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PubMedDate not supplied

Time course for plasma 11-hydroxycorticosteroid elevation in rats during stress.

The time course of plasma 11-hydroxysteroid elevation was studied in two stress situations: regular unsignalled foot shock which produces an intermediate steroid elevation and irregular signalled foot shock with the possibility of escape, which produces an extreme steroid elevation. The initial time course for steroid elevation followed a similar pattern for both treatment groups with the exception that in the irregular signalled group the plasma steroid elevation was more pronounced and there was an indication of biphasic response. The results are discussed in terms of possible inhibitory feedback pathways.

11-Hydroxycorticosteroids↗
PubMed1975

Correlation of pre-treatment serum 17-hydroxycorticosteroid values with survival in patients with prostatic cancer.

Total 17-OHCS values were determined before and after treatment in 715 patients with all stages of prostatic cancer. The pre-treatment 17-OHCS level was an important variable in predicting survival and appeared to be a better prognostic indicator of death in the first year than the patient's age, treatment or stage of disease. Generally, the higher the initial value of serum 17-OHCS the greater the probability of death in the first year of treatment. There was no preponderance of one type of death over another when patients with initial high and low values were compared.

17-Hydroxycorticosteroids↗
PubMed2003

Air oxidation of 17-hydroxycorticosteroids catalyzed by cupric acetate: formation of hemiacetal dimers.

Hydrocortisone, cortexolone, hydrocortisone-17-butyrate, and budesonide were oxidized into alpha-ketoaldehydes by air exposure in the presence of Cu(OAc)(2). When free hydroxyl functions were present at position 17, hydrocortisone and cortexolone, the formed oxidation products, were identified as hemiacetal dimeric structures involving the free hydroxyl functions at position 17 and the newly formed aldehydes at position 21. Dimeric structures were established by using 1H913C0 correlations (HSQC and HMBC) and 1H-1H correlations (COSY and ROESY). The hemiacetal function was further confirmed by reaction of the dimer formed from hydrocortisone with two equivalents of 3-methyl-2-benzotriazolinone hydrazine (MTBH), giving quantitatively two equivalents of the 3-methyl-2-benzotriazolinone hydrazone of 21-dehydrohydrocortisone. When no free hydroxyl function was present as in the case of hydrocortisone-17-butyrate and budesonide, the expected alpha-ketoaldehydes were obtained.

17-Hydroxycorticosteroids↗