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[Lymphography in cancer of the prostate].

The frequency and area of lymphogenic metastasis with relation to the histological structure, differentiation and degree of local dissemination of a primary tumor were determined at lymphography of 114 patients with prostatic cancer. Lymph node involvement was often observed in poorly differentiated and solid trabecular adenocarcinoma, scirrhous cancer and locally disseminated tumors extending beyond the prostatic capsule. Metastases were usually located in the external and common inguinal lymph nodes. Lymphography was shown to be indicated to patients with a local spread of prostatic cancer (T2, T3 and T4).

Adenocarcinoma↗

Lymphography in clinically localized prostate cancer.

Lymphography demonstrates the size, position, and internal architecture of the external iliac, common iliac, para-aortic, and paracaval lymph nodes. Importantly, the "surgical obturator" nodes are also routinely opacified because they are part of the external iliac chain. Analysis of the internal architecture permits detection of metastases in nodes of normal size, an advantage over cross-sectional imaging techniques. In a prospective study of 89 unselected, previously untreated patients with carcinoma limited to the prostate or periprostatic bed, lymphography was compared with histology of lymph nodes removed at surgical staging. The sensitivity was 53% (17 of 32), specificity 93% (53 of 57), accuracy 79% (70 of 89), and positive and negative predictive values were 81% (17 of 21) and 78% (53 of 68), respectively.

Humans↗

The value of lymphography in childhood solid tumours.

The lymphographic films of 40 children with solid tumours were re-evaluated to assess the value of lymphography. In 11 children the lymphographic findings were positive. In only one child with carcinoma of the small bowel the metastatic changes in a normal-sized lymph node were probably not demonstrable on ultrasound (US) or computed tomography (CT). In the most common childhood tumours the metastatic lymph nodes were enlarged and thus demonstrable on US or CT. Therefore we suggest that US or CT should be performed first, followed by lymphography in doubtful cases only.

Adolescent↗

[Fatty cerebral embolism after lymphography].

A 25 year-old man with Hodgkin's disease, presented a confusional state with choreatic movements, 1 hour after a lymphography. CT showed high density in the heads of both caudate nuclei, and in the cortex. The patient's state improved and he entirely recovered within 2 weeks, while CT returned to normal. No right-to-left shunt was demonstrated. The mechanisms of this infrequent complication of lymphography are discussed: exceeding filtration capacity of lung because of a too rapid administration of contrast or severe lung embolism? intracardiac right-to-left shunts? microscopic arteriovenous shunts in the lung? bad venous cerebral drainage consecutive to a vena cava superior syndrome?

Adult↗

[Lymphography in malignant testicular tumors].

Experience and results are reported on the basis of more than 380 lymphographic investigations in patients with a malignant testicular tumor. In 61% of these patients, there was suspicion of a metastatic infiltration of the retroperitoneal lymph nodes. In 75 patients, histological checking of the lymphographic finding was possible on the basis of a retroperitoneal lymphadenectomy. Lymphography was shown to have a precision of 81%. Lymphography is obligatory as a complement to other techniques of investigation such as sonography and computer tomography in patients with malignant testicular tumor, since the greatest diagnostic information can be expected from combined application of all three methods.

Humans↗

[Value of lymphography in the preoperative diagnosis of gynecologic cancers].

In advanced tumors, the imaging techniques such as ultrasound, computer tomography or magnetic resonance imaging are at the forefront. In order to plan surgical procedure, lymphography is indicated as a supplementary diagnostic measure mainly in tumors of the corpus and the cervix uteri, especially in the early and middle stages. In tumors of the ovary, the vagina and the vulva, diagnostic assistance in deciding on therapy is to be expected only in occasional cases. The indication for lymphography should not only be established in relation to the tumor stage, but also tumor grading, since a very much higher local regional metastatic spreading is to be reckoned with in increasing grading, so that the choice of therapeutic procedure is crucially affected. In using preoperative diagnostic measures, the postoperative morphological follow-up should be considered: Examinability of the removed lymph nodes, especially in preoperative suspicion of metastases. Behavior of the lymph nodes in the post-therapeutic phase with consideration of recurrence diagnostics. Planning of radiotherapeutic target volume considering collateral circulations and atypical lymphatics.

Combined Modality Therapy↗

[Percutaneous fine needle cytopuncture of lymph nodes opacified by lymphography, in urogenital pathology. Apropos of 174 cases].

Percutaneous fine needle puncture of lymph nodes after lymphography with contrast has been performed in 174 patients with urogenital tumors (bladder: 108, prostate: 41, testes: 25). Conducted under direct television screen control the procedure is simple to perform and provokes little discomfort for the patient, since it is painless and relatively non-traumatic. Needle puncture is a reliable technique resulting in no false positives and very few false negatives when carried out using the previously described technique (routine sampling and technical success). Combining lymphography with needle puncture is of undoubted value for detecting extension of tumor and improving choice of therapy.

Biopsy, Needle↗

[Indications for lymphography in bladder cancer].

Proceeding from an analysis of the clinical and x-ray findings on 333 bladder cancer patients the frequency of lymphogenic metastatic spread was determined with relation to a degree of local extent of disease: T1 and T2--no metastases; T3a--metastases in 11.5%; T3b--in 30.3%; T4a--in 36.4%; T4b--in 50% of the cases. Metastases were mainly detected in the external inguinal lymph nodes. The lumbar lymph node involvement was always combined with tumorous changes in the pelvic lymphatic plexuses. Indications to lymphography with relation to a primary tumor spread (T3a, T3b and T4a) were defined. The authors determined the role of x-ray monitoring and repeated lymphography for the detection of metastases and a study of their regression caused by therapeutic measures.

Adult↗

[Metastasis of cervical cancer (based on lymphography data)].

The frequency and extent of lymphogenic dissemination of cervical carcinoma versus histologic type, growth pattern and degree of local spread of tumor were studied on the basis of clinico-roentgenological data on 131 cases. Regional metastases developed in external and general iliac lymph nodes. Locally disseminated T1b, T2a and T3 tumors made the case for lymphography because it provided data necessary for radiation treatment planning. Roentgenologic follow-up and repeated lymphography were instrumental in evaluating the effectiveness of radiation treatment and detected lymphogenic metastases in 7.3% of cases.

Adenocarcinoma↗

[Value of computer tomography and lymphography for staging of malignant testicular tumors].

Findings of computer tomographic and lymphographic examinations of 74 patients were evaluated concerning their evidence in the pretherapeutic staging compared with the histological results of lymphonodectomy. The security of the computer tomography was about 82.4%, the specifity about 95.12%, the sensitivity about 66.66%. Lymphographically, a security of 85.14%, a specifity of 95.12% and a sensitivity of 66.66% was achieved. The combination of the methods achieved a security of 91.7%, a specifity of 100% and a sensitivity of 71.72% was achieved. Metastases of lymphatic nodes less than 0.5 cm diameter were not recognized by means of the two methods. In 2 cases no metastases, which were not covered by means of computer tomography, could not be recognized lymphographically in slightly enlarged lymphatic nodes. In contrast to this in 11 out of 74 patients (14.8%) in the computer tomography an enlargement of the findings was the result in comparison to lymphography. Since none of the two methods is absolutely reliable for the proof or the exclusion of smaller metastases, in a secure evidence of the computer tomography before a lymphonodectomy the lymphography can be omitted.

Adult↗

Mesenteric lymphography and ligation of the thoracic duct in a cat with chylothorax.

Mesenteric lymphography was used to identify and ligate the thoracic duct in a 1-year-old Himalayan cat with chylothorax. Lymphography revealed the thoracic duct to be intact; however, multiple dilated lymphatics, indicative of lymphangiectasia were evident in the cranial portion of the thorax. Hemostatic clips were used to ligate the thoracic duct. The effusion stopped, and 9 months after surgery, effusion has not recurred.

Animals↗

Mediastinal lymphography using non-ionic, water-soluble contrast medium.

To circumvent the "irritative" effects of oily contrast and the high permeability of ionic water contrast medium, we reexamined the usefulness of mediastinal lymphography in dogs and patients using non-ionic (low permeability) water soluble contrast. Despite better delineation of lymph channels and nodes by indirect (transcarinal bronchofiberscopy) and direct (nodal injection at thoracotomy) mediastinal lymphography, the problem of false positive and false negative imaging remains.

Animals↗

[Lymphography and fine needle puncture biopsy in the evaluation of lymph node involvement. Apropos of 207 cases].

Percutaneous fine needle puncture biopsy was performed on lymph nodes taking up contrast during lymphography in 207 patients with various disorders: urogenital (174 cases), gynecologic (13 cases), hematologic (17), others (3). At the present time, in fact, and simultaneously with the development of physical methods of diagnostic exploration (ultrasonography, computed tomography) needle puncture biopsy has become of increasing importance to confirm a suspected diagnosis. Needle puncture biopsy under television control is a simple, painless and practically nontraumatic procedure. When performed under precise conditions and a strict methodology (routine sampling as a function of the primary glandular chains), it establishes the correct diagnosis in a large number of lymphographies, enabling a rapid and more precise evaluation of the degree of extension and thus a better therapeutic choice.

Adult↗

Does lymphography promote dissemination of tumorous disease?

In two groups of patients with malignant melanoma on the lower limb and with metastases in the inguinal lymph nodes the authors followed the time of appearance of lung metastases and the survival time. In one group lymphography of the extremity was performed, the other one served as a control. Tabulated time data were mutually evaluated between the two groups by the parametric T-test and with the aid of the nonparametric Me-test. No significant difference was found between the two groups, not even with 20% probability. Thus, lymphography is not likely to have an influence on deissemination of malignant melanoma.

Humans↗

Results of lymphography in early mycosis fungoides.

Lymphography was performed in 28 patients with mycosis fungoides. In 22 of the patients, the investigation took place prior to 2 months after the diagnosis was established, and in 7 of these lymphography was made before the histological verification of mycosis fungoides was possible. Five patients with widespread, persistent and severe atopic dermatitis served as controls. Eighteen patients with mycosis fungoides (64%) had abnormal lymphograms, while all 5 controls had normal lymphograms. Abnormal findings were diagnosed in 12 of 22 patients at the earliest time possible during the course of their disease and even found in 5 of 7 patients who only had premycotic lesions at the time of investigation. These results may have some bearing on therapy, suggesting that systemic treatment could possibly be introduced at a far earlier disease stage than is the custom at present.

Dermatitis, Atopic↗

[Lymphography in testicular tumors].

In 45 patients with tumours of the testes (5 seminomas, 40 nonseminomas) the pretherapeutic lymphographic diagnosis could be histologically tested after a retroperitoneal removal of lymph nodes. The lymphographic security was more than 82%, 4 diagnoses each were falsely positive and falsely negative. The sensitivity was 81%, the specifity 83%. With these results the lymphography meets the requirements which are made upon a diagnostic method. It shall be relevant to therapy. An increase of the security by additional examinations (tomography and cavography) is possible. Taking into consideration its limits the bipedal lymphography belongs to the obligatory spread diagnosis in tumours of the testes, its results allow an estimation of the spread of the tumour, the therapeutic effect and the prognosis of the tumour disease.

Choriocarcinoma↗

[The advantages of lymphography in malignant melanoma (author's transl)].

The authors report the results of their observations on 27 cases of malignant melanoma having undergone lymphography. They insist on the absence of risk of this examination causing diffusion of the primary tumour and the advantages of lymphography in this particular cases: clinically palpable metastatic adenopathy and high risk malignant melanoma without palpable adenopathy.

Adult↗

[Importance of direct roentgeno-radioisotope lymphography in the diagnosis of lymphogenic metastasis].

Using the results of direct x-ray-radionuclide lymphography in 119 patients with malignant tumors of different sites lymphogenic metastases were diagnosed in 68% of the cases as compared to 52% with the use of radiopaque direct lymphography only and 36.5% of the cases detected on clinical examination. This method made it possible to change in 44 out of 119 patients a stage of the disease to a more advanced one.

Biopsy↗