic and subendocardial disturbances of cardiac metabolism and bradycardiac coronary diseases (author's transl)].

The action of the drug on the electrocardiograph and clinical investigations were carried out on 55 patients treated with Fludilat. It was shown that in vagotonic subjects and patients with subendocardial ischemia the high T wave in the ECG becomes flattened, in some of the cases the QT interval is prolonged and the U wave larger, parallel with the improvement in the symptoms. A better clinical effect than previously was observed as as result of the antianginal action of Fludilat.

Acute Disease↗
PubMedDate not supplied

[Effect of euphylline and halidor on several indices of catecholamine and serotonin metabolism in the brains and blood of rats].

Euphylline and galidore did not alter the concentration of catecholamines and serotonin in brain of intact rats, but exhibited opposite effects on metabolism of biogenic amines, if their precursors were administered into animals. Galidore decreased the activity of catechol-O-methyl transferase (COMT) and 5-hydroxytryptophane decarboxylase. Euphylline did not influence the COMT activity but increased the activity of 5-HT-decarboxylase. Both preparations did not alter the monoaminooxidase activity.

Aminophylline↗
PubMedDate not supplied

[Influence of halidor on experimental bronchospasm].

Through local stimulation of various structures of medulla oblongata a centrogenic bronchial spasm was simulated in acute tests on cats. A peripheral bronchial spasm was reporduced by stimulating the peripheral length of the vagus. An experimental bronchial spasm caused by activation of reticular nuclei and of a single fascicular nucleus halidor suppressed with doses half as large as the ones needed to inhibit the peripheral spasm. An application of halidor to the ground of the fourth ventricle tended to immediately lessen the intensity of the bronchial spasm, this suggesting a central component in the action of the drug.

Animals↗