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At least 199 records · Page 11Linked to original sources
PubMed1994

Competition between dopamine, beta-receptor agonists and promethazine in Escherichia coli plasmid replication.

The substrates in the phenylalanine, metabolism play key roles in the physiological processes of bacteria. Promethazine affects the phenylalanine metabolism in Escherichia coli. The antibacterial and anti-plasmid actions of promethazine were prevented by phenylalanine, tyrosine, phenylpyruvic acid, phenylacetic acid, noradrenaline and dopamine in minimal medium. Isoproterenol (and phenoxybenzamine) reduced, while propranolol, oxyprenolol and alprenolol isomers enhanced the anti-plasmid effect of promethazine. Propranolol itself induced an anti-plasmid effect. The effects of beta-receptor agonists and antagonists on promethazine-induced anti-plasmid action serve as an indirect evidence of beta adrenergic like binding sites in E. coli. These binding sites are involved in the plasmid replication process and are connected with promethazine binding sites in bacteria.

Adrenergic beta-Agonists↗
PubMedDate not supplied

[Disorders in the phenylalanine hydroxylase system of the liver in alcoholism].

Metabolism of phenylalanine and tyrosine was impaired in chronic alcoholism as shown by an increase in concentration of phenylalanine and by a decrease in content of tyrosine in blood serum as well as by elevated urinary excretion of phenylalanine and phenylpyruvic acid and by decreased excretion of homogentisinic acid. Loading with L-phenylalanine made these impairments more distinct. The data obtained suggest that the activity of phenylalanine hydroxylase system from liver tissue is decreased in chronic alcoholism. The most distinct impairment in phenylalanine metabolism was observed in alcohol withdrawal syndrom. The decrease in the activity of phenylalanine hydroxylase system may cause an accumulation of phenylalanine and its metabolites in brain tissue at well as an impairment of biogenic amines metabolism in central nervous system.

Adult↗