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PubMedDate not supplied

Diet and hyperkinesis: a review of the controversy.

Controlled scientific evaluation of the efficacy of the Kaiser-Permanente diet has just begun and no studies have proved or disproved its usefulness in controlling the hyperkinetic syndrome. Further studies with good controls are needed. The best studies done so far tend to support the thesis that control of diet may influence the disorder. It has not been shown that diet is the most important variable; nor have the effective substances been identified. The Kaiser-Permanente diet appears to be basically sound and perhaps superior to a normal diet, with the exception of its low Vitamin C content. Careful monitoring of the child on this diet by a professional would be advisable. The hyperkinetic syndrome may represent more than one disease entity and may, therefore, require different forms of therapy. A careful evaluation of the individual case should be made, considering diet; behavioral, psychological, and physical problems; and learning disabilities, before the diagnosis of hyperkinetic syndrome is established. Cooperation of the physician, educator, and psychologist is required. The best form of treatment (dietetic, psychiatric, behavioral, or pharmaceutic) should be predicated upon the assessment by these professionals.

Diagnosis, Differential↗
PubMed1976

Food additives and hyperkinesis: a controlled double-blind experiment.

A double-blind crossover trial involving a control diet and a diet eliminating artificial flavors, colors, and natural salicylates as recommended by Feingold was conducted on 15 hyperkinetic children. Teachers and parents observed the children for one month prior to treatment, using standardized rating scales. Both parents and teachers reported fewer hyperkinetic symptoms on the K-P diet as compared to the pretreatment baseline. The teachers noted a highly significant reduction of symptoms on the K-P diet as compared to the control diet but the parents did not. The control diet ratings did not differ from the baseline period ratings for either parents or teachers. It is concluded that the K-P diet may reduce hyperkinetic symptoms, though this result is put forth with caution in view of several features inherent in the present study which need further evaluation, including objective measures of change, manipulation of the independent variable, and reducing the independent variable to more specific components.

Child↗
PubMed1993

[The effect of the activation and blockade of the neostriatal dopaminergic system on the hyperkinesis evoked in rats by the intrastriatal administration of picrotoxin].

The effects of three-week daily intrastriatal 5 micrograms picrotoxine microinjections (m.i.) and influences of preceding similar haloperidol, metoclopramide (5 micrograms) or amphetamine (15 micrograms) m.i. in rats were investigated. The oro-facial dyskinesia and intensive choreo-myoclonic limb jerks (with the distinct generalization) after the picrotoxine m.i. were prevented by metoclopramide and party inhibited by haloperidol intrastriatal m.i. No hyperkinetic stimulant effects of amphetamine were registered, on the contrary--some inhibiting effect of its m.i. 20-24 hours before picrotoxin were observed. The role of the striatal GABA and dopamine systems in neuromotor dyskinesias and their functional relationship are discussed.

Amphetamine↗