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At least 199 records · Page 11Linked to original sources
PubMed1990

Outpatient illness incidence aboard U.S. Navy ships during and after the Vietnam conflict.

Outpatient illness rates aboard carriers and destroyers/frigates during the Vietnam conflict were contrasted with rates for similar ships in the same geographical region subsequent to the ceasefire. Both large and small ships exhibited higher overall outpatient rates after the conflict, although this difference did not reach a level of significance among carriers. Among the smaller ships the individual categories of infective and parasitic disorders, respiratory diseases, and skin and subcutaneous tissue problems yielded significantly higher rates after the conflict. The rate for accidents was significantly higher aboard carriers during combat operations than the period following the cease-fire. Across both sizes of ships, accidents accounted for a larger percentage of outpatient visits during the conflict, while skin disorders were responsible for a larger proportion of the post-conflict visits.

Ambulatory Care↗
PubMed1989

House dust mites in naval ships, military barracks, and homes in the Hampton Roads area of Virginia.

This survey was undertaken to determine the possible exposure of military personnel to house dust mites in ships, barracks, and homes in the Hampton Roads area of Virginia. During the period from April 1, 1982 through August 31, 1983, 524 dust samples were collected with vacuum cleaners. Mites were extracted from aliquots of dust, counted, and identified as to species and life stage. Dermatophagoides pterynssinus (European house dust mite) was more common in private homes, while Dermatophagoides farinae (North American house dust mite) was more common on ships. Berthing compartments had the highest density of mites of areas sampled aboard ships. There appears to be a trend between the density of personnel and mites. Ships had a smaller percentage of mite-infested samples than houses.

Animals↗
PubMedDate not supplied

[Preliminary ergonomic assessment of the work sites and living conditions for the crew on board the new t/h Ignacy Daszyński series of merchant ships].

The author describes the new merchant ship series B545-OT, built at the Szczecin shipyard. The preliminary appraisal of this vessel was made during the trial trip in November 1987. The experimented ship is a universal and very modern cargo boat, type B545-OT, which meets the requirements of the international conventions with respect to the prevention of sea pollution by ships. As regards its construction and equipment, the vessel complies with all conditions and international conventions on safety, as well as on health and environment protection. A control and actuation system centralized in the engine-room assures the functioning without a direct supervision. The automatic functioning of mechanisms is followed-up by means of a computed alarm system. The living-rooms, the recreation spaces, the cabins, which secure to the crew comfortable conditions on the ship, are built in a modern style. Less successfully was solved the placement of the kitchen, the dining-room and the larder on the upper deck, near the entrance to the engine-room, entailing thus the danger of steam penetration from the latter. The conditioned air assures in the cabins and living-rooms a temperature of +20 degrees C and a relative humidity of 40-60 per cent. The designers and builders have not used all the possibilities of lowering the intensity of noise.

Ergonomics↗
PubMed1983

Modern aspects of hygienic standardization of ship noise.

The basic aims of hygienic standardization of the long-term round-the-clock action of ship noise on the sailors include protection of health, prolonged professional activity, prevention of interference and provision of comfort conditions of rest. Neuro-emotional stress in the work of sailors aboard a ship has been another reason for starting the ship noise standardization. As a result of long-term hygienic, clinical, physiological, experimental and natural studies, there were established the hygienic significance of noise and vibration parameters, a combined increased effect of noise and work strain, as well as that of pitching and rolling, and also the potent combined effect of vibration and noise. During a 3-month voyage the cumulative effect of noise was identified and the physiological significance of acoustic comfort of post-watch rest was ascertained. The relation of sailors' health to ship acoustic conditions was determined. The obtained results served as a scientific motivation for a number of Soviet legislative documents. Unification of physiological and hygienic criteria and methods of assessment of noise and vibration effects meets the interests of protection of seamen's health in CMEA countries.

Adaptation, Physiological↗
PubMedDate not supplied

[Asbestos exposure on board ships: a study of the environmental situation on 2 classes of ferryboats].

The article describes the results of a study on contamination by airborne asbestos fibres on board a number of ships belonging to fleets operating from Civitavecchia, a port on the coast of central Italy. Asbestos was widely used throughout the ships as fire- and soundproofing insulation. Samples taken before, during and after removal of the insulation in areas of the ship outside the asbestos removal worksite gave concentration levels that were similar to those observed in other indoor environments (building), varying according to the sample location and the condition of the insulation material. The results are discussed taking into consideration the fact that a ship is also a living environment for crew and passengers.

Air Pollutants, Occupational↗
PubMed1996

Epidemiology of diarrheal disease outbreaks on cruise ships, 1986 through 1993.

OBJECTIVE: To describe the epidemiology of cruise-associated diarrheal disease outbreaks from 1986 through 1993, to determine if the incidence had changed since 1985, and to determine the preventability of outbreaks that continue to occur. DESIGN: The numerator data were collated from Centers for Disease Control and Prevention (CDC) outbreak investigation reports from 1986 through 1993. The denominator data were summations of cruise ship data on the number of passengers and length of cruises collected during routine diarrheal illness surveillance, available only for the period 1989 through 1993. SETTINGS: Cruise ships with outbreaks of diarrheal disease. PARTICIPANTS: Cruise ship passengers and crew of staff ho participated in the original investigations. MAIN OUTCOME MEASURES: The incidence of outbreaks during the study period, pathogens isolated, and vehicles of transmission implicated in investigations. RESULTS: Among cruises of 3 to 15 days, CDC staff investigated 1.4 outbreaks per 1000 cruises, or 2.3 outbreaks per 10 million passenger-days. An etiologic agent was implicated in 21 (68%) of 31 investigated outbreaks: bacterial in 12, viral in nine. A specific vehicle of transmission was identified in 16. The most common vehicles of transmission were undercooked scallops (three outbreaks caused by enterotoxigenic Escherichia coli), eggs (two outbreaks caused by Salmonella serotype Enteritidis, one by Norwalk-like virus), and food items provided by caterers during onshore excursions (three outbreaks, one caused by Shigella sonnei). CONCLUSIONS: Observance of two simple precautions could have prevented almost one third (5/16, or 31%) of the investigated outbreaks on cruise ships. Cruise lines have been reminded to cook seafoods thoroughly and to use pasteurized eggs for menu items calling for pooled eggs. Preventing food handlers from working while ill and not using onshore caterers for offship excursions might have prevented at least an additional one third (5/16) of these outbreaks.

Diarrhea↗
PubMed1998

Legionellosis associated with ships: 1977 to 1997.

Over one hundred cases of legionnaires' disease have been linked to ships, and ten cases are known to have died. Most of the cases were associated with cruise ships, but a variety of other vessels were also linked to cases. Few vessels were investigated microbiologically, and the cases associated with ferries were exposed to other sources of infection. Cases appear to be less common among crew members than among passengers. To prevent further cases, ship owners, operators, and captains need to be diligent in maintaining the water and air conditioning systems of their vessels. Whirlpool spas need particular care. Ship-associated cases of non-pneumonic legionellosis appear to be rare.

Humans↗
PubMed2003

The role of SHIP in cytokine-induced signaling.

The phosphatidylinositol (PI)-3 kinase (PI3K) pathway plays a central role in regulating many biological processes via the generation of the key second messenger PI-3,4,5-trisphosphate (PI-3,4,5-P3). This membrane-associated phospholipid, which is rapidly, albeit transiently, synthesized from PI-4,5-P2 by PI3K in response to a diverse array of extracellular stimuli, attracts pleckstrin homology (PH) domain-containing proteins to membranes to mediate its many effects. To ensure that the activation of this pathway is appropriately suppressed/terminated, the ubiquitously expressed tumor suppressor PTEN hydrolyzes PI-3,4,5-P3 back to PI-4,5-P2 while the 145-kDa hemopoietic-restricted SH2-containing inositol 5'- phosphatase, SHIP (also known as SHIP1), the 104-kDa stem cell-restricted SHIP (sSHIP) and the more widely expressed 150-kDa SHIP2 hydrolyze PI-3,4,5-P3 to PI-3,4-P2. In this review we will concentrate on the properties of the three SHIPs, with special emphasis being placed on the role that SHIP plays in cytokine-induced signaling.

Animals↗
PubMed1974

Redesigning the design process: superstructures of ships.

This paper, prepared for the International Ship Environmental Design Conference, emphasizes the social system on board ships as a function not only of large scale trends in society and the shipping industry, but also of the fact that the social system exists within the limits given by the superstructure and accomodation. By looking at a conventional superstructure we find that the traditional shipboard organization is physically built into this. If we want to change the traditional organization we also have to change the superstructure. The paper stresses that the design process of today gives those who operate ships few opportunities to have a superstructure according to their needs. At present, economic and technical criteria dominate the design process. If we wish to have decisions based on social criteria as well, another design approach must be found. The paper describes one alternative approach.

Journal Article↗
PubMed1987

Running and shipping elevate plasma levels of beta-endorphin-like substance (B-END-LI) in thoroughbred horses.

A specific RIA for beta-endorphin (B-END) was developed to measure horse plasma levels of B-END-like material (B-END-LI) during exercises and shipping. Three exercise speeds and durations were: trot at 260-300 m/min for 10 min; slow gallop at 390-420 m/min for 5 min and fast gallop at 700-800 m/min for 2 min. Blood samples were taken from 4 horses before, immediately after, 30 and 60 min after exercise. Trotting increased plasma B-END-LI from a basal level of 109 +/- 7 pg/ml to 172 +/- 22 at the end of exercise and returned to 127 +/- 17 and 107 +/- 10 pg/ml at 30 and 60 min after exercise. Similar results were obtained in slow gallop (121 +/- 6 to 210 +/- 17 then 155 +/- 8 and 131 +/- 11 pg/ml). However, fast gallop caused the greatest increase (352%) in B-END-LI to concentrations of 544 +/- 93 pg/ml and 276 +/- 74 pg/ml at 5 and 30 min after exercise. Plasma B-END-LI returned to 199 +/- 46 pg/ml in 1 hr. Sequential exercises of trot, slow and fast gallop were conducted in 6 horses. Plasma B-END-LI were 116 +/- 19 pg/ml (pre-exercise), 198 +/- 21 (trot), 361 +/- 51 (slow gallop), 500 +/- 57 (fast gallop) and 248 +/- 29, 171 +/- 24, 143 +/- 20 and 139 +/- 21 pg/ml at 0.5, 1, 2 and 3 hr, respectively, following exercises. Transportation in horse trailer also significantly increased plasma levels of B-END-LI from a basal level of 138 +/- 12 to 196 +/- 24 pg/ml within 30 min and this levels were maintained at 45 min (177 +/- 3 pg/ml). Plasma levels of B-END-LI began to decline at 60 min of shipping. These results showed that plasma B-END-LI was increased in all speeds of exercise and by shipping and returned to pre-exercise and pre-shipping level in 30 min except fast gallop which returned to pre-exercise level in 1 hr.

Animals↗
PubMed2001

"Captain of the ship" doctrine continues to take on water.

The captain of the ship doctrine, which has been interpreted to mean that the surgeon's mere presence in the OR subjects him or her to legal liability for everyone's negligence in that room (akin to the responsibility of the captain of a ship who is held responsible for everything that happens on that ship), emerged in 1949 and grew in popularity through the 1950s. The major reason for this doctrine's popularity was that injured patients were precluded from suing hospitals under the then applicable charitable immunity doctrine. Charitable immunity declined in the 1960s, and by the 1970s, so too was the captain of the ship doctrine in decline. Pennsylvania, which first used the picturesque phrase in 1949, rejected the doctrine in 1974. In the meantime, it has come under much criticism, even among states that adopted it. Despite this decline and despite court language that sometimes borders on ridicule (e.g., anachronistic, prostrate doctrine, indiscriminate repetition), the felicity of the phrase has kept it alive in some states and in many ORs, even in states that have expressly rejected the doctrine. Even more than 20 years after its first rejection, however, courts still are being asked to adopt the doctrine. In 2001, the Wisconsin Supreme Court declined to adopt the doctrine, adding to the litany of states that have taken an express position against it.

Cholecystectomy↗
PubMed1999

The role of SHIP in growth factor induced signalling.

The recently cloned, hemopoietic-specific, src homology 2 (SH2)-containing inositol phosphatase, SHIP, is rapidly gaining prominence as a potential regulator of all phosphatidylinositol (PI)-3 kinase mediated events since it has been shown both in vitro and in vivo to hydrolyze the 5' phosphate from phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3). Thus SHIP, and its more widely expressed counterpart, SHIP2, could play a central role in determining PI-3,4,5-P3 and PI-3,4-P2 levels in many cell types. To explore the in vivo function of SHIP further we recently generated a SHIP knock out mouse and in this review we discuss experiments carried out with bone marrow derived mast cells (BMMCs) from these animals.

Animals↗
PubMed2002

Association of the Src homology 2 domain-containing inositol 5' phosphatase (SHIP) to releasability in human basophils.

During the study of the biology of the Human recombinant Histamine Releasing Factor (HrHRF), we uncovered a hyperreleasable phenotype of basophils from HrHRF-responder donors. Basophils from these donors released histamne to HrHRF, IL-3 and D(2)O. While there has been a significant amount of work elucidating signal transduction events in human basophils, the reason for this hyperreleasable phenotype remained illusive. A clue to the releasability of these highly allergic, asthmatic HrHRF-responder donor basophils was demonstrated in studies using SHIP knockout mice. Bone marrow-derived mast cells from the SHIP knockout mice demonstrated hyperreleasability to stimuli through the IgE receptor and alteration of subsequent signal transduction events. We have demonstrated a highly significant negative correlation between the amount of SHIP protein per cell equivalent and maximum histamine release to HrHRF. These results provide a clue to the hyperreleasable phenotype and implicate SHIP as an additional regulator of secretion in human basophils.

Basophils↗
PubMed1999

SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis.

Fc gammaRIIB is an inhibitory receptor that terminates activation signals initiated by antigen cross-linking of the BCR through the recruitment of SHIP. Fc gammaRIIB can also signal independently of BCR coligation to directly mediate an apoptotic response, requiring only an intact transmembrane domain. Failure to recruit SHIP, either by deletion of SHIP or mutation of Fc gammaRIIB, results in enhanced Fc gammaRIIB-triggered apoptosis. Thus, in the germinal center, where ICs are retained by FDCs, Fc gammaRIIB may be an active determinant in the negative selection of B cells whose BCRs have reduced affinity for antigen as a result of somatic hypermutation. Selection of B cells may represent the sum of opposing signals generated by the interaction of ICs with the BCR and Fc gammaRIIB through pathways modulated by SHIP.

Agammaglobulinaemia Tyrosine Kinase↗
PubMed1998

SHIP modulates immune receptor responses by regulating membrane association of Btk.

Membrane recruitment of SHIP is responsible for the inhibitory signal generated by FcgammaRIIB coligation to the BCR. By reducing the level of PIP3, SHIP regulates the association of the tyrosine kinase Btk with the membrane through PH domain-phosphoinositol lipid interactions. Inhibition of BCR signaling by either FcgammaRIIB coligation, membrane expression of SHIP, or inhibition of P13K, conditions which result in decreased levels of PIP3, is suppressed by the expression of Btk as a membrane-associated chimera. Conversely, increasing PIP3 levels by deletion of SHIP results in increased Btk association with the membrane and hyperresponsive BCR signaling. These results suggest a central role for PIP3 in regulating the B cell stimulatory state by modulating Btk localization and thereby calcium fluxes.

Agammaglobulinaemia Tyrosine Kinase↗
PubMed1999

SHIPs ahoy.

In 1996 three groups independently cloned a hemopoietic specific, src homology 2-containing inositol 5'-phosphatase which, based on its structure, was called SHIP. More recently, a second more widely expressed SHIP-like protein has been cloned and called SHIP2. Both specifically hydrolyze phosphatidylinositol-3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in vitro. Moreover, SHIP has been shown in vivo to be the primary enzyme responsible for breaking down phosphatidylinositol-3,4,5-trisphosphate to phosphatidylinositol-3,4-bisphosphate in normal mast cells and, as a result, limits normal and prevents inappropriate mast cell degranulation. Because of their ability to break down phosphatidylinositol-3,4,5-trisphosphate, the SHIPs have the potential to regulate many, if not all, phosphatidylinositol-3-kinase induced events including, proliferation, differentiation, apoptosis, end cell activation, cell movement and adhesion and will thus likely be the subject of intensive research over the next few years.

Animals↗
PubMed1986

An outbreak of gastroenteritis on a passenger cruise ship.

In an outbreak of gastroenteritis on board a cruise ship 251 passengers and 51 crew were affected and consulted the ship's surgeon during a 14-day period. There was a significant association between consumption of cabin tap water and reported illness in passengers. Enterotoxigenic Escherichia coli were isolated from passengers and crew and coliforms were found in the main water storage tank. Contamination of inadequately chlorinated water by sewage was the most likely source of infection. A low level of reported illness and late recognition of the outbreak delayed investigation of what was probably the latest in a series of outbreaks of gastrointestinal illness on board this ship. There is a need for a national surveillance programme which would monitor the extent of illness on board passenger cruise ships as well as a standard approach to the action taken when levels of reported illness rise above a defined level.

Disease Outbreaks↗
PubMed2002

Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP.

Members of the transforming growth factor beta (TGF-beta) family regulate fundamental physiological processes, such as cell growth, differentiation and apoptosis, in almost all cell types. As a result, defects in TGF-beta signalling pathways have been linked to uncontrolled cellular proliferation and carcinogenesis. Here, we explored the signal transduction mechanisms downstream of the activin/TGF-beta receptors that result in cell growth arrest and apoptosis. We show that in haematopoietic cells, TGF-beta family members regulate apoptosis through expression of the inositol phosphatase SHIP (Src homology 2 (SH2) domain-containing 5' inositol phosphatase), a central regulator of phospholipid metabolism. We also demonstrated that the Smad pathway is required in the transcriptional regulation of the SHIP gene. Activin/TGF-beta-induced expression of SHIP results in intracellular changes in the pool of phospholipids, as well as in inhibition of both Akt/PKB (protein kinase B) phosphorylation and cell survival. Our results link phospholipid metabolism to activin/TGF-beta-mediated apoptosis and define TGF-beta family members as potent inducers of SHIP expression.

Activins↗