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At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

A qualitative study of perceptions regarding the non-nurse college graduate nurse practitioner.

Nurse practitioners (NPs) have become integral players in the current healthcare system. Some schools admit students with bachelor's degrees in other fields without prior nursing experience into accelerated BS-to-graduate NP programs. The purpose of this study is to examine healthcare providers' perceptions regarding these non-nurse college graduates (NNCGs) functioning as nurse practitioners. The literature review revealed no prior qualitative investigation examining healthcare providers' perceptions of NNCGs. This study elicited a textual response to an open-ended question. Criteria for inclusion included ages 21 and older and licensure in nursing (RN) or medicine (MD or DO). Fourteen textural responses were analyzed. An adaptation of Colaizzi's method of data analysis was used to extract and describe themes. The four thematic categories that emerged from the data included: "Role Complexity," "Experience as Teacher" "System Savvy," and "On the Plus Side," The results of this study will be used in the development of an instrument to be used in a quantitative investigation.

Adult↗
PubMedDate not supplied

[Sick bodies textualized through images: what contemporary intensive care units can teach us].

This paper belongs to a dissertation in which, what we have call "nursing worker cyborgizing" in intensive therapy is discussed. In order to carry out this discussion we based our work on cultural theorizing, as well as on Donna Haraway understanding of cyborg. For the corpses analysis manuals and assistance protocols were used. The methodological approach used in this work is the cultural analysis, as it has been used in the Poststructuralist Cultural Studies, in order to describe and analyze the production of images of sick bodies and its decoding process through a complex monitoring system in which sick bodies, machines and nursing practitioners, connect in different ways and effects. We have concluded that it is useful and relevant to consider and discuss these instances of production and diffusion of meanings attributed to the body, life, and the Nursing care.

Culture↗
PubMed2001

Detecting gene relations from Medline abstracts.

Research in bioinformatics in the past decade has generated a large volume of textual biological data stored in databases such as MEDLINE. It takes a copious amount of effort and time, even for expert users, to manually extract useful information embedded in such a large volume of retrieved data and automated intelligent text analysis tools are increasingly becoming essential. In this article, we present a simple analysis and knowledge discovery method that can identify related genes as well as their shared functionality (if any) based on a collection of relevant retrieved relevant MEDLINE documents. The relative computational simplicity of the proposed method makes it possible to process and analyze large volumes of data in a short time. Hence, it significantly contributes to and enhances a user's ability to discover such embedded information. Two case studies are presented that indicate the usefulness of the proposed method.

Abstracting and Indexing↗
PubMed2005

Inherited disorder phenotypes: controlled annotation and statistical analysis for knowledge mining from gene lists.

BACKGROUND: Analysis of inherited diseases and their associated phenotypes is of great importance to gain knowledge of underlying genetic interactions and could ultimately give clinically useful insights into disease processes, including complex diseases influenced by multiple genetic loci. Nevertheless, to date few computational contributions have been proposed for this purpose, mainly due to lack of controlled clinical information easily accessible and structured for computational genome-wise analyses. To allow performing phenotype analyses of inherited disorder related genes we implemented new original modules within GFINDer http://www.bioinformatics.polimi.it/GFINDer/, a Web system we previously developed that dynamically aggregates functional annotations of user uploaded gene lists and allows performing their statistical analysis and mining. RESULTS: New GFINDer modules allow annotating large numbers of user classified biomolecular sequence identifiers with morbidity and clinical information, classifying them according to genetic disease phenotypes and their locations of occurrence, and statistically analyzing the obtained classifications. To achieve this we exploited, normalized and structured the information present in textual form in the Clinical Synopsis sections of the Online Mendelian Inheritance in Man (OMIM) databank. Such valuable information delineates numerous signs and symptoms accompanying many genetic diseases and it is divided into phenotype location categories, either by organ system or type of finding. CONCLUSION: Supporting phenotype analyses of inherited diseases and biomolecular functional evaluations, GFINDer facilitates a genomic approach to the understanding of fundamental biological processes and complex cellular mechanisms underlying patho-physiological phenotypes.

Computational Biology↗
PubMed2006

A combined approach to data mining of textual and structured data to identify cancer-related targets.

BACKGROUND: We present an effective, rapid, systematic data mining approach for identifying genes or proteins related to a particular interest. A selected combination of programs exploring PubMed abstracts, universal gene/protein databases (UniProt, InterPro, NCBI Entrez), and state-of-the-art pathway knowledge bases (LSGraph and Ingenuity Pathway Analysis) was assembled to distinguish enzymes with hydrolytic activities that are expressed in the extracellular space of cancer cells. Proteins were identified with respect to six types of cancer occurring in the prostate, breast, lung, colon, ovary, and pancreas. RESULTS: The data mining method identified previously undetected targets. Our combined strategy applied to each cancer type identified a minimum of 375 proteins expressed within the extracellular space and/or attached to the plasma membrane. The method led to the recognition of human cancer-related hydrolases (on average, approximately 35 per cancer type), among which were prostatic acid phosphatase, prostate-specific antigen, and sulfatase 1. CONCLUSION: The combined data mining of several databases overcame many of the limitations of querying a single database and enabled the facile identification of gene products. In the case of cancer-related targets, it produced a list of putative extracellular, hydrolytic enzymes that merit additional study as candidates for cancer radioimaging and radiotherapy. The proposed data mining strategy is of a general nature and can be applied to other biological databases for understanding biological functions and diseases.

Biomarkers, Tumor↗
PubMed2000

[Analysis and investigation on annotations on synopsis of Jade book of golden chamber (Jin gui yi han yao lue shu yi)].

It is claimed that this Annotations on Synopsis of Jade Book of Golden Chamber written by the Japanese Kitamura Tadahiro may possibly recover, to a great extent, the original face of Jingui (Synopsis of Golden Chamber) through textual research. This is supported by the author's own study. It is also held that Kitamura's expounding on Jingui's theory is unique, based on his rich medical practice. This is of significant reference value to both clinical practice and textual research.

China↗
PubMed1999

Depression and the interpretation of ambiguity.

A number of studies have produced findings consistent with the possibility that depressives display a negative bias in interpretation. However, the results of such studies can equally well be explained by the operation of a depression-linked response bias, reflecting an elevated tendency for depressives to emit or endorse negatively-toned response options. The present experiment compares the patterns of interpretative processing displayed by subjects who differ in their BDI scores, using a priming methodology developed by anxiety researchers to eliminate the contaminating influence of emotional response bias. The pattern of priming effects obtained provides no evidence to support the existence of a negative interpretative bias in the more depressive individuals. Indeed, quite the reverse conclusion is sustained by the findings, which indicate that high BDI subjects showed an attenuated tendency to activate the more negative interpretations of the ambiguous textual stimuli. The conceptual and methodological implications of these findings are discussed, together with some specific suggestions for future research on this topic.

Adult↗
PubMed1994

Extraction of SNOMED concepts from medical record texts.

Clinicians have traditionally documented patient data using natural language text. With the increasing prevalence of computer systems in health care, an increasing amount of medical record text will be stored electronically. However, for such textual documents to be indexed, shared, and processed adequately by computers, it will be important to be able to identify concepts in the documents using a common medical terminology. Automated methods for extracting concepts in a standard terminology would enhance retrieval and analysis of medical record data. This paper discusses a method for extracting concepts from medical record documents using the medical terminology SNOMED-III (Systematized Nomenclature of Human and Veterinary Medicine, Version III). The technique employs a linear least squares fit that maps training set phrases to SNOMED concepts. This mapping can be used for unknown text inputs in the same domain as the training set to predict SNOMED concepts that are contained in the document. We have implemented the method in the domain of congestive heart failure for history and physical exam texts. Our system has a reasonable response time. We tested the system over a range of thresholds. The system performed with 90% sensitivity and 83% specificity at the lowest threshold, and 42% sensitivity and 99.9% specificity at the highest threshold.

Algorithms↗
PubMed1996

DAPAS, a computerised workplace for Digital Acquisition and Processing of Analog Signals, with up to two gigabytes data per registration.

A comprehensive and flexible arrangement for Digital long-term Acquisition and Processing of Analog Signals (DAPAS) has been developed. It is especially designed for neurophysiological laboratories and mainly based on IBM-compatible PC components. A/D converters are used, which allow sampling rates of up to 100 kHz (up to 16 bits, 1-16 channels). Signals are stored continuously on DOS devices and on a fast tape streamer, which uses standard video-8 tapes, and which is 2.8 times faster than DAT-based systems. As the recording speed is adapted to the sampling rate, one tape allows recording times of (uncompressed) data acquired at a sampling rate of 100 or 10 kHz of 6.8 and 68 h, respectively. Using a coprocessor-video device, recordings may be scrolled on- or off-line on the screen. In addition, up to eight multi-channel oscilloscopes are displayed simultaneously. DAPAS allows the use of a conventional matrix printer which can act as an inertia-free multi-pen recorder. Defined stored signals are recalled by means of a time code or textual markers. All sections of recordings lasting milliseconds to hours may be displayed within seconds. DAPAS supports export filters for further processing. Thus, this system replaces analog devices (multi-pen recorder, oscilloscope, data recorder), and enables quick, complete digital processing and analysis of neurophysiological data.

Action Potentials↗
PubMed2006

Reproducible statistical analysis in microarray profiling studies.

OBJECTIVES: Microarrays are a recent biotechnology that offers the hope of improved cancer classification. A number of publications presented clinically promising results by combining this new kind of biological data with specifically designed algorithmic approaches. But, reproducing published results in this domain is harder than it may seem. METHODS: This paper presents examples, discusses the problems hidden in the published analyses and demonstrates a strategy to improve the situation which is based on the vignette technology available from the R and Bioconductor projects. RESULTS: The tool of a compendium is discussed to achieve reproducible calculations and to offer an extensible computational framework. A compendium is a document that bundles primary data, processing methods (computational code), derived data, and statistical output with textual documentation and conclusions. It is interactive in the sense that it allows for the modification of the processing options, plugging in new data, or inserting further algorithms and visualizations. CONCLUSIONS: Due to the complexity of the algorithms, the size of the data sets, and the limitations of the medium printed paper it is usually not possible to report all the minutiae of the data processing and statistical computations. The technique of a compendium allows a complete critical assessment of a complex analysis.

Gene Expression Profiling↗
PubMed1998

A multifunctional system of the national genetic register.

The National (Federal) Russian Genetic Register operates as a multifunctional system. It is designed for finding solution to the following key problems: 1. Information provision to watch families having children with hereditary and congenital diseases. 2. Follow up of the diagnostic process (including that associated with molecular-cytogenetic studies) and making predictive decisions concerning a risk of hereditary disease in the family. 3. Monitoring of new cases of congenital/hereditary disease under the effect of genotoxic and general toxic environmental factors. 4. Rendering consulting services to those concerned and reference information on the organizational/methodological problems. The relational database is composed of textual and graphical data. This enables the doctors to enter and review the pedigree in the form they have got accustomed to. Numerous built-in classification schemes help simplify and speed up the completion of the medical records. An additional information can be entered in the textual form. When requested by the user, the information about the patient and his (her) family, stored in the database, can be displayed as a summary document (a statement). To do so, a special algorithm based on the results of the logical information analysis, as well as medical history of the patients themselves and their families' members has been put forward. The document thus compiled is open for being edited by the doctor. The local computer network is operated in the "user-server" mode. For information protection purposes, an authorized access system has been devised to protect various data categories. The software tools operate in the Windows environment for IBM-compatible personal computers. Also, use is made of Microsoft SQL-Server, Visual Fox-Pro 3.0, Visual C+2 2.1, and FORTRAN 5.1. The doctor decision modules are activated with mathematical models, an expert system, and a self-learning recognizing system. The Windows NT system is a choice for the existing Federal and Regional Genetic Centers. For territorial consulting purposes other alternatives might be Windows for Workgroup 3.11 or Windows 95. The local computer networks in individual organizations will be integrated to form a Corporate Medical Genetics Service of Russia. The system is to be completed before the year 2000 in a number of phases. Up to now, program packages for family database management and recurrent risk calculations have been worked out and tested.

Databases as Topic↗
PubMed1992

Nurses' professionalism in Canada: a labor process analysis.

This article draws on a body of research conducted by the author over the past ten years on the social organization of nursing work. It explores questions surrounding nurses' contemporary labor process control and its meaning for nurses' professionalization and proletarianization. Both are dynamic processes, changing as public administration of the Canadian health care system changes and as nurses are successful in winning more complete self-regulation. Nurses are currently being articulated more and more securely to dominant ideas of public sector management through textually mediated technologies. Nurses find new upwardly mobile careers and challenging, responsible, and more respected work. However, as the generation of objective information for professional accountability, cost-accounting, and managerial decision-making becomes unified in computerized patient information systems, producing and using such information becomes a central and determining core of everyday nursing work. It organizes nurses into a "managed" practice of patient care, contradictory for them in many ways. Outstanding among these contradictions is a new professionalized standpoint of cost-efficiency that subordinates nurses' traditional interests and grounding of their work in the standpoint of care.

Canada↗
PubMed2004

Evolution of document networks.

How does a network of documents grow without centralized control? This question is becoming crucial as we try to explain the emergent scale-free topology of the World Wide Web and use link analysis to identify important information resources. Existing models of growing information networks have focused on the structure of links but neglected the content of nodes. Here I show that the current models fail to reproduce a critical characteristic of information networks, namely the distribution of textual similarity among linked documents. I propose a more realistic model that generates links by using both popularity and content. This model yields remarkably accurate predictions of both degree and similarity distributions in networks of web pages and scientific literature.

Databases, Bibliographic↗
PubMed2006

Textual representations of diversity in COAMFTE accredited doctoral programs.

The use of the Internet is growing at a staggering pace. One significant use of the Internet is for potential students and the parents of potential students to explore educational possibilities. Along these lines potential marriage and family therapy students may have many questions that include a program's commitment to cultural diversity. This study utilized qualitative content analysis methodology in combination with critical race theory to examine how Commission On Accreditation for Marriage and Family Therapy Education (COAMFTE) accredited doctoral programs represented cultural text on their World Wide Web pages. Findings indicate that many COAMFTE-accredited doctoral programs re-present programmatic information about diversity that appear to be incongruent with cultural sensitivity. These apparent incongruities are highlighted by the codification, inconsistent, and isolated use of cultural text. In addition, cultural text related to social justice was absent. Implications and suggestions are discussed.

Accreditation↗
PubMed1995

Assessing the level of student reflection from reflective journals.

The concept of reflective learning has been widely adopted in many of the nursing curricula today. Reflective learning is of particular relevance to the education of professionals, as it encourages students to integrate theory with practice, appreciate the world on their own behalf, and turn every experience into a new potential learning experience. While nurse educators have widely accepted the educational benefits of reflection, research into reflective learning is hampered by the lack of reliable and widely accepted methods for assessing whether reflection takes place and the level of any reflection. This study attempted to develop and test coding systems for written reflective journals based on two well-known models of reflective thinking. The reflective journals submitted by the students were subjected to content analysis at two levels. The findings of this study suggest that student writing can be used as evidence for the presence or absence of reflective thinking. The process of allocating students to three categories of non-reflector, reflector and critical reflector was straightforward and reliable. Identifying textual elements within journals and allocating them to the finer levels of reflection within a more complex model of reflective thinking was, however, more problematic and considerably less reliable.

Autobiographies as Topic↗
PubMedDate not supplied

Enriching the portrait: methodological triangulation of life-closing theory.

Some researchers promote a triangulated or multiple-methods approach in studies that examine complex human phenomenon. Nonetheless, problems abound in combining 2 dissimilar data sets from 2 different methodologies. One way that numerical and textual data can be merged is through a research method called statistical triangulation. The purpose of this article was to describe the statistical triangulation of a simultaneous, between-methods causal model and grounded theory investigation that explained psychological adaptation in dying persons. The statistical triangulation involved the analysis of selected patterns of dying from the grounded theory study with the variables used in the causal model investigation. A 1-way analysis of variance confirmed that the variables of social support, physical function, and religious preference impacted end-of-life patterns. Post hoc comparisons validated the conceptualization of 3 patterns of dying (becoming, anguishing/agonizing, avoiding) that emerged from the qualitative data. Although there are limitations to this analysis, statistical triangulation shows promise as a research method for enriching qualitative description.

Adaptation, Psychological↗
PubMed1999

"Be unto me as a precious ointment": Lady Grace Mildmay, sixteenth-century female practioner.

Lady Grace Mildmay's manuscripts represent an unusual presentation of three interrelated areas of family, devotion, and medicine. By examining her autobiography, meditations, and medical papers, I draw together literary analysis and discourses of female devotional and social practices with that of medical discourses to illustrate the ways in which women practitioners may have acquired and disseminated medical knowledge, and interacted with their patients, as well as how Lady Mildnay, and presumably other landed women practitioners, formed a textual community of women who administerd medical treatment to lay people in late sixteenth-century England.

History, 16th Century↗
PubMed2002

Representation and processing of complex DNA spatial architecture and its annotated genomic content.

This paper presents a new general approach for the spatial representation and visualization of DNA molecule and its annotated information. This approach is based on a biological 3D model that predicts the complex spatial trajectory of huge naked DNA. With such modeling, a global vision of the sequence is possible, which is different and complementary to other representations as textual, linguistics or syntactic ones. The DNA is well known as a three-dimensional structure. Whereas, the spatial information plays a great part during its evolution and its interaction with the other biological elements This work will motivate investigations in order to launch new bioinformatics studies for the analysis of the spatial architecture of the genome. Besides, in order to obtain a friendly interactive visualization, a powerful graphic modeling is proposed including DNA complex trajectory management and its annotated-based content structuring. The paper describes spatial architecture modeling, with consideration of both biological and computational constraints. This work is implemented through a powerful graphic software tool, named ADN-Viewer. Several examples of visualization are shown for various organisms and biological elements.

DNA↗