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PubMed1991

The relationship of interparental conflict and global marital adjustment to aggression, anxiety, and immaturity in aggressive and nonclinic children.

Although there is agreement that marital problems are associated either directly or indirectly with particular child behavior problems, there is disagreement about the types of marital conflict associated with these problems and the differential effects on boys and girls in clinic and nonclinic samples. We examined the relationships among mothers' ratings of marital adjustment, parenting disagreements, and three child problem factors (aggression, anxiety, and immaturity) after the child's age and family socioeconomic status were controlled. These relationships were compared with samples of boys and girls (3 to 8 years of age) from clinic and nonclinic populations, revealing that parenting disagreement predicted aggression in all groups and that both marital adjustment and parenting disagreement predicted anxiety in boys. Neither marital variable predicted immaturity. Possible reasons for the results (including methodological limitations of the present data) are discussed.

Aggression↗
PubMed1994

Peer ratings of depression, anxiety, and aggression in inpatient and elementary school children: rating biases and influence of rater's self-reported depression, anxiety, and aggression.

Using parallel self-, peer, and teacher rating scales, several rating biases in children's peer ratings of depression, anxiety, and aggression were examined. Participants were 66 inpatient and 133 elementary school children (N = 199, 109 boys, 90 girls; 61% white, 39% black) aged 8 to 12, and their teachers. Results showed significant halo bias in both the children's peer ratings and the teachers' ratings. Children's self-reports on each of the three traits were significantly related to their peer ratings of the same trait, while adjusting for socioeconomic status and the peers' teachers' ratings of the same trait. Children who rated themselves as high on each trait rated their peers significantly higher on the same trait than children who rated themselves as medium or low; and for depression and anxiety, those who rated themselves as medium rated their peers significantly higher on those traits than those who rated themselves as low. For both depression and aggression, children's self-reports on the trait were significantly related to their peer ratings of the same trait, but not significantly related to their peer ratings of different traits. Disagreements between children's and teachers' ratings of the peers on all three traits were significantly related to child self-reports on each trait, indicating a possible distortion in children's peer ratings due to self-report. The implications of the results for both peer and others' assessments are discussed, and further investigation of rating biases in other informants' assessments is encouraged.

Aggression↗
PubMed1998

Intergenerational transfer of psychosocial risk in women with childhood histories of aggression, withdrawal, or aggression and withdrawal.

Intergenerational transfer of risk between mothers and children, based on mothers' childhood aggression and social withdrawal, was examined in an inner-city sample. Each of the 3 studies reported involved a subset of the 909 female participants in the Concordia Longitudinal Risk Project, initiated when the participants were of school age. Using medical records, Study 1 (n = 853) focused on prediction of teen motherhood, delivery complications during childbirth, multiparity, and close spacing of births. Study 2 (n = 428) examined pathways to school dropout and teen parenthood. Study 3 (n = 89) involved prediction of observed parent and child behavior from mothers' childhood characteristics. Mothers' childhood aggression was consistently predictive of negative outcomes in each area of intergenerational risk, especially when combined with social withdrawal and low levels of academic achievement. Education was protective: Mothers' years of schooling predicted positive outcomes.

Achievement↗
PubMed1987

Attention and short-term memory in normal children, aggressive children, and non-aggressive children with attention-deficit disorder.

In the present study, fifteen 7- to 9-year-old male school children with attention deficit disorder (ADD) as well as matched groups of aggressive and normal children were compared on scores obtained for initial acquisition of information and its maintenance in the short-term score under various attentional loads. Bi-colored, alphanumeric arrays were used in a partial-report technique. Retention was measured 0, 5, 10, and 20 s, after pre- and postexposure under both rehearsal and nonrehearsal conditions. ADD children (a) were deficient in original acquisition, (b) were unable to take sufficient advantage of decreased load conditions, and (c) showed decrements over time that paralleled those of the control group (CG). The results have been interpreted in light of maturational lag and the differences between ADD and aggressive groups.

Aggression↗
PubMed1975

[The role of serotonin in one of the types of aggressive behavior--"predatory aggression"].

Electrolytic lesion of the midbrain raphe nuclei in rats, lowering serotonin level in the forebrain, elicited mouse-killing behavior. After the lesion, 50% of previously non-killers rats became mouse-killers. 5-Hydroxytryptophan (100 mg/kg) administration elevated serotonin level to normal values and completely blocked predatory aggression. p-Chlorophenylalanine produced obvious reduction in brain serotonin and slightly stimulated aggressive behavior. These results suggest that the brain serotonin participates as an inhibitory factor in mouse-killing behavior in rats.

5-Hydroxytryptophan↗
PubMed1984

Serotonin levels and turnover in different brain areas of isolated aggressive or non-aggressive strains of mice.

After eight weeks of individual housing DBA/2 but not C57 B1/6 (C57) mice showed high levels of aggressive responses in comparison with grouped mice. Social isolation did not modify serotonin (5-HT) levels in either strain of mice, while it produced a decrease of turnover rate in amygdala, lateral hypothalamus and pons in C57 mice and in lateral hypothalamus and pons of DBA mice. When isolated mice of both C57 and DBA strains are compared, no differences in turnover rate in amygdala and pons are evident, while isolated DBA mice show significant lower turnover values in lateral hypothalamus in comparison with isolated C57 mice. A possible suggestion emerging from our results is that aggressive responses exhibited by isolated DBA mice but not by isolated C57 mice may be related to lower 5-HT turnover rate in lateral hypothalamus.

Aggression↗
PubMed1993

p53 protein in aggressive and non-aggressive basal cell carcinoma.

Basal cell carcinoma (BCC) is the most frequent cutaneous neoplasm, with a generally favorable clinical behavior. Sometimes, indeed, it recurs after therapy and/or metastasizes. As point mutations in the coding sequence of the p53 tumor suppressor gene have been implicated in the progression of many human tumors, we studied the expression of p53 protein on this neoplasia. We tested immunohistochemically the positivity for p53 protein (NCL-p53-CM1, YLEM) on 19 cases of morphologically "non aggressive" BCC (BCC1) and on 19 "aggressive" BCC (BCC2), all with one or more relapses and 3 with distant metastases also. Results were related to clinico-pathological and follow-up data. All but one BCC2 were found positive for p53 protein. Conversely, only 2 cases of BCC1 exhibited low immunoreactivity for p53 protein, with high statistical differences between the two groups. No correlation was found between the immunoreactivity, age of patients, and site of the lesions. The availability of immunohistochemistry and the relatively easy interpretation of the results make screening for p53 protein a possibly useful tool in the prognostic evaluation of BCC.

Adult↗
PubMed2002

An aggressive treatment for aggressive digital papillary adenocarcinoma.

Aggressive digital papillary adenoma (ADPA) and adenocarcinoma (ADPAca) are adnexal tumors that are not often recognized because of their rarity. We present a rare case of ADPAca involving the left middle finger of a 43-year-old man. Histopathological features of ADPAca are distinct from those of other eccrine sweat gland tumors; however, ADPAca may be misdiagnosed particularly for a metastasis of papillary adenocarcinoma originating in the colon, thyroid, or breast. Clinicopathological correlation is essential to ule out a possible risk of metastatic carcinoma of the skin. Recognition of these tumors is important because of a potential risk of local recurrence nd distant metastases. Aggressive surgical treatment consisting of digit amputation is advocated in the treatment of ADPAca.

Adenocarcinoma, Papillary↗
PubMed2006

The effect of chronic exposure to highly aggressive mice on hippocampal gene expression of non-aggressive subordinates.

Exposure to a chronic psychosocial stressor changes the behavioral and neuroendocrine response pattern and causes structural changes in the rodent hippocampus. However, the underlying molecular mechanism of these changes induced by chronic stress is largely unknown. Recently, it was shown that exposure to a dominant highly aggressive mouse in the sensory contact model induced long-lasting stress symptoms in subordinate mice genetically selected for long attack latency (LAL mice). The aim of the present study was to study the effect of chronic stress on hippocampal gene expression in these subordinate LAL mice. GeneChips (Affymetrix) were used to compare gene expression profiles of LAL mice exposed to a sensory contact stressor for 25 days and their controls (one array per mouse, n=5 per line). After this stress paradigm, 131 genes were found differentially expressed (P<0.01). Strikingly, all of these genes showed a subtle downregulation in response to a chronic stressor. Interestingly, a significant overrepresentation of genes encoding structural components of ribosomes were found, suggesting diminished protein biosynthesis in the hippocampus of chronically stressed LAL mice. In addition, several genes of the NFkappaB signaling cascade, a pathway crucially involved in neuronal viability and neurite growth, were found to be downregulated. Together, we hypothesize that reduced NFkappaB signaling and diminished protein biosynthesis form part of the molecular mechanisms by which a chronic psychosocial stressor induces structural alterations in hippocampus of LAL mice.

Aggression↗
PubMedDate not supplied

Serotonin and aggression and the alcohol-aggression relationship.

The consumption of an intoxicating dose of alcohol increases the likelihood of violent behaviour. Three possible mechanisms involving potentiation, inhibition, and disorganization of behaviour are presented. The manner in which these three effects may be mediated by serotonergic activity is briefly discussed. A more extensive review of the serotonin-aggression relationship is then presented.

Aggression↗
PubMed2003

Relation of orientation, verbal aggression, and physical aggression to compliance in speech-language therapy for adults with traumatic brain injury.

20 subjects with traumatic brain injury were tested over a 4-wk. period for aggressive behaviors; orientation to place, person, and time; and compliance in speech-language therapy sessions. Analysis showed significant correlations from .63 to .75 over the four sessions between orientation and compliance in speech-language therapy and suggest that orientation training could be a prerequisite to the formal treatment of other behavioral or communication disorders.

Adolescent↗
PubMed1999

Management of descending necrotizing mediastinitis: an aggressive treatment for an aggressive disease.

BACKGROUND: Descending necrotizing mediastinitis represent a virulent form of mediastinal infection requiring prompt diagnosis and treatment to reduce the high mortality associated with this disease. Surgical management and a particularly optimal form of mediastinal drainage remain controversial. METHODS: Over a 10-year period, 12 patients were treated at our institution. Surgical treatment consisted of 1 or several cervical drainages, associated with drainage of the mediastinum through a thoracic approach in 11 patients. Thoracic procedures included radical surgical debridement of the mediastinum with complete excision of the tissue necrosis, decortication, and pleural drainage with adequate placement of chest tubes for mediastinopleural irrigation. Transcervical mediastinal drainage was performed in only 1 patient. RESULTS: The outcome was favorable in 10 patients, 9 of whom had mediastinal drainage through thoracotomy. Two patients were initially drained through a minor thoracic approach; the first died of tracheal fistula and the second required new drainage through a thoracotomy. The patient who had transcervical mediastinal drainage without a thoracic approach presented an abscess limited to the anterior and superior mediastinum. In 3 patients, ongoing mediastinal sepsis required a second thoracotomy. CONCLUSION: A stepwise approach with transcervical mediastinal drainage is first justified in patients with very limited disease to the upper mediastinum. However, ongoing mediastinal sepsis requires new drainage, through a major thoracic approach, without delay. Extensive mediastinitis can not be adequately treated without mediastinal drainage including a thoracotomy. This aggressive surgical policy has allowed us to maintain a low mortality rate (16.5%) in a series of 12 patients with this highly lethal disease.

Acute Disease↗