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Results for “Promedol”

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At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

[The laparoscopic treatment of varicocele].

Laparoscopic treatment of varicocele is described for 37 patients. The operation was performed under endotracheal, epidural and intravenous anesthesia with ligation of the testicular vein in 18 patients. Ligation with the dissection was conducted in 19 patients. On the first postoperative day 2 patients were given promedol (2%, 1.0 ml), the rest were injected baralgin (2-3 injections). The patients were discharged after 1-2 days of hospital stay and resumed their usual way of life 2-7 days after the discharge. One month later varicocele disappeared in 29 patients, diminished in size in 7 patients, pain relief occurred in 15 patients. Due to its advantages (simple performance, good visualization of the testicular vein, minimal use of narcotic drugs, short hospital stay, absence of serious complications) laparoscopic treatment may be considered as a method of choice.

Adolescent↗
PubMed1997

[Correction of homeostasis disorders in postoperative patients with disseminated purulent peritonitis].

The results of the surgical treatment of 335 patients with a toxic stage of disseminated purulent peritonitis (DPP) are analysed. The toxic stage of the DPP is characterized by the pain syndrome, endotoxicosis, hypodynamic disorders of the blood circulation, respiration, and secondary immunodeficiency. The analgetic mixture of Analgin, Seduxen and No-Spa appeared to be more effective in pain relief than Promedol or Moradol. Slow body detoxication, long standing hypodynamic circulation disorders and immunodeficiency, high level of lethality (16.2%) are typical for patients with toxic stage of DPP treated with conventional therapy (infusion of desintoxic medicines, stimulated diuresis, peritoneal dialysis. The use of intravascular laser irradiation and hemosorption provides marked detoxic ating and immunostimulating effect. Hypoxia and circulatory hypodynamia and immunodeficiency are quickly eliminated with the use of hyperbaric oxygenation and immunocorrective medicines (T-activin, Decaris) and gives a chance to decrease mortality 2 times.

Analgesics↗
PubMed1996

Exogenous gaseous superoxide potentiates the antinociceptive effect of opioid analgesic agents.

The study examined the potentiation of the antinociceptive action of opioid analgesics produced by gaseous superoxide (GS) in the rat hind paw withdrawal test (PWT) and by GS or hydrogen peroxide (HP) in the formalin test. In the PWT, inhalation of GS for 50 minutes before i.p. injection of threshold doses of morphine (0.5 mg/kg) and trimeperidine (1.0 mg/kg) increased the threshold of nociception (TN) by a maximum of 43.0% (p < 0.05) and 113.4% (p < 0.01) respectively. The GS/trimeperidine-dependent increase in TN showed two peaks, the second of which could be suppressed by nialamide. Naloxone abolished the GS/ morphine-dependent increased in the TN. In the formalin test, a significant antinociceptive effect developed after GS inhalation or HP administration (intranasally, 2 x 5 microliters of 2 x 10(-5) mol/l solution in saline) in combination with low doses of Omnopon (0.06-0.75 mg/kg). These results suggest that both GS and HP potentiate the antinociceptive effects of opioid analgesics.

Analgesics, Opioid↗
PubMed1986

Racemic and optically active trans 2,6-dimethyl analogues of the reversed ester of pethidine.

The preparation and stereochemical characterization of (+/-)-1,trans 2,6-trimethyl-4-phenyl-4-propionoxypiperidine hydrochloride and its (+)- and (-)-antipodes are described. The absolute configurations of the antipodes were established by X-ray analysis of the corresponding (-)-4-piperidinol hydrobromide. In antinociceptive tests on mice and rats, the (+)-2S,6S ester proved the more potent antipode by factors of at least 10 (rats) and 20 (mice), a result consistent with earlier proposals made about the probable uptake conformation of pethidine reversed esters at opioid receptors.

Analgesics↗
PubMedDate not supplied

[Ways of improving postoperative analgesia].

Analysis of many-year experience gained in the use of a variety of methods and means for treating the painful syndrome in victims and patients after planned and urgent surgery allowed the authors to determine the optimal approaches to postoperative analgesia. Special attention is paid to introduction of new drugs and methods of analgesia with differentiated approach to prevention and treatment of the painful syndrome. A conclusion on the necessity of pathogenetically based and strictly individual postoperative analgesia is made; such analgesia is often to be multilevel and multicomponent, with consideration for the complex origin of painful reaction (including the components of the painful syndrome) and the armory of available means.

Analgesics↗
PubMed1992

[Last-generation synthetic opioid analgesics as alternative to opiates in oncologic surgery].

The present-day problem is the development of effective methods of general anesthesia and postoperative anesthesia on the basis of nonopiate central analgesics possessing no hazardous side effects of opiates. A study was made of synthetic analgesics of the last generation as agents for intra- and postoperative anesthesia as compared with conventional opiates. It has been established that synthetic analgesics belonging to the class of opiate agonists-antagonists, namely moradol and norphine, compare favourably enough with fentanyl. They are superior to fentanyl in antistressor properties, provide for a more powerful and longer analgesic effect and can replace conventional opiates in all the stages of surgical treatment of the patients. This is particularly important for the oncological clinic where opiates are to be preserved as reserve for the treatment of chronic painful syndrome.

Analgesics↗
PubMedDate not supplied

[Pharmacologic correction of postradiation changes of pain sensitivity in rats].

With radiation injury caused by superlethal doses of 150 Gy the analgesic effect of narcotic drugs decreases and the level of drug analgesia depends on the initial status of nociceptive reactions. The role of mu-opiate mechanisms in the development of postirradiation analgesia to thermal stimuli has been determined.

Analgesics, Opioid↗
PubMedDate not supplied

[The role of non-traditional methods of analgesia in the postoperative period].

192 patients, aged 33 to 67 years, predominantly after abdominal and small pelvic surgery have been examined. Non-conventional techniques of analgesia were used in most of patients: central electroanalgesia, transcutaneous peripheral and paravertebral electroanalgesia, corporal and auricular acupuncture. To ensure postoperative pain relief various types of electrical stimulation were applied using home-made devices, The efficacy of non-conventional anesthesia techniques in the postoperative period has been confirmed.

Abdomen, Acute↗
PubMedDate not supplied

[The analgesic activity of coordination compounds of methionine enkephalin with divalent metals].

Coordination compounds of methenkephalin with transition metals: copper, cobalt, nickel and zinc were shown to be superior to morphine by the analgesic activity and to morphine and methenkephalin by the duration of the analgesic effect. A more stable relationship between opiate receptors and copper-containing methenkephalin was shown in the experiments on the isolated neuronal membrane.

Acetates↗
PubMed1989

[Electrical activity of the heart in anti-ischemic protection of the myocardium].

The paper studies electrical activity of the heart during the anti-ischemic protection by cool high-potassium cardioplegic solution based on the blood. Parametres characterising automatism function and the myocardial state of the ventricles practically did not differ from the control data obtained during the experiments without ischemia. Atrioventricular conduction and the atrium myocardium were worse preserved. The positive effects of the papaverine addition to the cardioplegic perfusate has been also shown. The author came to the conclusion that it is necessary to pay special attention to the electrical activity of the supraventricular area of the heart for the adequate evaluation of the cardioplegia.

Animals↗