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At least 199 records · Page 11Linked to original sources
PubMed2000

Animal experimentation: a rational approach towards drug development.

Man's observation of animals as objects of study undoubtedly began in prehistoric times. The first recorded attempt involving the use of live animals for research was by Ersistratis in Alexandria in 300 B.C. Animal investigation has clearly made possible the enormous advances in drug development in this century. A cursory review of any modern text book of pharmacology or medicine will attest the many drugs currently available to benefit mankind in the struggle to eradicate and control diseases. The main purpose of this article is to describe some of the experimental work on animals which contributed to the discovery and development of drugs benefiting human beings and other animal species. Since animal experimentation has occupied a focal position in all the research leading to useful drugs, one will appreciate that it will be necessary to limit the discussion to certain aspects of this broad and interesting topic. With this in mind, an attempt is made to relate briefly the nature of animal investigations which were instrumental in the development of major classes of drugs. Some attention has also been focused on legislation's on animal experimentation of some developed countries with emphasis on India and to views on animal experimentation. We hope this article will stimulate the minds of the scientists for a rational debate on the future of animal experimentation.

Animal Rights↗
PubMed1997

[Not Available].

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Cross-Cultural Comparison↗
PubMed1995

[Animal regeneration experiments from 1686 to 1765. How to defend preexistence?].

This paper deals with the way in which the pre-existence of germs was defended in the face of experimental conclusions regarding animal regeneration in the period between the turn of the seventeenth century and the 1760's. From the experiments of Claude Perrault (1680), Antoine de Réaumur (1712), Abraham Trembley (1740-44) and Charles Bonnet (1740), it became clear that pre-existence delimited its objective so narrowly as to make it invulnerable to all possible experimental refutation. Moreover, we shall argue that this construction of the objective was linked with a renewed definition of the "community of Practitioners" built upon the notion of "scientific exclusion".

Animal Population Groups↗
PubMed1996

[Not Available].

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Animal Rights↗
PubMed1997

[Not Available].

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Animal Population Groups↗