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PubMedDate not supplied

Clinical investigation of the analgesic potency and respiratory depressant activity of fentanyl, a new narcotic analgesic.

A controlled clinical comparison of fentanyl and morphine in 75 postsurgical patients is presented. In addition, the ability of the two drugs to produce respiratory depression was determined in six healthy volunteers. The results of these studies indicate that 0.2 mg. fentanyl intramuscularly is equianalgesic with 10 mg. morphine intramuscularly, and it would appear that there is no advantage in the use of fentanyl for the relief of postsurgical pain.

Adult↗
PubMed1978

Kinetics of analgesic response in man; an example with two non-steroidal anti-inflammatory analgesic drugs.

A double-blind, controlled trial is described in which a total of forty hospital in-patients suffering from severe post-operative pain were randomly allocated to treatment with one of two non-steroidal anti-inflammatory drugs, namely, either indoprofen which has a short half-life (two-hours) or naproxen which has a long half-life (thirteen hours). The drugs were administered orally on a single-dose basis. The doses used in this way were 300 mg of indoprofen or 250 mg of naproxen. Patients scored the severity of their pain on a five-point scale and these scores were recorded prior to and at fixed time intervals up to eight hours following administration of medication. No significant differences emerged between the two test drugs and the duration of the response was also found to be similar for the two compounds despite their very different plasma half-life values.

Adolescent↗
PubMed1986

Comparison between transcutaneous nerve stimulation analgesic effect and electroacupuncture analgesic effect in rabbits.

To compare Transcutaneous Nerve Stimulation Analgesia (TNSA) with Electroacupuncture Analgesia (AA), we observed their effect and mechanism parallelly. The results are as follows: 1. Both TNSA and AA can produce significant current-dependent analgesia. The latency of AA is shorter than that of TNSA. 2. Under the present condition (lower-frequency, lower-intensity) naloxone can antagonize partly AA but not TNSA. 3. TNSA effect could be blocked partly by deep or intradermal injection of procaine into points. However, AA effect could be almost blocked completely by deep injection and not by intradermal injection of procaine.

Acupuncture Therapy↗