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Quasi-bandlimited properties of radon transforms and their implications for increasing angular sampling densities.

The n-dimensional (n-D) radon transform, which forms the mathematical basis for a broad variety of tomographic imaging applications, can be viewed as an n-D function in n-D sinogram space. Accurate reconstruction of continuous or discrete tomographic images requires full knowledge of the radon transform in the corresponding n-D sinogram space. In practice, however, one can have only a finite set of discrete samples of the radon transform in the sinogram space. One often derives the desired full knowledge of the radon transform from its discrete samples by invoking various interpolation algorithms. According to the Wittaker-Shannon sampling theorem, a necessary condition for a full and unique recovery of the radon transform from its discrete samples is that the radon transform itself be bandlimited. Therefore, it is necessary to analyze the bandlimited properties of the radon transform. In this work, we analyze explicitly the bandlimited properties of the radon transform and show that the radon transform is mathematically quasi-bandlimited [or essentially bandlimited] in two quantitative senses and can essentially be treated as bandlimited in practice. The quasi-bandlimited properties can be used for increasing the angular sampling density of the radon transform.

Image Processing, Computer-Assisted↗

Rural parents' perceptions of risks associated with their children's exposure to radon.

OBJECTIVES: To examine the level of awareness of radon issues, correlates of elective testing behaviors, and the accuracy of risk perception for radon exposures among rural residents receiving public health services. DESIGN: A cross-sectional design was used in which questionnaire data and household analytic data for radon levels were collected from a nonprobabilistic sample of rural households. SAMPLE: Thirty-one rural households with 71 adults and 60 children participated in the study. Primary household respondents were female (100%), Caucasian (97%), and primarily (94%) between 21 and 40 years of age. MEASUREMENT: Questionnaire data consisted of knowledge and risk perception items about radon and all homes were tested for the presence of radon. RESULTS: The prevalence of high airborne radon (defined as> or=4 pCi/l) was 32%. More than a third of the sample underestimated the seriousness of health effects of radon exposure, 39% disagreed that being around less radon would improve the long-term health of their children, and 52% were unsure whether radon could cause health problems. After adjusting for chance, only 21% of the subjects correctly understood their risk status. CONCLUSIONS: This study provides preliminary evidence that low-income rural citizens do not understand their risk of radon exposure or the deleterious consequences of exposure.

Adult↗

A mechanism for anomalous decline in radon precursory to an earthquake.

Mechanisms for interpreting anomalous decreases in radon in ground water prior to earthquakes are examined with the help of a case study to show that radon potentially is a sensitive tracer of strain changes in the crust preceding an earthquake. The 2003 Chengkung earthquake of magnitude (M) 6.8 on December 10, 2003, was the strongest earthquake near the Chengkung area in eastern Taiwan since 1951. The Antung radon-monitoring station was located 20 km from the epicenter. Approximately 65 d prior to the 2003 Chengkung earthquake, precursory changes in radon concentration in ground water were observed. Specifically, radon decreased from a background level of 780 pCi/L to a minimum of 330 pCi/L. The Antung hot spring is situated in a fractured block of tuffaceous sandstone surrounded by ductile mudstone. Given these geological conditions, we hypothesized that the dilation of brittle rock mass occurred at a rate faster than the recharge of pore water and gas saturation developed in newly created cracks preceding the earthquake. Radon partitioning into the gas phase may explain the anomalous decrease of radon precursory to the 2003 Chengkung earthquake. To support the hypothesis, vapor-liquid, two-phase radon-partitioning experiments were conducted at formation temperature (60 degrees C) using formation brine from the Antung hot spring. Experimental data indicated that the decrease in radon required a gas saturation of 10% developed in rock cracks. The observed decline in radon can be correlated with the increase in gas saturation and then with the volumetric strain change for a given fracture porosity.

Disasters↗

Exposure to atmospheric radon.

We measured radon (222Rn) concentrations in Iowa and Minnesota and found that unusually high annual average radon concentrations occur outdoors in portions of central North America. In some areas, outdoor concentrations exceed the national average indoor radon concentration. The general spatial patterns of outdoor radon and indoor radon are similar to the spatial distribution of radon progeny in the soil. Outdoor radon exposure in this region can be a substantial fraction of an individual's total radon exposure and is highly variable across the population. Estimated lifetime effective dose equivalents for the women participants in a radon-related lung cancer study varied by a factor of two at the median dose, 8 mSv, and ranged up to 60 mSv (6 rem). Failure to include these doses can reduce the statistical power of epidemiologic studies that examine the lung cancer risk associated with residential radon exposure.

Air Pollutants, Radioactive↗

Toward a more realistic appraisal of the lung cancer risk from radon: the effects of residential mobility.

OBJECTIVES: A consideration of the effects of residential mobility produces much more realistic estimates of typical individuals' radon exposures and mortality risks than those of the Environmental Protection Agency (EPA). METHODS: A model linking residential mobility, the distribution of radon in US homes, and lung cancer risk is used to simulate lifetime radon exposure, with and without mitigation of high-radon homes, for typical mobile individuals. Radon-related lung cancer mortality risks are then estimated for smokers and never-smokers. RESULTS: Most individuals residing in high-radon homes have equivalent lifelong radon exposures well below those they are currently experiencing. Consequently, actual lung cancer risks are generally well below those implied in the EPA's radon risk charts. For most people who mitigate high-radon homes, risk reduction is modest. CONCLUSIONS: Radon may indeed be responsible for as large a population risk of lung cancer as the EPA estimates. However, caution must be used in interpreting the EPA's risk assessment for individuals; in many cases, mitigation will have little effect on residents' health risks.

Adult↗

Assessment of exposure to radon decay products in realistic living conditions.

The development of an automated system for activity-weighted size distribution measurements now permits more complete exposure and dose assessment for indoor radon decay products. Exposures characterized by the semi-continuous measurement of activity-weighted size distributions of radon decay products were obtained over four test periods in three normally occupied houses, two of which were occupied by cigarette smokers. These measured activity size distributions were used to calculate exposure-dose conversion coefficients and the annual effective doses. These doses were found to be approximately two-fold higher than the values derived conventionally from the measured radon concentration, on the assumption that indoor exposure to 20 Bq m-3 radon gas concentration corresponds to an annual effective dose 1 mSv y-1. The degree to which aerosol-measurement-based dose estimates were higher than radon-gas-based estimates was found to be influenced if the study house occupant was a cigarette smoker. Reassessment of the measured PAEC-weighted radon progeny particle size distribution in terms of the classical "unattached" and "attached" modes yielded lower estimates of the exposure-effective dose conversion coefficient that were similar to the reference values derived from a recent study by the National Research Council. Thus, by not resolving the measured radon progeny PAEC that is associated with particles intermediate in size between the two classical radon progeny modes, the estimated annual effective doses were also found to be similar to the values derived conventionally from the measured radon gas concentration. It is concluded that the observed presence of 4 to 13% of the radon progeny PAEC in the size-range 1.5 to 15 nm diameter is a dosimetrically significant factor that appears to be commonplace in various home environments.

Air Pollution, Indoor↗

Canadian individual risks of radon-induced lung cancer for different exposure profiles.

BACKGROUND: Indoor radon has been determined to be the second leading cause of lung cancer after tobacco smoking. There is an increasing need among radiation practitioners to have numerical values of lung cancer risks for men and women, ever-smokers and never-smokers exposed to radon in homes. This study evaluates individual risks for the Canadian population exposed to radon in homes at different radon concentrations and for different periods of their lives. METHODS: Based on the risk model developed recently by U.S. Environmental Protection Agency (EPA), individual risks of radon-induced lung cancers are calculated with Canadian age-specific rates for overall and lung cancer mortalities (1996-2000) as well as the Canadian smoking prevalence data in 2002. RESULTS: Convenient tables of lifetime relative risks are constructed for lifetime exposures and short exposures between any two age intervals from 0 to 110, and for various radon concentrations found in homes from 50 to 1000 Bq/m3. CONCLUSIONS: The risk of developing lung cancer from residential radon exposure increases with radon concentration and exposure duration. For short exposure periods, such as 10 or 20 years, risks are higher in middle age groups (30-50) compared especially to the later years. Individuals could lower their risks significantly by reducing radon levels earlier in life. The tables could help radiation protection practitioners to better communicate indoor radon risk to members of the public.

Adolescent↗

Residential radon and lung cancer--detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiologic studies in Europe.

OBJECTIVES: Studies seeking direct estimates of the lung cancer risk associated with residential radon exposure lasting several decades have been conducted in many European countries. Individually these studies have not been large enough to assess moderate risks reliably. Therefore data from all 13 European studies of residential radon and lung cancer satisfying certain prespecified criteria have been brought together and analyzed. METHODS: Data were available for 7148 persons with lung cancer and 14,208 controls, all with individual smoking histories and residential radon histories determined by long-term radon gas measurements. RESULTS: The excess relative risk of lung cancer per 100 Bq/m3 increase in the observed radon concentration was 0.08 [95% confidence interval (95% CI) 0.03-0.16; P=0.0007] after control for confounding. The dose-response relationship was linear with no evidence of a threshold, and it remained significant when only persons with observed radon concentrations of <200 Bq/m3 were included. There was no evidence that the excess relative risk varied with age, sex, or smoking history. Removing the bias induced by random uncertainties related to radon exposure assessment increased the excess relative risk of lung cancer to 0.16 (95% CI 0.05-0.31) per 100 Bq/m3. With this correction, estimated risks at 0, 100, and 400 Bq/m3, relative to lifelong nonsmokers with no radon exposure, were 1.0, 1.2, and 1.6 for lifelong nonsmokers and 25.8, 29.9, and 42.3 for continuing smokers of 15-24 cigarettes/day. CONCLUSIONS: These data provide firm evidence that residential radon acts as a cause of lung cancer in the general population. They provide a solid basis for the formulation of policies with which to manage risk from radon and reduce deaths from the most common fatal cancer in Europe.

Case-Control Studies↗

Effectiveness of radon relative to acute 60Co gamma-rays for induction of micronuclei in vitro and in vivo.

Because radon and its progeny (referred to collectively here as radon) emit alpha particles with a wide range of energies, as well as beta particles and gamma-rays, it is important to quantitate the relationship between initial damage induced by radon and that by acute low-LET radiation. We have evaluated dose-response relationships for induction of micronuclei both in vivo and in vitro following exposure to radon or 60Co. To determine if isolation procedures altered the cells' responsiveness to 60Co gamma-ray exposures, animals were exposed before cell isolation, or cells were isolated and then exposed. The data were described by linear dose-response functions and were not significantly different when the radiation exposure was in vivo or in vitro (respectively micronuclei/1000 binucleated cells = 1.6 +/- 6.5 + 62 +/- 2.7 D; micronuclei/1000 binucleated cells = 15.4 +/- 26.0 + 54.6 +/- 11.4 D, where D is in Gy). Primary rat lung fibroblasts (RLF) or Chinese hamster ovary (CHO-K1) cells were exposed in vitro to either radon or 60Co gamma-rays. Radon was 10.9 +/- 2.6 and 12.5 +/- 2.4 times as effective per Gy of radiation dose in producing micronuclei as was 60Co in RLF and CHO-K1 cells respectively. To determine the relative biological effectiveness of in vivo radon exposure, animals were exposed to either radon or 60Co, and lung fibroblasts were isolated and evaluated for radiation-induced micronuclei. In vivo radon exposure was 10.6 +/- 1.0 times as effective as acute whole-body 60Co exposure in producing micronuclei in lung fibroblasts. Different cell lines and exposure conditions resulted in similar effectiveness factors. Such ratios help evaluate the biological damage, hazard and risk associated with radon inhalation.

Animals↗

Indoor radon levels in selected hot spring hotels in Guangdong, China.

Guangdong is one of the provinces that have most hot springs in China, and many hotels have been set up near hot springs, with spring water introduced into the bath inside each hotel room for hot spring bathing to attract tourists. In the present study, we measured radon in indoor and outdoor air, as well as in hot spring waters, in four hot spring hotels in Guangdong by using NR-667A (III) continuous radon detector. Radon concentrations ranged 53.4-292.5 Bq L(-1) in the hot spring water and 17.2-190.9 Bq m(-3) in outdoor air. Soil gas intrusion, indoor hot spring water use and inefficient ventilation all contributed to the elevated indoor radon levels in the hotel rooms. From the variation of radon levels in closed unoccupied hotel rooms, soil gas intrusion was found to be a very important source of indoor radon in hotel rooms with floors in contact with soils. When there was spring water bathing in the bathes, average radon levels were 10.9-813% higher in the hotel rooms and 13.8-489% higher in bathes compared to their corresponding average levels when there was no spring water use. Spring water use in the hotel rooms had radon transfer coefficients from 1.6x10(-4) to 5.0x10(-3). Radon in some hotel rooms maintained in concentrations much higher than guideline levels might thus have potential health risks to the hotel workers, and technical and management measures should be taken to lower their exposure of radon through inhalation.

Journal Article↗

Radon protection for new buildings: a practical solution from the UK.

If indoor radon levels are to be significantly reduced across Europe it is essential to ensure that all new buildings built in areas affected by radon are protected. In the United Kingdom the Building Research Establishment Ltd (BRE) has been carrying out research on behalf of the Department of the Environment, Transport and the Regions (DETR) to develop protective measures for use in new buildings. This work commenced in the mid-1980s and has resulted in the development of a range of practical cost-effective techniques for providing radon protection in new UK buildings. Guidance has been developed in support of the Building Regulations for England and Wales. First published in 1991 the technical solutions have been gradually improved in light of experience gained on site. Likewise, the areas for which the guidance applies have also been revised in light of radon surveys carried out by the National Radiological Protection Board. This continuous process of refinement is scheduled to result in a further version during 1999. The techniques developed in the UK mainly rely upon passive radon barriers, which are low cost and simple to install. Even in the worst affected areas of the country, where some 30% of existing houses have radon levels greater than 200 Bq/m3 (UK recommended action level), houses with protection measures regularly result in indoor radon levels close to 20 Bq/m3 (UK average for all house types). Radon protective measures are now being installed routinely in many parts of the UK. The cost of installation has reduced as protection has become a matter of routine through regulation, so that currently radon protection is unlikely to cost much more than 0.25% of the total construction cost of a typical UK house. It is our view that many of the techniques developed in the UK could be used directly or with minor modifications in other countries in Europe. This paper describes these latest techniques and approaches used in the UK to successfully provide radon protective measures.

Journal Article↗

Development of a high efficiency personal/environmental radon dosimeter using polycarbonate detectors.

Passive radon dosimeters, based on alpha particle etched track detectors, are widely used for the assessment of radon exposure. These methods are often applied in radon dosimetry for long periods of time. In this research work, we have developed a highly efficient method of personal/environmental radon dosimetry that is based upon the detection of alpha particles from radon daughters, (218)Po and (214)Po, using a polycarbonate detector (PC). The radon daughters are collected on the filter surface by passing a fixed flow of air through it and the PC detector, placed at a specified distance from the filter, is simultaneously exposed to alpha particles. After exposure, the latent tracks on the detector are made to appear by means of an electrochemical etching process; these are proportional to the radon dose. The air flow rate and the detector-filter distance are the major factors that can affect the performance of the dosimeter. The results obtained in our experimental investigations have shown that a distance of 1.5 cm between the detector and the filter, an absorber layer of Al with a thickness of 12 microm and an air flow rate of 4 l min(-1) offer the best design parameters for a high efficiency radon dosimeter. Then, the designed dosimeter was calibrated against different values of radon exposures and the obtained sensitivity was found to be 2.1 (tracks cm(-2)) (kBq h m(-3))(-1). The most important advantages of this method are that it is reliable, fast and convenient when used for radon dose assessment. In this paper, the optimized parameters of the dosimeter structure and its calibration procedure are presented and discussed.

Dose-Response Relationship, Radiation↗

Risk of lung cancer and residential radon in China: pooled results of two studies.

Studies of radon-exposed underground miners predict that residential radon is the second leading cause of lung cancer mortality; however, case-control studies of residential radon have not provided unambiguous evidence of an association. Owing to small expected risks from residential radon and uncertainties in dosimetry, large studies or pooling of multiple studies are needed to fully evaluate effects. We pooled data from 2 case-control studies of residential radon representing 2 large radon studies conducted in China. The studies included 1050 lung cancer cases and 1996 controls. In the pooled data, odds ratios (OR) increased significantly with greater radon concentration. Based on a linear model, the OR with 95% confidence intervals (CI) at 100 Becquerel/cubic-meter (Bq/m(3)) was 1.33 (1.01,1.36). For subjects resident in the current home for 30 years or more, the OR at 100 Bq/m(3) was 1.32 (1.07,1.91). Results across studies were consistent with homogeneity. Estimates of ORs were similar to extrapolations from miner data and consistent with published residential radon studies in North American and Europe, suggesting long-term radon exposure at concentrations found in many homes increases lung cancer risk.

Aged↗

Radon therapy for the treatment of rheumatic diseases--review and meta-analysis of controlled clinical trials.

OBJECTIVE: The aim of this study was to analyze the effect of radon therapy on pain in rheumatic diseases. METHODS: MEDLINE and MedKur databases were searched for the terms radon plus therapy, rheum, arthritis, and osteo. Radon therapy centers and experts in the field were contacted, proceedings hand-searched, and bibliographies checked for references of potential importance. Included were all prospective randomized controlled clinical trials that compared clinical effects of radon therapy with other interventions in patients with rheumatic diseases and studied pain intensity. Information concerning patients, interventions, results, and methodology were extracted in a standardized manner by all authors independently and summarized descriptively. Reports on pain reduction were pooled for meta-analysis. RESULTS: Five clinical trials with a total of 338 patients and comparing the effect on pain of radon baths (three trials) or radon speleotherapy (two trials) with control intervention in degenerative spinal disease (two trials), rheumatoid arthritis (one trial) and ankylosing spondylitis (two trials) met the inclusion criteria. In meta-analysis, the pooled data showed no difference immediately after treatment (P=0.13) but significantly better pain reduction in the radon group than the control group at 3 months (P=0.02) and 6 months (P=0.002) after treatment. CONCLUSIONS: The existing trials suggest a positive effect of radon therapy on pain in rheumatic diseases. With respect to the potential clinical effect and given the increasing public interest in radon therapy, there is an urgent need for further randomized controlled clinical investigations with long-term follow-up.

Arthritis, Rheumatoid↗

Radon exposure and cancers other than lung cancer among uranium miners in West Bohemia.

Recent observations have suggested that radon in the ambient air may cause cancers at sites other than the lung, but the evidence is indirect. We have studied site-specific cancer mortality in 4320 uranium miners in West Bohemia who have been followed-up for an average of 25 years, and in whom a four-fold radon-related excess of lung cancer has already been established. For all cancers other than lung cancer the number of deaths observed was slightly greater than that expected from national rates, but the increase was not significant statistically (ratio of observed to expected deaths [O/E] = 1.11, 95% confidence interval [CI] = 0.98-1.24) and mortality did not increase with duration of employment underground or with cumulative exposure to radon. Non-lung cancer mortality was significantly raised among men who started mining work aged under 25 but the increase was not related to cumulative radon exposure. When twenty-eight individual sites and types of cancer were examined, significantly increased risks were found for cancers of the liver (O/E = 1.67) and gallbladder and extrahepatic bile ducts (O/E = 2.26). For liver cancer, mortality did not increase with duration of employment underground or with cumulative radon exposure. For cancer of the gallbladder and extrahepatic bile ducts, mortality did not increase with duration of employment, but increased with cumulative exposure to radon. Mortality from multiple myeloma, although not significantly increased overall (O/E = 1.08), increased with cumulative exposure to radon. Mortality from leukaemia was not increased overall (O/E = 0.91) and was not related to cumulative radon exposure, but did increase with increasing duration of employment in the mines. There is no evidence in these miners that a radon-rich atmosphere increases the risk of any cancer other than lung cancer. Possible exceptions are cancer of the gallbladder and extrahepatic bile ducts and multiple myeloma but further study is needed before it can be concluded that the associations found are causal.

Adult↗

Inhaled radon-induced genotoxicity in Wistar rat, Syrian hamster, and Chinese hamster deep-lung fibroblasts in vivo.

This study was performed (1) to provide a comparison of the genotoxic effects of inhaled radon and radon progeny, referred to as radon in this paper, among three species of rodents: Wistar rats, Syrian hamsters, and Chinese hamsters; (2) to determine if initial chromosome damage was related to the risk of induction of lung cancer; and (3) to evaluate the tissue repair and long-term presence of cytogenetic damage in respiratory tract cells. These species were selected because Syrian hamsters are very resistant to radon induction of lung cancer and Wistar rats are sensitive; no literature is available on the in vivo effects of radon in the Chinese hamster. Exposure-response relationships were established for the rats and Syrian hamsters while the Chinese hamsters received a single exposure of radon. At 4 h (0.2 days), 15 days, and 30 days after the highest WLM exposure to radon, Wistar rats, Chinese hamsters, and Syrian hamsters were killed, and lung fibroblasts were isolated and grown in culture to determine the frequency of induced micronuclei. Animals at each level of exposure showed an increase in the frequency of micronuclei relative to that in controls (P < 0.05). The exposure-response relationship data for rats and Syrian hamsters killed 0.2 days after the end of exposure were fit to linear equations (micronuclei/1000 binucleated cells = 15.5 +/- 14.4 + 0.53 +/- 0.06 WLM and 38.3 +/- 15.1 + 0.80 +/- 0.08 WLM, respectively). For the single exposure level used (496 WLM) in Chinese hamsters killed at 0.2 days after exposure, the frequency of micronuclei/1000 binucleated cells/WLM was 1.83 +/- 0.02. A comparison of the sensitivity for induction of micronuclei/WLM illustrated that Chinese hamsters were three times more sensitive than rats. The Syrian hamsters also showed a significantly elevated response (P < 0.05) relative to rats. These data suggest that initial chromosome damage is not the major factor responsible for the high rate of radon-induced cancer in rats relative to Syrian hamsters. The frequency of micronuclei in radon-exposed rats, Syrian hamsters, and Chinese hamsters significantly decreased (P < 0.05) as a function of time after the exposure. The rate of loss of damaged cells from the lung was greatest in the Chinese hamsters, followed by Wistar rats and Syrian hamsters, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)

Air Pollutants, Radioactive↗

Assessment of radon-222 concentrations in buildings, building materials, water and soil in Jordan.

Monitoring of radon gas ((222)Rn) in Jordan was started in the early 1990s. Since then our radon group at Yarmouk University and others have carried out tens of studies that include measurements of indoor radon, radon in water, radon in soil and radon emanating from building materials. All major cities of Jordan had been surveyed, from the northern city of Irbid down to the southern port city of Aqaba. Most of these studies were carried out by using time-integrated passive radon dosimeters containing CR-39 solid-state nuclear track detectors. In addition to that, an active radon monitor was used to study the seasonal variation of (222)Rn in Al-Ruseifa that lies near abandoned phosphate mines and in Amman area. During such a study passive dosimeters were also used. The average radon concentrations in dwellings in Jordanian cities ranged from about 20 to 386 Bq/m(3) with the highest readings exhibited during the winter season around the town of Al-Ruseifa.

Air Pollution, Indoor↗

Factors underlying residential radon concentration: results from Galicia, Spain.

Radon causes lung cancer when inhaled for prolonged periods of time. A range of factors influence residential radon concentration and this study therefore sought to ascertain which dwelling-related factors exert an influence on radon levels. A cross-sectional study was conducted from 2001 to 2003 which analyzed 983 homes of as many subjects randomly selected from the 1991 census. Sampling was carried out by district and stratified by population density to ensure that more detectors were placed in the most heavily populated areas. Radon concentration and different dwelling characteristics were measured in each of the homes selected. Bivariate and multivariate analyses were performed to ascertain which factors influenced radon concentration. The geometric mean of radon concentration was 69.5 Bq/m3, and 21.3% of homes had concentrations above 148 Bq/m3. Factors shown to influence radon concentration in the bivariate analysis were: age of dwelling; interior building material; exterior building material; and storey on which the detector was placed. Explanatory variables in the multivariate analysis were: age of dwelling; number of storeys; distance off floor; and interior building material. The model was significant, but the variability explained was around 10%. These results highlight the fact that the study area is an area of high radon emission and that factors other than those directly related with the characteristics of the dwelling also influence radon concentration.

Air Pollution, Indoor↗