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At least 199 records · Page 11Linked to original sources
PubMed1983

[Phagocyte functional activity and bactericidal systems after exposure to rifampicin, lincomycin and methicillin].

To show possible mechanisms of the inhibitory effect of rifampicin, lincomycin and methicillin on the functional activity of the phagocytes, their effect on the intracellular bactericidal systems and the state of the regulatory function of the macrophages in the immunogenesis were studied. Correlation between the decrease in the values of the phagocytosis completeness and the changes in the activity of the myeloperoxidase bactericidal system and the alkaline phosphatase in the neutrophilic granulocytes was shown. The decrease in the number of the antibody producers at the maximum level of the immune response to administration of sheep red cells as the test antigen due to rifampicin or lincomycin was not accompanied by impairment of the immune regulatory function of the macrophages.

Animals↗
PubMed1978

[Aspects of the therapeutic action of proteolytic enzymes and antibiotics in experimental staphylococcal infection. The effect of lincomycin, chymotrypsin and their combinations on leukocyte phagocytic activity].

The effect of leucomycin, chimotrypsin and their combination on the leucocyte phagocytic activity was studied on mice with experimental staphylococcal infection. Lincomycin and chimotrypsin were administered in doses of 150 and 2 mg/kg respectively. In the study of the leucocyte phagocytic activity it was found on the 3rd, 7th, 14th and 21st days after the beginning of the animal infection and treatment that the experimental staphylococcal infection stimulated the non-specific phagocytosis. Lincomycin inhibited the leucocyte phagocytic activity. The use of chimotrypsin in the process of the staphylococcal infection treatment resulted in increased phagocytosis activity. The combined use of chimotrypsin and leucomycin decreased the inhibitory effect of the latter on phagocytosis.

Animals↗
PubMed1980

Sensitivity to macrolide antibiotics and lincomycin in Francisella tularensis holarctica.

Among the 345 F. tularensis holarctica strains isolated in Europe, Asia and North America, two variants were found: one sensitive and the other resistant to erythromycin, oleandomycin and lincomycin. These characteristics were not associated with virulence, antigenicity, biochemical activity or source of isolation and displayed high stability in passages in laboratory animals or multiple passages in culture media. The two variants are proposed to be designated as biotype (biovar) I, erythromycin sensitive (erys), and biotype (biovar)II, erythromycin resistant (eryR). A predominance of biotype I was observed for western Europe, eastern Siberia and the Far East, as well as North America, whereas biotype II prevailed in central Europe, the European part of USSR, especially the south, and western Siberia. The distribution of biotype II largely coincided with the habitat area of Arvicola terrestris, from which it was isolated with the highest frequency. Within the areas of biotype II prevalence, erythromycin and other macrolide antibiotics, as well as lincomycin should not be used for tularemia therapy.

Animals↗
PubMed1981

High-dose tobramycin combined with clindamycin or lincomycin in the treatment of septic peritonitis and intraabdominal sepsis.

Tobramycin in combination with clindamycin or lincomycin were used as systemic antibiotics in the treatment of 20 consecutive patients with septic peritonitis or intraabdominal sepsis, 10 of which were in septic shock. Doses were: tobramycin 1.5 mg/kg body weight every 8 hours, with prolonged dosage interval in patients with reduced renal function, clindamycin 0.9 g every 8 hours and lincomycin 1.2 g every 8 hours. Therapy was monitored by means of tobramycin serum concentration determinations and renal function tests. Eventual cure of the infection was obtained in 19 patients. In 2 of these, the effects of the antibiotics were doubtful. Side effects were observed on 8 occasions: One patient had a slight and temporary subjective hearing loss, coinciding with raised trough levels of tobramycin. Diarrhoea occurred in 3 cases and skin reactions in 3 cases. Superinfection with Candida albicans fungemia occurred in one patient. From the overall results it is concluded that the antibiotic regimen is of value in serious life-threatening infections. Although the tobramycin dose was higher than customarily used in Scandinavia at the time, 0 hour and 1 hour serum concentrations remained stable during therapy in patients whose renal function was normal at onset of therapy. Serum creatinine (S-Cr) levels in these patients were also essentially unchanged. Temporary reductions in osmolality (Osm) ratio Osm-urine/Osm-serum occurred in 11 patients despite normal S-Cr, but it was hard to attribute these impairments of renal function to tobramycin specifically. It was also doubtful whether tobramycin further aggravated renal function in those patients where it was impaired at onset of therapy. Thus, no conclusive evidence of clinically important tobramycin-induced nephrotoxicity were found. We suggest that the dosage schedule of tobramycin used in this study is applied when treating serious intraabdominal infections.

Adolescent↗
PubMed1980

[Effect of lincomycin on its own producer, Actinomyces roseolus, during prolonged passage on a liquid culture medium].

Act. roseolus rapidly lost its antibiotic activity on passages in liquid media. Degeneration with respect to the antibiotic production property was accompanied by changes in the physiological and morphological characteristics. The culture became low differentiated during the whole developmental cycle. The capacity of the ribosomes for formation of the polysomes and aggregation was decreased or completely lost. The developmental cycle of the culture was shortened because of earlier autolysis and limited formation of the daughter microcolonies. Lincomycin retarded the rate of these changes. The culture preserved its morphological similarity with the initial strain and its viability increased. Therefore, lincomycin promoted some stabilization of the properties of the culture during its passage.

Carbohydrate Metabolism↗
PubMed1980

[Characteristics of lincomycin penetration into the organs and tissues of laboratory animals].

The study on the pharmacokinetics of lincomycin and its 7-chloroderivative in rabbits and albino mice treated with the antibiotics in single and repeated doses administered parenterally or orally revealed significant differences in distribution of the drugs in the animals. The excretion rate of the lincomycins in the rabbits was much lower. They were mainly deposited in the intestine. This fact is probably one of the causes of diarrhea and colitis developing in the course of therapy with these drugs.

Animals↗
PubMed1980

[Lincomycin concentration in the blood and tissues when administered by electrophoresis in children with acute and chronic hematogenic osteomyelitis].

Twenty five children suffering from acute and chronic hematogenic osteomyelitis were subjected to lincomycin therapy in addition to surgical and general tonic treatment. The antibiotic was administered by means of electrophoresis in 15 children and by means of electrophoresis together with intramuscular injections in 10 children. It was found that administration of the drug by means of electrophoresis 1 hour after its intramuscular injection provided the highest lincomycin levels in the bone cavity favourable for the disease treatment.

Adolescent↗
PubMed1995

[Off-label use of lincomycin hydrochloride in 2 horses. Dysbacteriosis and fatal complications due to inadequate symptomatic therapy].

A lawyer inquired about the possible harmful effects of 'off-label use' of lincomycin in two trotting horses. From information in the relevant dossier it could be concluded that there was no direct indication to use antibiotics. In addition, mistakes were made in the medicinal treatment of horses, namely, the off-label use of lincomycin without prior consultation with the manufacturer, fluid and electrolyte replacement therapy not continued for long enough, and incorrect use of antipyretic analgesics. The intravenous administration of gentamicin to dehydrated patients is permissible only in combination with adequate administration of fluids and electrolytes.

Animals↗
PubMed1993

[Studies of the effect of cephradine and lincomycin on dynamics of selected parameters of nonspecific cellular immunity in experimental animals].

Rabbits of group I received cephradine i.m. and of group II lincomycin in mean therapeutic doses (calculated by body weight) for seven days. Determinations were performed before application of antibiotics and at 7, 14, 28 and 42 days of the study. Following tests were performed: phagocytosis index by determination of phagocytizing neutrophils, phagocytosis index and the NBT test. After application of cephradine, each determination revealed significant decrease of percentage of phagocytosing neutrophils, whereas phagocyte index was lowered at 14 day and the NBT value in 14 and 28 days of investigation. After application of lincomycin, value of percentage of phagocytosing neutrophils was lowered at the 14 day, and of phagocytosis index at the 7 day. NBT test values were lowered at 7 and 28 day and increased at the 42 day of the study.

Animals↗
PubMed1993

[Studies on the effect of cephradine, cefuroxime, lincomycin and amikacin on complement levels in experimental animals].

Rabbits were injected intramuscularily with antibiotics in mean therapeutic doses (calculated by body weight) for the period of 7 days. Group I received cephradine, group II--cefuroxime, group III--lincomycin and group IV--amikacin. Determination of complement level by CH50 method was performed before application of antibiotics and at 7, 14, 28 and 42 day of the study. Application of the cephalosporin antibiotics did not result in any changes in the complement level. After application of lincomycin, complement level increased at the 17 day and after amikacin treatment it was higher after 7 days of investigation.

Amikacin↗
PubMed1977

[Comparative study of the effect of aeration conditions on the biosynthesis of oxytetracycline by an actinomyces rimosus culture and of lincomycin by an Actinomyces roesolus culture].

The effect of aeration conditions on growth of the oxytetracycline- and lincomycin-producing organisms and antibiotic biosynthesis was studied. It was shown that the lincomycin-producing organism respiration rate was much higher and required better aeration condition-than the oxytetracycline-producing organism. The highest respiration rate of the young myces lium was observed in the growth phase. During the period of the antibiotic biosynthesis the rate of oxygen consumption somewhat decreased though remained sufficiently high. Decreased productivity of the mycelium at the end of the process was accompanied by a drop in the respiration rate. The lack of oxgen lowered the mycelium productivity with respect to the antibiotic formation to a much much greater extent than the culture growth rate. The limiting of the antibiotic biosynthesis process by the lack of dissolved oxygen was accompanied by changes in the culture metabolism evident from production of organic acids: ketoacids and volatile acids by Act. rimosus and volatile and lactic acids by Act. roseolus.

Aerobiosis↗
PubMed1995

[Excretion of erythromycin, clindamycin and lincomycin into the saliva].

In rabbit experiments (n = 10) the salivary and serum levels of several antibiotics were studied after per os (clindamycin, erythromycin and lincomycin) and iv. (erythromycin) administration. Erythromycin was excreted into the saliva in a considerable degree (in 60-75% of the serum level) and displayed therapeutical levels for 5-6 hrs, whereas clindamycin and lincomycin reached in the saliva only 25-30% of the serum level and therapeutic levels were maintained only for 3 hours.

Administration, Oral↗
PubMed1977

[Cytomorphological study of lincomycin toxicity].

It was concluded on the basis of the analysis pf the experimental data that lincomycin had a low cytotoxic effect in cell culture and exerted no embryotoxic effect on chick embryoes. Histological examinations showed that on intravenous administration lincomycin had a low irritating effect on the vessel walls and on intramuscular administration it had an insignificant irritating effect without any signs of total toxic effect.

Animals↗
PubMed1976

Suppression and control of experimentally induced procine coccidiosis with chlortetracycline combination, buquinolate, and lincomycin hydrochloride.

Weaned pigs were divided into nonmedicated control and medicated principal groups and 3 days later were exposed to infective oocysts comprised of mixed species of swine origin. In separate experiments, a chlortetracycline combination (plus sulfamethazine and penicilin), buquinolate, or lincomycin was administered prophylactically to the principals, starting 3 days before they were exposed to infection, and then was evaluated for efficacy against the experimental exposures. Comparisons between control and principal groups were made on the basis of fecal oocyst counts, fecal consistencies, and body weight gains. On the basis of oocyst counts, both chlortetracycline combination and buquinolate minimized the development of coccidial populations in groups given medicated feed; nonmedicated controls discharged substantial numbers of oocysts. Lincomycin medication was not effective in pigs given 111 mg/kg of feed; it was effective at dose levels of 330 mg/kg of feed and at 22 mg/kg body weight, intramuscularly. Medicated principals always gained more weight on the average than did their infected nonmedicated controls during the experiments. The data on oocyst production support the position that the 3 compounds can function as coccidiostats in swine.

Animals↗
PubMed1976

Screening and confirmatory methods for determining lincomycin residues in animal tissues.

Methods for screening and for confirming residues of lincomycin in animal tissues, both sensitive to 0.1 ppm, are described. In the screening technique, residues are extracted, cleaned up by solvent partition, and detected by microbiological plate assay. In the confirmatory technique, residues are cleaned up on an unfunctionalized macroreticular-type resin column, concentrated, chromatographed on thin layer plates, and detected by bioautography. This system was effective in identifying lincomycin in the presence of 20 other antibiotics and chemicals used in the animal health industry.

Animals↗
PubMed1976

Prophylactic lincomycin in the prevention of wound infection following appendicectomy: a double blind study.

The prophylactic use of a single dose of lincomycin in 100 patients undergoing appendicectomy reduced the incidence of postoperative wound infection from 17 to 6 per cent compared with a similar group of control patients. There was no correlation with the histological finding in the appendix, but patients with perforated appendicitis were excluded from the study. Bacteriological examination of the appendix area before surgery showed that Bacteroides fragilis and Escherichia coli were the organisms most frequently isolated. The majority of wound infections were due to B. fragilis, either alone or in association with aerobic organisms, but infection due to E. coli and Staphylococcus aureus also occurred. Systemic antibiotic therapy can successfully reduce the complications following appendicectomy but it is necessary to use a compound with activity against anaerobic organisms.

Adolescent↗
PubMed1980

Further observations in lincomycin-induced cholelithiasis in guinea-pigs.

Further experiments are reported on Lincomycin-induced cholelithiasis in guinea-pigs. The biochemical events in the bile and blood, and the chemical composition of gallstones, have been studied. The gallstones resemble human pigment stones in chemical composition. The clear hepatic bile and the normality of the bile salt--phospholipid--cholesterol equilibrium, the rise in beta-glucuronidase and hexosamine levels with the gallbladder, have reaffirmed that epithelial injury is most probably the primary lithogenic factor. Ligation of the cystic duct and the construction of a common hepatic duct-duodenum bypass did not prevent the development of acute cholecystitis, suggesting the lithogenic factor was mediated through the blood circulation and not through the enterohepatic circulation of bile.

Animals↗
PubMed1975

Familial pseudomembranous colitis and its relation to lincomycin therapy.

Severe pseudomembranous colitis was observed in 3 members of a single family: the father and 2 of his children. 2 of the affected family members received the antibiotic lincomycin prior to the onset of their symptoms. The findings in this family raise the possibility that antibiotic-induced pseudomembranous colitis in some patients may be the result of a pharmacogenetic interaction.

Adolescent↗