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At least 199 records · Page 11Linked to original sources
PubMed1999

The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision.

A series of inductive signals are necessary to subdivide the mesoderm in order to allow the formation of the progenitor cells of the heart. Mesoderm-endogenous transcription factors, such as those encoded by twist and tinman, seem to cooperate with these signals to confer correct context and competence for a cardiac cell fate. Additional factors are likely to be required for the appropriate specification of individual cell types within the forming heart. Similar to tinman, the zinc finger- and homeobox-containing gene, zfh-1, is expressed in the early mesoderm and later in the forming heart, suggesting a possible role in heart development. Here, we show that zfh-1 is specifically required for formation of the even-skipped (eve)-expressing subset of pericardial cells (EPCs), without affecting the formation of their siblings, the founders of a dorsal body wall muscle (DA1). In addition to zfh-1, mesodermal eve itself appears to be needed for correct EPC differentiation, possibly as a direct target of zfh-1. Epistasis experiments show that zfh-1 specifies EPC development independently of numb, the lineage gene that controls DA1 founder versus EPC cell fate. We discuss the combinatorial control mechanisms that specify the EPC cell fate in a spatially precise pattern within the embryo.

Animals↗
PubMed2005

Burkitt's lymphoma: an unusual cause of lip numbness.

A 38-year-old man was referred by his dental surgeon with a painful swelling in the right mandibular sulcus and an ipsilateral numb lip. Dental infection secondary to caries was initially diagnosed but biopsy revealed this to be a Burkitt's lymphoma. After intense chemotherapy, the patient is still in remission three years later. This case is a reminder that malignancy should always be high on a clinician's list of differential diagnoses of jaw swelling associated with neurological abnormalities and prompt referral is essential.

Adult↗
PubMed2006

Surgery for leg numbness with back pain, patient controlled analgesia, phantom limb pain.

This feature presents information for patients in a question and answer format. It is written to simulate actual questions that many pain patients ask and to provide answers in a context and language that most pain patients will comprehend. Issues addressed in this issue are why back pain surgery may relieve leg numbness but not the associated back pain, patient controlled analgesia, and phantom limb pain.

Analgesia, Patient-Controlled↗
PubMed1989

[A case of Burkitt's lymphoma with numb chin syndrome as the initial manifestation].

In 1963, Calverley and Mohnac reported four cases with sensory disturbance of the mental nerve region. They emphasized the symptomatological significance of that finding because of the underlying ominous diseases. The purpose of this paper is to emphasize the clinical importance of this symptom especially as the initial manifestation of the underlying malignant diseases. A 56-year-old Japanese female was seen in consultation because of complaints of the paresthesia over the distribution of the right mental nerve, diplopia and ptosis of the right side. The patient had been well until a hundred days prior to admission, when she noted numbness with pain of the right mental nerve region. This symptom was followed by ptosis of the right side and diplopia after five weeks. MRI-CT scan revealed an abnormally low intensity echo (in T1 weighted image) of the bone around sphenoid sinus and tumor of the cavernous sinus (in T2 weighted image) compressing the right internal carotid artery. The patient was transferred to this hospital 100 days after the occurrence of the initial symptom. Physical examination revealed neither superficial lymph node swelling nor buccal tumor. Abnormal findings were restricted to the cranial nerve regions such as diplopia, adduction disturbance, sluggish light reflex of the right side and hypesthesia on the right chin, lower lip and buccal mucous membrane. Other neurological findings were not significant. Laboratory findings showed elevated LDH (1,503 IU/L). Leucocyte cell count was 7,500/mm3 with almost normal composition. CSF was normal. A diagnosis of Burkitt's lymphoma stage IV was done by nasopharynx and bone marrow biopsies.(ABSTRACT TRUNCATED AT 250 WORDS)

Burkitt Lymphoma↗
PubMed1988

[Numbness of the lower lip following general anesthesia].

UNLABELLED: Injuries to nerves of the head occur infrequently following general anesthesia. Lesions of the facial and mental nerves have been reported. CASE REPORT: A healthy 40-year-old woman was scheduled for derotation osteotomy of the left femur. The previous medical history included ten uneventful general anesthetics mainly for abdominal and orthopedic surgery. Routine preoperative investigations were unremarkable. The patient received midazolam for premedication. Induction of anesthesia was carried out with thiopental and succinylcholine. Ventilation with the anesthesia mask was difficult, and considerable pressure was exerted on the mask. Intubation of the trachea was accomplished on the second attempt after additional doses of thiopental and succinylcholine and intermittent manual ventilation by mask, which lasted for 5-6 min. The further course of anesthesia was uneventful. The surgical procedure lasted for 1 1/2 h. On the 1st day after anesthesia the patient noticed numbness of the lower lip. Perception of temperature and touch was impaired. The area of paresthesia/anesthesia corresponded to the area of innervation of the upper branches of the mental nerves. Complete remission occurred within 6 weeks. DISCUSSION: Injury to nerves of the head due to pressure applied during anesthesia is infrequent. Lesions of branches of the facial nerve--mainly the marginal mandibular branch--have been reported. We found only two case reports of injury to the mental nerve in the literature. In general, long lasting anesthesia delivered via face mask preceded the injury. It was frequently difficult to retain airway patency.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1981

Numbness after blepharoplasty: the relation of the upper orbital fat to sensory nerves.

Numbness after blepharoplasty was infrequent complication (less than 1 percent). It represents nerve injury to terminal branches of the ophthalmic division division of the trigeminal nerve which are found superior and superomedial to fat in the upper orbital fat compartments. Nerve injury has multiple mechanisms and can be avoided by recognition of the proximity of sensory nerve fibers to orbital fat and by awareness of the mechanism of injury.

Adipose Tissue↗