Charles Estienne (Carolus Stephanus) (ca.1504-1564): physician and anatomist.
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Advances in network and imaging technology, coupled with the availability of 3-D datasets such as the Visible Human, provide a unique opportunity for developing information systems in anatomy that can deliver relevant knowledge directly to the clinician, researcher or educator. A software framework is described for developing such a system within a distributed architecture that includes spatial and symbolic anatomy information resources, Web and custom servers, and authoring and end-user client programs. The authoring tools have been used to create 3-D atlases of the brain, knee and thorax that are used both locally and throughout the world. For the one and a half year period from June 1995-January 1997, the on-line atlases were accessed by over 33,000 sites from 94 countries, with an average of over 4000 "hits" per day, and 25,000 hits per day during peak exam periods. The atlases have been linked to by over 500 sites, and have received at least six unsolicited awards by outside rating institutions. The flexibility of the software framework has allowed the information system to evolve with advances in technology and representation methods. Possible new features include knowledge-based image retrieval and tutoring, dynamic generation of 3-D scenes, and eventually, real-time virtual reality navigation through the body. Such features, when coupled with other on-line biomedical information resources, should lead to interesting new ways for managing and accessing structural information in medicine.
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One of the first centres of medical higher education in the Baltic countries was the University of Tartu (Dorpat), which was founded in 1632 by the Swedish King Gustavus Adolphus II. The University's first genuinely own building, however, the Old Anatomical Theatre, was completed only in 1805 after the re-opening of the University (1802). This year marks the 200th anniversary of its opening. The Old Anatomical Theatre has played an important role in Estonian medicine, and also a number of German morphologists, who have left a deep mark in world science, have worked in this building at different times.
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The relations between behavior, olfactory input (monitored by recording the activity of the olfactory mucosa), and the spontaneous field potentials of the dentate gyrus were studied in freely moving rats. Bursts of 30-80 Hz (gamma) waves were elicited in the dentate gyrus when a rat sniffed at a variety of objects but were not elicited by auditory, somesthetic, or visual inputs and were not related to the occurrence of locomotion. The presence of gamma wave activity was associated with an enhancement of the population spike elicited in the dentate gyrus by stimulation of the perforant path. Odorized air blown into a nostril via a cannula, inserted under light urethane anesthesia, elicited a gamma wave response bilaterally in the dentate gyrus. These and other data were reviewed to support the general hypothesis that the hippocampus is primarily an olfacto-motor mechanism and does not play any unique role in learning and memory, cognitive mapping, or emotion. The role of the hippocampus in the control of some forms of motor activity is supported by numerous anatomical and electrophysiological studies, studies of the effect of hippocampal lesions on behavior, and studies of the effects of electrical or chemical stimulation of the hippocampus on behavior.
Sir John Struthers (1823--1899), a past president of the Royal College of Surgeons of Edinburgh and Regius Professor of Anatomy at the University of Aberdeen, was an accomplished scientist and medical educator. Much of his career was spent in shaping the medical curriculum of the nineteenth century. He was a strong proponent of a sound basic science education as preparation for a career in medicine, but was also central in developing more formal clinical teaching for medical students. His interest in comparative anatomy and evolution has provided a rich legacy of human and zoological specimens that remain of value in everyday teaching. Much of his work on educational theory and the place of basic sciences in the medical curriculum remains relevant to this day, and is of particular interest given the ongoing debate regarding the place of the basic medical sciences in the undergraduate medical curriculum
Thomas Giordani Wright, a medical apprentice in Newcastle upon Tyne, attended Dr Robert Knox's anatomy classes in Edinburgh between November 1825 and April 1826, only two years before Burke and Hare began murdering people and selling the bodies of their victims to Knox's anatomy school. In March 1829, soon after the crimes came to light and Burke had been found guilty of murder and executed, Wright commented on the case in his diary, describing the practices in the dissection rooms and giving his views on Robert Knox, the teacher who had become his friend.
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