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At least 217 records · Page 12Linked to original sources
PubMed1993

Astroglial expression of ATL-derived factor, a human thioredoxin homologue, in the gerbil brain after transient global ischemia.

Distribution of adult T cell leukemia derived factor (ADF/TRX), a human thioredoxin homologue, was studied by immunohistochemistry in gerbil brain during reperfusion after transient cerebral ischemia. In control brains, immunoreactivity was observed widely in the central nervous system, including the ependyma, tanycytes, endothelial cells as well as subcommisural organs, and weakly in the neuronal cell bodies. During reperfusion, ADF/TRX was expressed in glial cells in the CA1 and dentate hilus of the hippocampus, and in a few cases in the lateral portion of the caudateputamen. ADF/TRX positive glias first appeared after reperfusion for 24 h, and the intensity of staining peaked at 72 h and diminished after 7 days of reperfusion. They were concentrated around microvessels and identified to be astroglia by double labeling immunohistochemistry with glial fibrillary acidic protein as marker. Immunoblotting analysis demonstrated an increase of ADF/TRX in the postischemic hippocampus. Astroglial expression of ADF/TRX in postischemic injuries suggests a role in neuroprotection by hydrogen peroxide reducing and protein-refolding activities or in modulation of local immune responses.

Animals↗
PubMed1988

ATLS paradigm fails.

Explore the source record for details and available documents.

Blood Pressure Determination↗
PubMed2002

Should we follow ATLS guidelines for the management of traumatic pulmonary contusion: the role of non-invasive ventilatory support.

OBJECTIVE: To assess the management of patients with blunt traumatic pulmonary contusion admitted to our hospital. To identify the role of early blood gas analysis, non-invasive ventilation and to assess the validity of the current Advanced Trauma Life Support manual statement that "Patients with significant hypoxia, i.e. PaO(2)<65 mm Hg or 8.6 kPa on room air, SaO(2)<90%, should be intubated and ventilated within the first hour after injury". SETTING: A 24 bed Intensive Care Unit in a major Trauma Centre situated in South Western Sydney, Australia. METHODS: Retrospective review of adults with blunt traumatic pulmonary contusion identified from the trauma registry. RESULTS: A total of 75 patients with an age range of 16-81 years were identified over a 2-year period. Arterial blood gas measurement was available for 32 patients during the immediate resuscitative period (<1 h from admission). All patients received supplemental oxygen and a PaO(2)/FiO(2) ratio was calculated. Seven patients had significant pulmonary contusion, indicated by an initial PaO(2)/FiO(2) ratio of <300, and were treated successfully with non-invasive ventilatory support. A further five patients without arterial blood gas (ABG) analysis on admission but with PaO(2)/FiO(2) ratio of <300 in the ICU were also managed with non-invasive ventilatory support. Multi-modal analgesia was commonly used. CONCLUSIONS: All major trauma patients admitted to our hospital received supplemental oxygen. Interpretation of ABG breathing room air was not used as an indicator for intubation. Most decisions to intubate early were based on clinical need. Patients with significant pulmonary contusion required intubation for reasons other than respiratory failure. Patients with significant pulmonary contusion were managed safely with non-invasive ventilatory support. Further investigation will determine the role of non-invasive ventilatory support in the management of these patients.

Adolescent↗
PubMed1996

CsTl: A New Example of Tetragonally Compressed Tl(6)(6)(-) Octahedra. Electronic Effects and Packing Requirements in the Diverse Structures of ATl (A = Li, Na, K, Cs).

The cesium-richest phase in the Cs-Tl system, CsTl, can be isolated as a pure crystalline phase through slow cooling of cesium-richer compositions in Ta followed by vacuum sublimation of the excess Cs at approximately 100 degrees C. The compound melts incongruently in the neighborhood of 150 degrees C. The structure was established by single crystal X-ray diffraction at room temperature (orthorhombic Fddd, Z = 48, a = 32.140(3) Å, b = 15.136(1) Å, and c = 9.2400(7) Å. The isolated Tl(6)(6)(-) ions in the structure, tetragonally compressed octahedra, exhibit D(2) symmetry with </=0.063(4) Å differences in edge lengths from D(4)(h)(). Extended Hückel calculations confirm the classical nature of the distortion in lowering the cluster electron count and charge. The diamagnetic CsTl differs from KTl, which contains more distorted Tl(6)(6)(-) ions (C(2)(h)()), in a doubled a axis and an additional interpenetrating cluster anion sublattice. The smaller distortion of the clusters in CsTl originates with the lower field of the same number of cation neighbors in a more symmetric arrangement. The structural trend from LiTl (CsCl type) through the classic NaTl (stuffed diamond) to the related KTl and CsTl with compressed octahedra (and the absence of any such Rb phase) relates to the efficient packing of A(+) and (Tl(-))(n)() over a widely varying range of A(+) sizes, with only Na(+) fitting well within a lattice. Similarly 4-bonded thallium in KTl and CsTl with somewhat shorter Tl-Tl distances is a necessary alternative when the infinite lattice cannot tolerate larger cations.

Journal Article↗
PubMed2000

Narrow-band ultraviolet B (ATL-01) phototherapy is an effective and safe treatment option for patients with severe seborrhoeic dermatitis.

BACKGROUND: Seborrhoeic dermatitis is a common papulosquamous dermatosis affecting 2-10% of the adult population. Current treatment options are limited and not always satisfactory. Objectives We aimed to investigate the efficacy of narrow-band ultraviolet (UV) B (TL-01) phototherapy as an alternative treatment for seborrhoeic dermatitis. METHODS: Eighteen patients with severe disease were enrolled in an open prospective study. Treatment was given three times weekly until complete clearing or to a maximum of 8 weeks. A clinical score assessing erythema, scaling, infiltration and pruritus was performed at baseline and every 2 weeks thereafter. Additionally, the patients were asked to rate the intensity of pruritus on a visual analogue scale. After completion of the study the patients were followed up to determine the median time interval until recurrence. RESULTS: All patients responded favourably to treatment, with six showing complete clearance and 12 marked improvement. The median clinical score decreased from 7.5 (range 4-8) at baseline to 0.5 (range 0-3) after 8 weeks of treatment (P = 0.005). The median pruritus score decreased from 4.5 (range 0-8) at baseline to 0 (range 0-3) at week 8 (P = 0.008). Relapses occurred in all patients after a median of 21 days (range 12-40). No side-effects of treatment were observed except occasional episodes of a moderate erythemal response. CONCLUSIONS: Narrow-band UVB phototherapy appears to be a very effective and safe treatment option for patients with severe seborrhoeic dermatitis.

Adolescent↗