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At least 199 records · Page 11Linked to original sources
PubMed1989

[Tocopherol Reference Standard (Control 881) of National Institute of Hygienic Sciences].

Tocopherol was tested for the preparation of "Tocopherol Reference Standard (Control 881)". Analytical data obtained were as follows: infrared spectrum, same as Tocopherol Reference Standard (Control 851); absorbance, E1%1cm (292 nm) = 73.7; thin-layer chromatography, contaminants were not detected until 12.5 micrograms; high-performance liquid chromatography, six contaminants were detected; assay, 100.4%. On the basis of those results, this material was authorized as the Japanese Pharmacopoeia Standard (Control 881).

Chromatography, High Pressure Liquid↗
PubMed1994

[The Testosterone Propionate Reference Standard (Control 881) of the National Institute of Health Sciences].

Raw testosterone propionate material was tested for preparation of the "Testosterone Propionate Reference Standard (Control 881)". Analytical data obtained were as follows: loss on drying, 0.1%; melting point, 120.6 degrees C; optical rotation [alpha]20D = + 85.4 degrees; ultraviolet spectrum, lambdamax = 241 nm and specific absorbance E 1cm1% (241 nm) = 483; infrared spectrum, the same as that of the NIHS Testosterone Propionate Reference Standard; thin-layer chromatography, no impurities were detected; high-performance liquid chromatography (HPLC), one impurity was detected; assay result, 100.6% by UV spectrophotometry. Based on the above findings, the raw material was authorized as the Testosterone Propionate Reference Standard (Control 881) of the National Institute of Health Sciences.

Chemical Phenomena↗
PubMed1990

[Betamethasone Sodium Phosphate Reference Standard (Control 881) of National Institute of Hygienic Sciences].

The raw material of betamethasone sodium phosphate was examined for preparation of the "Betamethasone Sodium Phosphate Reference Standard". Analytical results for the sample were as follows: pH 7.90; optical rotation + 100.5 degrees; IR spectrum the same as USP Reference Standard of Betamethasone Sodium Phosphate; TLC indicated no impurities, but 5 kinds of impurities were detected in small amounts by HPLC; water content 14.7%; assay 100.2% by HPLC. Based on the above results, this raw material was authorized to be the Reference Standard of the National Institute of Hygienic Sciences.

Betamethasone↗
PubMed1995

[Betamethasone valerate reference standard (Control 941) of the National Institute of Health Sciences].

The raw material for betamethasone valerate was tested for preparation of the "Betamethasone Valerate Reference Standard (Control 941)". Analytical data obtained were as follows: melting point, 194.3 degrees C (decomposition); UV and infrared spectra, the same as those for JP Betamethasone Valerate Reference Standard (Control 844); optical rotation, [alpha]20D = +79.4 degrees; thin-layer chromatography and high-performance liquid chromatography (HPLC), no impurities were detected; assay, 100.0% by HPLC. Based on the above results, the candidate material was authorized as the JP Betamethasone Valerate Reference Standard (Control 941).

Betamethasone Valerate↗
PubMed1995

[Prednisolone acetate reference standard (Control 941) of the National Institute of Health Sciences].

The raw material for prednisolone acetate was tested for preparation of the "Prednisolone Acetate Reference Standard (Control 941)". Analytical data obtained were as follows: melting point, 237.5 degrees C (decomposition); UV and infrared spectra, the same as those for JP Prednisolone Acetate Reference Standard (Control 903), respectively; specific absorbance at lambda max E1%1cm = 379; optical rotation, [alpha]20D = +115.2 degrees; thin-layer chromatography and high-performance liquid chromatography (HPLC), no impurities were detected, respectively; assay, 100.8% by HPLC. Based on the above results, the candidate material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 941).

Chemical Phenomena↗
PubMed1991

[Ergocalciferol Reference Standard (Control 901) of the National Institute of Hygienic Sciences].

Ergocalciferol Reference Standard for the Japanese Pharmacopoeia (JP RS) was prepared. The following analytical data were obtained: melting point 118.4 degrees C; UV and IR spectra were in agreement with both of the previous JP RS and USP RS of ergocalciferol; absorptivity at 265nm E1%lcm = 467; optical rotation [alpha]20D = 103 degrees; no impurities were detected by TLC and HPLC analyses; assay 100.1% by HPLC against the USP RS. Based on the above results, the raw material was authorized as the Reference Standard of the National Institute of Hygienic Sciences.

Chromatography, High Pressure Liquid↗
PubMed1991

[Cholecalciferol Reference Standard (Control 901) of the National Institute of Hygienic Sciences].

Cholecalciferol Reference Standard for the Japanese Pharmacopoeia (JP RS) was prepared. The following analytical data were obtained: melting point 85.8 degrees C; UV and IR spectra were in agreement with both of the previous JP RS and USP RS of Cholecalciferol; absorptivity at 265 nm E1%lcm = 476; optical rotation [alpha]20D = + 110.1 degrees; no impurities were detected by TLC and HPLC analyses; assay 100.1% by HPLC against the USP RS. Based on the above results, the raw material was authorized as the Reference Standard of the National Institute of Hygienic Sciences.

Cholecalciferol↗
PubMed1991

[Methylergometrine Maleate Reference Standard (Control 891) of National Institute of Hygienic Sciences].

The raw material of methylergometrine maleate was examined for the preparation of the "Methylergometrine Maleate Reference Standard". Analytical data obtained were as follows: melting point, 181.7 degrees C; ultraviolet spectrum, lambda max = 313 nm; absorbance, E1%1cm (313 nm) = 181.3; infrared spectrum, 3406, 2962, 2928, 1645, 1574 cm-1; thin-layer chromatography, 6 impurities were detected; high-performance liquid chromatography, no impurities were detected; loss on drying, 0.02%; optical rotation, [alpha]20D = + 44.04 degrees; assay, 99.5% against Ergometrine Maleate Reference Standard (Control 755). Based on the above results, this raw material was authorized to be the Reference Standard of the National Institute of Hygienic Sciences.

Chromatography, High Pressure Liquid↗
PubMed1990

[Dexamethasone Sodium Phosphate Reference Standard (Control 891) of National Institute of Hygienic Sciences].

The raw material of dexamethasone sodium phosphate was examined for preparation of the "Dexamethasone Sodium Phosphate Reference Standard". Analytical results were as follows: UV spectrum indicates absorption maxima at 242 nm and absorptivity at 242 nm is E1%1cm 304; optical rotation +79.0%; pH 7.7; ethanol 5.2%; water 6.0%; HPLC analysis indicates small amounts of three impurities and the purity was assumed to be 99.8%; assay by HPLC indicated 100.9% against the USP Reference Standard of "Dexamethasone Phosphate". Based on the results, the present raw material was authorized to be the Reference Standard of the National Institute of Hygienic Sciences.

Chromatography, High Pressure Liquid↗
PubMed1992

Quantitative studies of immunofluorescent staining. VII. Quantitative reference standard slide for standardization of fluorescence microscopes.

We evaluated a quantitative reference standard (QRS) slide with 10-microns beads with different concentrations of Coulter Electronics green dye No. 1. Microfluorospectrophotometric readings of the QRS slides provided quantitative comparisons between the sensitivity of the different fluorescence microscopes. The visual comparisons between beads with a range of intensities of fluorescence of Coulter Electronics green dye No. 1 indicated that the end points vary with different optical systems as do the end points in standard indirect immunofluorescent titrations. Fluorescent emission wavelength of QRS slide beads gave the same peak as fluorescein-labeled beads; both differed from the peak of orange beads of an 'Optical Standard' slide. Since shelf life studies show no changes in fluorescence intensity of beads over a period of 27 months or longer, QRS slide beads can afford a device for standardization of fluorescence microscopes used for immunofluorescent tests.

Animals↗
PubMed1989

[Long-term stability of Kallidinogenase Reference Standard].

The long-term stability of Kallidinogenase Reference Standard of National Institutes of Hygienic Sciences was studied. The standard was kept for a long term (60 months) at -5 degrees C, 20 degrees C, 37 degrees C and 50 degrees C. No decrease in kallidinogenase activity was observed at 60 months at -5 degrees C and 28 months at 20 degrees C. The decrease in the activity of the standard kept at 37 degrees C was only 7% at 10 months. The standard kept at 50 degrees C had lost nearly all activity at 4 months. Therefore, "Kallidinogenase Standard" was stable for prolonged storage (about 5 years) at -5 degrees C.

Drug Stability↗
PubMed1994

[Estradiol Reference Standard (Control 931) of National Institute of Health Sciences].

The raw material for estradiol was examined for preparation of the "National Institute of Health Sciences (NIHS) Estradiol Reference Standard (Control 931)". Analytical data obtained were as follows: melting point, 179.0 degrees C; infrared spectrum, the same as that of the present NIHS Estradiol Reference Standard; optical rotation, -alpha-20D = +80.4 degrees; thin-layer chromatography, no impurity was detected; high-performance liquid chromatography (HPLC), a trace amount of two impurities were detected; loss on drying, 0.24%; assay, 100.4% by UV spectrophotometry and 101.2% by HPLC. Based on the above results, the raw material was authorized as the NIHS Estradiol Reference Standard (Control 931).

Chemical Phenomena↗
PubMed1989

[Tocopherol Acetate Reference Standard (Control 881) of National Institute of Hygienic Sciences].

Tocopherol acetate was tested for the preparation of "Tocopherol Acetate Reference Standard (Control 881)". Analytical data obtained were as follows: infrared spectrum, same as Tocopherol Acetate Reference Standard (Control 851); absorbance, E1%1cm (284 nm) = 43.7; thin-layer chromatography, contaminants were not detected; high-performance liquid chromatography, one contaminant was detected; assay, 100.0%. On the basis of those results, this material was authorized as the Japanese Pharmacopoeia Standard (Control 881).

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

[Adolescent Body Mass Index data: what differences result using different reference standard curves?].

Childhood and adolescent obesity prevalence rates have steadily increased both in industrialised and developing countries in the last years. Data from literature show that BMI is an acceptable indicator to assess overweight and obesity also in children and adolescents. Different reference standard curves for BMI exist: the percentiles of Rolland-Chacherà, Luciano, the National Center for Health Statistics, Cole and Cacciari. Nevertheless, different cut off points are used by the authors to identify underweight, overweight and obesity. The aim of the present study was to investigate what differences can emerge when comparing adolescent BMI using different references standard curves. Five hundreds and thirty-five adolescent subjects, aged 15.4 +/- 0.7 years, were recruited in Aosta Valley (Northen Italy). BMI was calculated according to the following equation: BMI = weight/height2 (kg/m2). The data obtained were distributed according to BMI percentiles and than compared with references standard curves. The comparison shows different results especially when underweight, overweight and obesity are identified. In conclusion, it can be asserted that BMI is an useful indicator to assess adiposity (overweight and obesity) in adolescent, but one should be cautious when comparing results based on different references.

Adolescent↗
PubMed1986

Internal reference standards in ionic regulation and the predictability of ionic concentrations in animals.

The regulation of ions at similar concentrations in most individuals of a species suggests the existence of internal reference standards. Few have been identified, but many probably relate to cell membrane properties, including potentials, surface charge densities and equilibrium constants of receptor molecules. Solubility may sometimes determine the product [Ca2+] [CO2-3]. Reference standards must generally each relate to more than one ionic species. For some concentrations, including osmolality, there may be no direct reference standard.

Acid-Base Equilibrium↗
PubMed2004

Analysis of mutagenic activity of airborne particulate matter, standard reference materials and reference compounds using base pair-specific Salmonella typhimurium tester strains.

The mutagenicity profiles of organic extracts of airborne dust samples from Mannheim, Germany, and two standard reference materials (SRM) as well as eight compounds with different chemical properties were investigated using tester strains Salmonella typhimurium TA700x (Ames II Assay). Each strain of this series carries a unique missense mutation in the histidine operon and is reverted by only one specific base substitution out of six possible changes. Mutation patterns of eight compounds with different modes of genotoxic action reveal significant differences. Samples of airborne particulate matter (APM) from an industrialized town in Germany (Mannheim) were collected for five consecutive days once a month for 1 year using an automatic high-volume air sampler. Samples taken from Monday to Friday were Soxhlet-extracted and prepared according to standard methods. Although the threshold limit for the least active strains is not triggered by all samples, it can be concluded that mutation patterns of the samples do not vary between different seasons. Standard reference materials (SRMs) were prepared and tested using the same methods. SRMs and APM samples from Mannheim reveal similar mutagenicity profiles in TA700x strains. The comparison of the mutagenicity profiles of air dust extracts from Mannheim and the SRMs, respectively, with reference compounds investigated so far shows some similarities although the patterns do not fit perfectly. Mutagenicity profiles of TA700x-activity of nitro-aromatic compounds published so far are similar to those of APM collected in Mannheim, Germany, as well as to standard reference materials 1648 and 1649.

Air Pollutants↗
PubMed1991

[Fluocinolone Acetonide Reference Standard (Control 901) of the National Institute of Hygienic Sciences)].

Fluocinolone Acetonide Reference Standard (Control 901) for the Japanese Pharmacopoeia (JP RS) was prepared. The following analytical data were obtained: melting point 268 degrees C (decomposition); IR spectrum was same as the previous JP RS of Fluocinolone Acetonide; absorptivity at 237nm E1%1lcm = 363; optical rotation [alpha]20D = 105.7 degrees; no impurity was detected by TLC, but two impurities were detected by HPLC analysis; assay by HPLC against the previous JP RS 100.2%. Based on the above results, this raw material was authorized as the Reference Standard of the National Institute of Hygienic Sciences.

Chromatography, High Pressure Liquid↗
PubMed1991

[Prednisolone Acetate Reference Standard (Control 901) of the National Institute of Hygienic Sciences].

Prednisolone Acetate Reference Standard (Control 901) for the Japanese Pharmacopoeia (JP RS) was prepared. The following analytical data were obtained: melting point 236 degrees C (decomposition); IR spectrum was same as that of JP RS of prednisolone acetate; absorptivity at 243 nm E1%lcm = 379; optical rotation [alpha]20D = +113.0 degrees; no impurity was detected by TLC, but a small amount of two impurities was found by HPLC analysis; assay by HPLC against the JP RS 100.2%. Based on the above results, this raw material was authorized as the Reference Standard of the National Institute of Hygienic Sciences.

Chromatography, High Pressure Liquid↗