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At least 199 records · Page 11Linked to original sources
PubMed1975

Determination of the Optimum temperature for regional renal hypothermia during temporary renal ischaemia.

To determine the optimum temperature at which the in situ kidney should be maintained while it is ischaemic, 47 mongrel dogs were studied. 35 of these underwent 90 minutes of left renal ischaemia with the kidney temperature maintained at 37 degree, 30 degree, 22 degree, 15 degree and 0 degree C respectively. The effect on renal function was determined by measurements of G.F.R. before and at regular 15-minute intervals after the inschaemic period. Computer statistical analysis exposed the optimum temperature to be 15 degree C. Renal artery blood flow, renal histology, 15-Cr labelled platelets and renal arteriography were used to determine the mechanism of ischaemic injury. Quantitation of renal cell injury confirmed that no additional protection to ischaemia could be gained by colling below 15 degree C. 15 degree C is recommended as the optimum temperature for use in clinical renal hypothermia.

Aminohippuric Acids↗
PubMedDate not supplied

Different effect of diatrizoate and iopamidol on prostaglandin synthesis in perfused hamster lungs.

The synthesis of prostaglandins and other metabolic products of arachidonic acid (AA) was investigated in isolated perfused lungs of hamsters during the infusion of various concentrations of meglumine diatrizoate and iopamidol. Forty nmol of 14C-AA was infused into the pulmonary circulation with radiographic contrast media (RCM), and prostaglandins, thromboxanes, and metabolites of lipoxygenases were analyzed from the nonrecirculating perfusion effluent. Arachidonate infusion increased the perfusion pressure. This pressor response was decreased by iopamidol but was not changed by diatrizoate. The amount of radioactivity was decreased in the perfusion effluent and increased in lung lipids by iopamidol. Meglumine diatrizoate increased radioactivity in the effluent with minimal effects on the distribution of radioactivity in lung lipids. Almost all arachidonate metabolites were decreased significantly by iopamidol when compared with hypertonic saline whereas diatrizoate caused an increasing trend in the formation of the metabolites of AA. The present study shows that ionic and nonionic RCM have different effects on the metabolism of arachidonic acid.

Animals↗