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Can some facial rejuvenation techniques cause iatrogenia?

This article studies the changes produced with age in the different facial tissues, analyzes how these tissues can be affected by surgical manipulation, and sets out certain principles that should be kept in mind during facial rejuvenation surgery. Surgeons are alerted to the possibility of causing iatrogenia, in the sense of interfering with normal facial expression and accelerating the normal aging process. We present two techniques that use these principles.

Adult↗

Liposuction in cervical rejuvenation.

Superficial musculoaponeurotic system (SMAS) has represented a confusing anatomical structure because descriptions of it in classical treatises of anatomy are contradictory. Also, utilization of this system in facial rejuvenation also does not coincide with the true anatomical facts regarding the superficial musculo-aponeurosis. A macroscopic and histological study of the region was carried out in order to determine the areas of fat deposits and the distribution of the true cervical superficial aponeurosis, partly in accordance with the statements by Jost and leaving aside the concept proposed by Mitz and Peyronie. Cervical liposuction was combined with the techniques for cervicofacial rhytidectomy.

Adipose Tissue↗

Surgical advances. A comprehensive approach to surgical rejuvenation of the eyes.

Methods to rejuvenate the eye region include shortening of the forehead, raising the brow, improving the upper eyelids by excision of blepharochalasis tissue, and reducing lower eyelid fat pads by a transconjunctival approach and at the same time elevating the stretched lateral canthus by an effective canthopexy. The risks and complications of these procedures are minimal, circumscribing the shortcomings of conventional blepharoplasty.

Forehead↗

Refinements in rejuvenative facial lipomorphoplasty.

Facial planes and pilasters are introduced, defined, and classified. Their progressive changes in robustness, shape, and direction with age are demonstrated. These changes in the pilasters result largely from age-related fat atrophy which also leads to a structural volume deficit and chronic muscle action. Restoration of the pilasters to a more youthful position, shape, direction, and robustness enhances the results of rejuvenative facial lipomorphoplasty achieved by correction of the structural volume deficit in the early stages of aging.

Adipose Tissue↗

Rejuvenative facial lipomorphoplasty.

Aging of the face is staged. Rejuvenation by restoration of structural volume deficit with sedimented autogenous fat micrografts harvested by gentle syringe lipoaspiration is described. Atraumatic technique, avoidance of desiccation, and gentleness in handling the fat micrografts are required for successful vascularization and take of the grafts.

Adipose Tissue↗

[Volume and facial rejuvenation].

The request of care for facial aging has changed. Patients wish more and more a "natural" rejuvenation. The analysis of the different ways of aging shows that it is important to restore the mid-face volumes in order to obtain the fullness of youth. Numerous techniques have been used to increase the central volumes. After an historical study of the different methods, the authors present the new concepts that give a large place to lipostructure as described by Coleman. This technique can be used alone or in association with other techniques (lifting, collagen or other products injections...). The results are motivating; the process is simple and quick. The post-surgical oedemas are often important, but complications are exceptional. All these criteria correspond to current demands linked to aesthetic surgery considering medico-legal pressure. The future is based on the improvement of good grafts defining more precisely the factors of resorption of adipose graft tissues.

Adipose Tissue↗

Botulinum toxin for rejuvenation of the neck.

The use of botulinum toxin for cosmetically restoring an aging neck is a simple procedure that has great patient satisfaction. It is also a safe and effective therapeutic modality for any patient desiring rejuvenation of his or her neck, but who at the same time does not desire any recuperation time or is unwilling to undertake the potential risks associated with plastic surgery. Currently, both botulinum toxin type A (BTX-A) and B are being used to treat the aging neck with great success. However, our clinical experience has been more vast with BTX-A, and the accomplishment of several clinical trials with it has yielded more precise results. BTX-A can be used to correct early signs of aging as well as more advanced forms. It helps correct jowl formation and platysmal banding as well as horizontal rhytides in the neck.

Botulinum Toxins↗

Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies.

Acetylcholinesterase (AChE) inhibitor has been used as a drug for the symptomatic treatment of Alzheimer's disease. In order to search for new AChE inhibitors, 32 plants used in Thai traditional rejuvenating and neurotonic remedies were collected. The plant methanolic extracts were tested for AChE inhibitory activity using Ellman's colorimetric method in 96-welled microplates. The results showed that the methanolic extracts from roots of Stephania suberosa Forman. and Tabernaemontana divaricata (L.) R.Br. ex Roem. & Schult. at concentration of 0.1 mg/ml inhibited more than 90% of AChE activity. At the same concentration, four extracts, i.e. stems of Piper interruptum Opiz., seeds of Piper nigrum L., rootbarks of Butea superba Roxb. and roots of Cassia fistula L. extracts showed 50-65% inhibitory activity on AChE. The rest of the extracts showed the AChE inhibitory activity below 50%.

Acetylcholinesterase↗

Comprehensive treatment of the aging face--cutaneous and structural rejuvenation.

As people age, characteristic changes occur in the skin, the soft tissue envelope, and the bony skeleton of the face and result in the aging face syndrome. An understanding of the pertinent biomechanical and histologic changes is necessary for developing an appropriate treatment plan. The advent of many new techniques, including cosmetic exfoliation, laser skin resurfacing, open rhinoplasty, and endoscopic, multiplane plastic surgical procedures, has enhanced therapy for the aging face syndrome. Treatment protocols should be individualized for each patient's needs and desires. Several of these recent treatments for facial rejuvenation are reviewed herein.

Blepharoplasty↗

Posterior cervical rhytidectomy: a valuable adjunct in facial rejuvenation surgery.

OBJECTIVE: To describe the aesthetic indications and operative technique of posterior cervical rhytidectomy as a staged procedure after extended cervical-facial rhytidectomy. DESIGN: The senior author's series of patients requiring posterior cervical rhytidectomy is reviewed, including preoperative and postoperative aesthetic results. SETTING: A private practice plastic surgery clinic. PATIENTS: Eleven patients who underwent staged posterior cervical rhytidectomy after extensive cervical-facial rhytidectomy are presented, with follow-up ranging from 3 months to 8 years. During this same duration, 941 primary and 256 secondary cervical-facial rhytidectomies were performed. INTERVENTIONS: The preoperative and postoperative results are presented along with a description of the pertinent anatomy and the senior author's operative technique. Potential complications are reviewed. A discussion is included on ways to minimize these untoward sequelae. OUTCOME MEASURE: The aesthetic postoperative results are reviewed, and representative clinical photographs are presented. RESULTS: Staged posterior cervical rhytidectomy is a safe and effective means of improving certain stigmata of previous cervical-facial rhytidectomy in patients requiring extensive facial rejuvenation. CONCLUSIONS: Posterior cervical rhytidectomy is a valuable surgical adjunct in selective patients who demonstrate redundant skin and soft tissue in the posterior cervical region.

Adult↗

Rejuvenation of the disposable soma: repeated injury extends lifespan in an asexual annelid.

The disposable soma theory of senescence proposes that aging is the result of the accumulation of somatic damage with age resulting from insufficient somatic maintenance and repair. Comparative studies that show a positive correlation between longevity and DNA excision repair efficiency in mammals provide support for the theory but their validity has been questioned. A more satisfactory approach to investigate the role of somatic damage accumulation in aging would be to manipulate experimentally the levels of somatic repair and observe its effect on longevity. Here I report the results of studies in the asexual annelid Paranais litoralis where I have experimentally extended the worms' lifespan by subjecting them to repeated injury. I propose that repeated injury enhanced the normal level of repair of the worms, resulting in a rejuvenation of the soma. These results provide experimental support for the disposable soma theory of senescence.

Aging↗

Complications of botulinum toxin A use in facial rejuvenation.

The esthetic application of botulinum toxin type A is a safe treatment modality; nevertheless, complications can occur as a result of patient- and physician-related factors. Fortunately, adverse effects and undesirable sequelae after Botox injections are temporary. Complications may be more serious in patients who have more severe rhytids (which require more Botox), have undergone previous facial plastic surgery (altered anatomy), and those who have preexisting neuromuscular disease. The physician can reduce complications by using proper injection techniques, appropriate regional Botox dosing, and by being conservative in the overall approach to Botox-mediated facial rejuvenation.

Botulinum Toxins, Type A↗

Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao Keur", Pueraria mirifica. The known miroestrol may be an artifact.

Miroestrol (1) has been isolated previously as an active principle from "Kwao Keur" (Pueraria mirifica), a rejuvenating folk medicine from Thailand. Reinvestigation using bioassay-guided purification has resulted in the isolation of a new potent phytoestrogen, deoxymiroestrol (2). The facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.

Antineoplastic Agents, Phytogenic↗

Rejuvenation of the lithosphere by the Hawaiian plume.

The volcanism responsible for creating the chain of the Hawaiian islands and seamounts is believed to mark the passage of the oceanic lithosphere over a mantle plume. In this picture hot material rises from great depth within a fixed narrow conduit to the surface, penetrating the moving lithosphere. Although a number of models describe possible plume-lithosphere interactions, seismic imaging techniques have not had sufficient resolution to distinguish between them. Here we apply the S-wave 'receiver function' technique to data of three permanent seismic broadband stations on the Hawaiian islands, to map the thickness of the underlying lithosphere. We find that under Big Island the lithosphere is 100-110 km thick, as expected for an oceanic plate 90-100 million years old that is not modified by a plume. But the lithosphere thins gradually along the island chain to about 50-60 km below Kauai. The width of the thinning is about 300 km. In this zone, well within the larger-scale topographic swell, we infer that the rejuvenation model (where the plume thins the lithosphere) is operative; however, the larger-scale topographic swell is probably supported dynamically.

Journal Article↗

How are colloidal suspensions that age rejuvenated by strain application?

We present here a microscopic study of the effect of shear on a dense purely repulsive colloidal suspension. We use multispeckle diffusing wave spectroscopy to monitor the transient motions of colloidal particles after being submitted to an oscillatory strain. This technique proves efficient to record the time evolution of the distribution of relaxation times. After a high oscillatory shear, we show that this distribution displays full aging behavior. Conversely, when a moderate shear is applied the distribution is modified in a non-trivial way. Whereas high shear is able to erase all the sample history and rejuvenate it, a moderate shear helps it to age. We call this phenomenon overaging. We demonstrate that overaging can be understood if the complete shape of the relaxation time distribution is taken into account. We finally report how the soft glassy rheology model accounts for this effect.

Journal Article↗

Lip rejuvenation.

BACKGROUND: The management of the senile lip remains a dilemma. Allogenic fillers often feel unnatural, lip resurfacing is not adequate, and fat transfers may disappear. OBJECTIVE: To develop a more reliable step-by-step approach to lip augmentation. METHOD: Lips were divided into types: (1) the simple senile lip that had lost its fullness-treated with fat augmentation; (2) the lip with rhagades-treated with fat augmentation and laser resurfacing; and (3) the duckbill lip-treated with lip advancement, fat augmentation, and laser resurfacing. Tattooing to increase the degree of redness was performed on all types of lips. RESULT: If there had been a previously full lip, it was possible to rejuvenate the lip by simple augmentation with autologous fat transfer. The average number of fat transfer sessions to generate this pleasing lip was two to three. The lip with rhagades required fat filling, with laser resurfacing to achieve a new contour. The duckbill lip required a lip advancement along with lipofilling and laser resurfacing. All types benefited from lip tattooing. CONCLUSIONS: It was possible with fat augmentation and/or laser resurfacing to generate a pleasing lip in type 1 and 2 lips. Lip type 3 required a lip advancement along with fat augmentation and laser resurfacing. Lip tattooing accentuated all the lip types.

Adipose Tissue↗

Facial rejuvenation with a nonablative 1320 nm Nd:YAG laser: a preliminary clinical and histologic evaluation.

BACKGROUND: Rejuvenation of photoaged skin involves removal of the epidermis and superficial dermis, encouraging the production of new epidermis with collagenesis and remodeling. The facial appearance during healing is unpleasant, and the complication rate is high. OBJECTIVE: We evaluate a Q-switched Nd:YAG laser operating at 1320 nm, with a cryogen delivery system and a skin temperature sensor. The system cools the target skin, followed by the laser impulse which passes through the cooled epidermis into the dermis. METHODS: Ten patients are presented. Two treatments a week were given over 4 weeks, and the patients were seen at 2 and 6 weeks after the final treatment. RESULTS: The histology showed improvement in the condition of the dermis in all 10 patients, but only 2 of the 10 patients expressed satisfaction with the results, despite similar histologic findings. CONCLUSIONS: Careful patient selection is required. Better patient education is necessary to ensure that the patients' expectations are realistic. We should add treatments that will improve the youthful aspect of the epidermis. The system may well help in maintaining the effects of collagen remodeling following traditional ablative resurfacing procedures, but studies are necessary to show this.

Aged↗

Gross and microscopic findings in patients undergoing microdermabrasion for facial rejuvenation.

BACKGROUND: Microdermabrasion (MDA) is a new procedure used for the treatment of cosmetic problems, particularly to combat photoaging and intrinsic aging. Though excellent clinical improvement has been well documented, histologic support is limited. OBJECTIVE: To determine if microscopic changes correlate with clinical improvement and to examine the depth of penetration compared to chemical peels. METHODS: Seven women were submitted to five MDA sessions at weekly intervals. Skin biopsies were performed in all of them, before and after the treatment. Clinical and photographic assessments were recorded weekly. Data concerning skin features, including oiliness, thickness, dilated pores, and general appearance, were all assessed. Microscopic improvement of changes associated with cutaneous aging in the epidermis and dermis where all assessed. For statistical analysis, a t-test for small samples was utilized. RESULTS: All the patients showed clinical and microscopic improvement in all of the parameters assessed. The t-test for small samples showed a P <.05. CONCLUSION: MDA is a good alternative for facial rejuvenation. Improvements in both clinical and microscopic parameters are readily demonstrable.

Adult↗