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PubMed2022

Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study.

BACKGROUND: The associations between blood lipids and DNA methylation have been investigated in epigenome-wide association studies mainly among European ancestry populations. Several studies have explored the direction of the association using cross-sectional data, while evidence of longitudinal data is still lacking. RESULTS: We tested the associations between peripheral blood leukocytes DNA methylation and four lipid measures from Illumina 450 K or EPIC arrays in 1084 participants from the Chinese National Twin Registry and replicated the result in 988 participants from the China Kadoorie Biobank. A total of 23 associations of 19 CpG sites were identified, with 4 CpG sites located in or adjacent to 3 genes (TMEM49, SNX5/SNORD17 and CCDC7) being novel. Among the validated associations, we conducted a cross-lagged analysis to explore the temporal sequence and found temporal associations of methylation levels of 2 CpG sites with triglyceride and 2 CpG sites with high-density lipoprotein-cholesterol (HDL-C) in all twins. In addition, methylation levels of cg11024682 located in SREBF1 at baseline were temporally associated with triglyceride at follow-up in only monozygotic twins. We then performed a mediation analysis with the longitudinal data and the result showed that the association between body mass index and HDL-C was partially mediated by the methylation level of cg06500161 (ABCG1), with a mediation proportion of 10.1%. CONCLUSIONS: Our study indicated that the DNA methylation levels of ABCG1, AKAP1 and SREBF1 may be involved in lipid metabolism and provided evidence for elucidating the regulatory mechanism of lipid homeostasis.

Humans↗
PubMed1986

Effects of oral and intracecal pectin administration on blood lipids in minipigs.

The effects on blood lipids of oral and intracecal pectin administration for 4 wk were examined in six male adult hypercholesterolemic minipigs (total serum cholesterol = 8.4 mmol/L. The pigs were fitted with a cecal cannula and were assigned to three groups of two pigs each; the groups underwent an experiment in 3 X 3 Latin square design. The control period was designated as that during which water was infused into the cecum. Total serum cholesterol concentration was about 50% lower after feeding 75 g pectin per day than during the control period. The intracecal infusion of the same amount of pectin had no effect on total serum cholesterol concentration compared to the control period. The cholesterol level in the low density lipoproteins (LDL), in the very low density lipoproteins (VLDL) and in the high density lipoproteins (HDL) was lower after feeding pectin than in the control period. The HDL cholesterol, but not LDL or VLDL cholesterol, was at a lower level after intracecal infusion of pectin than during the control period. Thus, the study clearly demonstrates that the passage of pectin through the small intestine is necessary for its hypocholesterolemic action.

Administration, Oral↗
PubMed1977

[Behavior of blood lipids and lipoproteins in myocardial infarct].

Blood lipids and lipoproteins were evaluated in male and female subjects of various ages with acute myocardial infarct. Values were within the limits of normal in less than 50%, mostly in the aged. II B (24%), IV (18%) and II A (11%) lipoprotidaemic pictures were the most common. It is felt that abnormal values are not necessarily part of the infarct picture; if present, they are mainly of the II B type.

Adult↗
PubMed2005

[Study of Qingciguo oil's function on blood lipid and other functions].

OBJECTIVE: To study Qingciguo Oil's function on blood lipid and other functions. METHODS: 84 male SD rats were randomly divided into seven groups (control group, high lipid group, low dose group, middle dose group, high dose group, combined dose group and combined control group) based on the level of TC. We respectively feed each group of rats with the normal food, high lipid high cholesterol food, Qingciguo Oil's 4 ml/kg BW food, Qingciguo Oil's 8 ml/kg BW food, Qingciguo Oil's 12 ml/kg BW food, Qingciguo Oil's 12 ml/kg BW + 0.8% soybean PL + 0.05% VitE food & 0.8% soybean PL + 0.05% VitE food ninth week. RESULTS: At the fourth week, the TC of each group rats (except lower dose group) began to decreasing, and at sixth week, the TC of middle dose group was significantly lower than the high lipid group. At sixth week, the TG of low, middle and high dose group was significantly lower than the TG of high lipid group, the HDL of high lipid group and middle dose group decreased significantly, and the HDL of combined control dose group significantly higher than high lipid group. At the ninth week, the level of SOD of all experimental groups significantly higher than the high lipid group and the MDA of each group have no significant differents between each other. In vitro, we test the effect of different dose Qingciguo oil and fish oil on platelet aggragation of each blood by tuibidimetry, the results show that the platelet aggregation of Qingciguo oil high dose group was significantly lower than the control group. CONCLUSION: Under our condition, Qingciguo oil has certain functions of decreasing the level of blood lipids modulating the function of antioxidants and restraining the platelet aggregation in vitro.

Animals↗
PubMed2000

Long-term topical timolol and blood lipids: the Blue Mountains Eye Study.

OBJECTIVES: To examine whether an association exists between long-term use of topical timolol and blood lipids, including high-density lipoprotein cholesterol (HDL-C), cholesterol, and triglycerides, among participants of the Blue Mountains Eye Study. METHODS: From 1992 through 1994, a detailed medical and eye examination was performed in 3,654 people aged 49 years or older, representing 82% of permanent residents in two postcode areas west of Sydney. Glaucoma and ocular hypertension were diagnosed, and an ophthalmic history was taken, including use of topical timolol. Fasting blood tests were performed in 89% of subjects. Lipid levels were compared in subjects using topical timolol for at least 1 year with those not using timolol, after excluding people using oral beta-blockers, topical beta1-selective agents, or oral lipid-lowering medications. RESULTS: Analyses compared blood lipids of 63 people who had used topical timolol for at least 1 year with 2,597 nonusers. No statistically significant differences were found in any blood lipid mean levels between treated and untreated people, after multivariate adjustment. However, subgroup analyses of men and women separately showed that male timolol users had a mean value of HDL-C 0.13 mmol/L (11%) lower then the mean value of male nonusers, while female timolol users had a mean value of HDL-C 0.09 mmol/L (5%) higher than the mean for female nonusers. There were no statistically significant associations between timolol treatment duration and HDL-C or other lipid levels. Previously reported adverse effects of oral beta-blockers on blood lipid levels were confirmed. CONCLUSIONS: These population-based data suggest that long-term administration of topical timolol for glaucoma or ocular hypertension can cause adverse effects on HDL-C in men, but not in women. The magnitude of the effect in men was similar to that previously described in a number of short-term studies.

Adrenergic beta-Antagonists↗
PubMed1981

The effect of various intakes of omega 3 fatty acids on the blood lipid composition in healthy human subjects.

In a study with 52 healthy volunteers, the effect of different amounts of omega 3 fatty acids on the blood lipid composition was investigated. Doses of 1.4, 2.3, 4.1, and 8.2 g of omega 3 fatty acids were administered to these subjects daily over a period of 4 wk. Total cholesterol, high-density lipoprotein cholesterol, total triglycerides, and glucose were determined in blood serum and hemoglobin in whole blood in all individuals before, during, and after the intake of omega 3 fatty acids. In pooled serum samples, the lipoprotein composition and the fatty acid composition of blood lipids were determined. All dosages caused a shift in the fatty acid composition of blood serum lipids in a favor of omega 3 fatty acids and at the expense of omega 6 and/or omega 9 acids. In the sterol esters, only the percentage of C20:5 omega 3 increased. Maximum shifts depended on the amount of omega 3 acids ingested and were evident within 1 to 2 wk. Two wk after the last ingestion of omega 3 acids, the fatty acid composition of blood serum lipids had returned to the original state. In the groups receiving 8.2 of omega 3 fatty acids, there was a significant decrease in serum triglyceride and very low-density lipoprotein levels, which is in accord with earlier observations. In the other parameters, including cholesterol and high-density lipoprotein cholesterol, no decrease or increase was observed.

Adolescent↗
PubMed1991

Effect of increased training volume on blood lipids and lipoproteins in male collegiate swimmers.

This study was conducted to assess whether a previously described dose-response relationship between the amount of exercise and the magnitude of change in blood lipid and lipoprotein levels is observed with large volumes of exercise in young, healthy individuals. Blood lipid and lipoprotein levels were monitored during a 25-wk season of training and competition in experienced male collegiate swimmers, who were divided into two groups matched for swimming skill. After an initial 4-wk conditioning period for both groups, one group (N = 11) underwent a 6-wk period during which their training volume was increased from 22,000 m.wk-1 to 44,000 m.wk-1. The other group (N = 13) maintained their swimming distance at 22,000 m.wk-1 during this period. During the remaining 15 wk of the season, both groups swam approximately 22,000 m.wk-1. Swimmers' body weights did not change over the season, but body fat decreased significantly (P less than 0.01). No changes in HDL cholesterol were observed during the season in either the increased training or the regular training groups. Total and LDL cholesterol levels were lower at 20 wk than at the start of the study, but final levels did not differ from initial levels. Thus, the volume of swimming exercise may not be related to the degree of change in blood lipid and lipoprotein levels in healthy subjects with high activity levels.

Adult↗
PubMed2005

[Study on serum leptin level of urban resident and the relationship between body mass index, blood lipid, insulin and leptin level].

OBJECTIVE: To measure serum leptin concentration of urban residents and investigate the relationship between serum leptin concentration and body mass index(BMI), blood lipid, insulin. METHODS: One hundred fifty-eight men and women ages 18-72 years were initially drawn from a community in Ji'nan City. The parameters measured included height, weight, waist and hip circumference, insulin, blood lipid and leptin concentrations. Statistical analyses were performed with SPSS11.5. RESULTS: The mean serum concentration of leptin was (17.47 +/- 13.52)ng/ml, in male subjects was (8.38 +/- 6.31)ng/ml, in female subjects it was (24.98 +/- 13.29)ng/ml. Serum level of leptin was significantly positively correlated with BMI, waist and hip circumference, not correlated with WHR. Serum leptin level in females was positively correlated with WHR. There was no association between serum level of leptin and insulin. Serum leptin level in males was positively correlated to apo B, in females was positively correlated to TC, LDL-c. CONCLUSION: BMI is an important factor to determine serum leptin level. The relationships between plasma glucose, insulin, blood lipids and serum leptin are affected by gender. In males serum leptin level was positively correlated to apo B, in females was positively correlated to TC, LDL-c. We need further research to explain this difference.

Adolescent↗
PubMed2006

Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women.

Sesame ingestion has been shown to improve blood lipids in humans and antioxidative ability in animals. Sesamin, a sesame lignan, was recently reported to be converted by intestinal microflora to enterolactone, a compound with estrogenic activity and also an enterometabolite of flaxseed lignans, which are known to be phytoestrogens. Whether sesame can be a source of phytoestrogens is unknown. This study was designed to investigate the effect of sesame ingestion on blood sex hormones, lipids, tocopherol, and ex vivo LDL oxidation in postmenopausal women. Twenty-six healthy subjects attended, and 24 completed, this randomized, placebo-controlled, crossover study. Half of them consumed 50 g sesame seed powder daily for 5 wk, followed by a 3-wk washout period, then a 5-wk 50-g rice powder placebo period. The other half received the 2 supplements in reverse order. After sesame treatment, plasma total cholesterol (TC), LDL-C, the ratio of LDL-C to HDL-C, thiobarbituric acid reactive substances in oxidized LDL, and serum dehydroepiandrosterone sulfate decreased significantly by 5, 10, 6, 23, and 18%, respectively. The ratio of alpha- and gamma-tocopherol to TC increased significantly by 18 and 73%, respectively. All of these variables differed significantly between the 2 treatments. Serum sex hormone-binding globulin and urinary 2-hydroxyestrone (n = 8) increased significantly by 15 and 72%, respectively, after sesame treatment, and these concentrations tended to differ (P = 0.065 and P = 0.090, respectively) from those after the placebo treatment. These results suggest that sesame ingestion benefits postmenopausal women by improving blood lipids, antioxidant status, and possibly sex hormone status.

Aged↗
PubMed2006

Nine months aerobic fitness induced changes on blood lipids and lipoproteins in untrained subjects versus controls.

Regular endurance exercise has favorable effects on cardiovascular risk factors. However, the impact of an exercise-induced change in aerobic fitness on blood lipids is often inconsistent. The purpose of this study was to investigate the effect of nine consecutive months of training on aerobic fitness and blood lipids in untrained adults. Thirty subjects 35-55 years of age (wt: 73.1 +/- 13.6 kg, height 171.1 +/- 9.0 cm, %body fat 24.6 +/- 6.3%, 14 males and 16 females) were randomly assigned to an exercise (EG) (N = 20) and control (CG) (N = 10) group. All subjects completed an incremental treadmill test, anthropometric measurements, and venous blood sample collection before and after the 9 months of exercise. Participants in the exercise group were supervised and adjusted for improvements in running performance, whereas no change was administered for the control group. One-way and multivariate ANOVA was conducted to determine significant differences in means for time and group in selected variables [body mass, % body fat, BMI; VO(2peak), km/h at 2.0 (v-LA2) and 4.0 (v-LA4) mmol l(-1) blood lactate (LA) concentration, km/h of the last load (v-max); TC, LDL-C, HDL-C, TG, Apo B, Apo A-1, and Lp (a)]. Correlation coefficients and multivariate regression analysis was used to determine the association between aerobic fitness and blood lipids. The exercise group improved significantly (P < 0.0001) in VO(2peak), v-LA2, v-LA4, v-max and exhibited a significant decrease in Apo B (P < 0.04) compared to the control group (NS). In 9 months, E achieved 24% increase in VO(2peak) and 18% reduction in Apo B, denoting the impact of cardiovascular fitness on cardiovascular risk.

Adult↗
PubMed2003

[Effect of dandi tablet on blood lipids and sex hormones in women of postmenopausal stage].

OBJECTIVE: To explore the effect of Dandi Tablet (DDT), a TCM preparation for tonifying Shen and activating blood circulation, on blood lipids and sex hormones in women of postmenopausal stage. METHODS: Seventy-three women were randomly divided into two groups. The 46 subjects in the DDT group were treated with DDT (consisted of prepared Rehmannia Root 24 g, Dogwood Fruit 9 g, Poria 9 g, Water-plantain 9 g, Tuber Peony bark 9 g, Chinese Yam 12 g and Red Sage 15 g, etc.) twice a day, 4 tablets each time. The 27 subjects in the control group were treated with nylestriol (each tablet contains 2.5 mg of 17 alpha-ethynylestriol-3-cyclopentyl ether) 5 mg every month, for 3 successive months. Levels of blood lipids, including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C, LDL-C), apoprotein A and B (apoA, apoB) and sex hormones, including follicular stimulating hormone (FSH) and estradiol (E2) were determined before and after treatment. RESULTS: Compared with pre-treatment, after treatment, levels of TC/HDL-C and FSH significantly lowered, HDL-C and E2 increased in both groups (P < 0.05 or P < 0.01), levels of TG lowered and apoA increased significantly in the DDT group (P < 0.05). CONCLUSION: DDT has the effect of elevating levels of estrogen and improving blood lipid metabolism, therefore shows a coronary heart disease preventive effect in women of postmenopausal stage.

Adult↗
PubMed2004

Docosahexaenoic acid-enriched egg phospholipids supplementation induces accretion of arachidonic acid in rat blood lipids.

Animal and humans studies have shown that supplementation with triacylglycerides containing omega3 fatty acids, mainly docosahexaenoic acid (DHA) and eicosapentaenoic acid, can induce a decrease in arachidonic acid (AA) in blood lipids. Interestingly, we observed in a previous work that a supplementation with DHA enriched eggs in a healthy elderly population induced an accretion of AA in their blood lipids. The present study investigates whether purified DHA enriched egg phospholipids could be responsible for this effect. Four groups of rats were supplemented daily, for eight weeks, with DHA phospholipids (10, 30 or 60 mg/kg) or with soybean phospholipids. Red blood cell membranes and plasma fatty acid levels were compared with that of rats without supplementation. Soybean phospholipids supplementation increased the level of AA in blood lipids but decreased that of DHA. The doses of DHA phospholipids, 30 and 60 mg/kg, induced greater amounts of AA without affecting significantly DHA levels. In contrast, DHA phospholipids supplementation, 10 mg/kg, in which there was the greatest amount of AA, induced only a slight increase in AA levels. Moreover, DHA levels were decreased by this supplementation. These results demonstrate that specific increases in AA levels are preferentially associated with DHA phospholipids levels in supplementation.

Animals↗
PubMed1985

Effects of prazosin and alphamethyldopa on blood lipids and lipoproteins in hypertensive patients.

The effects of prazosin and alphamethyldopa on blood lipids and lipoproteins were assessed in 20 patients with mild or moderate arterial hypertension. Parameters measured included serum cholesterol (CHO), triglycerides (TG), high density lipoprotein-cholesterol (HDL-CHO), insulin (I), glucose (G), and non-esterified fatty acids (NEFA). Prazosin -4 mg/day for 6 weeks in hydrochlorothiazide-treated patients lowered blood pressure by 18.6/17.2 (systolic/diastolic pressure) mmHg. There was a significant decrease in CHO (-5.8%), in I (-16.5%), and in NEFA (-3.0%), and a significant increase in HDL-CHO (+15.5%). Alphamethyldopa 250-750 mg/day for 6 weeks in hydrochlorothiazide-treated patients lowered blood pressure by 18.8/14.6 (systolic/diastolic pressure) mmHg, accompanied by a non-significant decrease in CHO and TG, and significant increases in HDL-CHO (+10.3%), G (+8.5%) and NEFA (+6.4%). Thus, prazosin appears to have a more beneficial effect on blood lipids and lipoproteins than alphamethyldopa.

Adult↗
PubMed2001

Giessen Wholesome Nutrition Study: relation between a health-conscious diet and blood lipids.

OBJECTIVE: To study in humans the relationship between a diet consistent with most of the current recommendations for the prevention of nutrition-related diseases (Wholesome Nutrition) and the blood lipid profile (total cholesterol, LDL-, HDL-cholesterol, LDL/HDL-ratio, triglycerides). DESIGN: Cross-sectional study with two diet groups. SETTING: Former West Germany. SUBJECTS: Healthy women (n=243, aged 25-65 y) adhering to Wholesome Nutrition for at least 5 y (subdivided into 111 ovo-lacto vegetarians and 132 low-meat eaters) and an according control group of 175 women eating an average German mixed diet. They were all recruited through an advertisement campaign and selected on the basis of their food consumption. RESULTS: Considering potential confounders, the Wholesome Nutrition subgroups had higher HDL-cholesterol levels than the control group. No differences were observed for total cholesterol and LDL-cholesterol. For LDL/HDL-ratio and triglycerides the effect of diet was dependent on interaction terms. With increasing risk factors (age or body mass index (BMI)) the Wholesome Nutrition subgroups showed more favourable blood lipids. CONCLUSIONS: Women eating a preventive diet on a long-term basis exhibit more favourable blood lipid profiles than women consuming an average mixed diet. This is particularly obvious for HDL-cholesterol in the presence of certain risk factors and when an ovo-lacto vegetarian version is practised. SPONSORSHIP: Eden Foundation, Bad Soden, Germany.

Adult↗
PubMed1991

[Evaluating parachute-drop stress by measuring blood lipids].

An attempt to evaluate parachute-drop related stress by determining the blood lipid profile (cholesterol, LDL, HDL, apo-A, apo-B, and triglycerides) is reported. Measurements were made on starting the parachute course, just before the first jump, and just after the third jump. On these 3 occasions 38 combat troops answered psychological questionnaires and 30 of them gave blood samples. While there were significant fluctuations in level of all blood lipids and their apoproteins, they could not be correlated selectively with presumed levels of stress. The well-known difficulties in field studies in controlling crucial factors such as the exact timing of the measurements and food intake (specific diet or fasting) make questionable the use of biochemical markers in measuring stress under the conditions of our study. It is possible that the high rate of refusal to give blood samples biased the findings.

Apolipoproteins A↗
PubMed2001

Blood lipids and first-ever ischemic stroke/transient ischemic attack in the Bezafibrate Infarction Prevention (BIP) Registry: high triglycerides constitute an independent risk factor.

BACKGROUND: Despite unclear associations between blood lipids, including fractionated cholesterol and triglycerides, and stroke, recent evidence demonstrates that lipid-modifying agents decrease the risk of stroke in patients with coronary heart disease (CHD). METHODS AND RESULTS: Patients with documented CHD who were screened for but not included in the Bezafibrate Infarction Prevention study and had no history of stroke or transient ischemic attack (TIA) (n=11 177) were followed up. At baseline, medical histories were obtained and blood lipids assessed at a central study laboratory. During a 6- to 8-year follow-up period, 941 patients were identified as having nonhemorrhagic cerebrovascular disease, of whom 487 had verified ischemic stroke (per clinical findings and brain CT) or TIA. Patients experiencing an ischemic stroke/TIA had higher mean levels of triglycerides, lower levels of HDL cholesterol, and lower percentages of cholesterol contained in the HDL cholesterol moiety (%HDL; P<0.01 for all). In a logistic regression model, the adjusted ORs for developing an ischemic stroke/TIA were 1.27 (95% CI 1.01 to 1.60) associated with triglycerides >200 mg/dL and 0.87 (95% CI 0.78 to 0.97) associated with a 5% decrease in %HDL. The increased risk associated with high triglycerides was found across subgroups of age, sex, patient characteristics, and cholesterol fractions. CONCLUSIONS: High triglycerides constitute an independent risk factor for ischemic stroke/TIA across subgroups of age, sex, patient characteristics, and cholesterol fractions, whereas high %HDL was an independent protective factor among patients with CHD. These findings support the role of blood lipids, including triglycerides, as important modifiable stroke risk factors.

Age Factors↗
PubMed1996

Comparison of standard- and extended-length participation in cardiac rehabilitation on body composition, functional capacity, and blood lipids.

Participation in a standard-length outpatient cardiac rehabilitation program (CRP) for 3 months is known to result in positive changes in body composition, functional capacity, and blood lipids in patients with coronary artery disease. However, there has been little attempt to compare patients who remain active in a formal CRP for an extended length of >1 year with patients who exit after a standard length of 3 months. Consequently, 50 patients underwent a series of tests including a maximal graded exercise treadmill test, assessment of body composition, and fasting blood lipid analysis, at entry to CRP and after a follow-up period that ranged from 1 to 5 years. All patients participated in a standard multidisciplinary cardiac rehabilitation program for 3 months. Twenty-five patients discontinued participation after 3 months and received no other contact from the program staff until follow-up, whereas 25 patients remained active in the program until follow-up. After statistically adjusting for baseline differences between the groups, significant differences were observed between the extended- and standard-length groups at follow-up for body weight (177 vs 183 lbs), percent fat (22% vs 24%), METS (10.5 vs 8.4), high-density lipoprotein level cholesterol (44 vs 39 mg/dl), total cholesterol/high-density lipoprotein ratio (5.2 vs 6.1), and triglycerides (134 vs 204 mg/dl), respectively. No significant differences in the adjusted means were observed between the groups at follow-up for total cholesterol (209 vs 219 mg/dl) and low-density lipoprotein cholesterol (136 vs 138 mg/dl). Data from this study demonstrate the efficacy of extended participation in CRP on body composition, functional capacity, and blood lipids. Greater efforts need to be directed at retaining patients in low-cost, center-based maintenance programs and at extending monitoring of patients exiting standard length CRPs.

Adult↗
PubMed1999

Comparison of the effects of conjugated estrogen treatment on blood lipid and lipoprotein levels when initiated in the first or fifth postmenopausal year.

Although estrogen replacement therapy (ERT) is known to be protective against the development of cardiovascular disease in patients with surgical menopause, the effects of ERT on blood lipids when started late after the operation is not yet clear. In this prospective study, blood lipid and lipoprotein levels were measured within a 2 year period, in Group I (n = 28 patients) and in Group II (n = 21 patients), who had total abdominal hysterectomy and bilateral salphingo-oophorectomy 10-16 or 55-65 months ago, respectively. Each patient received 0.625 mg conjugated equine estrogen once daily. Blood levels of total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and very low density lipoprotein (VLDL) were measured at the beginning of the study as well as 12 and 24 months after ERT, was commenced. When the levels obtained after 12 and 24 months of ERT were compared to the baseline levels, LDL levels were decreased, whereas HDL levels were increased in Group I (p < 0.05); however, only the TC levels were significantly lower in Group II (p < 0.05). In conclusion, our results show that ERT is more effective on blood lipid changes when initiated within one year of oophorectomy compared with ERT initiated 5 years after the menopause.

Body Mass Index↗