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At least 199 records · Page 11Linked to original sources
PubMed1990

[Morphometric analysis of the activity of alkaline phosphatase in the small intestine of piglets infected with the coccidium Isospora suis].

Gnotobiotical one-day-old piglets were infected with 100,000 Isospora suis coccidia oocysts, and were immediately killed. In piglets killed on the 3rd to 11th day after infection (DAI), the morphometric analysis of alkaline phosphatase activity was performed in the area of the microvillus zone of small intestine. In the control 2-7 days old animals, the small intestine was not equally supplied with alkaline phosphatase. In duodenum the activity reached 88.37 per cent of the active length of absorbent surface (% LAac), in the middle jejunum 95.98 per cent LAac, in the dorsal jejunum 78.63% LAac and the ileum 90.55 % LAac. The width of the active area was more balanced and ranged from 5.003 microM in the ileum to 6.129 microM in the dorsal jejunum. In infected gnotobiotical piglets the lowest activity was found out on the 3rd to 4th DAI, with a greater decline on the 9th day after infection. The range from 25.99 to 40.50 per cent LAac with minimum in the duodenum and maximum in the ileum was observed on the 3rd DAI. In the middle and dorsal ileum the activity was nearly equal (28.34 and 27.69 per cent LAac). nI the dorsal jejunum a moderate increasing was up to 47.13% LAac on the 4th DAI, with the exception of the ileum, where the activity of alkaline phosphatase decreased to 24.96% LAac. On the 9th DAI the activity of alkaline phosphatase was nearly equal in the whole small intestine (from 55.70 to 60.01% LAac) with the maximum in the middle jejunum. In the width of the reaction product a direct dependence on the total activity of alkaline phosphatase was evident only in the segment of the middle and dorsal jejunum and ileum, but merely on the period of the 3rd to 4th DAI. The lowest values were measured in the middle jejunum (0.982 micron on the 3rd DAI and 0.709 micron on the 4th DAI). No dependence was observed between the total activity and the reaction product in the middle jejunum (0.982 micron on the 3rd DAI and 0.709 micron on the 4th DAI), there was no general stabilisation of the activity of alkaline phosphatase.

Alkaline Phosphatase↗
PubMed1990

[Treatment with doxycycline and nifuroxazide of Isospora belli infection in AIDS].

Isospora belli infection is the most frequent coccidiosis after cryptosporidiosis in AIDS patients. Chronic watery diarrhea is observed. Trimethoprim-sulfamethoxazole is the recommended treatment. Four AIDS patients were intolerant to this drug and were treated with doxycycline and nifuroxazide. Three patients were cured. Two patients died of other infections. The two last patients relapsed and were treated again with long term doxycycline. No relapse occurred during the following twelve months.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[The ratio of enterocytes and goblet cells in the mucosa of the small intestine in experimental infection of piglets with the coccidium Isospora suis].

The proportions of cup-shaped cells and enterocytes were studied in piglets infected the first and fifth day after birth with 200,000 oocysts of Isospora suis. The greatest imbalance was found in the ratio of the cells of the intestinal mucous membrane in the region of middle and lower jejunum (ratio of 10:1.75)--this was recorded the third to fourth day after infection when the ratio made 10:0.62, whereas in the control animals it was 10:5.7. On the eighth to ninth day after infection the number of cup-shaped cells began to increase, the ratio reaching the values of 10:2.62. Even the 13th day after infection the ratio remained far from normal (10:2.50).

Animals↗
PubMed1989

[Mucus synthesis in the goblet cells of the small intestine in experimental infection with the coccidium Isospora suis in piglets].

The state of mucus synthesis in the goblet cells of the small intestine was studied in conventional piglets infected with a dose of 200,000 oocytes of the coccidium Isospora suis the first and fifth day after parturition. The synthesis of mucus and its chemical characteristics undergo significant changes during the third and fourth day after infection. The activity of acid and neutral mucous substances declines; their level and the physiological synthetic function of goblet cells begin to return to the normal during the period starting on the eight to tenth day after infection. However, there were no fully functioning goblet cells in the broken numerical ratio even at the end of the period of investigation, i.e. the 13th day after infection. The thin surface layer of mucus remained almost unchanged within the whole extent of the small intestine parts studied.

Animals↗
PubMed1989

[Alkaline phosphatase activity levels during infection with the coccidia Isospora suis in piglets].

The activity of alkaline phosphatase (EC 3.1.3.1.) was studied in the small intestines of piglets infected with the coccidia Isospora suis on the first and fifth day of age. Alkaline phosphatase activity is reduced significantly the third to fourth day after infection (DAI) throughout the small intestine in piglets infected on the fifth day of age. Similar results were obtained in the piglets killed the eighth to tenth DAI which had also been infected on the fifth day of their age. Piglets infected the first day of age and killed on the 8th to 13th DAI exhibited no larger differences from the above-mentioned groups, but alkaline phosphatase activity was distributed more regularly all over the surface of the villi. The normal values, comparable with the controls, were not obtained within 13 days after infection (piglet age 14 days).

Alkaline Phosphatase↗
PubMed1989

[Activity of selected dehydrogenases and monoamine oxidases in the small intestine of gnotobiotic piglets infected with the coccidium Isospora suis].

In the small intestine of 16 gnotobiotic piglets infected a day post partum (DPP) by Isospora suis coccidia the activities were studied of selected dehydrogenases and monoaminoxidase (O2 oxidoreductase, MAOx, EC 1.4.3.4.). The following dehydrogenases were investigated: succinate dehydrogenase (SDH, EC 1.3.99.1.), glycerol-3-phosphate dehydrogenase (glycerol-3-phosphate:menadion oxidoreductase, GPOX, EC 1.1.99.5.) and tetrazolium oxidoreductase (NADH, ES 1.6.99.3.). The activities of NADH and GPOX were found to decrease, a decrease being somewhat milder in MAOx, at a high infection dose of I. suis oocysts (750,000 oocysts), in comparison with the control, already on the first day after infection (DAI). The SDH levels did not change. In piglets infected by a low infection dose of I. suis oocysts a double marked decrease (negative to slightly positive finding) was recorded in the period from the third to the eighth day after infection (DAI). A similar pattern with a longer time interval between the decreases was observed in GPOX (4th to 11th day after infection). The findings of SDH and MAOx activities were different. The SDH activity is maintained at the same level (++) for the whole period of investigation and there occurs a decrease (+) only on the 9th day after infection, persisting until 11 DAI. The MAOx activity and its change correspond to the SDH activity; the difference being that in the second group the starting level is high ( ) and on the eleventh day after infection it is low or medium (0-++), in comparison with the standard. This variability is discernible from 8th DAI.

Animals↗
PubMed1989

Case report--the acquired immunodeficiency syndrome and isospora belli infection.

A patient with the acquired immunodeficiency syndrome (AIDS) presenting with isospora belli infection is reported. The difficulties encountered in the diagnosis and therapy of isosporiasis are discussed. The diarrhoea responded to treatment with intravenous fluid replacement and oral furazolidone.

Acquired Immunodeficiency Syndrome↗
PubMed1988

[Isospora belli coccidiosis in immunocompetent subjects (a study of 40 cases seen in Paris)].

35 of the 40 cases with Isospora belli infection were from France: 33 patients presenting with "travellers diarrhoea" were infected abroad (especially in tropical Africa and the Middle East) but 7 were infected in France itself. Charcot-Leyden crystals were found together with I. belli oocysts in the stools of 35 subjects. 61% of the cases presented with hypereosinophilia of between 6 and 20%. The average eosinophilia was 7.6% or 649/mm3.

Adult↗
PubMed1988

[11 cases of isosporiasis (Isospora belli) in patients with AIDS].

The study of 11 cases of isosporiasis (Isospora belli) shows that this opportunistic coccidia, alone or with Cryptosporidium, causes severe prolonged diarrhoea which worsens the prognosis and evolution of AIDS patients. A low prevalence (0.7%) is found in subjects from tropical regions. The results of treatment are disappointing. Bactrim is the only drug found to be effective but prolonged parasitological surveillance is required to detect the frequent relapses, and assess the long-time usefulness of this drug.

Acquired Immunodeficiency Syndrome↗
PubMed1977

Host range characteristics of the primate coccidian, Isospora arctopitheci Rodhain 1933 (Protozoa: Eimeriidae).

Studies were conducted on 35 primates, 12 carnivores, and 2 marsupials to determine their susceptibility to the primate coccidian, Isospora arctopitheci. Patent oocyst infections resulted in 12 of the 14 species of animals investigated. These included 6 genera of New World primates native to Panama: Saguinus geoffroyi, Aotus trivirgatus, Ateles fusciceps, Cebus capucinus, Alouatta villosa, and Saimiri sciureus. In addition 4 families of carnivores (2 domestic and 2 sylvatic) and 1 species of marsupial became infected following experimental exposure. These animals are represented respectively by the following 6 genera and species: Canis familiaris; Felis catus; Nasua nasua, and Potos flavus; Eiria barbara; and Didelphis marsupialis. Four Old World rhesus monkeys, Macaca mulatta, and 1 carnivore, Bassaricyon gabbii, did not become oocyst positive. This unusually large host range makes this isosporan unique among the coccidia that have been investigated to date.

Alouatta↗
PubMed1983

Isospora belli infection as a cause of diarrhoea.

A case of Isospora belli infection in Thailand is reported. An 18 month-old Thai girl from a foster home was hospitalized for acute mucous diarrhoea. Immature oocysts of I. belli were detected in the stool examination by simple saline smear. The symptoms subsided spontaneously with the disappearance of parasite from the stools on the fifth day. The pathogenesis of mucous diarrhoea and the route of transmission was discussed.

Coccidiosis↗
PubMed1982

Induced Toxoplasma gondii, Toxocara canis, and Isospora canis infections in coyotes.

Six littermate laboratory-raised coyotes (No. 1-6) were used to study the transmission of Toxoplasma gondii from cats and mice, and Toxocara canis and Isospora canis from dogs and mice. Coyotes 1 and 2 were inoculated orally with 1,000 infective oocysts of the TC-1 strain of T gondii; coyotes 3 and 4 were fed mice infected with tissue cysts of the TC-1 strain of T gondii. Eight days after inoculation with T gondii, the same 4 coyotes were exposed to Toxocara canis: coyotes 1 and 2 were inoculated orally with 500 embryonated eggs, and coyotes 3 and 4 were fed mice infected with Toxocara canis. Fifteen days after exposure to Toxocara canis, the same 4 coyotes were fed mice infected with I canis. Two coyotes (No. 5 and 6) did not receive any organism and they served as controls. All 4 inoculated coyotes remained clinically normal but became infected with all 3 organisms. Toxoplasma gondii was recovered from the brain, heart, diaphragm, and muscles of limbs of coyotes killed 49 and 66 days after inoculation with oocysts, but only from muscles of limbs of coyote 4, killed at 84 days, and from the brain and muscles of limbs of coyote 3, killed at 72 days after feeding infected mice. Control coyotes did not acquire any of the 3 infections.

Animals↗
PubMed1975

A murine Sarcocystis that causes an Isospora-like infection in cats.

Sarcocysts similar to those of Sarcocystis muris were found in mice from the Iowa State University Mouse Genetics Laboratory. Muscle tissue from these mice was fed to 8 cats. Five cats developed an isosporan infection with oocysts most like those of Isospora felis. Sporulated oocysts from cat feces were fed to mice. In about 100 days mice developed sarcocysts that were visible to the unaided eye. Three cats were fed muscle tissue from the experimentally infected mice, and all cats developed an I. felis-like infection. Three cats fed muscle tissue from control mice from the same colony as the experimental mice did not develop isosporan infections. Thus it is demonstrated that this murine Sarcocystis is part of an isosporan life cycle.

Animals↗