SEARCH · Search PubMed
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Both sides of the bizarre, sadomasochistic relationship between physicians and hospitals bring baggage to the "arranged marriage" of the integrated healthcare system.
Explore the source record for details and available documents.
We investigate the bifurcation phenomena and the change in phase space structure connected with the transition from regular to chaotic scattering in classical systems with unbounded dynamics. The regular systems discussed in this paper are integrable ones in the sense of Liouville, possessing a degenerated unstable periodic orbit at infinity. By means of a McGehee transformation the degeneracy can be removed and the usual Melnikov method is applied to predict homoclinic crossings of stable and unstable manifolds for the perturbed system. The chosen examples are the perturbed radial Kepler problem and two kinetically coupled Morse oscillators with different potential parameters which model the stretching dynamics in ABC molecules. The calculated subharmonic and homoclinic Melnikov functions can be used to prove the existence of chaotic scattering and of elliptic and hyperbolic periodic orbits, to calculate the width of the main stochastic layer and of the resonances, and to predict the range of initial conditions where singularities in the scattering function are found. In the second example the value of the perturbation parameter at which channel transitions set in is calculated. The theoretical results are supplemented by numerical experiments.
Hippocampal 'place' cells and the head-direction cells of the dorsal presubiculum and related neocortical and thalamic areas appear to be part of a preconfigured network that generates an abstract internal representation of two-dimensional space whose metric is self-motion. It appears that viewpoint-specific visual information (e.g. landmarks) becomes secondarily bound to this structure by associative learning. These associations between landmarks and the preconfigured path integrator serve to set the origin for path integration and to correct for cumulative error. In the absence of familiar landmarks, or in darkness without a prior spatial reference, the system appears to adopt an initial reference for path integration independently of external cues. A hypothesis of how the path integration system may operate at the neuronal level is proposed.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
This paper is based on 4 years of practical experience with a developmental pre- Digital Imaging and Communications in Medicine (DICOM) picture archiving and communication system (PACS) plus analysis from the respecification study data for a DICOM/HTML PACS replacement. High-performance, but economic, workstations are required within PACS for radiologists to rapidly and accurately report images. For economic reasons such workstations should utilise standard landscape orientation monitors. They must have full Radiology Information System (RIS) integrated reporting functionality to optimise radiologists' work. The workstations must also be capable of displaying request data and both new and associated old images and image reports from multiple modalities. All images should be imported as "folders" according to semi-intelligent "knowledge table" based DICOM 3.0 standard Worklist control exerted by image management servers. This information can be obtained by relevant image lists and decision charts. A description of an optimal standard monitor workstation environment and related issues based on experience and literature review is given.
An integrative stepwise rehabilitation model for schizophrenics, especially those hospitalized for long periods, is described. The basic entities of this model are rehabilitation homes. The client moves from one step to the next according to their particular needs. The steps for living are: small homes, supported lodgings, rented quarters and own apartments. The steps of activities are: day care homes and day clubs, therapeutic sheltered workshop, test working, vocational training and labour market. The central rehabilitative aspects are the therapeutic community, living learning experiences, supporting of selfesteem and integrating with the social network. The psychiatric care system on the other hand and an important work of volunteers and friend services on the other support the rehabilitation. This work has shown during 14 years that the majority of clients can be rehabilitated to live as fairly independent and responsible persons.
Explore the source record for details and available documents.
Best-of-breed applications can baffle health care IS professionals with a Babel-like confusion of software tongues. Interface engines can provide some relief by acting as a computer interpreter which translates for multiple systems.
During lysogenic growth many temperate bacteriophage genomes are integrated into the host's chromosome and efficient integration and excision are therefore an essential part of the phage life cycle. The Streptomyces phage phiC31 encodes an integrase related to the resolvase/invertases and is evolutionarily and mechanistically distinct from the integrase of phage lambda. We show that during phiC31 integration the polarity of the recombination sites, attB and attP, is dependent on the sequences of the two base pairs (bp) where crossover occurs. A loss or switch in polarity of the recombination sites can occur by mutation of this dinucleotide, leading to incorrectly joined products. The properties of the mutant sites implies that phiC31 integrase interacts symmetrically with the substrates, which during synapsis can align apparently freely in either of two alternative forms that lead to correct or incorrect joining of products. Analysis of the topologies of the reaction products provided evidence that integrase can synapse and activate strand exchange even when recombinant products cannot form due to mismatches at the crossover site. The topologies of the recombination products are complex and indicative of multiple pathways to product formation. The efficiency of integration of a phiC31 derivative, KC859, into an attB site with switched polarity was assayed in vivo and shown to be no different from integration into a wild-type attB. Thus neither the host nor KC859 express a factor that influences the alignment of the recombination sites at synapsis.
The National Chronic Care Consortium developed the SASI tool to help health-care networks plan, implement, and measure chronic care integration across their full continuums of care. An integrated network for chronic care can be applied to any care population, and the SASI tool can assist in integration efforts in a variety of circumstances.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.