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At least 199 records · Page 11Linked to original sources
PubMed1990

Pulmonary diffusing capacity in left ventricular dysfunction.

The purpose of this study was to determine whether there are any consistent spirometric or Dsb findings in patients with LV dysfunction characterized by a clinical diagnosis of CHF and an EF less than 40 percent. We performed spirometry and Dsb in 34 patients, and found that EF correlated only with Dsb. When we separated the patients into those with rales and those without, Dsb correlated strongly with EF only in those with rales. There was no correlation with other spirometric values. Mean Dsb percent predicted was significantly lower in patients with rales despite similar mean EF. Only two of 23 patients without rales had a reduced Dsb while only one of 11 with rales had a normal Dsb. We conclude that Dsb is a good predictor of clinically evident heart failure. When rales are absent, Dsb should be normal in patients with LV dysfunction; when present, Dsb will be diminished in proportion to the EF.

Aged↗
PubMed1983

Maximal oxygen consumption and pulmonary diffusing capacity: a direct comparison of physiologic and morphometric measurements in canids.

The purpose of this study was to check the validity of the morphometric model for estimating physiological conductances for gases, DL. We make a direct comparison between the lung's conductance for carbon monoxide, measured physiologically using the single breath method, DLCO (sb), and that measured morphometrically using the previously published model, DLCO(mm). We also make a direct comparison between the maximum rate of oxygen uptake by the lung during exercise, VO2max, and the lung's conductance for oxygen DLO2(mm). We made these measurements on four species of canids (foxes, coyotes, dogs and wolves). We find a direct proportionality between morphometric and physiologic DLCO measurements, the morphometric being consistently larger by a factor of two. We also find that both DLCO and DLO2 increase more steeply with body mass than VO2max, the difference between the allometric slopes being the same as we had found previously in a wide range of mammalian species ranging from 2 g to 700 kg, although the slopes themselves were different. We conclude that the discordant scaling of DLO2 and VO2max with respect to body mass is not an artifact of the model for calculating DLO2 from morphometric data.

Animals↗
PubMedDate not supplied

[The effect of hemoglobin levels in the blood in pulmonary diffusing capacity].

Using a "single breath" method, diffusing lung capacity (DLCO) and unit DLCO (KCO) were measured in 19 patients with chronic sideropenic anemia and 19 healthy women who were without any clinical or radiologic evidence suggestive of cardiorespiratory disease. Anemic patients, compared to the control group, had significantly reduced DLCO (% predicted) and KCO (% predicted) (p < 0.01). Each 10 g/L hemoglobin (Hb) reduction below a normal value of 136 g/L corresponded to 2% DLCO% and 3% KCO% reductions. For all examinees, where the range of Hb was from 50 to 150 g/L, a significant positive low linear correlation was noted between DLCO% and HB (r = 0.31; p = 0.049) and KCO% and Hb (r = 0.43; p = 0.005). Analyzing only anemic patients, where the range of Hb was from 50 to 109 g/L, no significant correlation was found between Hb and DLCO% or KCO%. Therefore, in patients with chronic sideropenic anemia DLCO is lowered less then expected, so one should not adjust measured DLCO or KCO values to standard Hb concentration, because probably various pathophysiological compensatory mechanisms affect DLCO components in unknown manner, changing the relationship between Hb and DLCO.

Adult↗
PubMedDate not supplied

Pulmonary diffusing capacity for carbon monoxide in simple coal workers' pneumoconiosis.

The lung diffusing capacity for carbon monoxide (DLCO single-breath) and its two components, the capillary blood volume (Vc) and the diffusing capacity of the membrane (DMCO) were measured at rest in 43 miners and 141 control subjects, the values in whom enabled reference formulae to be established; in 30 control subjects and in the majority of the miners these indices were measured during exercise. The main results are as follows: the diffusion indices are on average slightly decreased in simple coal workers' pneumoconiosis; both DMCO and Vc contribute to the lowering of DLCO, at rest and during exercise; individually Vc is more often significantly altered than DMCO; on effort the percentage increase of DLCO is normal in coal miners; the data during exercise suggest that smoking habit contributes more to lowering DLCO than does pneumoconiosis itself; lastly the diffusion indices are lower in miners with "pin-head" than those with micronodular opacities: this tendency is more pronounced during exercise. These findings are discussed.

Adult↗
PubMedDate not supplied

[Pulmonary diffusing capacity in normal aged subjects of both sexes: the effect of smoking habit].

The diffusing capacity of the lung (DL) or transfer factor for the lung (T1) for carbon monoxide (DLCO) was determined, at rest, by single-breath method in 65 normal subjects ranging in age from 60 to 84 years. The subjects were divided into four groups: 15 male smokers (MS); 20 male non-smokers (MNS); 10 female smokers (FS); 20 female non-smokers (FNS). The DLCO was determined using the "Collins Computerized Modular Lung Analyser". The inspired mixture consisted of 0.3 per cent carbon monoxide, 10.0 per cent helium, 21.0 per cent oxygen and 68.7 per cent nitrogen. The mean values and the standard derivations for DLCO (ml/min/mmHg) were: 23.31 +/- 6.48 in MS; 29.33 +/- 6.27 in MNS; 19.74 +/- 5.87 in FS; 19.55 +/- 4.86 in FNS. The DLCO was found to be dependent upon age and body surface area (BSA). Regression equations for predicting normal DLCO have been determined for every one of the four groups (MS, MNS, FS, FNE). Difference, statistically significant was found for MS as compared to MNS, FS and FNS. Therefore two regression equations for predicting normal DLCO have been determined; one for male smokers (MS) and other for male non-smokers (MNS), female smokers (FS) and female non-smokers (FNS). The regression equation for predicting normal DLCO for male smokers (MS) was: DLCO (ML/min/mmHg) = 9.37 - 0.22 Age (Years) + 19.99 BSA (M2). The regression equation for predicting normal DLCO for male non-smokers (MNS), female smokers (FS) and female non-smokers (FNS) was: DLCO (ml/min/mmHg) = 25.05 - 0.27 Age (Years) + 8.41 BSA (m2).(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗
PubMedDate not supplied

[The effect of cigarette smoking on pulmonary diffusing capacity in asymptomatic smokers].

Ninety-seven subjects of which 72 smokers and 25 nonsmokers attending the Laboratory for Respiratory Functional Diagnostics of the University Hospital for Lung Diseases, Jordanovac, Zagreb were examined. The selection criteria were normal standard spirometric test values (FEV1, FVC, FEV1/FVC) in asymptomatic healthy, young smokers/nonsmokers who showed no signs of hematological, cardiovascular and chronic or acute pulmonary symptoms or diseases (according to a standardized questionnaire), and were not exposed to harmful environmental factors. The single-breath carbon monoxide diffusing capacity was measured in all patients. The results of our study confirm the findings of those authors who report reduced values of DLCO and DL/VA in smokers in comparison with the nonsmokers. A linear value diminution has been noticed in smokers and nonsmokers with increasing age, with the values being much lower in smokers. Our results also demonstrate a significant correlation between DLCO and DL/VA in young healthy smokers vs the duration of smoking and the number of cigarettes smoked per day (p < 0.01). The possibility to detect early reversible damages of lung function in young healthy smokers is an important contribution to the prevention of all diseases in which causal consecutive relation with cigarette smoking is confirmed.

Adult↗