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PubMedDate not supplied

[Receptor potential fluctuations in a pacinian corpuscle].

On the basis of the model proposed earlier fluctuations of the receptor potential and their dependence on the value of the latter are calculated. It is shown that the model of the corpuscle as a sum of independent mechanosensitive channels with fluctuating conductivity agrees satisfactorily with the experimental data.

Electrophysiology↗
PubMed1976

[Mg, Ca-activated ATP-ase of Pacinian corpuscles].

Adenosine triphosphatase (ATPase) activated by Mg2+ or Ca2+ ions was detected in single mechanoreceptors (Pacini's corpuscles) of cat; addition of Ca2+ (10(-5)M) to Mg-ATP-ase increased the activity by the factor of 1.6. The activity optimum of Mg- or Co-ATPase was in the alkaline pH zone. A high substrate specificity of Mg, Ca-ATPase was shown. Parachlorinemercury-benzoate (5muM) considerably reduced the activity of Mg, Ca-ATPase, whereas oubain (10(-5)M) failed to affect it significantly. It is supposed that Mg, Ca-ATPase of Pacini's corpuscles was close to actomyosine -like proteins.

Adenosine Triphosphatases↗
PubMed1981

[Characteristics of soluble proteins of Pacinian corpuscles].

The paper describes some characteristics of water- and salt-soluble proteins from tissue mechanoreceptors (Pacini's corpuscles). The proteins were divided into fractions with different molecular weights with a purpose of determining fraction wise the content of nucleotides and protein-carbohydrate complexes. Possibilities of performing metabolic functions by soluble proteins and of creating a specific tissue mechanoreceptor microenvironment are discussed.

Glycoproteins↗
PubMed1991

Coding of vibrotactile stimulus frequency by Pacinian corpuscle afferents.

Psychophysical and electrophysiological techniques were used to study the encoding and processing of information about the frequency content of vibrational stimuli applied to glabrous skin in humans and cats. Trained human subjects were asked to discriminate changes in stimulus frequency and harmonic content for pairs of mono- and diharmonic sinusoidal vibrations applied to the fingertips. These psychophysical tests supplied data on what information is available to the central nervous system about the frequency components of vibratory stimuli. Electrophysiological recordings from nerves innervating the glabrous skin of the paw in cats during presentation of the same stimuli used in the psychophysical study provided data on how the peripheral nervous system encodes information about the physical parameters of cutaneous vibratory stimuli. The two sets of data indicated that the subjects derived information about the frequency of vibrotactile stimuli from the mean interval between action potentials in afferent nerve fibers activated by the stimulus.

Acoustic Stimulation↗
PubMed1958

Generator processes of repetitive activity in a pacinian corpuscle.

Response patterns resulting from repetitive mechanical stimulation of the corpuscle depend on (1) the time course of recovery of the generator potential, on (2) the recovery of critical firing height, and on (3) the stimulus strength/generator potential function. By either augmenting stimulus frequency at constant strength, or by reducing strength at constant frequency, a sequence of propagated potentials is turned into a pattern of alternating regenerative and generator responses. In such a pattern an extra impulse can be set up whenever an extra stimulus produces a generator potential of enough amplitude to reach the firing height of the corresponding period. The new requirements of firing height introduced by the refractory trail of the extra impulse determine resetting of periodicity and appearance of a "compensatory pause." The decay time of the single generator potential is independent of stimulus duration. This is interpreted as a factor determining receptor adaptation. Upon repetitive stimulation at intervals above (1/2) decay time of the single generator potential, a compound generator potential is built up which shows no spontaneous decline. However, in spite of being considerably greater than the firing height for single impulses, the constant level of depolarization of the compound generator potential is unable to produce propagated potentials. A hypothesis is brought forward which considers the generator potential to arise from membrane units with fluctuating excitability scattered over the non-myelinated nerve ending.

Nerve Endings↗