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Cross-cultural differences in indicators of improvement from psychosis: the case of betel nut chewing.

This paper uses a case from the Micronesian Island of Yap to illustrate that indicators of improvement from an episode of schizophrenic psychosis can vary tremendously from culture to culture. At times, the clinician must search diligently for such indicators since the patient will not verbalize any perception of improvement. A 39-year-old Yapese woman was evaluated by a psychiatrist and was found to have been psychotic for several years, suffering from gross delusions, and auditory hallucinations, flattened affect, and social isolation. In addition, she had discontinued chewing betel nut that was used daily by virtually all of her fellow islanders on Yap. Two months after beginning treatment with twice monthly injectable antipsychotic medication she was still delusional, with flat affect, and heard the same voices. She was slightly less socially withdrawn and she had interestingly resumed chewing betel nut. It seemed that she had given up betel nut chewing during the socially withdrawn phase of her illness and had resumed it as she improved and became less autistically preoccupied. In her culture, betel chewing was a main avenue of social intercourse and an intrinsic part of almost all social activities. In her particular case, the resumption of betel chewing was a primary indicator of her improvement from psychosis and reintegration into her social group.

Adult↗

Dysphoric response to neuroleptic treatment in schizophrenia and its prognostic significance.

Data on the subjective responses to neuroleptic treatment and their prognostic implications are reported from a multidimensional double-blind study of the pharmacotherapeutic process in schizophrenia. From these data it seems that the occurrence of a dysphoric response in the course of neuroleptic treatment is associated with a less favorable therapeutic response and long-term prognosis. It is suggested that the dysphoric responders, many of whom belong to the category of nuclear or poor prognosis schizophrenia, may be fundamentally different from the others.

Adult↗

[Dynamics of schizophrenic apathetic psychosyndrome treated with Navane].

The results of the examinations confirm our own previous observations as well as the observations of other authors concerning the effectiveness of Navane in chronic schizophrenia. They also throw light on the schizophrenic syndrome which is often regarded as an unavoidable defect caused by the chronic process of the disease. The adaptability of the apathetic syndrome--independent of the extent of the changes before treatment--permits in every way the conclusion that this syndrom is a dynamic structure which succumbs to the effects of therapy.

Chronic Disease↗

The role of gamma-aminobutyric acid (GABA)-benzodiazepine neurotransmission in an animal model of methamphetamine-induced psychosis.

Repeated administration of amphetamine or methamphetamine (MA) results in an augmentation of its locomotor-activating effects, which is a phenomenon known as behavioral sensitization. In humans, chronic use of the drug elicits a progressive augmentation in paranoid symptoms that closely resemble schizophrenia. Behavioral sensitization has some common properties with other forms of neural plasticity such as kindling, learning and long-term potentiation (LTP). The author examined in the present study whether behavioral sensitization could be blocked by GABA-benzodiazepine agonists, known to inhibit kindling, learning as well as LTP. Rats (Male Wistar-King rats) treated with MA (1 mg/kg, s.c.) for 10 days displayed significantly enhanced motor activity when tested with MA (1 mg/kg) after a 7-8 day withdrawal period indicating the acquisition of behavioral sensitization. Treatment with clonazepam (CZP) (0.5 and 2.0 mg/kg), a GABA-benzodiazepine agonist, prior to MA administration prevented the acquisition of sensitization. In contrast, treatment with flumazenil (Flu) (10 mg/kg), a GABA-benzodiazepine antagonist, prior to MA administration did not affect the acquisition of sensitization. And treatment with Flu prior to CZP administration suppressed the inhibitory effect of CZP. CZP had no effect on the expression of sensitization in the sensitized rats, when given prior to the MA readministration. These results suggest that stimulation of GABA-benzodiazepine receptors plays a role in the acquisition but not in the expression of behavioral sensitization.

Animals↗

Critical issues in assessing the behavioral effects of amphetamine.

Amphetamine induces a behavioral syndrome in mammals that includes a variety of repetitive behaviors. An integral component of this syndrome in humans is the presence of a thought disturbance not unlike that manifest in idiopathic paranoid schizophrenia. The consistent pattern of behavioral changes produced by amphetamine across species, when considered in light of the psychosis it elicits in humans, has suggested to many that these drug-induced changes in animals may provide a model of the endogenous psychosis in humans. Amphetamine-induced changes in open-field behavior in the rat have been the most widely studied in attempts to formulate a model for investigating the neurobiological mechanisms underlying amphetamine psychosis and paranoid schizophrenia in humans and for testing the therapeutic efficacy of new antipsychotic drugs. The procedures used to assess the behavioral response to amphetamine, however, typically include rating scales or automated recordings that by their very nature ignore those components of the behavioral response that may be most critical for developing a viable animal model of the naturally occurring psychosis. Further, open-field behavior is often recorded during arbitrarily selected intervals without consideration for the multiphasic nature of the entire amphetamine response. We discuss how incomplete descriptive analyses of the amphetamine behavioral response in rats has led to confusion in the literature and describe behavioral research that is paradigmatic of the work we believe is most likely to eventuate in significant progress in the field.

Amphetamine↗

The reduction of seizure-like behaviors through contingency management.

A 22-year-old mildly retarded male, diagnosed as epileptic and paranoid schizophrenic, was admitted to an inpatient behavior unit for a medication assessment and possible behavioral treatment of uncontrolled seizure-like behavior. Since the patient had rarely been allowed out of his living unit in the past year, treatment consisted of a half-hour walk with a preferred staff member made contingent upon a 24-hr period of time free of any occurrence of seizure-like behaviors. An ABAB reversal design was used to assess experimental control. Data indicated that seizures decreased from a mean of 0.70 per day during the initial baseline phase to 0.36 per day during the final treatment phase. Additionally, the duration of seizures decreased from a mean of 50 min per seizure during the initial baseline phase to 17 min per seizure during the final treatment phase, although the contingency was applied irrespective of duration of seizure-like activity. The patient was discharged to a transitional setting until a community placement could be located.

Adult↗

The interrelations between psychosis, behavioral disturbance, and depression in Alzheimer disease.

Behavioral changes are common in Alzheimer disease (AD), and heterogeneous in their presentation. Subtle personality changes tend to occur early; these include apathy, irritability and inability to pay attention. Later agitation, aggression and disinhibited behaviors may appear. We have utilized the Columbia University Scale for Psychopathology in Alzheimer's Disease to monitor a number of behavioral symptoms in 235 patients with early probable AD. Markov analyses were used to predict the probability of developing or retaining a given symptom at 6-month follow-up. The results show that the symptoms of psychopathology in AD fluctuate with time. Agitation was both the most frequent and persistent symptom, while paranoid delusions and hallucinations were less persistent. Most behavioral disturbances, except paranoid delusions, were associated with greater cognitive impairment. There was no association between depressive features and either cognitive or functional impairment. These results have important implications for the optimal treatment of the psychopathological symptoms of AD.

Aged↗

'Theory of mind' in violent and nonviolent patients with paranoid schizophrenia.

The role of mentalizing abilities (or theory of mind) and empathic abilities in violent behavior were studied in 24 hospitalized males with paranoid schizophrenia (ICD-10). Patients were divided into violent and nonviolent groups based on their history of committing violent acts against others. To examine these abilities, patients heard a series of 12 short scenarios depicting social situations followed by questions that require making mental state or empathic inferencing. Our results show that violent patients have more difficulties than nonviolent patients in tasks involving empathic inferencing, and better abilities in inferring cognitive-mental states in others. In addition, violence seems to be associated with a history of alcohol and drug abuse, young age, and the hostility component of the Brief Psychiatric Rating Scale. Logistic regression analyses suggest that violence is associated with the combination of hostility towards others, good mentalizing abilities and poor empathy. These results are discussed in light of recent theories on violent behavior in psychiatric populations.

Adult↗

Hemispheric imbalances masquerading as paranoid and nonparanoid syndromes?

Evidence from psychophysiological and behavioral investigations of lateralization in psychosis separates two clinical syndromes. A speculative model is offered in which the syndromes approximate the clinical features of paranoid compared with nonparanoid patients in investigations in which the groups have been distinguished in the psychology laboratory (Magaro 1980), and encompass the distinction between acute functional psychoses and classical schizophrenia (Kety 1980). A parsimonious account is provided of the hemispheric imbalances of function tht underpin the syndromes.

Adolescent↗

Modification of behavioral responses induced by electrical stimulation of the ventral tegmental area in rats.

To investigate the role of the ventral tegmental area (VTA), a source of the mesolimbic dopaminergic pathway, in paranoid psychosis, a detailed analysis of the behavioral responses induced by electrical stimulation of the VTA was made. Abnormal behavior induced by bilateral high-frequency stimulation of the VTA consisted of two components: forward locomotion and exploration. Similar responses were obtained when the nucleus accumbens (NAC) or prefrontal cortex (PFC) were stimulated. The expression of behavioral responses to stimulation was significantly attenuated by dopamine (DA) receptor or antagonists, such as haloperidol, YM-09151-2 and SCH23390. These results indicate that VTA stimulation causes a transient hyperdopaminergic state in the brain, that resembles psychostimulant-induced abnormal behavior. The effects of chronic administration of methamphetamine (MAP) on the behavioral responses to electrical stimulation of the VAT were also investigated. Although an acute administration of MAP did not affect the behavioral responses to electrical stimulation of the VTA, chronic treatment with MAP (for 2 weeks) caused a long-lasting reduction in the electrical threshold for the induction of abnormal behavior, compared with chronic saline-treated rats. It is suggested that a lasting enhancement in the behavioral response to stimulation of VTA neurons may contribute to the etiology of paranoid schizophrenia and amphetamine psychosis.

Animals↗

Methamphetamine: putting the brakes on speed.

In only recent history, illicit use of methamphetamine, once isolated to urban areas on the West Coast, has spread into rural areas of the Midwest and southern United States. Although past and current methamphetamine legislation has increased penalties for methamphetamine manufacturers and tightened restrictions on sales of known precursors, the problem still persists. In fact, a 2004 survey indicates that an alarming 6.2% of high school seniors have tried methamphetamine. A number of biological, genetic, and environmental factors influence children's and adolescents' paths to substance abuse. Nurses should recognize the symptoms of methamphetamine abuse, which include agitation; aggressive behavior; rapid mood swings; hypertension; tachycardia; and eventually lesion-marked skin, clinical depression, and paranoid psychosis. Treatment for methamphetamine addiction includes behavioral therapy. Research on pharmacologic therapy is lacking. Educating youth on methamphetamine prevention appears to be the best approach to curb the spreading use of this addictive and deadly drug.

Acute Disease↗

Borderline personality-bipolar spectrum relationship.

BACKGROUND: The relationship between borderline personality disorder (BPD) and bipolar disorders, especially bipolar-II disorder (BP-II), is unclear. Several reviews on the topic have come to opposite conclusions, i.e., that BPD is a bipolar spectrum disorder or instead that it is unrelated to bipolar disorders. Study aim was to find which items of BPD were related to BP-II, and which instead had no relationship with BP-II. METHODS STUDY SETTING: An outpatient psychiatry private practice, more representative of mood disorders usually seen in clinical practice in Italy. INTERVIEWER: A senior clinical and mood disorder research psychiatrist. PATIENT POPULATION: A consecutive sample of 138 BP-II and 71 major depressive disorder (MDD) remitted outpatients. ASSESSMENT INSTRUMENTS: The Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV) was used for diagnosing, the SCID-II Personality Questionnaire was used by patients to self-assess borderline personality traits. Interview methods: Patients were interviewed with the SCID-CV to diagnose BP-II and MDD. The questions of the Personality Questionnaire relative to borderline personality were self-assessed by patients. As clinically significant distress or impairment of functioning was not assessed by the questionnaire, a diagnosis of borderline personality disorder could not be made, but borderline personality traits (BPT) could be assessed (i.e., all DSM-IV BPD items but not the impairment criterion). RESULTS: BPT items were significantly more common in BP-II versus MDD. The best combination of sensitivity and specificity for predicting BP-II was found by using a cutoff number of BPT items > or =5: specificity was 71.4%, sensitivity was 45.9%. BPT (defined by > or =5 items) was present in 29.5% of MDD and in 46.3% of BP-II (p=0.019). Logistic regression of BP-II versus BPT items number found a significant association. Principal component factor analysis of BPT items found two orthogonal factors: "affective instability" including unstable mood, unstable interpersonal relationships, unstable self-image, chronic emptiness, and anger, and "impulsivity" including impulsivity, suicidal behavior, avoidance of abandonment, and paranoid ideation. "Affective instability" was associated with BP-II (p=0.010), but "impulsivity" was not associated with BP-II (p=0.193). Interitem correlation was low. There was no significant correlation between the two factors. DISCUSSION: Study findings suggest that DSM-IV BPD may mix two sets of unrelated items: an affective instability dimension related to BP-II, and an impulsivity dimension not related to BP-II, which may explain the opposite conclusions of several reviews. A subtyping of BPD according to these dimensions is supported by the study findings.

Bipolar Disorder↗

Dentofacial disharmony: psychological status of patients seeking treatment consultation.

A sample of 194 patients whose dentofacial disharmonies were severe enough to warrant an orthognathic surgical treatment option completed the SCL-90-R, a 90-item assessment tool used to measure current level of psychological distress. Two global and nine primary dimension scores of psychological distress were computed. The average interpersonal sensitivity, psychoticism, and obsessive-compulsive dimension scores were higher than the nonpsychiatric patient population norms for both males and females, but the confidence intervals for these dimensions were still in the upper end of the normal range of functioning (< 1 SD above the normative mean). No statistically significant differences by gender or age group were observed. Over 15% of the patients were clinically elevated on obsessive-compulsive behavior, interpersonal sensitivity problems, hostility, paranoid ideation, and psychoticism; and 24.7% qualified as a positive diagnosis for a psychiatric disorder. It appears that a surprisingly large number of individuals with dentofacial disharmonies who are seeking treatment consultation are experiencing a level of psychological distress that warrants intervention.

Adolescent↗