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At least 199 records · Page 11Linked to original sources
PubMed1984

Specific olfactory receptor populations projecting to identified glomeruli in the rat olfactory bulb.

A critical gap exists in our knowledge of the topographical relationship between the olfactory epithelium and olfactory bulb. The present report describes the application to this problem of a method involving horseradish peroxidase conjugated to wheat germ agglutinin. This material was iontophoretically delivered to circumscribed glomeruli in the olfactory bulb and the characteristics and distribution of retrogradely labeled receptor cells were assessed. After discrete injections into small glomerular groups in the caudomedial bulb, topographically defined populations of receptor cells were labeled. Labeled receptor cell somata appeared at several levels within the epithelium. The receptor cell apical dendrites followed a tight helical course towards the surface of the epithelium. The data thus far demonstrate that functional units within the olfactory system may include not only glomeruli as previously suggested but, in addition, a corresponding matrix of receptor cells possessing functional and topographical specificity.

Animals↗
PubMed1984

Neurons in the ventral tegmentum have separate populations projecting to telencephalon and inferior olive, are histochemically different, and may receive direct visual input.

The connections of the ventral tegmental area (VTA) and medial terminal nucleus (MTN) of the accessory optic system were studied in the albino rat. Using injection of two fluorescent retrograde tracers it was found that individual neurons of the VTA project to frontal cortices or the inferior olive but not both structures. Using combined retrograde fluorescent tracers and glyoxylic acid histochemistry, it was found that although a third of the cells projecting to frontal cortex contained catecholamine, none of the cells projecting to the inferior olive contained catecholamine. Thus, these portions of the ascending and descending VTA systems are independent. In addition, using injections of the anterograde transneuronal tracer [3H]adenosine into one eye, it was found that cells in the VTA, as well as the MTN, contained the tracer. Therefore, there is a basis for direct retino-mesentelencephalic pathways through the VTA.

Animals↗
PubMed1990

Segregation and heterogeneity of thalamic cell populations projecting to superficial layers of posterior parietal cortex: a retrograde tracer study in cat and monkey.

The thalamic neurons projecting to the superficial layers of areas 5 and 7 in the cat, and area 5 in the monkey, were investigated by using superficial deposits of either horseradish peroxidase or Fast Blue in one hemisphere. In the contralateral hemisphere injections of the same tracer involving the full cortical depth were made in homotopical locations, and the distribution and soma size of retrogradely labeled thalamocortical neurons in each side of the thalamus were compared. It was found that, in the cat, labeled neurons in the lateral posterior pulvinar complex, and in paralaminar regions of the ventrolateral complex, were fewer in number and smaller in size in cases of superficial deposits than in cases of deep injection. In more lateral portions of the ventrolateral complex, however, there were no size differences. In the monkey, similar differences in number and size appeared in the caudal division of the ventrolateral complex and in the lateral posterior and pulvinar nuclei, whereas no such differences were found for neurons labeled in the oral and medial divisions of the ventrolateral complex, and in the ventral posteroinferior nucleus. In all cases the intralaminar and midline nuclei exhibited retrogradely labeled neurons only when deep layers were injected. These and previous findings point to the existence of a widely distributed layer I-projecting system of neurons which, in most nuclei, are interspersed among neurons projecting mainly to middle or deep layers. In some nuclei, however, as is the case with the ventromedial nucleus proper, layer I-projecting system neurons would make up the whole nucleus. The cell groups located in a paralaminar position, which would be but a part of this system, could provide through their projections to layer I in the posterior parietal and frontal cortical regions a final path for recruiting responses and spontaneous spindling activities.

Amidines↗
PubMed2003

Normalizing calcium intake: projected population effects for body weight.

Published data describing the inverse relationship between calcium intake and body weight in 564 women were evaluated for their dispersion around their means, and the fraction above any given weight or rate of weight gain was calculated from the parameters of the normal distribution for the variable concerned. At the 25th percentile of calcium intakes, 15% of young women were overweight, and that fraction fell to only 4% at calcium intakes in the range of currently recommended values. Similarly, obesity prevalence in this cohort fell from 1.4 to 0.2% across the same difference in calcium intakes. At midlife, women at the 25th percentile of intakes gained weight, on average, at a rate of 0.42 kg/y. This gain dropped to -0.011 kg/y at currently recommended calcium intakes. Although calcium intake explains only a small fraction of the variability in weight or weight gain, shifting the mean of the distributions downward by increasing calcium intake can be estimated to reduce the prevalence of overweight and obesity by perhaps as much as 60-80%.

Adult↗
PubMed2006

Sexual abuse histories of youth in child welfare residential treatment centers: analysis of the Odyssey Project population.

This multi-site examination of sexual abuse histories of youth in residential treatment centers asked, for the sample as a whole and by youth's gender: (a) How many perpetrators did each youth have? (b) What was the gender of the perpetrator? (c) What proportion of youth was abused by family members? (d) What proportion of youth was abused in a child welfare setting? And, (e) what proportion of sexually abused youth were also victims of physical abuse and/or neglect? Results revealed that males were more likely to have one perpetrator, a female perpetrator, and to have been abused in a child welfare setting and less likely be abused by a family member. Implications for refining programs and practices are discussed.

Adolescent↗