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Results for “Pyrithioxin”

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At least 199 records · Page 11Linked to original sources
PubMed2003

[Cognitive disturbances in patients with tics and Tourette's syndrome and their correction with encephabol].

Ninety-four patients with tick hyperkinesis (57) and Tourette's syndrome (37) were studied. Neuropsychological examination revealed memory, attention and audio-motor disturbances and symptoms of dysgraphia and dyslexia. Cognitive impairment may develop before ticks appearance and aggravate during hyperkinesis exacerbation. In the patients with Tourette's syndrome, cortical dysfunctions were mostly pronounced. These cognitive disturbances correlated with the indices of spectral analysis of bioelectrical brain activity in frontal and temporal areas. In 83 patients, an efficacy of encephabol treatment combined with basic therapy was studied. Encephabol given in dosage 200-300 mg daily to patients aged 5-7 years and 600 mg--to those aged over 7 years during 6 weeks significantly improved memory, attention and praxis function.

Adolescent↗
PubMedDate not supplied

[Efficiency of encefabol use in patients with dyscirculatory encephalopathy].

The article presents the findings of the Encefabol treatment of 50 patients aged 56-68 yy with vascular encephalopathy at the I-III stage, caused by atherosclerotic and high blood pressure pathological processes. The individual dose prescription of the medication to patients with vascular encephalopathy was substantiated in the article. The importance of psychodiagnostic tests in assessment of Encefabol treatment efficiency of the disease was shown in the article.

Aged↗
PubMedDate not supplied

Stability-indicating methods for determination of pyritinol dihydrochloride in the presence of its precursor and degradation product by derivative spectrophotometry.

A first-derivative spectrophotometric (1D) method and a derivative-ratio zero-crossing spectrophotometric (1DD) method were used to determine pyritinol dihydrochloride (I) in the presence of its precursor (II) and its degradation product (III) with 0.1N hydrochloric acid as a solvent. Linear relationships were obtained in the ranges of 6-22 microg/mL for the (1D) method and 6-20 microg/mL for the (1DD) method. By applying the proposed methods, it was possible to determine pyritinol dihydrochloride in its pure powdered form with an accuracy of 100.36 +/- 1.497% (n = 9) for the (1D) method and an accuracy of 99.92 +/- 1.172% (n = 8) for the (1DD) method. Laboratory-prepared mixtures containing different ratios of (I), (II), and (III) were analyzed, and the proposed methods were valid for concentrations of < or = 10% (II) and < or = 50% (III). The proposed methods were validated and found to be suitable as stability-indicating assay methods for pyritinol in pharmaceutical formulations.

Chemistry Techniques, Analytical↗
PubMed1991

[Detection of nootropic activity indicated by acute inhibition of orientation reaction].

Exploratory locomotor activity was studied in the experiments on adult male mice. It was shown that routine nootropic drugs as well as newly synthesized nootropic compounds were able to facilitate the development of inhibition during one registration session. Inhibition may be used for revealing only selective nootropic drugs devoid of sedative and stimulating effects.

Animals↗
PubMed1990

[Nootropic activity of nicotinamide and its structural analogs].

It is known that endogenic nicotinamide has a tranquilizing and stress-protective activity. The present investigations show the nootropic effect of this drug and its analogs nicomorpholine and acethylnicotinate on acute models of hypoxia and amnesia. The present results revealed that the observed nootropic activity of nicotinamide and its analogs is more expressed than this of piracetam, pyritinol and meclofenoxate. Having in mind the similarity of pharmacological effects of piracetam and nicotinamide (antihypoxic, antiamnestic and anxiolytic) we try if these drugs have electronic-structure similarities. The analysis revealed some similarity of these drugs' molecules in relation to the composition and distribution of polar centres pi- and p-electronic areas) distance between them, topography of separate molecule parts.

Amnesia↗
PubMed1990

Effect of repeated application of nootropic drugs on sleep in rats.

The effects of repeated application of nootropic drugs on the sleep-wake cycle were investigated in rats. Piracetam, meclofenoxate and pyritinol were injected intraperitoneally, 100 mg/kg per day, during a period of 10 days. The sleep-wake cycle was recorded each day between 8 a.m. and 4 p.m. Repeated administration of piracetam and meclofenoxate led to an increase of the paradoxical sleep, a decrease of waking, and a very small increase of slow-wave sleep. Pyritinol, on the other hand, decreased the amount of paradoxical sleep. The paradoxical sleep latency was reduced by piracetam and meclofenoxate and enhanced by pyritinol, respectively. These findings and also previous results show that nootropic drugs have different effects on sleep, especially on paradoxical sleep. The possible relationship between sleep effects and memory effects of nootropic drugs and the usefulness of sleep studies for screening of nootropics are discussed.

Animals↗
PubMed1989

[Drug-induced pemphigus diseases].

An overview is given on pemphigus diseases induced by certain drugs. Well known inducers are D-penicillamine, and pyritinol-chlorhydrate. Besides that in some rather rare cases other drugs were connected to pemphigus induction: rifampicin, INH, etambutol, practolol, propranolol, phenylbutazone, aurothiomalate, ibuprofen, heroin, penicillin, ampicillin, captopril, thiopromine, alpha-mercaptopropionylglycine and piroxicam.

Drug Eruptions↗