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Results for “Immunologic Memory”

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At least 199 records · Page 11Linked to original sources
PubMed1998

Immunological memory after somatic transgene immunization is positively affected by priming with GM-CSF and does not require bone marrow-derived dendritic cells.

Inoculation of plasmid DNA is a promising vaccination approach but optimal regimes and ways to enhance immunogenicity remain to be established. Among natural immunological adjuvants, granulocyte-macrophage colony-stimulating factor (GM-CSF) was shown to increase the potency of immunization against tumor cells and protein antigens. Here we studied the effect of GM-CSF on memory responses against a 12-mer B cell epitope in mice primed with a single DNA inoculation. The results show that GM-CSF given at priming as a DNA/GM-CSF chimeric vaccine enhances the magnitude of the anamnestic response irrespective of the form of antigen used subsequently in the booster immunization. Using mice lacking bone marrow-derived dendritic cells we also determined that the enhancing effect is not strictly dependent on these cells. These results expand our understanding of the activity of GM-CSF in vivo as a modulator of the immune response including immunological memory.

Animals↗
PubMed1978

[Suppressive effect of normal lymphoid cells on manifestations of immunologic memory].

The authors studied the influence of the cells of normal lymphoid organs on the level of immunological response in the recipients of splenic cells from the suppressed animals. The organ cells were mixed with the suppressed ones and were administered to the recipients together with the reimmunizing dose of the antigen. Cells of the spleen, of the lymph nodes, the thymus or of the bone marrow suppressed the capacity of the memory cells to the realization of the immunological response to sheep red blood cells and egg albumin. The spleen cells of one and a half month old mice were more active than the cells of young or old animals. The suppressor activity persisted after the administration to donors of various doses of cortisone or heating of the cells transferred at 56 degrees C. Treatment with T-antiserum or heating at 80 degrees C led to reduction of the suppressor action of normal cells.

Age Factors↗
PubMed1975

[Natural immune response and immunological memory in the effects of a 2d unrelated antigen].

In combined administration of two nonaffiliated erythrocytic antigens there can be seen both depression and stimulation of the immunological response to the participating antigens. The end result of the interaction depended on the "power", the dose and the order of administration of the antigens. Distribution of the antigen in the animals whose immune response was depressed as a result of preliminary administration of the nonaffiliated antigen remained unchanged. The factor determining the effect on the immunological response to the other antigen did not serve as an antibody.

Animals↗